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Article: Brugada Syndrome-Associated Genetic Loci Are Associated With J-Point Elevation and an Increased Risk of Cardiac Arrest.

Andreasen, Laura / Ghouse, Jonas / Skov, Morten W / Have, Christian T / Ahlberg, Gustav / Rasmussen, Peter V / Linneberg, Allan / Pedersen, Oluf / Platonov, Pyotr G / Haunsø, Stig / Svendsen, Jesper H / Hansen, Torben / Kanters, Jørgen K / Olesen, Morten S

Frontiers in physiology

2018 Volume 9, Page(s) 894

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2018-07-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.00894
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Numerous Brugada syndrome-associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality.

Ghouse, Jonas / Have, Christian T / Skov, Morten W / Andreasen, Laura / Ahlberg, Gustav / Nielsen, Jonas B / Skaaby, Tea / Olesen, Søren-Peter / Grarup, Niels / Linneberg, Allan / Pedersen, Oluf / Vestergaard, Henrik / Haunsø, Stig / Svendsen, Jesper H / Hansen, Torben / Kanters, Jørgen K / Olesen, Morten S

Genetics in medicine : official journal of the American College of Medical Genetics

2016 Volume 19, Issue 5, Page(s) 521–528

Abstract: ... in the general population have an effect on J-point elevation as well as whether carriers of BrS variants were more prone ... pattern. Mean J-point elevation in V1 and V2 were within normal guideline limits for carriers and ...

Abstract	Purpose: We investigated whether Brugada syndrome (BrS)-associated variants identified in the general population have an effect on J-point elevation as well as whether carriers of BrS variants were more prone to experience syncope and malignant ventricular arrhythmia and had increased mortality compared with noncarriers. Methods: All BrS-associated variants were identified using the Human Gene Mutation Database (HGMD). Individuals were randomly selected from a general population study using whole-exome sequencing data (n = 870) and genotype array data (n = 6,161) and screened for BrS-associated variants. Electrocardiograms (ECG) were analyzed electronically, and data on syncope, ventricular arrhythmias, and mortality were obtained from administrative health-care registries. Results: In HGMD, 382 BrS-associated genetic variants were identified. Of these, 28 variants were identified in the study cohort. None of the carriers presented with type 1 BrS ECG pattern. Mean J-point elevation in V1 and V2 were within normal guideline limits for carriers and noncarriers. There was no difference in syncope susceptibility (carriers 8/624; noncarriers 98/5,562; P = 0.51), ventricular arrhythmia (carriers 4/620; noncarriers 9/5,524; P = 0.24), or overall mortality (hazard ratio 0.93, 95% CI 0.63-1.4). Conclusions: Our data indicate that a significant number of BrS-associated variants are not the monogenic cause of BrS.Genet Med advance online publication 06 October 2016.
MeSH term(s)	Adult ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology ; Brugada Syndrome/complications ; Brugada Syndrome/genetics ; Brugada Syndrome/mortality ; Brugada Syndrome/physiopathology ; Denmark/epidemiology ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Heart/physiopathology ; Humans ; Male ; Middle Aged ; Oligonucleotide Array Sequence Analysis/methods ; Random Allocation ; Registries ; Syncope/epidemiology ; Syncope/etiology ; Whole Exome Sequencing/methods
Language	English
Publishing date	2016-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1038/gim.2016.151
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Article ; Online: Comment on Neiser et al. Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA). Int. J. Mol. Sci. 2016, 17, 1185.

Strom, Claes C / Andreasen, Hans B

International journal of molecular sciences

2017 Volume 18, Issue 1

Abstract: All IV iron complexes carry a risk of potentially fatal allergic type hypersensitivity reactions. The mechanism(s) behind these reactions is unknown but the limited data available suggests that classic IgE mediated allergy is exceedingly rare, if ever ... ...

