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  1. Book ; Conference proceedings: In vitro monitoring of asthma

    Ahlstedt, Staffan

    proceedings from a Workshop [In Vitro Monitoring of Asthma] held in Uppsala, Sweden, 25 - 26 April, 1993

    (Allergy : Supplement ; 17)

    1993  

    Institution Workshop In Vitro Monitoring of Asthma
    European Academy of Allergology and Clinical Immunology
    Author's details ed.: Staffan Ahlstedt ... European Academy of Allergology and Clinical Immunology
    Series title Allergy : Supplement ; 17
    Allergy
    Allergy ; Supplement
    Collection Allergy
    Allergy ; Supplement
    Keywords Inflammation / diagnosis / congresses ; Asthma / diagnosis / congresses ; Laboratory Techniques and Procedures / congresses ; Bronchialasthma
    Subject Asthma bronchiale ; Asthma
    Language English
    Size 164 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book ; Conference proceedings
    HBZ-ID HT006144358
    ISBN 87-16-15067-8 ; 978-87-16-15067-7
    Database Catalogue ZB MED Medicine, Health

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  2. Article: The Economic Burden of Food Allergy: What We Know and What We Need to Learn.

    Fong, Andrew T / Ahlstedt, Staffan / Golding, Michael A / Protudjer, Jennifer L P

    Current treatment options in allergy

    2022  Volume 9, Issue 3, Page(s) 169–186

    Abstract: Purpose of review: Food allergy management and treatment require dietary modification, are associated with significant burdens, and affect food choices and behaviours. Emerging therapies, such as oral immunotherapy (OIT), provide a glimmer of hope for ... ...

    Abstract Purpose of review: Food allergy management and treatment require dietary modification, are associated with significant burdens, and affect food choices and behaviours. Emerging therapies, such as oral immunotherapy (OIT), provide a glimmer of hope for those living with the condition. Some burdens have received substantial focus, whereas many knowledge gaps on the significance of other impacts, including economic burden, remain.
    Recent findings: Evidence from many countries, but disproportionately from the United States, supports that food allergy carries significant healthcare and societal costs. Early introduction for the prevention of food allergies is theoretically cost-effective, but remains largely undescribed. Unique considerations, such as those to cow's milk protein allergy, which affects a substantial proportion of infants, and adrenaline autoinjectors, which have a high cost-per-use, require a balance between cost-effectiveness to the healthcare system and adverse outcomes. Household costs have largely been explored in two countries, but owing to different healthcare structures and costs of living, comparisons are difficult, as are generalisations to other countries. Stock epinephrine in schools may present a cost-effective strategy, particularly in economically disadvantaged areas. Costs relating to OIT must be examined within both immediate benefits, such as protection from anaphylaxis, and long-term benefits, such as sustained unresponsiveness.
    Summary: Although the absolute costs differ by region/country and type of food allergy, a consistent pattern persists: food allergy is a costly condition, to those who live with it, and the multiple stakeholders with which they interact.
    Supplementary information: The online version contains supplementary material available at 10.1007/s40521-022-00306-5.
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2196-3053
    ISSN 2196-3053
    DOI 10.1007/s40521-022-00306-5
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  3. Article ; Online: Associations between food allergy and perceived life status.

    Middelveld, Roelinde / Gunnarsson, Nina V / Ahlstedt, Staffan / Protudjer, Jennifer Lisa Penner

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2020  Volume 125, Issue 6, Page(s) 703–705.e1

    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; Family Characteristics ; Female ; Food Hypersensitivity/epidemiology ; Health Status ; Humans ; Male ; Middle Aged ; Mothers ; Perception ; Quality of Life ; Surveys and Questionnaires ; Sweden/epidemiology ; Visual Analog Scale
    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2020.07.021
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  4. Article ; Online: Magnetic Seed vs Guidewire Breast Cancer Localization With Magnetic Lymph Node Detection: A Randomized Clinical Trial.

    Pantiora, Eirini / Jazrawi, Allan / Hersi, Abdi-Fatah / Abdsaleh, Shahin / Ahlstedt, Hanna / Molnar, Eva / Wärnberg, Fredrik / Eriksson, Staffan / Karakatsanis, Andreas

    JAMA surgery

    2023  Volume 159, Issue 3, Page(s) 239–246

    Abstract: Importance: Guidewires have been the standard for breast lesion localization but pose operative and logistic challenges. Paramagnetic seeds have shown promising results, but to the authors' knowledge, no randomized comparison has been performed.: ... ...

