LIVIVO - Search results -

Search results

Result 1 - 10 of total 84

Search options

Article: The contribution of neutrophils to bacteriophage clearance and pharmacokinetics in vivo.

Echterhof, Arne / Dharmaraj, Tejas / McBride, Robert / Berry, Joel / Hopkins, Max / Selvakumar, Hemaa / Miesel, Lynn / Chia, Ju-Hsin / Lin, Kun-Yuan / Shen, Chien-Chang / Lee, Yu-Ling / Yeh, Yu-Chuan / Liao, Wei Ting / Suh, Gina / Blankenberg, Francis G / Frymoyer, Adam R / Bollyky, Paul L

bioRxiv : the preprint server for biology

2024

Abstract: With the increasing prevalence of antimicrobial-resistant bacterial infections, there is great interest in using lytic bacteriophages (phages) to treat such infections. However, the factors that govern bacteriophage ... ...

Abstract	With the increasing prevalence of antimicrobial-resistant bacterial infections, there is great interest in using lytic bacteriophages (phages) to treat such infections. However, the factors that govern bacteriophage pharmacokinetics
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.25.577154
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: A novel roadmap connecting the

Iorio, Egidio / Podo, Franca / Leach, Martin O / Koutcher, Jason / Blankenberg, Francis G / Norfray, Joseph F

European radiology experimental

2021 Volume 5, Issue 1, Page(s) 5

Abstract: This review describes a cellular adaptive stress signalling roadmap connecting ... ...

Abstract	This review describes a cellular adaptive stress signalling roadmap connecting the
MeSH term(s)	Choline ; Humans ; Magnetic Resonance Spectroscopy ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Proton Magnetic Resonance Spectroscopy ; Retrospective Studies
Chemical Substances	Choline (N91BDP6H0X)
Language	English
Publishing date	2021-01-15
Publishing country	England
Document type	Journal Article ; Review
ISSN	2509-9280
ISSN (online)	2509-9280
DOI	10.1186/s41747-020-00192-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Apoptosis imaging: anti-cancer agents in medicinal chemistry.

Blankenberg, Francis G

Anti-cancer agents in medicinal chemistry

2010 Volume 9, Issue 9, Page(s) 944–951

Abstract: There is a rapid expansion in the number of new anti-cancer drugs with remarkably different mechanisms of action that can augment traditional chemotherapy. As these agents are often used in combination with traditional chemotherapy testing the effects of ...

Abstract	There is a rapid expansion in the number of new anti-cancer drugs with remarkably different mechanisms of action that can augment traditional chemotherapy. As these agents are often used in combination with traditional chemotherapy testing the effects of these novel agents has proven difficult requiring large sample sizes to detect relatively small differences in patient survival. Despite the wide variety of mechanisms, most new drugs are thought to ultimately induce apoptosis of tumor cells or their supportive vasculature. Imaging agents that can non-invasively monitor apoptosis in response to these new drugs could therefore help streamline the drug development process. They may also help guide oncologists to identify those patients that could best benefit from a given therapeutic regimen, dose, or duration of drug. In this article we will outline the existing imaging agents and modalities that are currently undergoing clinical testing and those that could be rapidly translated into humans.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Autophagy ; Caspases/metabolism ; Humans ; Magnetic Resonance Imaging ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/metabolism ; Positron-Emission Tomography ; Signal Transduction ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Antineoplastic Agents ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2010-03-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/187152009789377727
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5583: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Imaging the molecular signatures of apoptosis and injury with radiolabeled annexin V.

Blankenberg, Francis G

Proceedings of the American Thoracic Society

2009 Volume 6, Issue 5, Page(s) 469–476

Abstract: Annexin V is a ubiquitous intracellular protein in humans that has a variety of intriguing characteristics, including a nanomolar affinity for the membrane-bound constitutive anionic phospholipid known as phosphatidylserine (PS). PS is selectively ... ...

Abstract	Annexin V is a ubiquitous intracellular protein in humans that has a variety of intriguing characteristics, including a nanomolar affinity for the membrane-bound constitutive anionic phospholipid known as phosphatidylserine (PS). PS is selectively expressed on the surface of apoptotic or physiologically stressed cells. As such, radiolabeled forms of annexin V have been used in both animal models and human Phase I and Phase II trials to determine if this tracer can be employed as an early surrogate marker of therapeutic efficacy in NSCLC and non-Hodgkin's lymphoma. Many other pulmonary imaging applications of radiolabeled annexin V are also possible, including the detection and monitoring of active pulmonary inflammation and other pathophysiologic stressors in a variety of diseases. In this article, the salient molecular features of apoptosis (and other forms of cell death) that permits imaging with radiolabeled annexin V will be discussed. The latest results from Phase II imaging trials with NSCLC and non-Hodgkin's lymphoma will be also be detailed. Finally, the potential future application of this tracer for the imaging of other pulmonary pathologies will be outlined.
MeSH term(s)	Annexin A5 ; Apoptosis/physiology ; Autophagy ; Fluorodeoxyglucose F18 ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/physiopathology ; Molecular Imaging/methods ; Positron-Emission Tomography ; Radiopharmaceuticals ; Tomography, Emission-Computed, Single-Photon
Chemical Substances	Annexin A5 ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2009-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2132421-9
ISSN	1943-5665 ; 1546-3222
ISSN (online)	1943-5665
ISSN	1546-3222
DOI	10.1513/pats.200901-001AW
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5828: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.

