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Article: Santé des migrants et exigence éthique.

Bernabe-Gelot, Antoinette

2019 Volume 65, Issue 843-844, Page(s) 24–27

Abstract: Migrants' health is a subject that is often called up for aspects that are often presented as negative (insecurity, carelessness of public finances, major cultural replacement) in the name of which suspicion and rejection take hold. This vision does not ... ...

Title translation	Migrant health and ethical requirements.
Abstract	Migrants' health is a subject that is often called up for aspects that are often presented as negative (insecurity, carelessness of public finances, major cultural replacement) in the name of which suspicion and rejection take hold. This vision does not survive the factual analysis of public health, social and economic data. Nevertheless, National Consultative Ethics Committee in its opinion 127 in 2017 draws up a serious, and still topical, assessment of the situation with regard to the health of migrants. In it, he denounced the use of migrant health care as an instrument for political purposes and advocated hospitality and fraternity.
MeSH term(s)	Ethics ; Health Status ; Humans ; Transients and Migrants
Language	French
Publishing date	2019-08-28
Publishing country	France
Document type	Journal Article
ZDB-ID	604655-1
ISSN	0038-0814
ISSN	0038-0814
DOI	10.1016/S0038-0814(20)30048-7
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Article: Editorial: What does human pathology bring to the understanding of the fundamental mechanisms of development?

Represa, Alfonso / Martinez, Salvador / Gelot, Antoinette

Frontiers in neuroanatomy

2022 Volume 16, Page(s) 1003607

Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2452969-2
ISSN	1662-5129
ISSN	1662-5129
DOI	10.3389/fnana.2022.1003607
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Article: Progression of Fetal Brain Lesions in Tuberous Sclerosis Complex.

Gelot, Antoinette Bernabe / Represa, Alfonso

Frontiers in neuroscience

2020 Volume 14, Page(s) 899

Abstract: Tuberous sclerosis (TSC) is a multisystem autosomal dominant genetic disorder due to loss of function ... ...

Abstract	Tuberous sclerosis (TSC) is a multisystem autosomal dominant genetic disorder due to loss of function of
Language	English
Publishing date	2020-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2020.00899
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Article ; Online: Educational level and characteristics of invasive breast cancer: findings from a French prospective cohort.

Berger, Eloïse / Gelot, Amandine / Fournier, Agnès / Dossus, Laure / Boutron-Ruault, Marie-Christine / Severi, Gianluca / Castagné, Raphaële / Delpierre, Cyrille

Cancer causes & control : CCC

2024

Abstract: Purpose: Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent conclusions. We aimed to investigate ... ...

Abstract	Purpose: Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent conclusions. We aimed to investigate the impact of education on BC stage, grade, and hormone receptor (HR) status, while adjusting for potential confounders including a broad set of health behaviors, anthropometric measures, and reproductive factors. Methods: In the French E3N cohort, 5236 women developed a primary invasive BC for which there was available information on stage, grade, and HR status. No multivariate analyses was performed for BC stage based on the lack of association in bivariate analyses. Odds ratios and confidence intervals were estimated using multinomial logistic regression models for BC grade or binomial logistic regression models for HR status of BC. Results: Women with a lower education were diagnosed with higher grade BC compared to women with a higher education (1.32 [1.12; 1.57]). This association was slightly attenuated after adjustment for covariates independently and more strongly affected in the fully adjusted model (1.20 [0.99; 1.45]). A significant association was observed between lower education and HR- status of BC (1.20 [1.02; 1.42]) attenuated after adjustment for age at first childbirth (1.12 [0.95; 1.33]). Conclusion: In this cohort, education was associated with BC grade and HR status but not stage at diagnosis. The link between education and BC grade was not entirely explained by the different adjustments. A specific mechanism could be at play and deserves further investigations.
Language	English
Publishing date	2024-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-024-01873-5
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Article ; Online: In Vivo Corneal Confocal Microscopy in Mucolipidosis Type IV.

Martin, Gilles C / Bernabe-Gelot, Antoinette / Gabison, Eric

Ophthalmology

2021 Volume 128, Issue 4, Page(s) 521

MeSH term(s)	Biopsy ; Child ; Consanguinity ; Corneal Diseases/diagnostic imaging ; Corneal Diseases/genetics ; Female ; Humans ; Microscopy, Confocal ; Microscopy, Electron ; Mucolipidoses/diagnostic imaging ; Mucolipidoses/genetics ; Mutation ; Skin/ultrastructure ; Transient Receptor Potential Channels/genetics
Chemical Substances	MCOLN1 protein, human ; Transient Receptor Potential Channels
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2020.11.003
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Article ; Online: Association between endometriosis and risk of type 2 diabetes: Results from the prospective E3N cohort.

Vaduva, Patricia / Laouali, Nasser / Fagherazzi, Guy / Gelot, Amandine / Bonnet, Fabrice / Kvaskoff, Marina

Maturitas

2023 Volume 177, Page(s) 107805

Abstract: Objective: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes.: Study design!# ...

Abstract	Objective: Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes. Study design: E3N is a prospective cohort of 98,995 French women aged 40-65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status. Results: Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92-1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80-1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05). Conclusions: Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
MeSH term(s)	Female ; Humans ; Endometriosis/complications ; Endometriosis/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Risk Factors ; Prospective Studies ; Proportional Hazards Models ; Diet, Mediterranean ; Infertility
Language	English
Publishing date	2023-07-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2023.107805
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Article ; Online: Dietary Inflammatory Index and risk of breast cancer: evidence from a prospective cohort of 67,879 women followed for 20 years in France.

Hajji-Louati, Mariem / Gelot, Amandine / Frenoy, Pauline / Laouali, Nasser / Guénel, Pascal / Romana Mancini, Francesca

European journal of nutrition

2023 Volume 62, Issue 5, Page(s) 1977–1989

Abstract: Background: Inflammation is implicated in breast cancer development, and diet is one of the modifiable risk factors involved in the regulation of chronic inflammation. Previous studies on the association between breast cancer risk and Dietary ... ...

Abstract	Background: Inflammation is implicated in breast cancer development, and diet is one of the modifiable risk factors involved in the regulation of chronic inflammation. Previous studies on the association between breast cancer risk and Dietary Inflammatory Indexes (DII) derived from food frequency questionnaires and data on inflammatory potential of dietary components have reported inconsistent results. Objective: To investigate the association between the DII and the risk of breast cancer using data from a large population-based cohort study. Design: A total of 67,879 women from the E3N cohort were followed from 1993 to 2014. A total of 5686 breast cancer cases were diagnosed during the follow-up. The food frequency questionnaire administered at baseline in 1993 was used to calculate an adapted DII. Cox proportional hazard models using age as the time scale were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Spline regression was used to determine any dose-response relationship. We also evaluated effect modification by menopausal status, body mass index, smoking status and alcohol consumption. Results: The median DII score of the study population was slightly pro-inflammatory (DII = + 0.39); ranged from - 4.68 in the lowest quintile to + 4.29 in the highest quintile. The HR increased linearly with the DII (HR per 1SD = 1.04 [95% CI: 1.01, 1.07]), and reached 1.13 [95% CI: 1.04, 1.23] in the 5th quintile group as compared to the first. A positive linear dose-response relationship was also observed when modeling DII with spline functions. Slightly higher HRs were observed in non-smokers (HR Conclusion: Our results suggest a positive association between DII and breast cancer risk. Consequently, the promotion of anti-inflammatory diet may contribute to breast cancer prevention.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/epidemiology ; Cohort Studies ; Prospective Studies ; Diet/adverse effects ; Risk Factors ; Inflammation/epidemiology ; Inflammation/etiology
Language	English
Publishing date	2023-03-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-023-03108-w
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Article ; Online: Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women.

Vedie, Anne-Laure / Laouali, Nasser / Gelot, Amandine / Severi, Gianluca / Boutron-Ruault, Marie-Christine / Rebours, Vinciane

United European gastroenterology journal

2023

Abstract: Objectives: Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore ... ...

