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Article ; Online: Pharmacists' prescribing authority: The Oregon approach.

Frost, Timothy P / Millard, Michael E / Doyle, Ian C

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2019 Volume 77, Issue 1, Page(s) 47–51

MeSH term(s)	Drug Prescriptions ; Group Processes ; Humans ; Oregon ; Pharmacists ; Professional Role
Language	English
Publishing date	2019-11-03
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxz256
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Article ; Online: Nearshore wave buoy data from southeastern Australia for coastal research and management.

Kinsela, Michael A / Morris, Bradley D / Ingleton, Timothy C / Doyle, Thomas B / Sutherland, Michael D / Doszpot, Neil E / Miller, Jeff J / Holtznagel, Stephen F / Harley, Mitchell D / Hanslow, David J

Scientific data

2024 Volume 11, Issue 1, Page(s) 190

Abstract: Wind wave observations in shallow coastal waters are essential for calibrating, validating, and improving numerical wave models to predict sediment transport, shoreline change, and coastal hazards such as beach erosion and oceanic inundation. Although ... ...

Abstract	Wind wave observations in shallow coastal waters are essential for calibrating, validating, and improving numerical wave models to predict sediment transport, shoreline change, and coastal hazards such as beach erosion and oceanic inundation. Although ocean buoys and satellites provide near-global coverage of deep-water wave conditions, shallow-water wave observations remain sparse and often inaccessible. Nearshore wave conditions may vary considerably alongshore due to coastline orientation and shape, bathymetry and islands. We present a growing dataset of in-situ wave buoy observations from shallow waters (<35 m) in southeast Australia that comprises over 7,000 days of measurements at 20 locations. The moored buoys measured wave conditions continuously for several months to multiple years, capturing ambient and storm conditions in diverse settings, including coastal hazard risk sites. The dataset includes tabulated time series of spectral and time-domain parameters describing wave height, period and direction at half-hourly temporal resolution. Buoy displacement and wave spectra data are also available for advanced applications. Summary plots and tables describing wave conditions measured at each location are provided.
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02865-x
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Article ; Online: Cardiovascular Disease Implementation and Policy Priorities for Australia: Recommendations From an Australian Stakeholder Roundtable.

Redfern, Julie / Shang, Catherine / Hsu, Meng-Ping / Doyle, Kerry / Nutbeam, Don / Audehm, Ralph / Inglis, Sally C / Hamilton-Craig, Christian / Raffoul, Natalie / Shaw, Timothy / Figtree, Gemma A / Jennings, Garry

Heart, lung & circulation

2023 Volume 32, Issue 10, Page(s) 1141–1147

Abstract: The Australian Cardiovascular Alliance (ACvA), the Cardiac Society of Australia and New Zealand (CSANZ) and the National Heart Foundation of Australia (NHFA) recently joined forces to bring the cardiovascular and stroke community together to convene and ... ...

Abstract	The Australian Cardiovascular Alliance (ACvA), the Cardiac Society of Australia and New Zealand (CSANZ) and the National Heart Foundation of Australia (NHFA) recently joined forces to bring the cardiovascular and stroke community together to convene and document a national discussion and propose a national CVD Implementation and Policy agenda and action plan. This includes prevention and screening, acute care and secondary prevention.
MeSH term(s)	Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Australia/epidemiology ; Policy ; New Zealand/epidemiology
Language	English
Publishing date	2023-09-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2020980-0
ISSN	1444-2892 ; 1443-9506
ISSN (online)	1444-2892
ISSN	1443-9506
DOI	10.1016/j.hlc.2023.07.009
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Article ; Online: Time and motion study of pharmacist prescribing of oral hormonal contraceptives in Oregon community pharmacies.

Frost, Timothy P / Klepser, Donald G / Small, Danielle C / Doyle, Ian C

Journal of the American Pharmacists Association : JAPhA

2019 Volume 59, Issue 2, Page(s) 222–227

Abstract: Objectives: The aim of this time and motion study was to evaluate the procedural time and steps of performing an oral hormonal contraceptive pharmacist prescribing service in an Oregon community pharmacy.: Methods: A standardized patient seeking oral ...

Abstract	Objectives: The aim of this time and motion study was to evaluate the procedural time and steps of performing an oral hormonal contraceptive pharmacist prescribing service in an Oregon community pharmacy. Methods: A standardized patient seeking oral hormonal contraception visited 13 community pharmacies throughout February 2018 in the tri-county Portland, Oregon, metropolitan area for pharmacist-prescribed hormonal contraception services for a total of 26 patient encounters. An observer was present at each encounter to record the time for each step and the total encounter time. Each pharmacist was asked to perform assessment procedures and prescribing for each of 2 standardized patient presentations: in cohort 1 (n = 13), the pharmacist's assessment resulted in a hormonal contraception prescription written; in cohort 2 (n = 13), pharmacist's assessment detected contraindications and resulted in a medical referral to another health care prescriber. Results: The average total patient time from arrival at the pharmacy to the generation of either a written prescription for hormonal contraception or referral to another health care provider was 17.9 and 14.1 minutes, respectively. Without accounting for documentation or dispensing the prescription, the average total pharmacist time to perform the service and issue a prescription, or refer the patient, was 7.8 and 5.4 minutes, respectively. Conclusion: The results indicate that the pharmacist prescribing service for oral hormonal contraception requires a modest amount of pharmacist time. Incorporation of practice into regular workflow appears to have an impact similar to other clinical services, such as immunizations and point-of-care testing. The patient time spent with the pharmacist was similar to other health care provider visits.
MeSH term(s)	Community Pharmacy Services/organization & administration ; Contraceptives, Oral, Hormonal/administration & dosage ; Female ; Humans ; Oregon ; Pharmacists/organization & administration ; Professional Role ; Referral and Consultation/statistics & numerical data ; Time Factors ; Time and Motion Studies
Chemical Substances	Contraceptives, Oral, Hormonal
Language	English
Publishing date	2019-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2018.12.015
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Article ; Online: Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome.

