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  1. Article ; Online: SU-E-J-87: Building Deformation Error Histogram and Quality Assurance of Deformable Image Registration.

    Park, S B / Kim, H / Yao, M / Ellis, R / Machtay, M / Sohn, J W

    Medical physics

    2012  Volume 39, Issue 6Part7, Page(s) 3672

    Abstract: Purpose: To quantify the systematic error of a Deformable Image Registration (DIR) system and establish Quality Assurance (QA) procedure.: Methods: To address the shortfall of landmark approach which it is only available at the significant visible ... ...

    Abstract Purpose: To quantify the systematic error of a Deformable Image Registration (DIR) system and establish Quality Assurance (QA) procedure.
    Methods: To address the shortfall of landmark approach which it is only available at the significant visible feature points, we adapted a Deformation Vector Map (DVM) comparison approach. We used two CT image sets (R and T image sets) taken for the same patient at different time and generated a DVM, which includes the DIR systematic error. The DVM was calculated using fine-tuned B-Spline DIR and L-BFGS optimizer. By utilizing this DVM we generated R' image set to eliminate the systematic error in DVM,. Thus, we have truth data set, R' and T image sets, and the truth DVM. To test a DIR system, we use R' and T image sets to a DIR system. We compare the test DVM to the truth DVM. If there is no systematic error, they should be identical. We built Deformation Error Histogram (DEH) for quantitative analysis. The test registration was performed with an in-house B-Spline DIR system using a stochastic gradient descent optimizer. Our example data set was generated with a head and neck patient case. We also tested CT to CBCT deformable registration.
    Results: We found skin regions which interface with the air has relatively larger errors. Also mobile joints such as shoulders had larger errors. Average error for ROIs were as follows; CTV: 0.4mm, Brain stem: 1.4mm, Shoulders: 1.6mm, and Normal tissues: 0.7mm.
    Conclusions: We succeeded to build DEH approach to quantify the DVM uncertainty. Our data sets are available for testing other systems in our web page. Utilizing DEH, users can decide how much systematic error they would accept. DEH and our data can be a tool for an AAPM task group to compose a DIR system QA guideline. This project is partially supported by the Agency for Healthcare Research and Quality (AHRQ) grant 1R18HS017424-01A2.
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1118/1.4734922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Network meta-analyses of systemic treatments for psoriasis: a critical appraisal: Original Articles: Jabbar-Lopez ZK, Yiu ZZN, Ward V et al. Quantitative evaluation of biologic therapy options for psoriasis: a systematic review and network meta-analysis. J Invest Dermatol 2017; 137:1646-54. Sbidian E, Chaimani A, Garcia-Doval I et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev 2017; 12:CD011535.

    Ellis, A G / Flohr, C / Drucker, A M

    The British journal of dermatology

    2018  Volume 180, Issue 2, Page(s) 282–288

    Abstract: Aim: There are numerous systemic medications in use for psoriasis, with additional investigational agents being studied. However, head-to-head, randomized clinical trials are rare and cannot feasibly compare all treatments. A network meta-analysis (NMA) ...

    Abstract Aim: There are numerous systemic medications in use for psoriasis, with additional investigational agents being studied. However, head-to-head, randomized clinical trials are rare and cannot feasibly compare all treatments. A network meta-analysis (NMA) synthesizes the available evidence to provide estimates for all pairwise comparisons. Here, we summarize and appraise two recent NMAs that assessed systemic therapies for moderate-to-severe psoriasis.
    Setting and design: Two systematic reviews searched databases and the grey literature to identify relevant randomized clinical trials.
    Study participants: The reviews mostly included trials that involved adults with moderate-to-severe psoriasis. One of the reviews also included two trials involving children.
    Study exposure: Interventions common to both reviews include adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, secukinumab and methotrexate. One of the reviews included additional interventions, primarily other biological agents along with new small-molecule treatments and systemic conventional treatments.
    Primary outcomes: One review focused on 'clear/nearly clear' and withdrawals from adverse events as study outcomes, while the second review focused on improvement of ≥ 90% measured on the Psoriasis Area and Severity Index (PASI 90) and serious adverse events.
    Outcomes: Additional outcomes included quality of life, PASI 75, Physician's Global Assessment of 0/1 and any adverse event.
    Results: Overall, both NMAs are of high quality and provide a comprehensive summary of the evidence base and treatment effects. Results, in terms of both estimates and rankings, suggest that newer biologics targeting the interleukin (IL)-12/23 and IL-17 axes appear to be more effective than older biologics and oral agents.
    Conclusions: Patients, clinicians and policy makers can use the relative efficacy assessments of NMAs to inform decision making regarding the clearance of psoriasis skin lesions at relevant time points and improvement in quality of life.
    MeSH term(s) Adult ; Biological Therapy ; Child ; Etanercept ; Humans ; Network Meta-Analysis ; Psoriasis ; Quality of Life
    Chemical Substances Etanercept (OP401G7OJC)
    Language English
    Publishing date 2018-12-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.17335
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  3. Article ; Online: Enantioselective total synthesis of brevetoxin A: unified strategy for the B, E, G, and J subunits.

