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  1. Article ; Online: A novel mass cytometry protocol optimized for immunophenotyping of low-frequency antigen-specific T cells.

    Balz, Kathrin / Grange, Magali / Pegel, Uta / Karamya, Zain A / Mello, Marielle / Zhou, Xiaoying / Berger, Thilo / Bloch, Konstantin / Dunham, Diane / Chinthrajah, Sharon / Nadeau, Kari / Luche, Hervé / Skevaki, Chrysanthi

    Frontiers in cellular and infection microbiology

    2024  Volume 13, Page(s) 1336489

    Abstract: Understanding antigen-specific T-cell responses, for example, following virus infections or ... on optimizing immunophenotyping of T cells after antigen stimulation by improving staining procedures for flow ... for the detection of low-frequency T-cell response using a dual-barcoding system for individual samples and ...

    Abstract Understanding antigen-specific T-cell responses, for example, following virus infections or allergen exposure, is of high relevance for the development of vaccines and therapeutics. We aimed on optimizing immunophenotyping of T cells after antigen stimulation by improving staining procedures for flow and mass cytometry. Our method can be used for primary cells of both mouse and human origin for the detection of low-frequency T-cell response using a dual-barcoding system for individual samples and conditions. First, live-cell barcoding was performed using anti-CD45 antibodies prior to an
    MeSH term(s) Humans ; Animals ; Mice ; Flow Cytometry/methods ; Immunophenotyping ; Antigens ; T-Lymphocytes ; Staining and Labeling ; CD8-Positive T-Lymphocytes
    Chemical Substances Antigens
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1336489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Evaluation of T Cell Response to SARS-CoV-2 in Kidney Transplant Recipients Receiving Monoclonal Antibody Prophylaxis and the Utility of a Bivalent mRNA Vaccine Booster Dose.

    Bertrand, Dominique / Laurent, Charlotte / Lemoine, Mathilde / Lebourg, Ludivine / Hanoy, Mélanie / Le Roy, Frank / Nezam, Dorian / Pruteanu, Diana / Grange, Steven / De Nattes, Tristan / Lemée, Véronique / Guerrot, Dominique / Candon, Sophie

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: ... studied in this context. We assessed the T cell response to SARS-CoV-2 in 97 patients on the day ... antibody titers and spike-reactive T cells increased significantly in patients under tacrolimus but not ...

    Abstract Monoclonal antibodies have been administered to kidney transplant recipients (KTRs) with a poor or non-responder status to SARS-CoV-2 vaccination. The cellular response to SARS-CoV-2 has been poorly studied in this context. We assessed the T cell response to SARS-CoV-2 in 97 patients on the day of the injection of tixagevimab/cilgavimab using an IFNγ enzyme-linked immunospot assay (ELISPOT). Among the 97 patients, 34 (35%) developed COVID-19 before the injection. Twenty-nine (85.3%) had an ELISPOT compatible with a SARS-CoV-2 infection. There was no difference between KTRs under belatacept or tacrolimus treatment. Sixty-three patients (64.9%) had no known COVID-19 prior to the ELISPOT, but nine (14.3%) had a positive ELISPOT. In 21 KTRs with a positive ELISPOT who received a booster dose of a bivalent mRNA vaccine, median antibody titers and spike-reactive T cells increased significantly in patients under tacrolimus but not belatacept. Our study emphasizes the potential usefulness of the exploration of immune cellular response to SARS-CoV-2 by ELISPOT. In KTRs with a positive ELISPOT and under CNI therapy, a booster dose of mRNA vaccine seems effective in inducing an immune response to SARS-CoV-2.
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040722
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  3. Article ; Online: Survival and Prognostic Factors in Patients with Aggressive Cutaneous T-cell Lymphomas.