Takahashi, Tatsunori / Sakai, Noriaki / Iwasaki, Tomonori / Doyle, Timothy C / Mobley, William C / Nishino, Seiji

Scientific reports

2020 Volume 10, Issue 1, Page(s) 21323

Abstract: A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS ...

Abstract	A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway obstruction of human DS and can serve as an experimental platform for OSA research. This study, thus, aimed to quantitatively characterize the upper airway as well as craniofacial abnormalities in Dp(16)1Yey (Dp16) mice. Dp16 mice demonstrated craniofacial hypoplasia, especially in the ventral part of the skull and the mandible, and rostrally positioned hyoid. These changes were accompanied with a shorter length and smaller cross-sectional area of the upper airway, resulting in a significantly reduced upper airway volume in Dp16 mice. Our non-invasive approach, a combination of computational fluid dynamics and high-resolution micro-CT imaging, revealed a higher negative pressure inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway collapse. Our study indicated that Dp16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility of DS and to evaluate the efficacy of therapeutic interventions for breathing and sleep anomalies.
MeSH term(s)	Animals ; Craniofacial Abnormalities/diagnostic imaging ; Disease Models, Animal ; Down Syndrome/diagnostic imaging ; Female ; Male ; Mice ; Plethysmography ; Sleep Apnea, Obstructive/diagnostic imaging ; Tomography, X-Ray/methods
Language	English
Publishing date	2020-12-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-78278-2
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Article: Tropical Forest and Wetland Losses and the Role of Protected Areas in Northwestern Belize, Revealed from Landsat and Machine Learning

Doyle, Colin / Beach, Timothy / Luzzadder-Beach, Sheryl

Remote Sensing. 2021 Jan. 22, v. 13, no. 3

2021

Abstract: Changes in land-use and land-cover, including both agricultural expansion and the establishment of protected areas, have altered the landscape pattern and extent of forest and wetland cover in the tropics. In Central America, land-use and land-cover ... ...

Abstract	Changes in land-use and land-cover, including both agricultural expansion and the establishment of protected areas, have altered the landscape pattern and extent of forest and wetland cover in the tropics. In Central America, land-use and land-cover change is also threatening the cultural resources of the region’s ancient Maya heritage since many ancient sites have been degraded by burning, deforestation, and plowing. In this study of Orange Walk District of northern Belize, from the 1980s to the present, we used multitemporal Landsat data with a random forest classifier to reveal trends in land-use and land-cover change and the increasing loss of forest and wetlands. We develop a random forest classifier that is time-generalized to map land-use and land-cover across the entire Landsat record, including Landsat 4, 5, 7, and 8, with a single algorithm. Including multiyear and seasonal composites was important for obtaining cloud-free coverage and distinguishing between different land-use and land-cover types. Early deforestation (1984–1987) was in small patches scattered across the landscape and likely driven by small scale agriculture such as milpa and smaller area tractor and horse-drawn plowing. The establishment of protected areas in the late 1980s and early 1990s allowed for forest regrowth in these areas, while wetland losses were high at 15%. The transition to industrial agriculture in the 2000s, however, drove a 43.6% expansion of agriculture and a 7.5% loss of forest and a 28.2% loss of wetlands during the ~15 years. Protected areas initiated in the 1980s led to a nearly 100 km² decrease in agriculture from 1984–1987 to 1999–2001, and they became essential refugia for habitat and maintaining ecosystem services.
Keywords	Landsat ; algorithms ; deforestation ; ecosystems ; land use and land cover maps ; landscapes ; reforestation ; refuge habitats ; small-scale farming ; tractors ; tropical forests ; wetlands ; Belize
Language	English
Dates of publication	2021-0122
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13030379
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome

Tatsunori Takahashi / Noriaki Sakai / Tomonori Iwasaki / Timothy C. Doyle / William C. Mobley / Seiji Nishino

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 11

Abstract: Abstract A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We ... ...

