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  1. Article ; Online: Harnessing Next-Generation Sequencing as a Timely and Accurate Second-Tier Screening Test for Newborn Screening of Inborn Errors of Metabolism.

    Chan, Toby Chun Hei / Mak, Chloe Miu / Yeung, Matthew Chun Wing / Law, Eric Chun-Yiu / Cheung, Jana / Wong, Tsz Ki / Cheng, Vincent Wing-Sang / Lee, Jacky Kwan Ho / Wong, Jimmy Chi Lap / Fung, Cheuk Wing / Belaramani, Kiran Moti / Kwok, Anne Mei Kwun / Tsang, Kwok Yeung

    International journal of neonatal screening

    2024  Volume 10, Issue 1

    Abstract: In this study, we evaluated the implementation of a second-tier genetic screening test using an amplicon-based next-generation sequencing (NGS) panel in our laboratory during the period of 1 September 2021 to 31 August 2022 for the newborn screening (NBS) ...

    Abstract In this study, we evaluated the implementation of a second-tier genetic screening test using an amplicon-based next-generation sequencing (NGS) panel in our laboratory during the period of 1 September 2021 to 31 August 2022 for the newborn screening (NBS) of six conditions for inborn errors of metabolism: citrullinemia type II (MIM #605814), systemic primary carnitine deficiency (MIM #212140), glutaric acidemia type I (MIM #231670), beta-ketothiolase deficiency (#203750), holocarboxylase synthetase deficiency (MIM #253270) and 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (MIM # 246450). The custom-designed NGS panel can detect sequence variants in the relevant genes and also specifically screen for the presence of the hotspot variant IVS16ins3kb of
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-515X
    ISSN (online) 2409-515X
    DOI 10.3390/ijns10010019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The extended chondrocyte lineage: implications for skeletal homeostasis and disorders.

    Tsang, Kwok Yeung / Cheah, Kathryn Se

    Current opinion in cell biology

    2019  Volume 61, Page(s) 132–140

    Abstract: Endochondral bone formation relies on a finely controlled sequence of chondrocyte proliferation, maturation and hypertrophy that establishes the growth plate which, combined with the deposition of bone upon the cartilage template, mediates longitudinal ... ...

    Abstract Endochondral bone formation relies on a finely controlled sequence of chondrocyte proliferation, maturation and hypertrophy that establishes the growth plate which, combined with the deposition of bone upon the cartilage template, mediates longitudinal skeletal growth. Recent lineage studies support a chondrocyte-osteoblast differentiation continuum and the presence of skeletal stem cells within cartilage. The biological significance of the lineage extension and the mechanisms controlling the process are unclear. In this review, we describe recent work on the extended chondrocyte-osteoblast lineage and its contribution to the development, growth and repair of bone and to bone disorders that provides insight into the process and the molecular controls involved. The implications for skeletal homeostasis are discussed.
    MeSH term(s) Animals ; Bone Development/physiology ; Bone Diseases/embryology ; Bone Diseases/genetics ; Bone and Bones/embryology ; Cartilage/cytology ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Chondrocytes/cytology ; Growth Plate/embryology ; Homeostasis ; Osteoblasts/cytology
    Language English
    Publishing date 2019-09-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2019.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism.

    Chu, Tsz Long / Chen, Peikai / Yu, Anna Xiaodan / Kong, Mingpeng / Tan, Zhijia / Tsang, Kwok Yeung / Zhou, Zhongjun / Cheah, Kathryn Song Eng

    eLife

    2023  Volume 12

    Abstract: Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts ... ...

    Abstract Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts arise from perichondrium-derived osteoprogenitors and hypertrophic chondrocytes (HC). We found, via single-cell transcriptomics, that HC-descendent cells activate membrane-type 1 metalloproteinase 14 (MMP14) and the PTH pathway as they transition to osteoblasts in neonatal and adult mice. Unlike
    MeSH term(s) Animals ; Mice ; Osteogenesis/physiology ; Chondrocytes/metabolism ; Matrix Metalloproteinase 14/genetics ; Matrix Metalloproteinase 14/metabolism ; Receptor, Parathyroid Hormone, Type 1/genetics ; Receptor, Parathyroid Hormone, Type 1/metabolism ; Osteoblasts/metabolism
    Chemical Substances Matrix Metalloproteinase 14 (EC 3.4.24.80) ; Receptor, Parathyroid Hormone, Type 1
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.82142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Use of high flow nasal cannula oxygen therapy for patients infected with SARS-CoV-2 outside intensive care setting.