    Franceschi, Joséphine / Ehret, Marine / Visseaux, Laetitia / Durlach, Anne / Barbe, Coralie / Durot, Éric / Grange, Florent

    Acta dermato-venereologica

    2022  Volume 102, Page(s) adv00676

    Abstract: Aggressive primary cutaneous T-cell lymphomas include advanced-stage mycosis fungoides (stage ≥ IIB ... CD8+ T-cell lymphoma and some cutaneous lymphomas not otherwise specified. To evaluate their long-term ...

    Abstract Aggressive primary cutaneous T-cell lymphomas include advanced-stage mycosis fungoides (stage ≥ IIB mycosis fungoides), Sézary syndrome, gamma/delta cutaneous lymphoma, nasal type lymphoma, aggressive epidermotropic CD8+ T-cell lymphoma and some cutaneous lymphomas not otherwise specified. To evaluate their long-term prognosis, we conducted a retrospective cohort study of 85 patients diagnosed between 2005 and 2020 with advanced-stage mycosis fungoides (n = 48), Sézary syndrome (n = 28) or aggressive non-mycosis fungoides/Sézary syndrome subtypes (n = 9). The median survival times in these 3 groups were 118.7, 45.7 and 11.2 months, respectively, and the 5-year survival rates were 55.3%, 27.8% and 33.3%, respectively. Multivariate analyses in patients with mycosis fungoides/Sézary syndrome identified age ≥ 70 years, Eastern Cooperative Oncology Group Performance Status ≥  2, and the high-risk group according to the Cutaneous Lymphoma International Consortium prognostic model, as adverse prognostic factors. Seven patients in this mycosis fungoides/ Sézary syndrome group were in complete long-term remission after treatment with bexarotene, including 4 patients living without any treatment for 16-101 months.
    MeSH term(s) Aged ; Humans ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/drug therapy ; Prognosis ; Retrospective Studies ; Sezary Syndrome/diagnosis ; Sezary Syndrome/drug therapy ; Skin Neoplasms/diagnosis ; Skin Neoplasms/drug therapy
    Language English
    Publishing date 2022-03-22
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v102.1087
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  4. Article ; Online: Syringotropic Mycosis Fungoides with Vasculopathic Ulcers and Expression of T-follicular-helper Cell Markers.

    Ribereau-Gayon, Emanuel / Le Borgne De Lavillandre, Joann / Deschamps, Thibaut / Balme, Brigitte / Harou, Olivier / Grange, Florent

    Acta dermato-venereologica

    2021  Volume 101, Issue 10, Page(s) adv00569

    MeSH term(s) Biomarkers ; Humans ; Mycosis Fungoides/diagnosis ; Skin Neoplasms ; T-Lymphocytes, Helper-Inducer ; Ulcer
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-10-14
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3868
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  5. Article ; Online: Allogeneic transplantation in advanced cutaneous T-cell lymphomas (CUTALLO): a propensity score matched controlled prospective study.

    de Masson, Adèle / Beylot-Barry, Marie / Ram-Wolff, Caroline / Mear, Jean-Baptiste / Dalle, Stéphane / d'Incan, Michel / Ingen-Housz-Oro, Saskia / Orvain, Corentin / Abraham, Julie / Dereure, Olivier / Charbonnier, Amandine / Cornillon, Jérôme / Longvert, Christine / Barete, Stéphane / Boulinguez, Serge / Wierzbicka-Hainaut, Ewa / Aubin, François / Rubio, Marie-Thérèse / Bernard, Marc /
    Schmidt-Tanguy, Aline / Houot, Roch / Pham-Ledard, Anne / Michonneau, David / Brice, Pauline / Labussière-Wallet, Hélène / Bouaziz, Jean-David / Grange, Florent / Moins-Teisserenc, Hélène / Jondeau, Katayoun / Michel, Laurence / Mourah, Samia / Battistella, Maxime / Daguindau, Etienne / Loschi, Michael / Picard, Alexandra / Franck, Nathalie / Maillard, Natacha / Huynh, Anne / Nguyen, Stéphanie / Marçais, Ambroise / Chaby, Guillaume / Ceballos, Patrice / Le Corre, Yannick / Maury, Sébastien / Bay, Jacques-Olivier / Adamski, Henri / Bachy, Emmanuel / Forcade, Edouard / Socié, Gérard / Bagot, Martine / Chevret, Sylvie / Peffault de Latour, Régis

    Lancet (London, England)

    2023  Volume 401, Issue 10392, Page(s) 1941–1950

    Abstract: Background: Advanced-stage cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and ...