Abstract	Abstract A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway obstruction of human DS and can serve as an experimental platform for OSA research. This study, thus, aimed to quantitatively characterize the upper airway as well as craniofacial abnormalities in Dp(16)1Yey (Dp16) mice. Dp16 mice demonstrated craniofacial hypoplasia, especially in the ventral part of the skull and the mandible, and rostrally positioned hyoid. These changes were accompanied with a shorter length and smaller cross-sectional area of the upper airway, resulting in a significantly reduced upper airway volume in Dp16 mice. Our non-invasive approach, a combination of computational fluid dynamics and high-resolution micro-CT imaging, revealed a higher negative pressure inside the airway of Dp16 mice compared to wild-type littermates, showing the potential risk of upper airway collapse. Our study indicated that Dp16 mice can be a useful model to examine the pathophysiology of increased upper airway collapsibility of DS and to evaluate the efficacy of therapeutic interventions for breathing and sleep anomalies.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Branching Ratios, Radiative Lifetimes, and Transition Dipole Moments for YbOH.

Mengesha, Ephriem Tadesse / Le, Anh T / Steimle, Timothy C / Cheng, Lan / Zhang, Chaoqun / Augenbraun, Benjamin L / Lasner, Zack / Doyle, John

The journal of physical chemistry. A

2020 Volume 124, Issue 16, Page(s) 3135–3148

Abstract: Medium resolution (Δν̃ ∼ 3 GHz) laser-induced fluorescence (LIF) excitation spectra of a rotationally cold sample of YbOH in the 17300-17950 ... ...

Abstract	Medium resolution (Δν̃ ∼ 3 GHz) laser-induced fluorescence (LIF) excitation spectra of a rotationally cold sample of YbOH in the 17300-17950 cm
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.0c00850
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Article: Space Use and Habitat Selection of American Badgers (Taxidea Taxus) in Southwestern Wisconsin

Doyle, James C / Long, Lindsey / Sample, David W / Van Deelen, Timothy R

American midland naturalist. 2019 July 10, v. 182, no. 1

2019

Abstract: Badger (Taxidea taxus) life history and ecology are poorly described despite widespread distribution in North America. We used radio-telemetry to estimate home range size and quantify habitat selection for badgers living in agricultural habitat in ... ...

Abstract	Badger (Taxidea taxus) life history and ecology are poorly described despite widespread distribution in North America. We used radio-telemetry to estimate home range size and quantify habitat selection for badgers living in agricultural habitat in southwestern Wisconsin, U.S.A. Badgers in Wisconsin established relatively large home ranges (3 to 30km2), with those of males tending to be larger than females. Badgers selected broadly for nonforested grassland habitat in a matrix of agriculture, although fine-scale use varied substantially by individual. These patterns suggest that badgers tolerate levels of human alteration associated with agriculture in Wisconsin, although there may be limits to that tolerance.
Keywords	anthropogenic activities ; badgers ; females ; grasslands ; habitats ; home range ; life history ; males ; radio telemetry ; Taxidea taxus ; Wisconsin
Language	English
Dates of publication	2019-0710
Size	p. 63-74.
Publishing place	University of Notre Dame
Document type	Article
ZDB-ID	2052733-0
ISSN	0003-0031 ; 0271-6844
ISSN	0003-0031 ; 0271-6844
DOI	10.1674/0003-0031-182.1.63
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Protein kinetics of superoxide dismutase-1 in familial and sporadic amyotrophic lateral sclerosis.

Ly, Cindy V / Ireland, Margaret D / Self, Wade K / Bollinger, James / Jockel-Balsarotti, Jennifer / Herzog, Hillary / Allred, Peggy / Miller, Leah / Doyle, Michael / Anez-Bruzual, Isabel / Trikamji, Bhavesh / Hyman, Ted / Kung, Tyler / Nicholson, Katherine / Bucelli, Robert C / Patterson, Bruce W / Bateman, Randall J / Miller, Timothy M

Annals of clinical and translational neurology

2023 Volume 10, Issue 6, Page(s) 1012–1024

Abstract: Objective: Accumulation of misfolded superoxide dismutase-1 (SOD1) is a pathological hallmark of SOD1-related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understanding in vivo ... ...

Abstract	Objective: Accumulation of misfolded superoxide dismutase-1 (SOD1) is a pathological hallmark of SOD1-related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understanding in vivo protein kinetics may clarify how SOD1 influences neurodegeneration and inform optimal dosing for therapies that lower SOD1 transcripts. Methods: We employed stable isotope labeling paired with mass spectrometry to evaluate in vivo protein kinetics and concentration of soluble SOD1 in cerebrospinal fluid (CSF) of SOD1 mutation carriers, sporadic ALS participants and controls. A deaminated SOD1 peptide, SDGPVKV, that correlates with protein stability was also measured. Results: In participants with heterozygous SOD1 Interpretation: These results highlight the ability of stable isotope labeling approaches and peptide deamidation to discern the influence of disease mutations on protein kinetics and stability and support implementation of this method to optimize clinical trial design of gene and molecular therapies for neurological disorders. Trial registration: Clinicaltrials.gov: NCT03449212.
MeSH term(s)	Humans ; Superoxide Dismutase-1/genetics ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/cerebrospinal fluid ; Superoxide Dismutase/genetics ; Kinetics
Chemical Substances	Superoxide Dismutase-1 (EC 1.15.1.1) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.51784
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