Abstract	All IV iron complexes carry a risk of potentially fatal allergic type hypersensitivity reactions. The mechanism(s) behind these reactions is unknown but the limited data available suggests that classic IgE mediated allergy is exceedingly rare, if ever occurring. Iron-carbohydrate molecules are complex nano-particles and trying to reduce the risk of serious hypersensitivity to antibody binding of an artificial antibody seems meaningless. A recently published analysis of safety data from randomized clinical trials confirms the method reported by Neiser to be useless to predict reaction risk. In conclusion, the study by Neiser et al. is biased, contains no new information, and has no clinical relevance. We are concerned that the association of the authors with a commercial entity has caused a conflict of interest that biases not only the results, but the entire experimental setup against competitors. (Comment on Neiser et al.
MeSH term(s)	Anaphylaxis ; Dextrans ; Enzyme-Linked Immunosorbent Assay ; Humans ; Iron ; Iron-Dextran Complex/immunology
Chemical Substances	Dextrans ; Iron-Dextran Complex (9004-66-4) ; Iron (E1UOL152H7)
Language	English
Publishing date	2017-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18010121
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Article ; Online: Comment on Neiser et al. Assessment of Dextran Antigenicity of Intravenous Iron Preparations with Enzyme-Linked Immunosorbent Assay (ELISA). Int. J. Mol. Sci. 2016, 17, 1185.

Claes C. Strom / Hans B. Andreasen

International Journal of Molecular Sciences, Vol 18, Iss 1, p

2017 Volume 121

Abstract: ... the results, but the entire experimental setup against competitors. (Comment on Neiser et al. Int. J. Mol. Sci ...

Abstract	All IV iron complexes carry a risk of potentially fatal allergic type hypersensitivity reactions. The mechanism(s) behind these reactions is unknown but the limited data available suggests that classic IgE mediated allergy is exceedingly rare, if ever occurring. Iron–carbohydrate molecules are complex nano-particles and trying to reduce the risk of serious hypersensitivity to antibody binding of an artificial antibody seems meaningless. A recently published analysis of safety data from randomized clinical trials confirms the method reported by Neiser to be useless to predict reaction risk. In conclusion, the study by Neiser et al. is biased, contains no new information, and has no clinical relevance. We are concerned that the association of the authors with a commercial entity has caused a conflict of interest that biases not only the results, but the entire experimental setup against competitors. (Comment on Neiser et al. Int. J. Mol. Sci. 2016, 17, 1185, doi:10.3390/ijms17071185).
Keywords	anaphylaxis ; antidextran ; intravenous iron ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: J.J. Pindborg og Dansk Hospitalsodontologi. Nogle refleksioner fra Rigshospitalets afdeling for tand-, mund- og kaebesygdomme.

Hjørting-Hansen, E / Andreasen, J O

Tandlaegebladet

1981 Volume 85, Issue 13, Page(s) 385–390

Title translation	J.J. Pindborg and Danish hospital dentistry. Various thoughts on State hospital separation of dental, oral and periodontal diseases.
MeSH term(s)	Denmark ; Dental Service, Hospital/history ; Dental Service, Hospital/organization & administration ; History, 20th Century ; Hospitals, Public/organization & administration ; Hospitals, State/organization & administration ; Mouth Diseases/therapy ; Periodontal Diseases/therapy ; Tooth Diseases/therapy
Language	Danish
Publishing date	1981-08
Publishing country	Denmark
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	414055-2
ISSN	0039-9353
ISSN	0039-9353
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Article ; Online: Reprint of: Relationship Between Surface and Inflammatory Resorption and Changes in the Pulp After Replantation of Permanent Incisors in Monkeys.

Andreasen, J O

Journal of endodontics

2021 Volume 47, Issue 6, Page(s) 865–872

Abstract: The etiology of surface and inflammatory root resorption after the replantation of incisors was examined in green vervet monkeys. The teeth were examined histologically and histobacteriologically for pulpal healing and root resorption 2 and 8 weeks after ...