    Abstract Background: Advanced-stage cutaneous T-cell lymphomas (CTCLs) are rare, usually refractory, and fatal diseases. Case series have suggested that allogeneic haematopoietic stem cell transplantation (HSCT) might improve the prognosis of advanced-stage CTCLs. The objective of this study was to investigate the effect of allogeneic HSCT compared with non-HSCT therapy on the outcome of individuals with advanced-stage CTCLs.
    Methods: In this prospective, multicentre, matched controlled trial, conducted at 30 hospitals, participants with advanced CTCLs were allocated treatment: if they had an available compatible related donor they were assigned to allogeneic HSCT, or if not they were allocated to non-allogeneic HSCT therapy. Key inclusion criteria were participants aged 18-70 years, with advanced stage mycosis fungoides or Sézary syndrome, and at least one poor prognostic criteria. Participants were excluded if they were not in complete or partial remission of the disease. Propensity score 1:1 matching with replacement (ie, that each participant treated with HSCT was matched to the participant with the closest propensity score treated with non-HSCT therapy, even if they had already been matched) was used to handle confounding factors, with the balance of covariate distribution between HSCT and non-HSCT groups assessed using standardised mean differences. The primary endpoint was progression-free survival in the matched intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02520908), and is currently active but not recruiting.
    Findings: From June 1, 2016, to March 3, 2022, total of 99 participants were enrolled at 17 centres in France. Participants with a sibling or matched unrelated donor were assigned to allogeneic HSCT (HSCT group, n=55 [56%]) and participants without a donor were assigned to non-allogeneic HSCT treatment (non-HSCT group, n=44 [44%]). The median follow-up among survivors was 12·6 months (IQR 11·0-35·2). In the HSCT group, 51 participants (93%) were 1:1 matched to participants from the non-HSCT group. In the intention-to-treat analysis, median progression-free survival was significantly longer in the HSCT group (9·0 months [95% CI 6·6-30·5]) than in the non-HSCT group (3·0 months [2·0-6·3]), with a hazard ratio of 0·38 (95% CI 0·21-0·69; p<0·0001). In the per-protocol population, 40 participants (78%) in the HSCT group had 101 serious events and 29 participants (67%) in the non-HSCT group had 70 serious adverse events. The most common serious adverse event other than graft-versus-host disease in both groups was infections, occurring in 30 participants (59%) in the HSCT group and in 19 participants (44%) in the non-HSCT group.
    Interpretation: Allogeneic HSCT was associated with significantly longer progression-free survival in participants with advanced-stage CTCLs. These results indicate that allogeneic HSCT treatment should be made available to individuals with high-risk, advanced-stage mycosis fungoides or Sézary syndrome who achieve pre-transplant disease remission.
    Funding: French Ministry of Health, National Cancer Institute, Programme Hospitalier de Recherche Clinique en Cancérologie.
    MeSH term(s) Humans ; Prospective Studies ; Sezary Syndrome/therapy ; Sezary Syndrome/etiology ; Propensity Score ; Lymphoma, T-Cell, Cutaneous/therapy ; Lymphoma, T-Cell, Cutaneous/etiology ; Transplantation, Homologous ; Hematopoietic Stem Cell Transplantation/methods ; Mycosis Fungoides/etiology ; Mycosis Fungoides/pathology ; Skin Neoplasms/therapy ; Skin Neoplasms/etiology
    Language English
    Publishing date 2023-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00329-X
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  6. Article ; Online: Infection complications in febrile chimeric antigen receptor (CAR)-T recipients during the peri-CAR-T cell treatment period examined using metagenomic next-generation sequencing (mNGS).