    Abstract Importance: Guidewires have been the standard for breast lesion localization but pose operative and logistic challenges. Paramagnetic seeds have shown promising results, but to the authors' knowledge, no randomized comparison has been performed.
    Objective: To determine whether the combination of a paramagnetic seed and superparamagnetic iron oxide (SPIO) is equivalent to guidewire and SPIO for breast cancer localization and sentinel lymph node detection (SLND).
    Design, setting, and participants: This was a phase 3, pragmatic, equivalence, 2-arm, open-label, randomized clinical trial conducted at 3 university and/or community hospitals in Sweden from May 2018 to May 2022. Included in the study were patients with early breast cancer planned for breast conservation and SLND. Study data were analyzed July to November 2022.
    Interventions: Participants were randomly assigned 1:1 to a paramagnetic seed or a guidewire. All patients underwent SLND with SPIO.
    Main outcomes and measures: Re-excision rate and resection ratio (defined as actual resection volume / optimal resection volume).
    Results: A total of 426 women (median [IQR] age, 65 [56-71] years; median [IQR] tumor size, 11 [8-15] mm) were included in the study. The re-excision rate was 2.90% (95% CI, 1.60%-4.80%), and the median (IQR) resection ratio was 1.96 (1.15-3.44). No differences were found between the guidewire and the seed in re-excisions (6 of 211 [2.84%] vs 6 of 209 [2.87%]; difference, -0.03%; 95% CI, -3.20% to 3.20%; P = .99) or resection ratio (median, 1.93; IQR, 1.18-3.43 vs median, 2.01; IQR, 1.11-3.47; P = .70). Overall SLN detection was 98.6% (95% CI, 97.1%-99.4%) with no differences between arms (203 of 207 [98.1%] vs 204 of 206 [99.0%]; difference, -0.9%; 95% CI, -3.6% to 1.8%; P = .72). More failed localizations occurred with the guidewire (21 of 208 [10.1%] vs 4 of 215 [1.9%]; difference, 8.2%; 95% CI, 3.3%-13.2%; P < .001). Median (IQR) time to specimen excision was shorter for the seed (15 [10-22] minutes vs 18 [12-30] minutes; P = .01), as was the total operative time (69 [56-86] minutes vs 75.5 [59-101] minutes; P = .03). The experience of surgeons, radiologists, and surgical coordinators was better with the seed.
    Conclusions and relevance: The combination of SPIO and a paramagnetic seed performed comparably with SPIO and guidewire for breast cancer conserving surgery and resulted in more successful localizations, shorter operative times, and better experience.
    Trial registration: ISRCTN.org Identifier: ISRCTN11914537.
    MeSH term(s) Humans ; Female ; Aged ; Breast Neoplasms/surgery ; Sentinel Lymph Node Biopsy/methods ; Lymphatic Metastasis ; Lymph Nodes/pathology ; Magnetic Phenomena ; Ferric Compounds
    Chemical Substances ferric oxide (1K09F3G675) ; Ferric Compounds
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6520
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  5. Article ; Online: A scoping review of the caregiver burden of pediatric food allergy.

    Golding, Michael A / Gunnarsson, Nina V / Middelveld, Roelinde / Ahlstedt, Staffan / Protudjer, Jennifer L P

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2021  Volume 127, Issue 5, Page(s) 536–547.e3

    Abstract: Objective: Although a number of articles have described the psychosocial impact of raising a child with a food allergy, recent attempts at synthesizing this literature have been narrow in focus or methodologically limited. Consequently, this study aimed ...

