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Article ; Online: Nummular headache responsive to anti-calcitonin gene-related peptide monoclonal antibodies in a patient with migraine.

López-Bravo, Alba / Oliveros-Cid, Antonio / Mínguez-Olaondo, Ane / Cuadrado, María Luz

2022 Volume 62, Issue 8, Page(s) 1063–1066

Abstract: Background: Nummular headache (NH) is defined by the presence of localized pain circumscribed to a round or elliptical area of the scalp, with a well-defined contour and a diameter of 1-6 cm. Although some evidence supports a peripheral mechanism, its ... ...

Abstract	Background: Nummular headache (NH) is defined by the presence of localized pain circumscribed to a round or elliptical area of the scalp, with a well-defined contour and a diameter of 1-6 cm. Although some evidence supports a peripheral mechanism, its etiopathogenesis remains unclear. Case: We report the case of a 64-year-old man with high-frequency episodic migraine who has used topiramate, beta-blockers, flunarizine, and amitriptyline without effect. In the last 8 years he also had continuous pain in an oval area of the scalp, consistent with NH. Triptans were ineffective for this new pain, and preventive therapy with gabapentin and onabotulinumtoxinA in the painful area had no effect. NH remitted when the patient received monthly treatment with subcutaneous galcanezumab for his migraine. Conclusions: Monoclonal antibodies against calcitonin gene-related peptide (CGRP), in particular galcanezumab, might be an effective therapy in some patients with NH. CGRP may have a role in the etiopathogenesis of this headache, which warrants further investigation.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Calcitonin Gene-Related Peptide ; Headache ; Humans ; Male ; Middle Aged ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Pain ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14372
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Article ; Online: Cognitive performance in patients with episodic cluster headache outside and inside the active cluster.

Navarro-Pérez, María Pilar / Bellosta-Diago, Elena / Viloria-Alebesque, Alejandro / Garrido-Fernández, Alberto / López-Bravo, Alba / Santos-Lasaosa, Sonia

Headache

2021 Volume 61, Issue 1, Page(s) 209–215

Abstract: Background: Previous studies have shown worse cognitive performance in cluster headache (CH) patients compared to healthy controls; however, little is known about cognitive performance in episodic CH (ECH) patients outside and inside the active cluster ( ...

Abstract	Background: Previous studies have shown worse cognitive performance in cluster headache (CH) patients compared to healthy controls; however, little is known about cognitive performance in episodic CH (ECH) patients outside and inside the active cluster (AC). Objective: Our aim is to compare cognitive function in ECH patients outside and inside the AC. Methods: In this cross-sectional, observational study, four neuropsychological tests (Trail Making Test [TMT], Stroop Test [ST], verbal fluency [VF], and Symbol Digit Modalities Test [SDT]) were completed by 21 ECH patients at two different points in time: outside and inside the AC. We also assessed self-reported sleep quality and the presence of anxiety or depressive symptoms. Scores were compared. Results: There was not any difference between the scores of the neuropsychological tests performed outside and inside the AC (TMT-A: 23 vs. 23.5; p = 0.984; TMT-B: 96.5 vs. 85.9; p = 0.104; ST word reading: 101.0 vs. 101.2; p = 0.938; ST color naming: 73.0 vs. 73.4; p = 0.858; ST color word: 44.0 vs. 46.0; p = 0.498; SDMT: 44.0 vs. 44.6; p = 0.961; VF phonemic: 29.5 vs. 30.2; p = 0.714; VF semantic: 20 vs. 21; p = 0.489). We found a worsening in the sleep quality component of the Pittsburgh Sleep Quality Index median scores in patients outside the AC (2 vs. 1; p = 0.046). Conclusions: Our findings suggest that patients with ECH have a similar cognitive performance outside and during the AC.
MeSH term(s)	Adult ; Cluster Headache/complications ; Cluster Headache/physiopathology ; Cognition/physiology ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Time Factors
Language	English
Publishing date	2021-02-22
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14052
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Article: Psychological Factors Associated with Functional Disability in Patients with Hip and Knee Osteoarthritis.

López-Bravo, María Dolores / Zamarrón-Cassinello, María Dolores / Touche, Roy La / Muñoz-Plata, Rosa / Cuenca-Martínez, Ferran / Ramos-Toro, Mónica

Behavioral medicine (Washington, D.C.)

