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  1. Article ; Online: Of chloroquine and COVID-19.

    Touret, Franck / de Lamballerie, Xavier

    Antiviral research

    2020  Volume 177, Page(s) 104762

    Abstract: Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this ... ...

    Abstract Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
    MeSH term(s) Antiviral Agents/adverse effects ; Antiviral Agents/pharmacology ; Antiviral Agents/standards ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; China ; Chloroquine/adverse effects ; Chloroquine/pharmacology ; Chloroquine/standards ; Chloroquine/therapeutic use ; Clinical Trials as Topic/standards ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/standards ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-03-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model.

    Driouich, Jean-Sélim / Bernadin, Ornéllie / Touret, Franck / de Lamballerie, Xavier / Nougairède, Antoine

    Antiviral research

    2023  Volume 215, Page(s) 105638

    Abstract: The successive emergence of SARS-CoV-2 Omicron variants has completely changed the modalities of use of therapeutic monoclonal antibodies. Recent in vitro studies indicated that only Sotrovimab has maintained partial activity against BQ.1.1 and XBB.1. In ...

    Abstract The successive emergence of SARS-CoV-2 Omicron variants has completely changed the modalities of use of therapeutic monoclonal antibodies. Recent in vitro studies indicated that only Sotrovimab has maintained partial activity against BQ.1.1 and XBB.1. In the present study, we used the hamster model to determine whether Sotrovimab retains antiviral activity against these Omicron variants in vivo. Our results show that at exposures consistent with those observed in humans, Sotrovimab remains active against BQ.1.1 and XBB.1, although for BQ.1.1 the efficacy is lower than that observed against the first globally dominant Omicron sublineages BA.1 and BA.2.
    MeSH term(s) Animals ; Cricetinae ; Humans ; COVID-19 ; SARS-CoV-2 ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances sotrovimab (1MTK0BPN8V) ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-05-18
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate.

    Touret, Franck / Baronti, Cécile / Bouzidi, Hawa Sophia / de Lamballerie, Xavier

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4683

    Abstract: The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of the ... ...

    Abstract The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of the Omicron variant, we analyzed the neutralizing power of eight currently used monoclonal antibodies compared to the ancestral B.1 BavPat1 D614G strain. We observed that six of these antibodies have lost their ability to neutralize the Omicron variant. Of the antibodies still having neutralizing activity, Sotrovimab/Vir-7831 shows the smallest reduction in activity, with a factor change of 3.1. Cilgavimab/AZD1061 alone shows a reduction in efficacy of 15.8, resulting in a significant loss of activity for the Evusheld cocktail (42.6-fold reduction) in which the other antibody, Tixagevimab, does not retain significant activity against Omicron. Our results suggest that the clinical efficacy of the initially proposed doses should be rapidly evaluated and the possible need to modify doses or propose combination therapies should be considered.
    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral/therapeutic use ; COVID-19/drug therapy ; Humans ; Membrane Glycoproteins ; Neutralization Tests ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; Membrane Glycoproteins ; Spike Glycoprotein, Coronavirus ; Viral Envelope Proteins ; spike protein, SARS-CoV-2 ; tixagevimab ; cilgavimab (1KUR4BN70F) ; sotrovimab (1MTK0BPN8V)
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-08559-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Of chloroquine and COVID-19

    Touret, Franck / de Lamballerie, Xavier

    Antiviral Research

    2020  Volume 177, Page(s) 104762

    Keywords Pharmacology ; Virology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104762
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate

    Franck Touret / Cécile Baronti / Hawa Sophia Bouzidi / Xavier de Lamballerie

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 5

    Abstract: Abstract The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of ... ...

    Abstract Abstract The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently available vaccines and therapeutic antibodies. Using a clinical strain of the Omicron variant, we analyzed the neutralizing power of eight currently used monoclonal antibodies compared to the ancestral B.1 BavPat1 D614G strain. We observed that six of these antibodies have lost their ability to neutralize the Omicron variant. Of the antibodies still having neutralizing activity, Sotrovimab/Vir-7831 shows the smallest reduction in activity, with a factor change of 3.1. Cilgavimab/AZD1061 alone shows a reduction in efficacy of 15.8, resulting in a significant loss of activity for the Evusheld cocktail (42.6-fold reduction) in which the other antibody, Tixagevimab, does not retain significant activity against Omicron. Our results suggest that the clinical efficacy of the initially proposed doses should be rapidly evaluated and the possible need to modify doses or propose combination therapies should be considered.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Of chloroquine and COVID-19

    Touret, Franck / de Lamballerie, Xavier

    Antiviral Res

    Abstract: Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this ... ...