Abstract	The etiology of surface and inflammatory root resorption after the replantation of incisors was examined in green vervet monkeys. The teeth were examined histologically and histobacteriologically for pulpal healing and root resorption 2 and 8 weeks after replantation. In contrast to surface resorption, inflammatory resorption was related to infected necrotic tissue or an infected leukocyte zone in the root canal. The following theory for surface and inflammatory resorption is presented. Damaged periodontal ligament areas and damaged parts of the root surface are attacked by a resorption process whereby resorption of cementum and dentin may occur. Inflammatory resorption or surface resorption will then occur depending on the pulpal status and the depth of the resorption cavity. If the resorption cavity penetrates the intermediate layer of cementum and contacts dentinal tubules that are in communication with infected necrotic pulp tissue or an infected leukocyte zone, then inflammatory resorption will take place as a result of the diffusion of toxic elements from the pulp canal to the resorption cavity. However, if the resorption cavity is shallow and does not penetrate the intermediate layer of cementum, a tooth that displays similar pulpal changes will elicit only surface resorption because the intermediate layer of cementum will tend to arrest the diffusion of toxic elements. Finally, if the pulp contains vital, inflamed, or noninflamed tissue or if root canal treatment has been performed, surface resorption will occur regardless of the depth of the cavity.
MeSH term(s)	Animals ; Chlorocebus aethiops ; Dental Pulp ; Haplorhini ; Incisor ; Periodontal Ligament ; Root Resorption/etiology ; Tooth Replantation ; Tooth Root
Language	English
Publishing date	2021-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	752412-2
ISSN	1878-3554 ; 0099-2399
ISSN (online)	1878-3554
ISSN	0099-2399
DOI	10.1016/j.joen.2021.03.017
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Book ; Online: Holocene sea-surface reconstructions for the Californian margin, supplementary data to: Herbert, Timothy D; Schuffert, J; Andreasen, Dyke; Heusser, Linda E; Lyle, Mitchell W; Mix, Alan C; Ravelo, Ana Christina; Stott, Lowell D; Herguera, Juan Carlos (2001): Collapse of the California current during glacial maxima linked to climate change on land. Science, 293(5527), 71-76

Herbert, Timothy D / Andreasen, Dyke / Herguera, Juan Carlos / Heusser, Linda E / Lyle, Mitchell W / Mix, Alan C / Ravelo, Ana Christina / Schuffert, J / Stott, Lowell D

2001

Abstract: Time series of alkenone unsaturation indices gathered along the California margin reveal large (4° to 8°C) glacial-interglacial changes in sea surface temperature (SST) over the past 550,000 years. Interglacial times with SSTs equal to or exceeding that ... ...

Abstract	Time series of alkenone unsaturation indices gathered along the California margin reveal large (4° to 8°C) glacial-interglacial changes in sea surface temperature (SST) over the past 550,000 years. Interglacial times with SSTs equal to or exceeding that of the Holocene contain peak abundances in the pollen of redwood, the distinctive component of the temperate rainforest of the northwest coast of California. In the region now dominated by the California Current, SSTs warmed 10,000 to 15,000 years in advance of deglaciation at each of the past five glacial maxima. SSTs did not rise in advance of deglaciation south of the modern California Current front. Glacial warming along the California margin therefore is a regional signal of the weakening of the California Current during times when large ice sheets reorganized wind systems over the North Pacific. Both the timing and magnitude of the SST estimates suggest that the Devils Hole (Nevada) calcite record represents regional but not global paleotemperatures, and hence does not pose a fundamental challenge to the orbital ("Milankovitch") theory of the Ice Ages.
Language	English
Dates of publication	2001-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1126/science.1059209
DOI	10.1594/PANGAEA.701440
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Exercise-based real-time telerehabilitation for older patients recently discharged after transcatheter aortic valve implantation: An extended feasibility study.

Brocki, Barbara Cristina / Andreasen, Jan Jesper / Aarøe, Jens / Andreasen, Jane / Thorup, Charlotte B

Journal of geriatric cardiology : JGC

2023 Volume 20, Issue 11, Page(s) 767–778

Abstract: Objectives: To assess the extended feasibility of a telerehabilitation program and its effects on physical performance in older adults who have recently undergone transcatheter aortic valve implantation (TAVI).: Methods: In this single-center ... ...