    Abstract Objective: Although a number of articles have described the psychosocial impact of raising a child with a food allergy, recent attempts at synthesizing this literature have been narrow in focus or methodologically limited. Consequently, this study aimed to synthesize both the quantitative and qualitative literature to achieve a better understanding of the psychosocial and financial burdens faced by families who raise children with food allergy.
    Data sources: Searches were performed on PubMed, Scopus, PsycInfo, and Cumulative Index to Nursing and Allied Health Literature databases for articles related to the psychosocial and financial burden experienced by individuals who care for a child with food allergy.
    Study selections: English language, original research articles were included in this review.
    Results: A total of 54 articles were deemed eligible for review. Results from the quantitative literature revealed that parents of children with food allergy (ie, food allergy and food protein-induced enterocolitis, proctocolitis, and enteropathy) consistently reported lower quality of life than their comparison groups. Within-group analyses suggest that this burden is increased for parents who manage multiple food allergies, severe food allergy, and comorbid allergic conditions. Thematic synthesis of the qualitative literature suggests that the psychosocial burden shouldered by parents of children with food allergy stems, in part, from the unpredictable threat of exposure and the practical and social burdens of managing a food allergy. In addition to psychosocial burdens, a small but growing body of literature suggests that families with food allergy also incur greater financial costs.
    Conclusion: Findings suggest that pediatric food allergy imposes considerable burdens on parents both quantitatively and qualitatively.
    MeSH term(s) Adolescent ; Caregiver Burden/psychology ; Child ; Child, Preschool ; Female ; Food/adverse effects ; Food Hypersensitivity/economics ; Food Hypersensitivity/pathology ; Food Hypersensitivity/psychology ; Humans ; Infant ; Male ; Parents/psychology ; Quality of Life/psychology ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2021.04.034
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  6. Article ; Online: The burden of food allergy on children and teens: A systematic review.

    Golding, Michael A / Batac, Ayel L R / Gunnarsson, Nina V / Ahlstedt, Staffan / Middelveld, Roelinde / Protudjer, Jennifer L P

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 3, Page(s) e13743

    Abstract: Background: Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health-related quality of life (HRQL) and psychosocial well-being of children and teens. In response, a number of reviews ... ...

    Abstract Background: Over the last two decades, researchers have placed increasing attention on understanding how food allergy affects the health-related quality of life (HRQL) and psychosocial well-being of children and teens. In response, a number of reviews have been published that aim at synthesizing the literature. However, many of these papers focus narrowly on HRQL or suffer from methodological limitations.
    Method: The current review aims to fill this gap by providing a comprehensive overview of the burden of pediatric food allergy by synthesizing the quantitative and qualitative literature.
    Results: Findings from the present review provide evidence of reduced HRQL among children and teens with food allergy, particularly older children and those with more severe manifestations of the condition. In comparison to HRQL, the link between food allergy and psychosocial functioning is less clear; however, some evidence can be cited linking food allergy to greater levels of psychological distress. Qualitative evidence suggests that the burden of pediatric food allergy largely stems from worries surrounding exposures outside of the home and the social consequences of the condition. The current review also highlights several gaps in the literature, including a paucity of longitudinal research, research focused on predictors of psychological distress among children and teens with food allergy as well as a dearth of studies comparing rates of bullying in food-allergic and non-food-allergic samples.
    Conclusion: More emphasis should be placed on not only alleviating the social and psychological consequences of food allergy, but also on identifying and assisting those most acutely burdened by the condition.
    MeSH term(s) Adolescent ; Allergens ; Anxiety ; Child ; Food ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/psychology ; Humans ; Quality of Life/psychology
    Chemical Substances Allergens
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13743
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    Zs.A 3096: Show issues Location:
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  7. Book: Recent trends in allergen and complement research

    Ahlstedt, Staffan / Kallós, Paul

    32 tab

    (Progress in allergy ; 30)

    1982  

    Author's details vol. ed. Paul Kallós. Contributors S. Ahlstedt
    Series title Progress in allergy ; 30
    Collection
    Keywords ALLERGENS ; COMPLEMENT ; RESEARCH ; Allergen ; Komplement ; Immunpathologie ; Allergie
    Subject Hypersensibilität ; Allergose ; Allergische Krankheit ; Allergische Reaktion ; Allergien ; Immunopathologie ; Complement ; Komplementsystem
    Language English
    Size XIV, 234 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT001112211
    ISBN 3-8055-2580-X ; 978-3-8055-2580-0
    Database Catalogue ZB MED Medicine, Health

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    UH III ZS 129 -30- verfügbar in Königswinter Königswinter

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  8. Article: Food allergy-related concerns during the transition to self-management.

    Protudjer, Jennifer Lisa Penner / Middelveld, Roelinde / Dahlén, Sven-Erik / Ahlstedt, Staffan

    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

    2019  Volume 15, Page(s) 54

    Abstract: Background: Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe associations between allergies to ...