    Abstract Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #4426
    Database COVID19

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  7. Article ; Online: Of chloroquine and COVID-19

    Touret, Franck / De Lamballerie, Xavier

    ISSN: 0166-3542 ; Antiviral Research ; https://www.hal.inserm.fr/inserm-02519612 ; Antiviral Research, Elsevier Masson, 2020, 177, pp.104762. ⟨10.1016/j.antiviral.2020.104762⟩

    2020  

    Abstract: International audience ... Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community ... ...

    Abstract International audience

    Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
    Keywords 2019-nCoV ; Antiviral ; COVID-19 ; Chloroquine ; SARS-CoV-2 ; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ; covid19
    Language English
    Publishing date 2020-03-05
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Of chloroquine and COVID-19

    Touret, Franck / De Lamballerie, Xavier

    ISSN: 0166-3542 ; Antiviral Research ; https://www.hal.inserm.fr/inserm-02519612 ; Antiviral Research, Elsevier Masson, 2020, 177, pp.104762. ⟨10.1016/j.antiviral.2020.104762⟩

    2020  

    Abstract: International audience ... Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community ... ...

    Abstract International audience

    Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
    Keywords 2019-nCoV ; Antiviral ; COVID-19 ; Chloroquine ; SARS-CoV-2 ; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ; covid19
    Language English
    Publishing date 2020-03-05
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: Of chloroquine and COVID-19

    Touret, Franck / De Lamballerie, Xavier

    ISSN: 0166-3542 ; Antiviral Research ; https://www.hal.inserm.fr/inserm-02519612 ; Antiviral Research, Elsevier Masson, 2020, 177, pp.104762. ⟨10.1016/j.antiviral.2020.104762⟩

    2020  

    Abstract: International audience ... Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community ... ...

    Abstract International audience

    Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research.
    Keywords 2019-nCoV ; Antiviral ; COVID-19 ; Chloroquine ; SARS-CoV-2 ; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ; covid19
    Language English
    Publishing date 2020-03-05
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  10. Article ; Online: Hybrid molecules based on an emodin scaffold. Synthesis and activity against SARS-CoV-2 and

    Li, Youzhi / Touret, Franck / de Lamballerie, Xavier / Nguyen, Michel / Laurent, Marion / Benoit-Vical, Françoise / Robert, Anne / Liu, Yan / Meunier, Bernard

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 36, Page(s) 7382–7394

    Abstract: Since the Covid-19 epidemic, it has been clear that the availability of small and affordable drugs that are able to efficiently control viral infections in humans is still a challenge in medicinal chemistry. The synthesis and biological activities of a ... ...

    Abstract Since the Covid-19 epidemic, it has been clear that the availability of small and affordable drugs that are able to efficiently control viral infections in humans is still a challenge in medicinal chemistry. The synthesis and biological activities of a series of hybrid molecules that combine an emodin moiety and other structural moieties expected to act as possible synergistic pharmacophores in a single molecule were studied. Emodin has been reported to block the entry of the SARS-CoV-2 virus into human cells and might also inhibit cytokine production, resulting in the reduction of pulmonary injury induced by SARS-CoV-2. The pharmacophore associated with emodin was either a polyamine residue (emodin-PA series), a choice driven by the fact that a natural alkyl PA like spermine and spermidine play regulatory roles in immune cell functions, or a diphenylmethylpiperazine derivative of the norchlorcyclizine series (emoxyzine series). In fact, diphenylmethylpiperazine antagonists of the H1 histamine receptor display activity against several viruses by multiple interrelated mechanisms. In the emoxyzine series, the most potent drug against SARS-CoV-2 was (
    MeSH term(s) Humans ; SARS-CoV-2 ; Emodin/pharmacology ; COVID-19 ; Plasmodium ; Antimalarials/pharmacology
    Chemical Substances Emodin (KA46RNI6HN) ; Antimalarials
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01122d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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