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Article ; Online: Transperineal microwave thermoablation for benign prostatic hyperplasia-related lower urinary tract symptoms in an elderly patient.

Türk, Yaşar / Devecioğlu, İsmail / Çilesiz, Nusret Can / Nuhoğlu, Barış

Diagnostic and interventional radiology (Ankara, Turkey)

2024

Abstract: Transperineal prostate microwave thermoablation (TPMT) has been established as a safe means of treating benign prostatic hyperplasia (BPH); however, its effectiveness in addressing BPH-related lower urinary tract symptoms (LUTS) remains unexplored. This ... ...

Abstract	Transperineal prostate microwave thermoablation (TPMT) has been established as a safe means of treating benign prostatic hyperplasia (BPH); however, its effectiveness in addressing BPH-related lower urinary tract symptoms (LUTS) remains unexplored. This case study aims to evaluate the efficacy of TPMT in LUTS attributed to BPH. An 84-year-old man with LUTS due to BPH-induced bladder outlet obstruction, unresponsive to previous medical treatments, and failed prostate artery embolization, underwent TPMT. Three coaxial needles were positioned at the midline, right, and left sides of the hypertrophic transitional zone of the prostate. Microwave energy, with parameters determined using liver data and targeted ablation area, was applied at 2,450 MHz in continuous mode. The tissue temperature was monitored using bilateral thermocouple sensors. The patient exhibited no changes in defecation rhythm, abdominal discomfort, or anorectal pain. Temporary postoperative hematuria was promptly resolved through saline irrigation within 6 hours, and hematological evaluations showed normal results. Significant clinical improvements were observed (e.g., prostate volume, prostate-specific antigen levels) accompanied by an increase in peak flow rate. Thus, TPMT appears to be a promising intervention for bladder outlet stenosis and LUTS induced by BPH.
Language	English
Publishing date	2024-02-29
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3612
ISSN (online)	1305-3612
ISSN	1305-3612
DOI	10.4274/dir.2024.232639
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Article ; Online: The probiotic-induced disregulation of immune-related genes in colon cells and relation with colorectal cancer.

Türk, Seyhan / Yılmaz, Ayşegül / Safari Baesmat, Ayriana / Malkan, Umit Yavuz / Ucar, Gulberk / Türk, Can

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 4, Page(s) 37–45

Abstract: Supplemental probiotics available without a doctor's prescription have become a booming global market in past few years. Medical research has shown that probiotics may benefit both healthy people and cancer patients by improving their immune systems and ... ...

Abstract	Supplemental probiotics available without a doctor's prescription have become a booming global market in past few years. Medical research has shown that probiotics may benefit both healthy people and cancer patients by improving their immune systems and digestive health. Even though they seldom produce serious side effects, it's important to note that they are generally safe to use. But further investigation into the role of probiotics and gut microbes in the etiology of colorectal cancer is required. Here we used computational methods to identify the transcriptome alterations induced by probiotic treatment of colon cells. The impacts of genes with substantially altered expression were assessed in relation to the progression of colorectal cancer. Following probiotic treatment, substantial and high-level changes in the expression of genes were determined. BATF2, XCL2/XCL1, RCVRN and, FAM46B were up-regulated while IL13RA2, CEMIP, CUL9, Cand XCL6, PTCH2 were down-regulated in probiotic-treated colonic tissue and tumor samples. Also, immune-related pathways were determined that contribute to colorectal cancer formation and progression, as well as genes with opposing roles. This suggests that the length and dosage of probiotic use, in addition to the specific bacterial strain, maybe the most important determinants in the association between probiotics and colorectal cancer.
MeSH term(s)	Humans ; Transcriptome ; Probiotics/therapeutic use ; Colorectal Neoplasms/genetics
Language	English
Publishing date	2023-04-30
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.4.6
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Article ; Online: Prognostic gene biomarkers for c-Src inhibitor Si162 sensitivity in melanoma cells.

Türk, Seyhan / Yilmaz, Ayşegül / Malkan, Ümit Yavuz / Uçar, Gülberk / Türk, Can

Turkish journal of biology = Turk biyoloji dergisi

2023 Volume 48, Issue 1, Page(s) 13–23

Abstract: Background/aim: Early detection and treatment are crucial in combating malignant melanoma. Src is an important therapeutic target in melanoma due to its association with cancer progression. However, developing effective Src-targeting drugs remains ... ...

