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  1. Article ; Online: Response to commentary on"Umbilical cord cyst with patent urachus presenting as urine jet from umbilicus: A case report".

    Lin, Chun-Chia / Huang, Chung-Bin / Su, Jian-Chiou / Chou, Yu-Kung / Chiang, Kuo-Liang

    Pediatrics and neonatology

    2022  Volume 63, Issue 4, Page(s) 439–440

    MeSH term(s) Cysts ; Female ; Gastrointestinal Diseases ; Humans ; Pregnancy ; Ultrasonography, Prenatal ; Umbilical Cord/diagnostic imaging ; Umbilicus ; Urachus/diagnostic imaging
    Language English
    Publishing date 2022-05-16
    Publishing country Singapore
    Document type Case Reports ; Letter ; Comment
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2022.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Umbilical cord cyst with patent urachus presenting as a urine jet from the umbilicus: A case report.

    Lin, Chun-Chia / Huang, Chung-Bin / Su, Jian-Chiou / Chou, Yu-Kung / Chiang, Kuo-Liang

    Pediatrics and neonatology

    2021  Volume 63, Issue 1, Page(s) 105–106

    MeSH term(s) Cysts ; Female ; Humans ; Pregnancy ; Ultrasonography, Prenatal ; Umbilical Cord/diagnostic imaging ; Umbilicus ; Urachus/diagnostic imaging
    Language English
    Publishing date 2021-12-02
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2021.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Acute kidney disease: an overview of the epidemiology, pathophysiology, and management.

    Kung, Chin-Wei / Chou, Yu-Hsiang

    Kidney research and clinical practice

    2023  Volume 42, Issue 6, Page(s) 686–699

    Abstract: Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), and AKI and CKD are seen as interconnected syndromes. Acute kidney disease (AKD) is defined as subacute damage and/or loss of kidney function occurring 7 to 90 days after AKI, ... ...

    Abstract Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), and AKI and CKD are seen as interconnected syndromes. Acute kidney disease (AKD) is defined as subacute damage and/or loss of kidney function occurring 7 to 90 days after AKI, during which period key interventions may be initiated to hinder the development of CKD. While AKD is usually under-recognized, it is associated with high morbidity and mortality globally. This review article aims to summarize the current knowledge concerning the epidemiology, pathophysiology, and management of AKD with the aim to develop monitoring strategies and therapeutic agents of AKD. Generally, AKD tends to occur more frequently in the elderly and those with chronic diseases, such as hypertension, diabetes mellitus, and metabolic syndrome. In addition, the severity, duration, and frequency of AKI are independent risk factors for AKD. Investigations of several mechanisms of AKD, such as renal tubular epithelium cell-cycle arrest, epigenetic change, chronic inflammation, mitochondria dysfunction, failed regeneration of tubular cells, metabolic reprogramming, and renin-angiotensin system (RAS) activation, have identified additional potential pharmacotherapy targets. Management of AKD includes prevention of repeated AKI, early and regular follow-up by a nephrologist, resumption and adjustment of essential medication, optimization of blood pressure control and nutrition management, and development of new pharmaceutical agents including RAS inhibitors. Finally, we outline a care bundle for AKD patients based on important lessons learned from studies and registries and identify the need for clinical trials of RAS inhibitors or other novel agents to impede ensuing CKD development.
    Language English
    Publishing date 2023-05-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.23.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Stroke and suicide among people with severe mental illnesses.

    Liao, Chun-Hui / Chang, Chen-Shu / Kung, Pei-Tseng / Chou, Wen-Yu / Tsai, Wen-Chen

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4991

    Abstract: The associations between people with severe mental illnesses (SMI) and the risks of stroke, suicide, and death remain unclear. We examined healthcare service usage among adults with and without SMI and explored the risk of stroke, suicide, and death. We ... ...