    Abstract Background: Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe associations between allergies to common foods and HRQL with consideration to gender and age.
    Methods: Adolescents and adults (N = 137; 49.6% males) with specialist-diagnosed allergy to milk, egg and/or wheat completed age-appropriate versions of the Food Allergy Quality of Life Questionnaire (FAQLQ). We pooled common questions and calculated overall- and domain-specific HRQL in association with number and severity of symptoms and time elapse since worst reaction.
    Results: In the entire study population, HRQL was not affected by gender or age, whereas gender-specific age categories affected HRQL among males only. For example, males 18-39 years had worse overall- (β = 0.77; 95% CI 0.08-1.45) and domain-specific HRQL vs. males < 18 years. Among participants with 1-3 food allergy symptoms, no associations were found. Among participants with 4-6 symptoms, the domain allergen avoidance and dietary restrictions was worse among older participants (e.g. 40+ years: β = 0.71; 95% CI 0.05-1.37 vs. < 18 years), and males 18-39 vs. < 18 years. Among participants with severe symptoms, females vs. males, and participants 18-39 vs. < 18 years had worse HRQL. At least 4 years since worst reaction was associated with worse HRQL for participants 40+ years vs. < 18 years, and older males vs. males < 18 years. Nearly all differences exceeded the clinical relevance threshold of ≥ 0.5.
    Conclusions: Associations between allergies to common foods and HRQL are affected by gender and age. Most affected are males 18-39 years. Among females, HRQL is more stable across age groups.
    Language English
    Publishing date 2019-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2434973-2
    ISSN 1710-1492 ; 1710-1484
    ISSN (online) 1710-1492
    ISSN 1710-1484
    DOI 10.1186/s13223-019-0370-1
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  9. Article ; Online: Epinephrine dispensings, allergy hospitalizations and the elimination of co-payments in Sweden.

    Protudjer, Jennifer L P / Middelveld, Roelinde / Ballardini, Natalia / Wai, Hay Mar / Ahlstedt, Staffan / Nilsson, Lennart / Kivistö, Juho E

    Allergy

    2019  Volume 74, Issue 6, Page(s) 1197–1200

    MeSH term(s) Adolescent ; Anaphylaxis/drug therapy ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/economics ; Anti-Allergic Agents/therapeutic use ; Child ; Child, Preschool ; Drug Prescriptions ; Epinephrine/administration & dosage ; Epinephrine/economics ; Epinephrine/therapeutic use ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Prescription Fees ; Sweden ; Young Adult
    Chemical Substances Anti-Allergic Agents ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2019-02-21
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13733
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  10. Article: Pediatric food allergy-related household costs are influenced by age, but not disease severity.

    Wai, Hay Mar / Middelveld, Roelinde / Thörnqvist, Victoria / Ballardini, Natalia / Nilsson, Evalill / Strömquist, Jennie / Nilsson, Lennart / Ahlstedt, Staffan / Protudjer, Jennifer Lisa Penner

    The World Allergy Organization journal

    2019  Volume 12, Issue 9, Page(s) 100061

    Abstract: Objective: The economic burden of food allergy on households is poorly understood. We evaluated the household costs associated with specialist-diagnosed pediatric food allergy, with focus on age and disease severity.: Study design: A cross-sectional ... ...

    Abstract Objective: The economic burden of food allergy on households is poorly understood. We evaluated the household costs associated with specialist-diagnosed pediatric food allergy, with focus on age and disease severity.
    Study design: A cross-sectional study of 70 Swedish case-control pairs (59% boys) was conducted using Food Allergy Economic questionnaire. Household costs were analyzed between age- and gender-matched cases (children aged 0-17 years, with specialist-diagnosed food allergy) and controls (non-food allergic households).
    Results: Parents were predominantly university-educated and employed full-time. Most cases had parent-reported previous anaphylaxis. Mean total annual household costs were comparable between cases and controls. However, compared to controls, cases had significantly higher direct medical-, and non-medical related costs; higher indirect medical-related costs, and higher intangible costs (all p < 0.05). In a sensitivity analyses of only cases aged 0-12 years, direct household costs, including lost earnings due to child's hospitalization, were significantly higher than controls. Results from only children with severe disease paralleled those of all cases vs. controls.
    Conclusions: Although pediatric food allergy is not associated with higher total annual household costs, these households have significantly higher direct medical-related, indirect and intangible costs vs. non-food allergic households. Higher household costs were identified amongst younger children, but not disease severity.
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2019.100061
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