    Nie, Jiali / Yang, Li / Huang, Liang / Gao, Lili / Young, Ken He / Le Grange, Jehane Michael / Yang, Xingcheng / Wei, Jia / Xiao, Min / Zhou, Jianfeng

    Cancer communications (London, England)

    2022  Volume 42, Issue 5, Page(s) 476–480

    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Metagenomics ; Receptors, Chimeric Antigen ; T-Lymphocytes
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-01-15
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12260
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  7. Article ; Online: T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity.

    Visseaux, L / Durlach, A / Barete, S / Beylot-Barry, M / Bonnet, N / Chassine, A / Franck, N / Herve, G / Leclec'h, C / Machet, L / Ingen-Housz-Oro, S / Petrella, T / Vergier, B / Ortonne, N / Grange, F

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2018  Volume 32, Issue 9, Page(s) 1469–1475

    Abstract: ... a dense dermal lymphocytic infiltrate predominantly composed of T lymphocytes (100%), with frequent ... T-cell clone was present.: Conclusion: We propose the denomination 'T-cell papulosis associated ... with a secondary, predominant, T-cell immune reaction could explain the clinicopathologic aspect and the prolonged ...

    Abstract Background: A distinctive eruption referred to as 'insect bite-like reaction' or 'eosinophilic dermatosis of haematological malignancy' has been described during the course of haematological B-cell malignancies (BCM). However, its clinical evolution, histopathological features and pathogenesis remain unclear.
    Objectives: To characterize this eruption and to investigate its pathogenesis and relationship with the underlying BCM.
    Methods: In this multicenter retrospective study of the French Study Group on Cutaneous Lymphomas, 37 patients with a BCM and a cutaneous eruption consisting in chronic and/or recurrent papules, papulo-vesicles and/or nodules were included. Clinical, histopathological, immunohistochemical and molecular data were reviewed.
    Results: No significant insect bite history or seasonal predominance was recorded. Patients had pruritic papules (81%), papulo-vesicles (43%) and nodules (38%), often predominated in the head and neck region (84%), without complete remission periods in most cases (57%). The predominant associated BCM was chronic lymphocytic leukaemia (73%). Histological and immunohistochemical review showed a dense dermal lymphocytic infiltrate predominantly composed of T lymphocytes (100%), with frequent eosinophils (77.6%); a perivascular and periadnexal (most often folliculotropic) pattern (77.6%), sometimes suggestive of a folliculotropic mycosis fungoides; clusters of tumour B cells were identified in 47% of cases using appropriate phenotyping markers. In 10/14 cases (71.4%) tested for B-cell IgH gene rearrangement, a B-cell clone was identified in skin lesions (identical to the blood clone in nine cases), whereas no T-cell clone was present.
    Conclusion: We propose the denomination 'T-cell papulosis associated with B-cell malignancy' (TCP-BCM) for this distinctive eruption. Although resulting in various histopathological pictures, it can be easily recognized by clinicians and may be identified by informed pathologists relying on some key features. An extravasation of tumour B cells with skin-homing properties associated with a secondary, predominant, T-cell immune reaction could explain the clinicopathologic aspect and the prolonged regressive and recurrent course of the disease.
    MeSH term(s) Aged ; B-Lymphocytes/pathology ; Biopsy ; Female ; Humans ; Immunohistochemistry ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Retrospective Studies ; Skin Diseases/drug therapy ; Skin Diseases/etiology ; Skin Diseases/pathology ; T-Lymphocytes/pathology ; Terminology as Topic
    Language English
    Publishing date 2018-02-12
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.14805
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  8. Article ; Online: Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients.

    de Masson, Adèle / Darbord, Delphine / Dobos, Gabor / Boisson, Marie / Roelens, Marie / Ram-Wolff, Caroline / Cassius, Charles / Le Buanec, Hélène / de la Grange, Pierre / Jouenne, Fanélie / Louveau, Baptiste / Sadoux, Aurélie / Bouaziz, Jean-David / Marie-Cardine, Anne / Bagot, Martine / Moins-Teisserenc, Hélène / Mourah, Samia / Battistella, Maxime

    Blood

    2021  Volume 139, Issue 12, Page(s) 1820–1832

    Abstract: Cutaneous T-cell lymphomas (CTCLs) are rare malignancies involving primarily the skin. Responses ... tumor cells and peripheral memory blood regulatory T cells, has been associated with long-lasting ... throughput sequencing analysis of T-cell receptor β genes in skin and blood flow cytometry confirmed ...