    Abstract The associations between people with severe mental illnesses (SMI) and the risks of stroke, suicide, and death remain unclear. We examined healthcare service usage among adults with and without SMI and explored the risk of stroke, suicide, and death. We divided 18-80-year-old adults with SMI into catastrophic and non-catastrophic illness groups. These groups were subjected to a 1:5:5 propensity score matching with people without SMI. Data on demographic characteristics, economic factors, environmental factors, comorbid conditions, self-injury behavior, the number of outpatients and ED visits, and hospitalization were collected. The primary outcomes were risks of stroke, suicide, and death. We included 19,570 people with catastrophic SMI, 97,850 with non-catastrophic SMI, and 97,850 controls. Patients with SMI, especially those with catastrophic illnesses, had higher stroke risk, suicide, and death than those without SMI. People with SMI used health services more frequently than those without SMI. Patients with a history of hospitalization or ED access had a higher risk of stroke, suicide, and death. Our data indicate that special attention should be given to patients with SMI, particularly those with a history of healthcare service utilization, such as through more extended hospital stays with high-intensity interventions.
    MeSH term(s) Adult ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Suicide ; Stroke/epidemiology ; Stroke/complications ; Hospitalization ; Length of Stay
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55564-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Outbreak of recombinant coxsackievirus A2 infection and polio-like paralysis of children, Taiwan, 2014.

    Chiang, Kuo-Liang / Wei, Sung-Hsi / Fan, Hueng-Chuen / Chou, Yu-Kung / Yang, Jyh-Yuan

    Pediatrics and neonatology

    2018  Volume 60, Issue 1, Page(s) 95–99

    Language English
    Publishing date 2018-02-08
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2018.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of multidisciplinary team care on patient survival in chronic hepatitis B or C hepatocellular carcinoma.

    Tseng, Yu-Chen / Kung, Pei-Tseng / Peng, Cheng-Yuan / Chou, Wen-Yu / Tsai, Wen-Chen

    Frontiers in oncology

    2023  Volume 13, Page(s) 1251571

    Abstract: Introduction: Multidisciplinary team care coordinates with medical teams to improve the quality of cancer care. This study explored multidisciplinary team care in hepatitis B or hepatitis C virus-related hepatocellular carcinoma patients from the time ... ...

    Abstract Introduction: Multidisciplinary team care coordinates with medical teams to improve the quality of cancer care. This study explored multidisciplinary team care in hepatitis B or hepatitis C virus-related hepatocellular carcinoma patients from the time of diagnosis to the first-time treatment interval and investigated treatment outcomes and prognosis.
    Methods: This retrospective cohort study included data from a nationwide population from 2007 to 2016. Data were collected from the Taiwan Cancer Registry Database, linked to the Taiwan National Health Insurance Research Database. Propensity score matching was applied at a ratio of 1:2 to reduce the selection bias. A multiple regression model with generalized estimating equations was used to analyze whether multidisciplinary team care affected the diagnosis-to-treatment interval. The stratified Cox proportional hazards model examined whether involvement in multidisciplinary team care influenced survival status.
    Results: A total of 10,928 and 21,856 patients with hepatocellular carcinoma received multidisciplinary and non-multidisciplinary care, respectively. Participants with multidisciplinary care had a longer diagnosis-to-treatment interval but a lower risk of cumulative cancer death (HR=0.88, 95% CI:0.84-0.92). In patients with intermediate- to advanced-stage hepatocellular carcinoma, multidisciplinary team care has obvious benefits for improving survival.
    Conclusion: Patients with hepatocellular carcinoma who participated in multidisciplinary team care had a longer diagnosis-to-treatment interval but a lower risk of cancer death. Patients with intermediate- to advanced-stage hepatocellular carcinoma who received multidisciplinary team care significantly benefited from this outcome. Hospitals should provide HCC patients with multidisciplinary team care to improve cancer care.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1251571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Prospective Study of Clinical Features of Anterior Uveitis in Taiwan.

    Chiang, Wei-Yu / Chen, Shih-Chou / Sheu, Shwu-Jiuan / Kuo, Hsi-Kung

    Journal of ophthalmology

    2023  Volume 2023, Page(s) 9647418

    Abstract: In this study, we reported the patterns, epidemiology, and clinical features of anterior uveitis (AU) in Taiwan, an area of Eastern Asia. This prospective, cross-sectional case series study was performed to identify patients with AU at two tertiary ... ...