2020 Volume 47, Issue 4, Page(s) 285–295

Abstract: Several studies have shown an association between psychosocial variables and functional capacity in chronic pain processes such as osteoarthritis. The aim of this study was to test a structural equations model that shows the predictive weight of certain ... ...

Abstract	Several studies have shown an association between psychosocial variables and functional capacity in chronic pain processes such as osteoarthritis. The aim of this study was to test a structural equations model that shows the predictive weight of certain variables such as catastrophizing, self-efficacy and kinesiophobia on functional pain and WOMAC subscales scores of pain and physical function of older patients diagnosed with hip and knee osteoarthritis. We also assessed the specific weight of age in terms of the factors. The study was conducted on a sample of 170 patients (142 women and 28 men mean age, 74.44 years range, 50-96 years). The main variables evaluated were WOMAC subscales scores of pain and physical function, self-efficacy, catastrophizing and kinesiophobia. To assess these variables, we used the Spanish validated version of the Western Ontario and McMaster Universities questionnaire, the Chronic Pain Self-Efficacy Scale, the Pain Catastrophizing Scale and the Tampa Scale for Kinesiophobia, respectively. We tested a structural equations model (IBM SPSS Amos version 22). The results showed the predominant predictive weight (both direct and indirect) of catastrophizing while simultaneously ruling out the relevance of age as a predictor of WOMAC subscales scores of pain and physical function. This study provides data of interest on the explanatory mechanisms that underlie the direct and inverse relationships between the studied psychological variables.
MeSH term(s)	Aged ; Catastrophization ; Female ; Humans ; Male ; Osteoarthritis, Hip ; Osteoarthritis, Knee ; Pain ; Pain Measurement
Language	English
Publishing date	2020-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	623101-9
ISSN	0896-4289
ISSN	0896-4289
DOI	10.1080/08964289.2020.1813682
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Article ; Online: Immunogenicity and efficacy of a novel multi-patch SARS-CoV-2/COVID-19 vaccine candidate.

Perdiguero, Beatriz / Marcos-Villar, Laura / López-Bravo, María / Sánchez-Cordón, Pedro J / Zamora, Carmen / Valverde, José Ramón / Sorzano, Carlos Óscar S / Sin, Laura / Álvarez, Enrique / Ramos, Manuel / Del Val, Margarita / Esteban, Mariano / Gómez, Carmen Elena

Frontiers in immunology

2023 Volume 14, Page(s) 1160065

Abstract: Introduction: While there has been considerable progress in the development of vaccines against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has been made with vaccines delivering different viral antigens with cross- ... ...

Abstract	Introduction: While there has been considerable progress in the development of vaccines against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has been made with vaccines delivering different viral antigens with cross-reactive potential. Methods: In an effort to develop an immunogen with the capacity to induce broad antigen presentation, we have designed a multi-patch synthetic candidate containing dominant and persistent B cell epitopes from conserved regions of SARS-CoV-2 structural proteins associated with long-term immunity, termed CoV2-BMEP. Here we describe the characterization, immunogenicity and efficacy of CoV2-BMEP using two delivery platforms: nucleic acid DNA and attenuated modified vaccinia virus Ankara (MVA). Results: In cultured cells, both vectors produced a main protein of about 37 kDa as well as heterogeneous proteins with size ranging between 25-37 kDa. In C57BL/6 mice, both homologous and heterologous prime/boost combination of vectors induced the activation of SARS-CoV-2-specific CD4 and CD8 T cell responses, with a more balanced CD8 Discussion: These findings revealed a novel immunogen with the capacity to control SARS-CoV-2 infection, using a broader antigen presentation mechanism than the approved vaccines based solely on the S antigen.
MeSH term(s)	Humans ; Animals ; Mice ; COVID-19 Vaccines ; Genetic Vectors ; SARS-CoV-2 ; Viral Vaccines ; COVID-19/prevention & control ; Mice, Inbred C57BL ; Vaccinia virus/genetics
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1160065
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Article ; Online: Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction.

Feo-Lucas, Lidia / Godio, Cristina / Minguito de la Escalera, María / Alvarez-Ladrón, Natalia / Villarrubia, Laura H / Vega-Pérez, Adrián / González-Cintado, Leticia / Domínguez-Andrés, Jorge / García-Fojeda, Belén / Montero-Fernández, Carlos / Casals, Cristina / Autilio, Chiara / Pérez-Gil, Jesús / Crainiciuc, Georgiana / Hidalgo, Andrés / López-Bravo, María / Ardavín, Carlos

Frontiers in immunology

2023 Volume 14, Page(s) 1125984

Abstract: Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains ... ...