Abstract	Background/aim: Early detection and treatment are crucial in combating malignant melanoma. Src is an important therapeutic target in melanoma due to its association with cancer progression. However, developing effective Src-targeting drugs remains challenging and personalized medicine relies on biomarkers and targeted therapies for precise and effective treatment. This study focuses on Si162, a newly synthesized c-Src inhibitor, to identify reliable biomarkers for predicting Si162 sensitivity and explore associated biological characteristics and pathways in melanoma cells. Materials and methods: Primary melanoma cells (M1, M21, M24, M84, M133, M307, and M2025) were obtained from patients diagnosed with melanoma. Si162 cytotoxicity tests were performed using luminescent adenosine triphosphate detection and the half-maximal inhibitory concentration (IC Results: The cells revealed significant differences in response to Si162 based on the IC Conclusion: These findings contribute to our understanding of the underlying biological differences among melanoma cells and suggest potential biomarkers and pathways associated with Si162 response and resistance.
Language	English
Publishing date	2023-11-06
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046470-8
ISSN	1303-6092 ; 1303-6092
ISSN (online)	1303-6092
ISSN	1303-6092
DOI	10.55730/1300-0152.2678
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Article ; Online: A new technique for closure of pericardial defects: pericardial rug weave.

Fındık, Göktürk / Çetin, Mehmet / Nomenoğlu, Hakan / Türk, İlteriş / Acemoğlu, Serdar / Solak, Necati / Can, Mehmet Ali

BMC surgery

2024 Volume 24, Issue 1, Page(s) 106

Abstract: Background: Pericardial defect that occurs after intrapericardial pneumonectomy can cause many fatal complications, and closing the defect with mesh is a widely used surgical method to prevent these complications.: Methods: Data of patients who ... ...

Abstract	Background: Pericardial defect that occurs after intrapericardial pneumonectomy can cause many fatal complications, and closing the defect with mesh is a widely used surgical method to prevent these complications. Methods: Data of patients who underwent intrapericardial pneumonectomy and pericardial resection in our clinic between October 2010 and June 2022 were retrospectively reviewed. Patients were divided into two groups, those who had prolene mesh used to close the pericardial defect and those who underwent the "Rug Weave" technique we proposed as an alternative, and the results were compared. Results: The study included 23 patients, one of whom was female. All patients underwent surgery due to malignancy. The vast majority of the patients had a diagnosis of squamous cell lung carcinoma (86.9%). Atrium was added to three patients and rib resection was added to one patient during intrapericardial pneumonectomy and pericardial resection. There was no significant difference between the two groups in terms of average age, gender, and length of hospital stay. There was no significant difference between the two groups in terms of complications, including atrial fibrillation, which is commonly seen in these patients (p = 0.795). The Rug Weave group had an average defect width of 23.96 cm2 and was found to be advantageous in terms of overall survival compared to the mesh group (p = 0.017). Conclusions: The "Rug Weave" technique we proposed for closing pericardial defects after pneumonectomy can be used as a cheaper method safely and effectively that reduces complications as much as the traditional method of using mesh.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Heart Diseases ; Pneumonectomy ; Pericardium/surgery ; Lung Neoplasms/surgery
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-024-02368-5
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Article: Norfloxacin removal by ultraviolet-activated sodium percarbonate and sodium hypochlorite: process optimization and anion effect.

Yazici Guvenc, Senem / Turk, Oruc Kaan / Can-Güven, Emine / Garazade, Narmin / Varank, Gamze

Water science and technology : a journal of the International Association on Water Pollution Research

2023 Volume 87, Issue 11, Page(s) 2872–2889

Abstract: The efficiency of UV-activated sodium percarbonate (SPC) and sodium hypochlorite (SHC) in Norfloxacin (Norf) removal from an aqueous solution was assessed. Control experiments were conducted and the synergistic effect of the UV-SHC and UV-SPC processes ... ...

Abstract	The efficiency of UV-activated sodium percarbonate (SPC) and sodium hypochlorite (SHC) in Norfloxacin (Norf) removal from an aqueous solution was assessed. Control experiments were conducted and the synergistic effect of the UV-SHC and UV-SPC processes were 0.61 and 2.89, respectively. According to the first-order reaction rate constants, the process rates were ranked as UV-SPC > SPC > UV and UV-SHC > SHC > UV. Central composite design was applied to determine the optimum operating conditions for maximum Norf removal. Under optimum conditions (UV-SPC: 1 mg/L initial Norf, 4 mM SPC, pH 3, 50 min; UV-SHC: 1 mg/L initial Norf, 1 mM SHC, pH 7, 8 min), the removal yields for the UV-SPC and UV-SHC were 71.8 and 72.1%, respectively. HCO
MeSH term(s)	Sodium Hypochlorite ; Norfloxacin ; Water Pollutants, Chemical/analysis ; Oxidation-Reduction ; Anions ; Carbonates ; Ultraviolet Rays ; Hydrogen Peroxide
Chemical Substances	sodium percarbonate (Z7G82NV92P) ; Sodium Hypochlorite (DY38VHM5OD) ; Norfloxacin (N0F8P22L1P) ; Water Pollutants, Chemical ; Anions ; Carbonates ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	764273-8
ISSN	1996-9732 ; 0273-1223
ISSN (online)	1996-9732
ISSN	0273-1223
DOI	10.2166/wst.2023.159
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Article ; Online: Determination of drug sensitivity subgroups in acute myeloid leukemia to increase treatment efficacy by imatinib and its analog imatinib B

Can Turk / Esma Eryilmaz Dogan

Medicine Science, Vol 10, Iss 3, Pp 828-

2021 Volume 34

Abstract: While chemotherapeutics without any selective properties were used in cancer treatment in the past, they are now replaced by targeted drugs. Imatinib has common use in the treatment of acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) but ... ...

Abstract	While chemotherapeutics without any selective properties were used in cancer treatment in the past, they are now replaced by targeted drugs. Imatinib has common use in the treatment of acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML) but not Acute myeloid leukemia (AML). It is a highly effective oral drug treatment and provides stable remission in many people treated. Treatment of imatinib mesylate can cause various side effects such as swelling around the eyes, nausea, and vomiting. However, it is likely to act on normal cells, and this effect causes side effects. To create a better design with increased bioactivity with decreased possible side effects of imatinib we calculated the molecular pharmaceutical properties and biological activity and investigated its analogs. Also, we figured out which genetically subclasses of AML can benefit from therapy with imatinib analog, imatinib B. The gene expression data were retrieved from the E-MTAB-783 Cancer Genome Project database. Gene expression data for available genes in cell lines belonging to various types of leukemia were chosen for use in the analysis. Three subgroups were determined using all genome expression profiles and drug sensitivity data of AML cell lines associated with imatinib sensitivity. Genes with statistical significance between groups, network connections, and related pathways to which they belong were introduced. Thirty-two genes and 18 pathways that can predict sensitivity to imatinib in AML cell lines were identified. Also, our results show these genes are closely linked with each other. Today, the use of Imatinib in the treatment of AML is limited. By redesigning the imatinib molecule, it will be possible to effectively treat certain AML subgroups by reducing harmful side effects. [Med-Science 2021; 10(3.000): 828-34]
Keywords	bioactivity ; drug-likeness ; drug design ; boron ; biomarker ; imatinib ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article ; Online: How advantageous is it to use computed tomography image-based artificial intelligence modelling in the differential diagnosis of chronic otitis media with and without cholesteatoma?

Ayral, M / Türk, Ö / Can, Ş / Esen, D / Topçu, I / Akil, F / Temiz, H

European review for medical and pharmacological sciences

2022 Volume 27, Issue 1, Page(s) 215–223

Abstract: Objective: Cholesteatoma (CHO) developing secondary to chronic otitis media (COM) can spread rapidly and cause important health problems such as hearing loss. Therefore, the presence of CHO should be diagnosed promptly with high accuracy and then ... ...

Abstract	Objective: Cholesteatoma (CHO) developing secondary to chronic otitis media (COM) can spread rapidly and cause important health problems such as hearing loss. Therefore, the presence of CHO should be diagnosed promptly with high accuracy and then treated surgically. The aim of this study was to investigate the effectiveness of artificial intelligence applications (AIA) in documenting the presence of CHO based on computed tomography (CT) images. Patients and methods: The study was performed on CT images of 100 CHO, 100 non-cholesteatoma (N-CHO) COM, and 100 control patients. Two AIA models including ResNet50 and MobileNetV2 were used for the classification of the images. Results: Overall accuracy rate was 93.33% for the ResNet50 model and 86.67% for the MobilNetV2 model. Moreover, the diagnostic accuracy rates of these two models were 100% and 95% in the CHO group, 90% and 85% in the N-CHO group, and 90% and 80% in the control group, respectively. Conclusions: These results indicate that the use of AIA in the diagnosis of CHO will improve the diagnostic accuracy rates and will also help physicians in terms of reducing their workload and facilitating the selection of the correct treatment strategy.
MeSH term(s)	Humans ; Cholesteatoma, Middle Ear/complications ; Diagnosis, Differential ; Artificial Intelligence ; Otitis Media/diagnostic imaging ; Otitis Media/complications ; Tomography, X-Ray Computed/methods ; Chronic Disease
Language	English
Publishing date	2022-12-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202301_30874
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Article ; Online: Can deep learning replace histopathological examinations in the differential diagnosis of cervical lymphadenopathy?

Can, Sermin / Türk, Ömer / Ayral, Muhammed / Kozan, Günay / Arı, Hamza / Akdağ, Mehmet / Baylan, Müzeyyen Yıldırım

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2023 Volume 281, Issue 1, Page(s) 359–367

Abstract: Introduction: We aimed to develop a diagnostic deep learning model using contrast-enhanced CT images and to investigate whether cervical lymphadenopathies can be diagnosed with these deep learning methods without radiologist interpretations and ... ...