Guihaire, Julien / Deuse, Tobias / Wang, Dong / Spin, Joshua M / Blankenberg, Francis G / Fadel, Elie / Reichenspurner, Hermann / Schrepfer, Sonja

Stem cells and development

2021 Volume 30, Issue 10, Page(s) 515–525

Abstract: Inflammation plays a major role in the pathogenesis of pulmonary hypertension (PH). We sought to investigate the effects of a cell-based immunomodulation in a dysimmune model of PH. PH was induced in athymic nude rats using semaxinib (Su group, ...

Abstract	Inflammation plays a major role in the pathogenesis of pulmonary hypertension (PH). We sought to investigate the effects of a cell-based immunomodulation in a dysimmune model of PH. PH was induced in athymic nude rats using semaxinib (Su group,
MeSH term(s)	Animals ; Disease Models, Animal ; Gene Expression Profiling/methods ; Humans ; Hypertension, Pulmonary/immunology ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/therapy ; Immune Tolerance/immunology ; Immunomodulation/immunology ; Immunotherapy/methods ; Indoles/pharmacology ; Lung/drug effects ; Lung/metabolism ; Lung/physiopathology ; Macrophages/immunology ; Male ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Potassium Channels, Tandem Pore Domain/genetics ; Potassium Channels, Tandem Pore Domain/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrroles/pharmacology ; Rats, Nude ; Rodentia ; Stroke Volume/drug effects ; Stroke Volume/immunology ; Stroke Volume/physiology ; Tomography, Emission-Computed, Single-Photon ; Rats
Chemical Substances	Indoles ; Nerve Tissue Proteins ; Potassium Channels, Tandem Pore Domain ; Protein Kinase Inhibitors ; Pyrroles ; potassium channel subfamily K member 3 (1HQ3YCN4GS) ; Semaxinib (71IA9S35AJ)
Language	English
Publishing date	2021-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2142214-X
ISSN	1557-8534 ; 1547-3287
ISSN (online)	1557-8534
ISSN	1547-3287
DOI	10.1089/scd.2021.0007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3616: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: In vivo imaging of apoptosis.

Blankenberg, Francis G

Cancer biology & therapy

2008 Volume 7, Issue 10, Page(s) 1525–1532

Abstract: Despite over a decade of intense investigation there is still no routine method for the clinical imaging of apoptosis in oncologic patients. There have been multiple tracers proposed but none as of yet has received FDA approval. Radiolabeled annexin V is ...

Abstract	Despite over a decade of intense investigation there is still no routine method for the clinical imaging of apoptosis in oncologic patients. There have been multiple tracers proposed but none as of yet has received FDA approval. Radiolabeled annexin V is one of the few radiotracers that has been widely used in Phase II trials and is still under development. In this review we will first detail the general mechanisms involved with apoptosis and other common forms of cell death. Next we will outline the latest in vivo imaging data in animal models and humans including that obtained with radiolabeled annexin V. It is hoped that improved understanding of the complex biochemical pathways involved with cell death will lead to at least several radiopharmaceuticals with the ability to image apoptosis as part of improving the care and treatment of patients suffering from cancer.
MeSH term(s)	Aged ; Animals ; Annexin A5/chemistry ; Apoptosis ; Autophagy ; Clinical Trials as Topic ; Diagnostic Imaging/instrumentation ; Diagnostic Imaging/methods ; Fluorodeoxyglucose F18/pharmacology ; Humans ; Male ; Mitochondria/metabolism ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Proteasome Endopeptidase Complex/metabolism ; Radionuclide Imaging ; Radiopharmaceuticals ; Signal Transduction
Chemical Substances	Annexin A5 ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2008-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.4161/cbt.7.10.6934
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5887: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: In vivo detection of apoptosis.

Blankenberg, Francis G

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2008 Volume 49 Suppl 2, Page(s) 81S–95S

Abstract: After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of ... ...

Abstract	After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apoptosis). In addition, effective therapy of tumors requires the iatrogenic induction of programmed cell death by radiation, chemotherapy, or both. Given the central role of apoptosis, it would be desirable to have a noninvasive imaging method to serially detect and monitor this process in cancer patients undergoing conventional radiation and chemotherapy treatments as well as for the development and testing of new drugs. In this article, the latest modalities and contrast agents described in the literature for the imaging of apoptosis in vivo are reviewed. First, the most recent developments in the biochemical characterization of the many intracellular pathways involved in this complex process are discussed. Next, a variety of new radionuclide tracers, including radiolabeled annexin V and caspase inhibitors for PET and SPECT, are described. Finally, the use of MRI, MR spectroscopy, and ultrasound as possible alternative imaging modalities for the imaging of apoptosis is addressed.
MeSH term(s)	Animals ; Annexin A5/physiology ; Apoptosis/physiology ; Caspase Inhibitors ; Caspases/metabolism ; Cell Death/physiology ; Contrast Media ; Humans ; Lipid Metabolism ; Magnetic Resonance Imaging ; Mice ; Neoplasms/diagnostic imaging ; Neoplasms/metabolism ; Neoplasms/pathology ; Positron-Emission Tomography ; Radiopharmaceuticals ; Ultrasonography
Chemical Substances	Annexin A5 ; Caspase Inhibitors ; Contrast Media ; Radiopharmaceuticals ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2008-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80272-4
ISSN	1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0161-5505 ; 0097-9058 ; 0022-3123
DOI	10.2967/jnumed.107.045898
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recent advances in the molecular imaging of programmed cell death: Part II--non-probe-based MRI, ultrasound, and optical clinical imaging techniques.