Abstract	Objectives: Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women. Methods: The study included 96,594 women from the E3N prospective cohort, mean age: 49 years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow-up. Cases were classified according to the International Classification of Diseases 10. Associations with passive and active smoking and effect modification by the ABO blood group were investigated with multivariable Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI). Results: During a 24-year median follow-up, 346 incident PC cases were identified. Current smoking compared with never and former smoking (HR 1.51 [95% CI 1.08-2.10]), and passive smoking in childhood compared with no childhood exposure (HR 1.47 [95% CI 1.08-2.00]) were associated with increased PC risk, but not passive exposure in adulthood (HR 1.16 [95% CI 0.91-1.47]). Exposure to both passive smoking in childhood and current smoking was associated with a stronger risk (HR 2.80 [95% CI 1.42-5.52]) than exposure to both current smoking and passive smoking only in adulthood (HR 1.68 [95% CI 1.10-2.57]) compared with neither passive nor active smoking. Associations between active smoking and PC risk were strongest in the O or B groups, while associations with passive smoking were strongest in the A or AB blood groups, but the interaction terms were not statistically significant. Conclusions: Both current smoking and passive smoking in childhood were associated with PC risk, with a maximal risk of current smokers exposed to passive smoking during childhood. Possible interactions between blood groups and active or passive smoking must be investigated in a larger series.
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12487
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Article: Corrigendum to "Measles Sclerosing Subacute PanEncephalitis (SSPE), an intriguing and ever-present disease: Data, Assumptions and new Perspectives" [Rev. Neurol. 177 (2021) 1059-68].

Lebon, P / Gelot, A / Zhang, S-Y / Casanova, J-L / Hauw, J-J

Revue neurologique

2022 Volume 178, Issue 6, Page(s) 634

Language	English
Publishing date	2022-05-21
Publishing country	France
Document type	Published Erratum
ZDB-ID	4593-7
ISSN	2213-0004 ; 0035-3787
ISSN (online)	2213-0004
ISSN	0035-3787
DOI	10.1016/j.neurol.2022.04.002
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Article ; Online: Passive smoking in childhood and adulthood and risk of rheumatoid arthritis in women: results from the French E3N cohort study.

Nguyen, Yann / Salliot, Carine / Gelot, Amandine / Mariette, Xavier / Boutron-Ruault, Marie-Christine / Seror, Raphaele

RMD open

2022 Volume 8, Issue 1

Abstract: Objective: The association between passive smoking exposure in childhood or in adulthood, and the risk of rheumatoid arthritis (RA) has been incompletely investigated. We aimed to assess the relationship between exposure to passive smoking and the risk ... ...

Abstract	Objective: The association between passive smoking exposure in childhood or in adulthood, and the risk of rheumatoid arthritis (RA) has been incompletely investigated. We aimed to assess the relationship between exposure to passive smoking and the risk of incident RA in a French prospective cohort of healthy women. Methods: The E3N Study ( Results: Among 79 806 women, 698 incident cases of RA were identified; 10 810 (13.5%) women were exposed to passive smoking in childhood, and 42 807 (53.6%) in adulthood. Median age at inclusion was 47.8 years. Passive smoking in childhood and in adulthood was associated with RA risk in all models (HRs (95% CIs) 1.24 (1.01 to 1.51) and 1.19 (1.02 to 1.40), respectively). The absolute risk of RA among never smokers with exposure to passive smoking in childhood and/or adulthood (47.6/100 000 person-years) was close to the risk of ever smokers with no passive smoking exposure (47.2/100 000 person-years), while it was highest in ever smokers also exposed to passive smoking (53.7/100 000 person-years). Conclusion: Exposure to passive smoking in childhood and/or adulthood increases the risk of RA by the same order than active smoking. Such exposure should be suppressed, especially in individuals at risk of RA.
MeSH term(s)	Adult ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/etiology ; Cohort Studies ; Female ; Humans ; Proportional Hazards Models ; Prospective Studies ; Tobacco Smoke Pollution/adverse effects
Chemical Substances	Tobacco Smoke Pollution
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2021-001980
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