Abstract	Objectives: To assess the extended feasibility of a telerehabilitation program and its effects on physical performance in older adults who have recently undergone transcatheter aortic valve implantation (TAVI). Methods: In this single-center feasibility study, patients underwent an eight-week telerehabilitation program, involving web-based home exercise training twice weekly, an activity tracker, access to an informative website, and one online session with a nurse, starting one-week postoperative. Data collection was performed before surgery and three months postoperative. The feasibility of the intervention was based on recruitment and adherence to the program. As a secondary outcome, we evaluated the change in six-minute walk distance from before surgery to three months postoperative. Results: Forty-one patients scheduled for TAVI were assessed for eligibility; 15 patients (37%) were enrolled. Of these, eight were excluded after surgery due to tiredness ( Conclusion: Web-based telerehabilitation, including supervised exercise training, in older adults who have recently undergone TAVI was feasible for a small number of patients who completed the eight-week intervention. This was reflected in an improvement in their walked distance three months after the surgery. However, the low recruitment and retention rates do question the overall feasibility of this intervention in a frail, older population of post-TAVI patients.
Language	English
Publishing date	2023-12-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.26599/1671-5411.2023.11.003
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Article: Multidimensional frailty and its determinants among acutely admitted older people: a cross-sectional study using the Tilburg Frailty Indicator.

Gobbens, Robbert J J / Andreasen, Jane

European geriatric medicine

2020 Volume 12, Issue 1, Page(s) 151–160

Abstract: Purpose: This study aimed to establish which determinants had an effect on frailty among acutely admitted patients, where frailty was identified at discharge. In particular, our study focused on associations of sex with frailty.: Methods: A cross- ... ...

Abstract	Purpose: This study aimed to establish which determinants had an effect on frailty among acutely admitted patients, where frailty was identified at discharge. In particular, our study focused on associations of sex with frailty. Methods: A cross-sectional study was designed using a sample of 1267 people aged 65 years or older. The Tilburg Frailty Indicator (TFI), a user-friendly self-report questionnaire was used to measure multidimensional frailty (physical, psychological, social) and determinants of frailty (sex, age, marital status, education, income, lifestyle, life events, multimorbidity). Results: The mean age of the participants was 76.8 years (SD 7.5; range 65-100). The bivariate regression analyses showed that all determinants were associated with total and physical frailty, and six determinants were associated with psychological and social frailty. Using multiple linear regression analyses, the explained variances differed from 3.5% (psychological frailty) to 20.1% (social frailty), with p values < 0.001. Of the independent variables age, income, lifestyle, life events, and multimorbidity were associated with three frailty variables, after controlling for all the other variables in the model. At the level of both frailty domains and components, females appeared to be more frail than men. Conclusion: The present study showed that sociodemographic characteristics (sex, age, marital status, education, income), lifestyle, life events, and multimorbidity had a different effect on total frailty and its domains (physical, psychological, social) in a sample of acute admitted patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/diagnosis ; Geriatric Assessment ; Humans ; Male ; Surveys and Questionnaires
Language	English
Publishing date	2020-09-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-020-00388-x
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Article ; Online: The prediction of readmission and mortality by the domains and components of the Tilburg Frailty Indicator (TFI): A prospective cohort study among acutely admitted older patients.

Gobbens, Robbert J J / Andreasen, Jane

Archives of gerontology and geriatrics

2020 Volume 89, Page(s) 104077

Abstract: Purpose: To assess the predictive value of three different frailty domains (physical, psychological, social) for both readmission and mortality in a population of acutely admitted older patients, and to determine which components of the individual three ...

Abstract	Purpose: To assess the predictive value of three different frailty domains (physical, psychological, social) for both readmission and mortality in a population of acutely admitted older patients, and to determine which components of the individual three frailty domains had an effect on readmission and mortality. Methods: This prospective cohort study was conducted in a sample of 1,328 Danish acutely admitted patients aged 65 years or older. The follow-up period on readmission and death was six months. The Tilburg Frailty Indicator (TFI), a validated questionnaire, was used to assess the three frailty domains and their 15 components. Results: After using sequential logistic regression analyses, including controlling for socio-demographic characteristics and comorbidity, physical and social frailty predicted readmission and death, while psychological frailty predicted only readmission. The analyses also demonstrated that the component weight loss had predictive value for both outcomes, and feeling down and missing people around you were only associated with readmission, after controlling for all the predictors. Conclusion: Our study emphasizes the importance of a multidimensional measurement of frailty, including a physical, psychological and social domain. Health care professionals aiming to prevent readmission and death among acutely admitted patients should at least conduct interventions focused on unintentional weight loss, feeling down, and missing people around you, because their effect on the outcomes was the largest.
MeSH term(s)	Aged ; Frail Elderly ; Frailty ; Geriatric Assessment ; Humans ; Patient Readmission ; Prospective Studies ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2020-04-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2020.104077
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