Blankenberg, Francis G / Strauss, H William

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2013 Volume 54, Issue 1, Page(s) 1–4

Abstract: There is much that can be done to detect apoptosis and other forms of cell death with existing clinical modalities including ultrasound, MRI, and optical imaging without the need for current or new intravenous contrast agents. We will discuss how these ... ...

Abstract	There is much that can be done to detect apoptosis and other forms of cell death with existing clinical modalities including ultrasound, MRI, and optical imaging without the need for current or new intravenous contrast agents. We will discuss how these widely available imaging technologies can readily be applied to the imaging of apoptosis in patients undergoing chemotherapy or radiation treatment. The limiting factor of course is the lack of knowledge of the optimal times after the start of treatment for the most accurate assessment of apoptosis and necrosis with each modality and specific technique. It is hoped that imaging studies that systematically look at treatment response can soon be performed to address these issues.
MeSH term(s)	Animals ; Apoptosis ; Humans ; Magnetic Resonance Imaging/methods ; Molecular Imaging/methods ; Neoplasms/diagnosis ; Neoplasms/pathology ; Neoplasms/therapy ; Optical Imaging/methods ; Ultrasonography/methods
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.112.111740
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Monitoring of treatment-induced apoptosis in oncology with PET and SPECT.

Blankenberg, Francis G

Current pharmaceutical design

2006 Volume 14, Issue 28, Page(s) 2974–2982

Abstract: The early assessment of a solid tumor's response to conventional or new drug therapy to complement or replace current RECIST (or other clinical) criteria remains an elusive goal. The work horse PET tracer (18)F-FDG, may represent the most immediate ... ...

Abstract	The early assessment of a solid tumor's response to conventional or new drug therapy to complement or replace current RECIST (or other clinical) criteria remains an elusive goal. The work horse PET tracer (18)F-FDG, may represent the most immediate method to track individual tumor response to therapy for many types of cancer. Newer radiotracers such as radiolabeled annexin V, have also shown the ability to selectively localize to tumor cells undergoing apoptosis (programmed cell death) in response to successful treatment in vivo. In this article we will review therapy reduced tumor apoptosis and the radiotracers used to date to image this process in both animal models and clinical trials.
MeSH term(s)	Animals ; Annexin A5/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Clinical Trials as Topic ; Disease Models, Animal ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Radiopharmaceuticals/pharmacokinetics ; Tomography, Emission-Computed/methods ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	Annexin A5 ; Antineoplastic Agents ; Radiopharmaceuticals
Language	English
Publishing date	2006-01-23
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/138161208786404353
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4714: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A novel roadmap connecting the 1H-MRS total choline resonance to all hallmarks of cancer following targeted therapy

Egidio Iorio / Franca Podo / Martin O. Leach / Jason Koutcher / Francis G. Blankenberg / Joseph F. Norfray

European Radiology Experimental, Vol 5, Iss 1, Pp 1-

2021 Volume 14

Abstract: Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalling, ... ...

Abstract	Abstract This review describes a cellular adaptive stress signalling roadmap connecting the 1H magnetic resonance spectroscopy (MRS) total choline peak at 3.2 ppm (tCho) to cancer response after targeted therapy (TT). Recent research on cell signalling, tCho metabolism, and TT of cancer has been retrospectively re-examined. Signalling research describes how the unfolded protein response (UPR), a major stress signalling network, transduces, regulates, and rewires the total membrane turnover in different cancer hallmarks after a TT stress. In particular, the UPR signalling maintains or increases total membrane turnover in all pro-survival hallmarks, whilst dramatically decreases turnover during apoptosis, a pro-death hallmark. Recent research depicts the TT-induced stress as a crucial event responsible for interrupting UPR pro-survival pathways, leading to an UPR-mediated cell death. The 1H-MRS tCho resonance represents the total mobile precursors and products during the enzymatic modification of phosphatidylcholine membrane abundance. The tCho profile represents a biomarker that noninvasively monitors TT-induced enzymatic changes in total membrane turnover in a wide variety of existing and new anticancer treatments targeting specific layers of the UPR signalling network. Our overview strongly suggests further evaluating and validating the 1H-MRS tCho peak as a powerful noninvasive imaging biomarker of cancer response in TT clinical trials.
Keywords	Biomarkers ; Choline ; Magnetic resonance spectroscopy ; Neoplasms ; Unfolded protein response ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	570
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED