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  1. Article ; Online: Answer to the letter to the editor of L. Uhrenholt et al. concerning "do X-ray-occult fractures play a role in chronic pain following a whiplash injury?" by Hertzum-Larsen R, Petersen H, Kasch H, Bendix T, Eur Spine J, 2014; DOI 10.1007/s00586-014-3362-3.

    Hertzum-Larsen, R / Petersen, Henrik / Kasch, Helge / Bendix, Tom

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2014  Volume 23, Issue 10, Page(s) 2225

    MeSH term(s) Accidents, Traffic ; Chronic Pain/diagnostic imaging ; Female ; Fractures, Closed/diagnostic imaging ; Humans ; Male ; Pain Measurement ; Radiography ; Whiplash Injuries/diagnostic imaging
    Language English
    Publishing date 2014-10
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-014-3493-6
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    Zs.A 3437: Show issues Location:
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  2. Book: Floodplains

    Opperman, Jeffrey J. / Moyle, Peter B. / Larsen, Eric W. / Florsheim, Joan L. / Manfree, Amber D.

    processes and management for ecosystem services

    2017  

    Author's details Jeffrey J. Opperman, Peter B. Moyle, Eric W. Larsen, Joan L. Florsheim, and Amber D. Manfree
    Keywords Überschwemmungsgebiet ; Ökologie
    Subject Umweltbiologie ; Ecology ; Überschwemmung
    Language English
    Size x, 258 Seiten, Illustrationen, Diagramme, Karten
    Publisher University of California Press
    Publishing place Oakland
    Publishing country United States
    Document type Book
    HBZ-ID HT019365793
    ISBN 978-0520-29306-9 ; 978-0520-29410-3 ; 9780520966321 ; 0520-29306-1 ; 0520-29410-6 ; 0520966325
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    Shelf markLoan statusLocation
    174/209 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Nanoparticle-mediated delivery of non-viral gene editing technology to the brain.

    Williams, Lucian / Larsen, Jessica

    Progress in neurobiology

    2023  Volume 232, Page(s) 102547

    Abstract: Neurological disorders pose a significant burden on individuals and society, affecting millions worldwide. These disorders, including but not limited to Alzheimer's disease, Parkinson's disease, and Huntington's disease, often have limited treatment ... ...

    Abstract Neurological disorders pose a significant burden on individuals and society, affecting millions worldwide. These disorders, including but not limited to Alzheimer's disease, Parkinson's disease, and Huntington's disease, often have limited treatment options and can lead to progressive degeneration and disability. Gene editing technologies, including Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector Nucleases (TALEN), and Clustered Regularly Interspaced Short Palindromic Repeats-associated Protein 9 (CRISPR-Cas9), offer a promising avenue for potential cures by targeting and correcting the underlying genetic mutations responsible for neurologic disorders. However, efficient delivery methods are crucial for the successful application of gene editing technologies in the context of neurological disorders. The central nervous system presents unique challenges to treatment development due to the blood-brain barrier, which restricts the entry of large molecules. While viral vectors are traditionally used for gene delivery, nonviral delivery methods, such as nanoparticle-mediated delivery, offer safer alternatives that can efficiently transport gene editing components. Herein we aim to introduce the three main gene editing nucleases as nonviral treatments for neurologic disorders, the delivery barriers associated with brain targeting, and the current nonviral techniques used for brain-specific delivery. We highlight the challenges and opportunities for future research in this exciting and growing field that could lead to blood-brain barrier bypassing therapeutic gene editing.
    MeSH term(s) Humans ; Gene Editing/methods ; Genetic Therapy/methods ; Parkinson Disease ; Nanoparticles ; Brain
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2023.102547
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  4. Article ; Online: Preference for artificial range enrichment design features in free-range commercial laying hens.

    Larsen, H / Rault, J-L

    British poultry science

    2021  Volume 62, Issue 3, Page(s) 311–319

    Abstract: 1. This study examined what elements of artificial enrichment structures attract hens in the outdoor range, and what behaviours hens perform around these structures. Three principles of cover design (height, orientation and visual density) were tested ... ...

    Abstract 1. This study examined what elements of artificial enrichment structures attract hens in the outdoor range, and what behaviours hens perform around these structures. Three principles of cover design (height, orientation and visual density) were tested for laying hen preference in the outdoor range of a commercial egg farm using a 2 × 3 × 3 factorial design. The factors were height: 0.5 m or 1.5 m; orientation: vertical, horizontal or horizontal cover with one vertical side; and visual density: 0% (control), 50% or 90% UV blocking cloth.2. A significant three-way interaction between all factors was found (P < 0.001). The most preferred visual density of these structures was the 90%, followed by 50% UV blocking cloth. Horizontal structures with one vertical side, of either height, were highly preferred. Short horizontal structures were preferred to tall ones, and tall vertical structures were slightly preferred over short ones.3. The most common behaviours observed around the structures were interaction with the structure (pecks, scratches and vigilance directed at the structure; 32.7%), foraging (32.2%), locomotion (9.9%), and air foraging (pecks and snapping in the air; 9.0%). A three-way interaction between the design principles influenced the proportion of hens performing each of these behaviours (P < 0.001). Hens foraged more around structures with no shade cloth and interacted more with structures that had dense shade cloth.4. These results highlighted the complexity of designing attractive outdoor environments for laying hens. By testing the combination of elements that hens prefer it is possible to understand how to design attractive outdoor ranges that attract hens and promote a diverse range of behaviours on commercial farms.
    MeSH term(s) Animal Welfare ; Animals ; Chickens ; Female ; Housing, Animal
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 956653-3
    ISSN 1466-1799 ; 0007-1668
    ISSN (online) 1466-1799
    ISSN 0007-1668
    DOI 10.1080/00071668.2021.1879993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Preference for artificial range enrichment design features in free-range commercial laying hens

    Larsen, H / Rault, J-L

    British poultry science. 2021 May 04, v. 62, no. 3

    2021  

    Abstract: 1. This study examined what elements of artificial enrichment structures attract hens in the outdoor range, and what behaviours hens perform around these structures. Three principles of cover design (height, orientation and visual density) were tested ... ...

    Abstract 1. This study examined what elements of artificial enrichment structures attract hens in the outdoor range, and what behaviours hens perform around these structures. Three principles of cover design (height, orientation and visual density) were tested for laying hen preference in the outdoor range of a commercial egg farm using a 2 × 3 × 3 factorial design. The factors were height: 0.5 m or 1.5 m; orientation: vertical, horizontal or horizontal cover with one vertical side; and visual density: 0% (control), 50% or 90% UV blocking cloth. 2. A significant three-way interaction between all factors was found (P < 0.001). The most preferred visual density of these structures was the 90%, followed by 50% UV blocking cloth. Horizontal structures with one vertical side, of either height, were highly preferred. Short horizontal structures were preferred to tall ones, and tall vertical structures were slightly preferred over short ones. 3. The most common behaviours observed around the structures were interaction with the structure (pecks, scratches and vigilance directed at the structure; 32.7%), foraging (32.2%), locomotion (9.9%), and air foraging (pecks and snapping in the air; 9.0%). A three-way interaction between the design principles influenced the proportion of hens performing each of these behaviours (P < 0.001). Hens foraged more around structures with no shade cloth and interacted more with structures that had dense shade cloth. 4. These results highlighted the complexity of designing attractive outdoor environments for laying hens. By testing the combination of elements that hens prefer it is possible to understand how to design attractive outdoor ranges that attract hens and promote a diverse range of behaviours on commercial farms.
    Keywords air ; eggs ; locomotion
    Language English
    Dates of publication 2021-0504
    Size p. 311-319.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 956653-3
    ISSN 1466-1799 ; 0007-1668
    ISSN (online) 1466-1799
    ISSN 0007-1668
    DOI 10.1080/00071668.2021.1879993
    Database NAL-Catalogue (AGRICOLA)

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    Z 1354: Show issues

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  6. Article ; Online: Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site.

    Schwabenlander, Marc D / Bartz, Jason C / Carstensen, Michelle / Fameli, Alberto / Glaser, Linda / Larsen, Roxanne J / Li, Manci / Shoemaker, Rachel L / Rowden, Gage / Stone, Suzanne / Walter, W David / Wolf, Tiffany M / Larsen, Peter A

    Prion

    2024  Volume 18, Issue 1, Page(s) 72–86

    Abstract: Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is ... ...