    Abstract Cutaneous T-cell lymphomas (CTCLs) are rare malignancies involving primarily the skin. Responses to treatment are usually short-lived in advanced CTCL. The determinants of long-term CTCL control are unclear. Mogamulizumab, an anti-human CCR4 antibody that acts by antibody-dependent cell cytotoxicity against CCR4+ CTCL tumor cells and peripheral memory blood regulatory T cells, has been associated with long-lasting remissions and immune adverse events. Here, we reported skin rashes in 32% of 44 patients with CTCL treated with mogamulizumab, associated with significantly higher overall survival (hazard ratio, 0.16; 0.04-0.73; P = .01). Rash occurred in patients with Sézary syndrome and was associated with longer time to progression. These rashes were characterized by a CD163+ granulomatous and/or CD8+ lichenoid skin infiltrate. High-throughput sequencing analysis of T-cell receptor β genes in skin and blood flow cytometry confirmed the depletion of CTCL tumor cells, as well as the recruitment of new reactive T-cell clones in skin at the time of skin rash. CXCL9 and CXCL11, two macrophage-derived chemokines that recruit CXCR3+ T cells to skin, were overexpressed in skin rashes. A higher frequency of TIGIT+ and PD1+ exhausted reactive blood T cells was observed at baseline in patients with rash, and this frequency decreased with mogamulizumab treatment. These data are consistent with mogamulizumab-induced long-term immune CTCL control by activation of the macrophage and T-cell responses in patients with rash.
    MeSH term(s) Antibodies, Monoclonal, Humanized ; Chemokine CXCL11 ; Chemokine CXCL9 ; Exanthema/chemically induced ; Humans ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/pathology ; Macrophages/pathology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; T-Lymphocytes, Regulatory
    Chemical Substances Antibodies, Monoclonal, Humanized ; CXCL11 protein, human ; CXCL9 protein, human ; Chemokine CXCL11 ; Chemokine CXCL9 ; mogamulizumab (YI437801BE)
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013341
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  9. Article ; Online: Primary Cutaneous Gamma-Delta T-cell Lymphoma: Not an Aggressive Disease in All Cases.

    Khallaayoune, Mehdi / Grange, Florent / Condamina, Morgane / Szablewski, Vanessa / Guillot, Bernard / Dereure, Olivier

    Acta dermato-venereologica

    2020  Volume 100, Issue 1, Page(s) adv00035

    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Disease Progression ; Fatal Outcome ; Female ; Humans ; Lymphoma, T-Cell, Cutaneous/drug therapy ; Lymphoma, T-Cell, Cutaneous/immunology ; Lymphoma, T-Cell, Cutaneous/pathology ; Male ; Receptors, Antigen, T-Cell, gamma-delta/analysis ; Remission Induction ; Skin Neoplasms/drug therapy ; Skin Neoplasms/immunology ; Skin Neoplasms/pathology ; Treatment Outcome
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2020-01-23
    Publishing country Sweden
    Document type Case Reports
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-3340
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  10. Article: Ancient Retrovirus Targeted by Engineered T Cells in Melanoma--Letter.

    Grange, John M / Krone, Bernd

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2015  Volume 21, Issue 19, Page(s) 4494

    MeSH term(s) Animals ; Genetic Therapy/methods ; Humans ; Immunotherapy, Adoptive/methods ; Melanoma/virology ; T-Lymphocytes/transplantation ; Viral Proteins/immunology
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2015-10-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-15-1548
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