    Tong, Chak Kwan / Chan, Yu Hong / Leung, Cheuk Cheung Derek / Kwok, Chin Tong / Ng, Lo Wa / Wong, Oi Fung / Yeung, Yiu Cheong / Tsang, Tak Yin / Chan, Ngai Yin / Law, Chun Bon

    Journal of thoracic disease

    2023  Volume 15, Issue 7, Page(s) 3699–3707

    Abstract: Background: In early 2022, there was a sudden surge of patients infected by the Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Hong Kong (HK), resulting in 9,163 deaths as of 29 May 2022. Many of the local population ... ...

    Abstract Background: In early 2022, there was a sudden surge of patients infected by the Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Hong Kong (HK), resulting in 9,163 deaths as of 29 May 2022. Many of the local population had not been vaccinated before this wave. The number of patients who developed coronavirus disease 2019 (COVID-19) related respiratory failure outnumbered the capacity of intensive care unit (ICU) beds. Some of these patients had to be supported with high flow nasal cannula (HFNC) therapy outside ICU setting. HK was in crisis situation. The primary objective of this study is to assess the 28-day mortality of this group of patients. The secondary objective is to explore any predictors of non-survivors to help clinical decision-making in future crisis.
    Methods: This is a retrospective observational study of patients suffering from COVID-19 related respiratory failure who received HFNC therapy in general medical wards of two hospitals during the period of 17 Mar to 30 Apr 2022. Survival and risk factors were reviewed.
    Results: Forty-nine patients were recruited. Twenty-six patients (53%) survived at 28-day after initiation of HFNC support. Three clinical parameters were found to be significantly associated with mortality at 28-day: (I) SpO
    Conclusions: Use of HFNC outside ICU setting showed benefit to patients suffering from COVID-19 related acute hypoxemic respiratory failure (AHRF). Serial SF ratio monitoring at 48 and 72 hours after therapy initiation might serve as predictors of outcome and thus guide clinical decision-making for medical resource allocation in outbreak situation.
    Language English
    Publishing date 2023-07-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.

    Qiao, Wei / Lau, Hui En / Xie, Huizhi / Poon, Vincent Kwok-Man / Chan, Chris Chung-Sing / Chu, Hin / Yuan, Shuofeng / Yuen, Terrence Tsz-Tai / Chik, Kenn Ka-Heng / Tsang, Jessica Oi-Ling / Chan, Chris Chun-Yiu / Cai, Jian-Piao / Luo, Cuiting / Yuen, Kwok-Yung / Cheung, Kenneth Man-Chee / Chan, Jasper Fuk-Woo / Yeung, Kelvin Wai-Kwok

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 3139

    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30952-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Validation of amplicon-based next generation sequencing panel for second-tier test in newborn screening for inborn errors of metabolism

    Tsang, Kwok Yeung / Chan, Toby Chun Hei / Yeung, Matthew Chun Wing / Wong, Tsz Ki / Lau, Wan Ting / Mak, Chloe Miu

    Journal of laboratory medicine

    2021  Volume 45, Issue 6, Page(s) 267

    Language English
    Document type Article
    ZDB-ID 2909041-6
    ISSN 2567-9430
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1354: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Development of generic student engagement scale in higher education: An application on healthcare students.

    Li, Shuang / Kwok, Stephen Wai Hang / Siu, Summer Cho Ngan / Chung, Jessie Yuk Seng / Lam, Hemio Chung Yan / Tsang, Eva Yuen Mei / Li, Kam Cheong / Yeung, Joanna Wing Yan / Lam, Simon Ching

    Nursing open

    2022  Volume 10, Issue 3, Page(s) 1545–1555

    Abstract: Aim: Student engagement is an important factor to the success of higher education. This study aimed to develop a Generic Student Engagement Scale (GSES) for face-to-face and online learning.: Design: This was a cross-sectional psychometric study.: ... ...

    Abstract Aim: Student engagement is an important factor to the success of higher education. This study aimed to develop a Generic Student Engagement Scale (GSES) for face-to-face and online learning.
    Design: This was a cross-sectional psychometric study.
    Methods: We tested the psychometric properties of GSES in 451 students at the school of nursing and health studies undertaking online and face-to-face learning at a local university in Hong Kong between 2016 and 2018.
    Results: Content validity, face validity and test-retest reliability of GSES were satisfactory. The 29-item GSES contains five factors "self-regulated learning," "cognitive strategy use," "experienced emotion," "teacher-student interaction," and "enjoyment of school life" with the good model fit. The GSES is a reliable and valid psychometric instrument to measure student engagement in face-to-face and online learning among undergraduates and higher diploma students. Our results implied that student engagement can be assessed in routine or research by using our instrument.
    MeSH term(s) Humans ; Reproducibility of Results ; Cross-Sectional Studies ; Students, Nursing/psychology ; Learning ; Delivery of Health Care
    Language English
    Publishing date 2022-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2809556-X
    ISSN 2054-1058 ; 2054-1058
    ISSN (online) 2054-1058
    ISSN 2054-1058
    DOI 10.1002/nop2.1405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author Correction

    Wei Qiao / Hui En Lau / Huizhi Xie / Vincent Kwok-Man Poon / Chris Chung-Sing Chan / Hin Chu / Shuofeng Yuan / Terrence Tsz-Tai Yuen / Kenn Ka-Heng Chik / Jessica Oi-Ling Tsang / Chris Chun-Yiu Chan / Jian-Piao Cai / Cuiting Luo / Kwok-Yung Yuen / Kenneth Man-Chee Cheung / Jasper Fuk-Woo Chan / Kelvin Wai-Kwok Yeung

    Nature Communications, Vol 13, Iss 1, Pp 1-

    SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

    2022  Volume 1

    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Flexibility of Room-Temperature-Synthesized Amorphous CdO-In

    Wang, Ying / Li, Menglin / Fan, Baobing / Wong, Yeung Sum / Lo, Chung Yan / Kwok, Cheuk Kai Gary / Shil, Sujit Kumer / Yip, Hin-Lap / Jen, Alex K-Y / Tsang, Sai-Wing / Yu, Kin Man

    ACS applied materials & interfaces

    2021  Volume 13, Issue 36, Page(s) 43795–43805

    Abstract: Due to their low-temperature deposition, high mobility (>10 ... ...

    Abstract Due to their low-temperature deposition, high mobility (>10 cm
    Language English
    Publishing date 2021-08-31
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c14722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.

    Qiao, Wei / Lau, Hui En / Xie, Huizhi / Poon, Vincent Kwok-Man / Chan, Chris Chung-Sing / Chu, Hin / Yuan, Shuofeng / Yuen, Terrence Tsz-Tai / Chik, Kenn Ka-Heng / Tsang, Jessica Oi-Ling / Chan, Chris Chun-Yiu / Cai, Jian-Piao / Luo, Cuiting / Yuen, Kwok-Yung / Cheung, Kenneth Man-Chee / Chan, Jasper Fuk-Woo / Yeung, Kelvin Wai-Kwok

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2539

    Abstract: Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though ...

    Abstract Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterize the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. Moreover, we show that the bone loss is associated with SARS-CoV-2-induced cytokine dysregulation, as the circulating pro-inflammatory cytokines not only upregulate osteoclastic differentiation in bone tissues, but also trigger an amplified pro-inflammatory cascade in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.
    MeSH term(s) Animals ; COVID-19/complications ; Cricetinae ; Disease Models, Animal ; Humans ; Mesocricetus ; SARS-CoV-2
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30195-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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