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  1. Article ; Online: Fascia Layer-A Novel Target for the Application of Biomaterials in Skin Wound Healing.

    Ye, Haifeng / Rinkevich, Yuval

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual ... ...

    Abstract As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual intervention for treatment. Therefore, therapeutic tools such as stem cells, biomaterials, and cytokines have been applied to the treatment of skin wounds. Skin microenvironment modulation is a key technology to promote wound repair and skin regeneration. In recent years, a series of novel bioactive materials that modulate the microenvironment and cell behavior have been developed, showing the ability to efficiently facilitate wound repair and skin attachment regeneration. Meanwhile, our lab found that the fascial layer has an indispensable role in wound healing and repair, and this review summarizes the research progress of related bioactive materials and their role in wound healing.
    MeSH term(s) Humans ; Wound Healing ; Biocompatible Materials/pharmacology ; Skin/injuries ; Fascia ; Stem Cells
    Chemical Substances Biocompatible Materials
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fascia Layer—A Novel Target for the Application of Biomaterials in Skin Wound Healing

    Haifeng Ye / Yuval Rinkevich

    International Journal of Molecular Sciences, Vol 24, Iss 2936, p

    2023  Volume 2936

    Abstract: As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual ... ...

    Abstract As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual intervention for treatment. Therefore, therapeutic tools such as stem cells, biomaterials, and cytokines have been applied to the treatment of skin wounds. Skin microenvironment modulation is a key technology to promote wound repair and skin regeneration. In recent years, a series of novel bioactive materials that modulate the microenvironment and cell behavior have been developed, showing the ability to efficiently facilitate wound repair and skin attachment regeneration. Meanwhile, our lab found that the fascial layer has an indispensable role in wound healing and repair, and this review summarizes the research progress of related bioactive materials and their role in wound healing.
    Keywords fascia layer ; biomaterials ; new target ; wound healing ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Physiological changes during torpor favor association with

    Hyams, Yosef / Rubin-Blum, Maxim / Rosner, Amalia / Brodsky, Leonid / Rinkevich, Yuval / Rinkevich, Baruch

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1072053

    Abstract: Environmental perturbations evoke down-regulation of metabolism in some multicellular organisms, leading to dormancy, or torpor. Colonies of the ... ...

    Abstract Environmental perturbations evoke down-regulation of metabolism in some multicellular organisms, leading to dormancy, or torpor. Colonies of the urochordate
    Language English
    Publishing date 2023-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1072053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Improved Media Formulations for Primary Cell Cultures Derived from a Colonial Urochordate.

    Qarri, Andy / Kültz, Dietmar / Gardell, Alison M / Rinkevich, Baruch / Rinkevich, Yuval

    Cells

    2023  Volume 12, Issue 13

    Abstract: The cultivation of marine invertebrate cells in vitro has garnered significant attention due to the availability of diverse cell types and cellular potentialities in comparison to vertebrates and particularly in response to the demand for a multitude of ... ...

    Abstract The cultivation of marine invertebrate cells in vitro has garnered significant attention due to the availability of diverse cell types and cellular potentialities in comparison to vertebrates and particularly in response to the demand for a multitude of applications. While cells in the colonial urochordate
    MeSH term(s) Animals ; Urochordata ; Primary Cell Culture ; Vertebrates ; Cell Culture Techniques
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12131709
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  5. Article ; Online: Converting fibroblastic fates leads to wound healing without scar.

    Jiang, Dongsheng / Rinkevich, Yuval

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 332

    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cicatrix/genetics ; Cicatrix/pathology ; Fibroblasts/cytology ; Homeodomain Proteins/genetics ; Humans ; Mammals/genetics ; Mice ; Wound Healing/genetics
    Chemical Substances EN1 protein, human ; Homeodomain Proteins
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00738-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: States and Fates of Skin Fibroblasts Revealed through Chromatin Accessibility.

    Correa-Gallegos, Donovan / Machens, Hans-Günther / Rinkevich, Yuval

    The Journal of investigative dermatology

    2022  Volume 142, Issue 7, Page(s) 1767–1770

    MeSH term(s) Chromatin/genetics ; Chromatin Assembly and Disassembly ; Fibroblasts
    Chemical Substances Chromatin
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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  7. Book ; Online ; Thesis: AAV-mediated gene delivery in the cutaneous wound healing

    Zhu, Shaohua [Verfasser] / Rinkevich, Yuval [Akademischer Betreuer]

    2023  

    Author's details Shaohua Zhu ; Betreuer: Yuval Rinkevich
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Furnishing Wound Repair by the Subcutaneous Fascia.

    Jiang, Dongsheng / Rinkevich, Yuval

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed ... ...

    Abstract Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia's unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.
    MeSH term(s) Animals ; Cicatrix/pathology ; Fascia/pathology ; Humans ; Mice ; Skin/pathology ; Subcutaneous Tissue/metabolism ; Subcutaneous Tissue/pathology ; Subcutaneous Tissue/physiology ; Wound Healing/physiology
    Language English
    Publishing date 2021-08-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22169006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Distinct fibroblasts in scars and regeneration.

    Jiang, Dongsheng / Rinkevich, Yuval

    Current opinion in genetics & development

    2021  Volume 70, Page(s) 7–14

    Abstract: The skin is home to a collection of fibroblastic cell types from varying embryonic origins. These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an ... ...

    Abstract The skin is home to a collection of fibroblastic cell types from varying embryonic origins. These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin's wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.
    MeSH term(s) Animals ; Cell Lineage ; Cicatrix/pathology ; Fibroblasts/cytology ; Fibroblasts/pathology ; Fibroblasts/physiology ; Gene Expression ; Humans ; Regeneration/physiology ; Regenerative Medicine/methods ; Single-Cell Analysis ; Skin/cytology ; Wound Healing
    Language English
    Publishing date 2021-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2021.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3240: Show issues Location:
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  10. Article ; Online: Cutting into wound repair.

    Correa-Gallegos, Donovan / Rinkevich, Yuval

    The FEBS journal

    2021  Volume 289, Issue 17, Page(s) 5034–5048

    Abstract: The skin is home to an assortment of fibroblastic lineages that shape the wound repair response toward scars or regeneration. In this review, we discuss the distinct embryonic origins, anatomic locations, and functions of fibroblastic lineages, and how ... ...

    Abstract The skin is home to an assortment of fibroblastic lineages that shape the wound repair response toward scars or regeneration. In this review, we discuss the distinct embryonic origins, anatomic locations, and functions of fibroblastic lineages, and how these distinct lineages of fibroblasts dictate the skin's wound response across injury depths, anatomic locations, and embryonic development to promote either scarring or regeneration. We highlight the supportive role of the fascia in dictating scarring outcomes; we then discuss recent findings that indicate fascia mobilization by its resident fibroblasts supersede the classical de novo deposition program of wound matrix formation. These recent findings reconfigure our traditional view of wound repair and present exciting new therapeutic avenues to treat scarring and fibrosis across a range of medical settings.
    MeSH term(s) Cicatrix/metabolism ; Cicatrix/pathology ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Skin/metabolism ; Wound Healing
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
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