    Crimmins, Michael T / Ellis, J Michael / Emmitte, Kyle A / Haile, Pamela A / McDougall, Patrick J / Parrish, Jonathan D / Zuccarello, J Lucas

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2009  Volume 15, Issue 36, Page(s) 9223–9234

    Abstract: ... as well as 22 tetrahedral stereocenters. Herein, we describe a unified approach to the B, E, G, and J ... technologies developed in our laboratory allowed access to the precursor acyclic dienes for the B, E, and G ...

    Abstract Brevetoxin A is a decacyclic ladder toxin that possesses 5-, 6-, 7-, 8-, and 9-membered oxacycles, as well as 22 tetrahedral stereocenters. Herein, we describe a unified approach to the B, E, G, and J rings based upon a ring-closing metathesis strategy from the corresponding dienes. The enolate technologies developed in our laboratory allowed access to the precursor acyclic dienes for the B, E, and G medium-ring ethers. The strategies developed for the syntheses of these four monocycles ultimately provided multigram quantities of each of the rings, supporting our efforts toward the completion of a convergent synthesis of brevetoxin A.
    MeSH term(s) Alkylation ; Cyclization ; Ethers/chemical synthesis ; Ethers/chemistry ; Marine Toxins/chemical synthesis ; Marine Toxins/chemistry ; Molecular Structure ; Oxocins/chemical synthesis ; Oxocins/chemistry ; Stereoisomerism ; Structure-Activity Relationship
    Chemical Substances Ethers ; Marine Toxins ; Oxocins ; Brevetoxin A (98112-41-5)
    Language English
    Publishing date 2009-08-04
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.200900776
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  4. Article ; Online: The Effects of Signal to Noise Ratio, T60 , Wide-Dynamic Range Compression Speed, and Digital Noise Reduction in a Virtual Restaurant Setting.

    Ellis, Gregory M / Crukley, Jeff / Souza, Pamela E

    Ear and hearing

    2024  Volume 45, Issue 3, Page(s) 760–774

    Abstract: Objectives: Hearing aid processing in realistic listening environments is difficult to study effectively. Often the environment is unpredictable or unknown, such as in wearable aid trials with subjective report by the wearer. Some laboratory experiments ...

    Abstract Objectives: Hearing aid processing in realistic listening environments is difficult to study effectively. Often the environment is unpredictable or unknown, such as in wearable aid trials with subjective report by the wearer. Some laboratory experiments create listening environments to exert tight experimental control, but those environments are often limited by physical space, a small number of sound sources, or room absorptive properties. Simulation techniques bridge this gap by providing greater experimental control over listening environments, effectively bringing aspects of the real-world into the laboratory. This project used simulation to study the effects of wide-dynamic range compression (WDRC) and digital noise reduction (DNR) on speech intelligibility in a reverberant environment with six spatialized competing talkers. The primary objective of this study was to determine the efficacy of WDRC and DNR in a complex listening environment using virtual auditory space techniques.
    Design: Participants of greatest interest were listeners with hearing impairment. A group of listeners with clinically normal hearing was included to assess the effects of the simulation absent the complex effects of hearing loss. Virtual auditory space techniques were used to simulate a small restaurant listening environment with two different reverberation times (0.8 and 1.8 sec) in a range of signal to noise ratios (SNRs) (-8.5 to 11.5 dB SNR). Six spatialized competing talkers were included to further enhance realism. A hearing aid simulation was used to examine the degree to which speech intelligibility was affected by slow and fast WDRC in conjunction with the presence or absence of DNR. The WDRC and DNR settings were chosen to be reasonable estimates of hearing aids currently available to consumers.
    Results: A WDRC × DNR × Hearing Status interaction was observed, such that DNR was beneficial for speech intelligibility when combined with fast WDRC speeds, but DNR was detrimental to speech intelligibility when WDRC speeds were slow. The pattern of the WDRC × DNR interaction was observed for both listener groups. Significant main effects of reverberation time and SNR were observed, indicating better performance with lower reverberation times and more positive SNR.
    Conclusions: DNR reduced low-amplitude noise before WDRC-amplified the low-intensity portions of the signal, negating one potential downside of fast WDRC and leading to an improvement in speech intelligibility in this simulation. These data suggest that, in some real-world environments that include both reverberation and noise, older listeners with hearing impairment may find speech to be more intelligible if DNR is activated when the hearing aid has fast compression time constants. Additional research is needed to determine the appropriate DNR strength and to confirm results in wearable hearing aids and a wider range of listening environments.
    MeSH term(s) Humans ; Speech Perception ; Hearing Loss, Sensorineural/rehabilitation ; Signal-To-Noise Ratio ; Restaurants ; Noise ; Hearing Aids
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603093-2
    ISSN 1538-4667 ; 0196-0202
    ISSN (online) 1538-4667
    ISSN 0196-0202
    DOI 10.1097/AUD.0000000000001469
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  5. Article: The opposing roles of lethal and nonlethal effects of parasites on host resource consumption.