    Abstract Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (
    MeSH term(s) Animals ; Deer ; Wasting Disease, Chronic/transmission ; Prions/genetics ; Prions/metabolism ; Microsatellite Repeats/genetics
    Chemical Substances Prions
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267671-5
    ISSN 1933-690X ; 1933-690X
    ISSN (online) 1933-690X
    ISSN 1933-690X
    DOI 10.1080/19336896.2024.2343298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Novel reverse Ishiguro Kirschner wire technique for the repair of osseous flexor digitorum profundus avulsion injuries.

    Briffa, James / Willemot, Laurent / Dong, Xavier / Larsen, Mikko

    ANZ journal of surgery

    2023  Volume 93, Issue 9, Page(s) 2254–2256

    MeSH term(s) Humans ; Bone Wires ; Finger Injuries/surgery ; Hand ; Bone and Bones
    Language English
    Publishing date 2023-04-06
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.18444
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    Zs.A 180: Show issues Location:
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  8. Article ; Online: Design and Construction of a Multi-Tiered Minimal Actin Cortex for Structural Support in Lipid Bilayer Applications.

    Smith, Amanda J / Larsen, Theodore R B / Zimmerman, Harmony K / Virolainen, Samuel J / Meyer, Joshua J / Keranen Burden, Lisa M / Burden, Daniel L

    ACS applied bio materials

    2024  Volume 7, Issue 3, Page(s) 1936–1946

    Abstract: Artificial lipid bilayers have revolutionized biochemical and biophysical research by providing a versatile interface to study aspects of cell membranes and membrane-bound processes in a controlled environment. Artificial bilayers also play a central ... ...

    Abstract Artificial lipid bilayers have revolutionized biochemical and biophysical research by providing a versatile interface to study aspects of cell membranes and membrane-bound processes in a controlled environment. Artificial bilayers also play a central role in numerous biosensing applications, form the foundational interface for liposomal drug delivery, and provide a vital structure for the development of synthetic cells. But unlike the envelope in many living cells, artificial bilayers can be mechanically fragile. Here, we develop prototype scaffolds for artificial bilayers made from multiple chemically linked tiers of actin filaments that can be bonded to lipid headgroups. We call the interlinked and layered assembly a multiple minimal actin cortex (multi-MAC). Construction of multi-MACs has the potential to significantly increase the bilayer's resistance to applied stress while retaining many desirable physical and chemical properties that are characteristic of lipid bilayers. Furthermore, the linking chemistry of multi-MACs is generalizable and can be applied almost anywhere lipid bilayers are important. This work describes a filament-by-filament approach to multi-MAC assembly that produces distinct 2D and 3D architectures. The nature of the structure depends on a combination of the underlying chemical conditions. Using fluorescence imaging techniques in model planar bilayers, we explore how multi-MACs vary with electrostatic charge, assembly time, ionic strength, and type of chemical linker. We also assess how the presence of a multi-MAC alters the underlying lateral diffusion of lipids and investigate the ability of multi-MACs to withstand exposure to shear stress.
    MeSH term(s) Lipid Bilayers ; Actins ; Cell Membrane ; Cytoskeleton ; Actin Cytoskeleton
    Chemical Substances Lipid Bilayers ; Actins
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c01267
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  9. Article ; Online: Music Therapy Intervention to Reduce Symptom Burden in Hospice Patients: A Descriptive Study.

    Estell, Madison H / Whitford, Kevin J / Ulrich, Angela M / Larsen, Brianna E / Wood, Christina / Bigelow, Maureen L / Dockter, Travis J / Schoonover, Kimberly L / Stelpflug, Amy J / Strand, Jacob J / Walton, Monica P / Lapid, Maria I

    The American journal of hospice & palliative care

    2024  , Page(s) 10499091241237991

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074344-3
    ISSN 1938-2715 ; 1049-9091
    ISSN (online) 1938-2715
    ISSN 1049-9091
    DOI 10.1177/10499091241237991
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  10. Article: Behavioural characteristics of fatal piglet crushing events under outdoor conditions

    Kobek-Kjeldager, C. / Pedersen, L.J. / Larsen, M.L.V.

    Livestock science

    2023  Volume 268, Issue -, Page(s) 105164

    Language English
    Document type Article
    ZDB-ID 2226176-X
    ISSN 1871-1413
    Database Current Contents Nutrition, Environment, Agriculture

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