    Abstract In this study, we reported the patterns, epidemiology, and clinical features of anterior uveitis (AU) in Taiwan, an area of Eastern Asia. This prospective, cross-sectional case series study was performed to identify patients with AU at two tertiary medical centers (Kaohsiung Chang Gung Memorial Hospital and Kaohsiung Veterans General Hospital) located at the southern Taiwan between December 1, 2018, and March 31, 2020. The clinical diagnoses, ocular presentations, and laboratory data, including the results of the aqueous polymerase chain reaction tests, were investigated in these patients. A total of 112 patients, with a mean age of 48.9 years, were included. Most patients (87.5%) presented with unilateral eye disease, with 30 cases of ocular hypertension at the first presentation (27%). The most common clinical diagnoses were idiopathic AU (37.5%), human leukocyte antigen (HLA)-B27-associated acute AU (25.0%), and herpetic AU (18.8%). Among patients with herpetic AU, cytomegalovirus (CMV) was the most common pathogen (17/21, 81%). Compared to HLA-B27-associated acute AU, CMV-related AU was mostly observed in patients that were older in age, exhibited higher intraocular pressure, more keratic precipitates, greater iris atrophy, and more pseudophakia, but was least reported in those with posterior synechiae. This prospective study identified the pattern and clinical features of AU in southern Taiwan.
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2023/9647418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Assessment of factors influencing physicians' intention to prescribe transfusion using the theory of planned behavior.

    Liao, Yu-Han / Tang, Kung-Pei / Chou, Chih-Yu / Kuo, Chien-Feng / Tsai, Shin-Yi

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 973

    Abstract: Background: Blood shortage is a persistent problem affecting Taiwan's health-care system. The theory of planned behavior (TPB) has been commonly used in studies of health advocacy. The purpose of this study was to develop a questionnaire measuring ... ...

    Abstract Background: Blood shortage is a persistent problem affecting Taiwan's health-care system. The theory of planned behavior (TPB) has been commonly used in studies of health advocacy. The purpose of this study was to develop a questionnaire measuring clinicians' intention to prescribe transfusion based on the TPB.
    Method: A questionnaire comprising 15 items for assessing clinicians' intention to prescribe blood transfusion was developed, and it collected demographic characteristics, tested patient blood management (PBM) and perceived knowledge of PBM. Furthermore, the questionnaire contained four subscales related to the TPB. A total of 129 clinicians participated in this pilot study between July and December2020. Item analysis and exploratory factor analysis were conducted to examine the validity and reliability of this measurement instrument.
    Results: The results indicated no statistically significant correlations between the demographic characteristics and PBM test scores. Regarding perceived knowledge, the results of a one-way analysis of variance revealed that the effect of age, hierarchy of doctors, and education level were significant. In terms of subjective norms, a significant effect on education level was noted [t (129) = 2.28, p < 0.05], with graduate school graduates receiving higher scores than college graduates. An analysis of variance demonstrated the effects of hierarchy, education level, and medical specialty on perceived behavioral control. The results of the regression analyses revealed that perceived knowledge (β = 0.32, p < 0.01) and subjective norms (β = 0.22, p < 0.05) were significantly related to clinicians' behavioral intentions.
    Conclusions: This study revealed that factors affecting clinicians' blood transfusion management can be explained using the TPB-based questionnaire. This study demonstrated that physicians' perceptions of whether most people approve of PBM and their self-assessment of their PBM knowledge affect their intentions to proceed with PBM. According to this finding, a support system among physicians must be established and maintained to increase physicians' confidence in promoting PBM.
    MeSH term(s) Humans ; Intention ; Pilot Projects ; Reproducibility of Results ; Theory of Planned Behavior ; Blood Transfusion ; Physicians
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-09946-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of introducing biologics to patients with rheumatoid arthritis on the risk of venous thromboembolism: a nationwide cohort study.

    Chen, Chao-Ping / Kung, Pei-Tseng / Chou, Wen-Yu / Tsai, Wen-Chen

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 17009

    Abstract: In the United States, 100,000-300,000 patients die from venous thromboembolism (VTE) each year, with more than 500,000 people related hospitalizations. While in Europe, 500,000 people die from VTE each year. Patients with rheumatoid arthritis are at ... ...