    Resetarits, Emlyn J / Ellis, William T / Byers, James E

    Ecology and evolution

    2023  Volume 13, Issue 4, Page(s) e9973

    Abstract: Although parasites can kill their hosts, they also commonly cause nonlethal effects on their hosts, such as altered behaviors or feeding rates. Both the lethal and nonlethal effects of parasites can influence host resource consumption. However, few ... ...

    Abstract Although parasites can kill their hosts, they also commonly cause nonlethal effects on their hosts, such as altered behaviors or feeding rates. Both the lethal and nonlethal effects of parasites can influence host resource consumption. However, few studies have explicitly examined the joint lethal and nonlethal effects of parasites to understand the net impacts of parasitism on host resource consumption. To do this, we adapted equations used in the indirect effects literature to quantify how parasites jointly influence basal resource consumption through nonlethal effects (altered host feeding rate) and lethal effects (increased host mortality). To parametrize these equations and to examine the potential temperature sensitivity of parasite influences, we conducted a fully factorial lab experiment (crossing trematode infection status and a range of temperatures) to quantify feeding rates and survivorship curves of snail hosts. We found that infected snails had significantly higher mortality and ate nearly twice as much as uninfected snails and had significantly higher mortality, resulting in negative lethal effects and positive nonlethal effects of trematodes on host resource consumption. The net effects of parasites on resource consumption were overall positive in this system, but did vary with temperature and experimental duration, highlighting the context dependency of outcomes for the host and ecosystem. Our work demonstrates the importance of jointly investigating lethal and nonlethal effects of parasites and provides a novel framework for doing so.
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.9973
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  6. Article ; Online: Ultrahigh magnetic resonance contrast switching with water gated polymer-silica nanoparticles.

    Yuan, Daohe / Ellis, Connor M / Mózes, Ferenc E / Davis, Jason J

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 40, Page(s) 6008–6011

    Abstract: ... Very ... ...

    Abstract Very high
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01205k
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  7. Article ; Online: Social Class, Sex, and the Ability to Recognize Emotions: The Main Effect is in the Interaction.

    Brener, Susan A / Frankenhuis, Willem E / Young, Ethan S / Ellis, Bruce J

    Personality & social psychology bulletin

    2023  , Page(s) 1461672231159775

    Abstract: Previous research has demonstrated an inverse relation between subjective social class (SSC) and performance on emotion recognition tasks. Study 1 ( ...

    Abstract Previous research has demonstrated an inverse relation between subjective social class (SSC) and performance on emotion recognition tasks. Study 1 (
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2047603-6
    ISSN 1552-7433 ; 0146-1672
    ISSN (online) 1552-7433
    ISSN 0146-1672
    DOI 10.1177/01461672231159775
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  8. Article ; Conference proceedings: The Effect of Pulsed Therapeutic Ultrasound on Equine Bone Marrow-Derived Mesenchymal Stem Cells

    Vermillion, E. A. / Ellis, K. L. / Gordon, J. / Moorman, V. J. / Peroni, J.

    VCOT Open

    2024  Volume 07, Issue S 01

    Event/congress 2024 American College of Veterinary Sports Medicine and Rehabilitation Symposium Scientific/Clinical Abstract Sessions, Arthrex Campus, Naples, Florida, United States, 2024-04-11
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2934191-7
    ISSN 2625-2325 ; 2625-2325
    ISSN (online) 2625-2325
    ISSN 2625-2325
    DOI 10.1055/s-0044-1786210
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  9. Article ; Online: Axion dark matter: What is it and why now?

    Chadha-Day, Francesca / Ellis, John / Marsh, David J E

    Science advances

    2022  Volume 8, Issue 8, Page(s) eabj3618

    Abstract: The axion has emerged in recent years as a leading particle candidate to provide the mysterious dark matter in the cosmos, as we review here for a general scientific audience. We describe first the historical roots of the axion in the Standard Model of ... ...

    Abstract The axion has emerged in recent years as a leading particle candidate to provide the mysterious dark matter in the cosmos, as we review here for a general scientific audience. We describe first the historical roots of the axion in the Standard Model of particle physics and the problem of charge-parity invariance of the strong nuclear force. We then discuss how the axion emerges as a dark matter candidate and how it is produced in the early universe. The symmetry properties of the axion dictate the form of its interactions with ordinary matter. Astrophysical considerations restrict the particle mass and interaction strengths to a limited range, which facilitates the planning of experiments to detect the axion. A companion review discusses the exciting prospect that the axion could be detected in the near term in the laboratory.
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abj3618
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  10. Article ; Online: Relocation sustains intestinal stem-cell numbers.

    Ellis, Stephanie J / Fuchs, Elaine

    Nature

    2022  Volume 607, Issue 7919, Page(s) 451–452

    MeSH term(s) Cell Count ; Cell Proliferation ; Intestinal Mucosa ; Intestines ; Regeneration ; Stem Cells
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-01596-0
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