Abstract	Introduction: We aimed to develop a diagnostic deep learning model using contrast-enhanced CT images and to investigate whether cervical lymphadenopathies can be diagnosed with these deep learning methods without radiologist interpretations and histopathological examinations. Material method: A total of 400 patients who underwent surgery for lymphadenopathy in the neck between 2010 and 2022 were retrospectively analyzed. They were examined in four groups of 100 patients: the granulomatous diseases group, the lymphoma group, the squamous cell tumor group, and the reactive hyperplasia group. The diagnoses of the patients were confirmed histopathologically. Two CT images from all the patients in each group were used in the study. The CT images were classified using ResNet50, NASNetMobile, and DenseNet121 architecture input. Results: The classification accuracies obtained with ResNet50, DenseNet121, and NASNetMobile were 92.5%, 90.62, and 87.5, respectively. Conclusion: Deep learning is a useful diagnostic tool in diagnosing cervical lymphadenopathy. In the near future, many diseases could be diagnosed with deep learning models without radiologist interpretations and invasive examinations such as histopathological examinations. However, further studies with much larger case series are needed to develop accurate deep-learning models.
MeSH term(s)	Humans ; Deep Learning ; Diagnosis, Differential ; Retrospective Studies ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/pathology ; Neck/pathology
Language	English
Publishing date	2023-08-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-023-08181-9
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Article: Incidental intracranial lipomas: Assessment of 163 patients.

Türk, Okan / Yaldiz, Can

Ideggyogyaszati szemle

2019 Volume 72, Issue 3-4, Page(s) 89–92

Abstract: Intracranial lipomas (ILs) are rare congenital lesions which consist 0.1-0.5% of intracranial lesions. They are usually asymptomatic. Our serial of 163 patients is the largest IL serial in literature. Files of the patients who were diagnosed with IL at ... ...

Title translation	Véletlenül talált intracranialis lipomák: 163 beteg vizsgálata.
Abstract	Intracranial lipomas (ILs) are rare congenital lesions which consist 0.1-0.5% of intracranial lesions. They are usually asymptomatic. Our serial of 163 patients is the largest IL serial in literature. Files of the patients who were diagnosed with IL at outpatient clinic of neurosurgery between 2009 and 2018 were screened retrospectively. A total of 163 patients were detected to have been diagnosed with IL according to radiologic findings between 2009 and 2018. Of the patients, 96 were female and 67 were male. Intracranial lipomas are self-limited, slowly growing benign lesions which do not cause a mass effect. We believe that the present study would be a main source due to the currently available insufficient number of studies in literature.
MeSH term(s)	Brain Neoplasms/diagnosis ; Brain Neoplasms/surgery ; Female ; Humans ; Lipoma/diagnosis ; Lipoma/surgery ; Magnetic Resonance Imaging ; Male ; Neurosurgical Procedures ; Retrospective Studies
Language	English
Publishing date	2019-04-08
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2240317-6
ISSN	0019-1442
ISSN	0019-1442
DOI	10.18071/isz.72.0089
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Article ; Online: A correlation coefficient-based feature selection approach for virus-host protein-protein interaction prediction.

Ibrahim, Ahmed Hassan / Karabulut, Onur Can / Karpuzcu, Betül Asiye / Türk, Erdem / Süzek, Barış Ethem

PloS one

2023 Volume 18, Issue 5, Page(s) e0285168

Abstract: Prediction of virus-host protein-protein interactions (PPI) is a broad research area where various machine-learning-based classifiers are developed. Transforming biological data into machine-usable features is a preliminary step in constructing these ... ...

Abstract	Prediction of virus-host protein-protein interactions (PPI) is a broad research area where various machine-learning-based classifiers are developed. Transforming biological data into machine-usable features is a preliminary step in constructing these virus-host PPI prediction tools. In this study, we have adopted a virus-host PPI dataset and a reduced amino acids alphabet to create tripeptide features and introduced a correlation coefficient-based feature selection. We applied feature selection across several correlation coefficient metrics and statistically tested their relevance in a structural context. We compared the performance of feature-selection models against that of the baseline virus-host PPI prediction models created using different classification algorithms without the feature selection. We also tested the performance of these baseline models against the previously available tools to ensure their predictive power is acceptable. Here, the Pearson coefficient provides the best performance with respect to the baseline model as measured by AUPR; a drop of 0.003 in AUPR while achieving a 73.3% (from 686 to 183) reduction in the number of tripeptides features for random forest. The results suggest our correlation coefficient-based feature selection approach, while decreasing the computation time and space complexity, has a limited impact on the prediction performance of virus-host PPI prediction tools.
MeSH term(s)	Algorithms ; Random Forest ; Machine Learning
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285168
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