    Abstract In the United States, 100,000-300,000 patients die from venous thromboembolism (VTE) each year, with more than 500,000 people related hospitalizations. While in Europe, 500,000 people die from VTE each year. Patients with rheumatoid arthritis are at increased risk of VTE. The use of biologics in patients with rheumatoid arthritis may be associated with an increased risk of VTE. We identified all patients who had been newly approved for Catastrophic Illness Card of rheumatoid arthritis extracted the claims data from the National Health Insurance research database and Registry for Catastrophic Illness Patient Database from 2003 to 2016. VTE was defined as the presence of inpatient VTE diagnostic codes (including DVT or PE) according to the discharge diagnosis protocol. An analysis of VTE variables indicated that the incidence of VTE in the biologic group (14.33/10,000 person-years) was higher than that in the conventional drug group (12.61/10,000 person-years). As assessed by the Cox proportional hazards model, the relative HR for VTE in the biologic group (HR: 1.11; 95% CI 0.79-1.55) versus that in the conventional drug group did not reach a significant difference. In conclusion, this study found no significant differences in risk were observed between the use of conventional DMARDs and biologics.
    MeSH term(s) Antirheumatic Agents/pharmacology ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cohort Studies ; Humans ; Middle Aged ; Propensity Score ; Proportional Hazards Models ; Risk Factors ; Venous Thromboembolism/etiology
    Chemical Substances Antirheumatic Agents ; Biological Products
    Language English
    Publishing date 2021-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-96508-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disparities in the first-ever diagnosed liver cancers between the emergency department and outpatient department in Taiwan: a population-based study.

    Hsu, Tai-Yi / Ye, Jhu-Jing / Ye, Sih-Yun / Tseng, Hsiao-Yuan / Chou, Wen-Yu / Kung, Pei-Tseng / Tsai, Wen-Chen

    BMC public health

    2023  Volume 23, Issue 1, Page(s) 283

    Abstract: Background: Liver cancer is ranked fifth in incidence and second in mortality among cancers in Taiwan. Nevertheless, the Taiwan government does not screen for liver cancer in its free cancer screening and preventive health examination service. This ... ...

    Abstract Background: Liver cancer is ranked fifth in incidence and second in mortality among cancers in Taiwan. Nevertheless, the Taiwan government does not screen for liver cancer in its free cancer screening and preventive health examination service. This study compared the differences in cancer stage and survival between patients who received an initial liver cancer diagnosis in outpatient departments (OPDs) and those who received such a diagnosis in emergency departments (EDs).
    Methods: This retrospective cohort study used the 2000-2016 National Health Insurance Database to obtain a sample from 2 million Taiwanese residents. To evaluate the effect of the utilization of the adult health examination offered to people aged ≥ 40 years, patients aged ≥ 40 years who received an initial liver cancer diagnosis between 2003 and 2015 were followed up until December 31, 2016.
    Results: In total, 2,881 patients were included in this study. A greater proportion of cancer cases in the OPD group were non-advanced than those in the ED group (75.26% vs. 54.23%). Having stage C or D cancer, having a low monthly salary, and a Charlson comorbidity index score ≥ 8, not having hepatitis B, being divorced, and attending a non-public hospital as the primary care institution were risk factors for initial ED diagnosis. The risk of liver cancer-specific death among the ED group patients was 1.38 times that among the OPD group patients (adjusted hazard ratio = 1.38, 95% confidence interval [CI] = 1.14-1.68, P < 0.001). However, the use of health examination did not exert a significant effect on the likelihood of liver cancer diagnosis in an ED (adjusted odds ratio = 0.86, 95% CI = 0.61-1.21, P = 0.381).
    Conclusion: Government-subsidized health examinations are insufficient to prevent first-ever diagnosed liver cancers in EDs. Patients with liver cancers diagnosed in EDs had a higher risk of advanced stage and mortality. For early detection and treatment, the government may consider implementing liver cancer screening for high-risk and low-socioeconomic people.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Outpatients ; Taiwan/epidemiology ; Emergency Service, Hospital ; Liver Neoplasms/diagnosis ; Liver Neoplasms/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15218-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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