Abstract	Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains unaddressed. To explore whether airway allergy causes alveolar dysfunction that might contribute to the pathology of allergic asthma, alveolar structural and functional alterations were analyzed during house dust mite (HDM)-induced airway allergy in mice, by flow cytometry, light and electron microscopy, monocyte transfer experiments, assessment of intra-alveolarly-located cells, analysis of alveolar macrophage regeneration in
MeSH term(s)	Mice ; Animals ; Macrophages, Alveolar/metabolism ; Hypersensitivity/complications ; Asthma/metabolism ; Inflammation/complications ; Pulmonary Surfactants ; Surface-Active Agents
Chemical Substances	Pulmonary Surfactants ; Surface-Active Agents
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1125984
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Article ; Online: Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity.

Vega-Pérez, Adrián / Villarrubia, Laura H / Godio, Cristina / Gutiérrez-González, Alejandra / Feo-Lucas, Lidia / Ferriz, Margarita / Martínez-Puente, Natalia / Alcaín, Julieta / Mora, Alfonso / Sabio, Guadalupe / López-Bravo, María / Ardavín, Carlos

Immunity

2021 Volume 54, Issue 11, Page(s) 2578–2594.e5

Abstract: Peritoneal immune cells reside unanchored within the peritoneal fluid in homeostasis. Here, we examined the mechanisms that control bacterial infection in the peritoneum using a mouse model of abdominal sepsis following intraperitoneal Escherichia coli ... ...

Abstract	Peritoneal immune cells reside unanchored within the peritoneal fluid in homeostasis. Here, we examined the mechanisms that control bacterial infection in the peritoneum using a mouse model of abdominal sepsis following intraperitoneal Escherichia coli infection. Whole-mount immunofluorescence and confocal microscopy of the peritoneal wall and omentum revealed that large peritoneal macrophages (LPMs) rapidly cleared bacteria and adhered to the mesothelium, forming multilayered cellular aggregates composed by sequentially recruited LPMs, B1 cells, neutrophils, and monocyte-derived cells (moCs). The formation of resident macrophage aggregates (resMφ-aggregates) required LPMs and thrombin-dependent fibrin polymerization. E. coli infection triggered LPM pyroptosis and release of inflammatory mediators. Resolution of these potentially inflammatory aggregates required LPM-mediated recruitment of moCs, which were essential for fibrinolysis-mediated resMφ-aggregate disaggregation and the prevention of peritoneal overt inflammation. Thus, resMφ-aggregates provide a physical scaffold that enables the efficient control of peritoneal infection, with implications for antimicrobial immunity in other body cavities, such as the pleural cavity or brain ventricles.
MeSH term(s)	Animals ; Bacterial Infections/etiology ; Bacterial Infections/metabolism ; Biomarkers ; Cellular Microenvironment/immunology ; Disease Models, Animal ; Disease Susceptibility/immunology ; Host-Pathogen Interactions/immunology ; Inflammation Mediators/metabolism ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/metabolism ; Mice ; Peritoneal Cavity/microbiology ; Peritonitis/etiology ; Peritonitis/metabolism ; Peritonitis/pathology
Chemical Substances	Biomarkers ; Inflammation Mediators
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.10.007
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Article ; Online: Effect of Process Parameters and Postprocessing on Mechanical Properties of Additive Manufacturing Polylactic Acid Obtained by Fused Deposition Modeling.

Rivera-López, Fernando / Hernández-Molina, María / Del Medico Bravo, Alejandro / Laz Pavón, Maria Milagros

3D printing and additive manufacturing

2023 Volume 10, Issue 1, Page(s) 60–69

Abstract: The aim of this article is to study the influence of some printing parameters and postprocessing on mechanical properties of polylactic acid samples manufactured by fused deposition modeling with a 3D printer. The effects of different building ... ...

Abstract	The aim of this article is to study the influence of some printing parameters and postprocessing on mechanical properties of polylactic acid samples manufactured by fused deposition modeling with a 3D printer. The effects of different building orientations, concentric infill, and postprocessing by annealing were analyzed. In this sense, uniaxial tensile and three-point bending tests were performed to determine the ultimate strength, modulus of elasticity, and elongation at break. Among all printing parameters of interest, the print orientation can be considered one of the most important, being fundamental in the mechanical behavior. Once samples were fabricated, annealing processes were also considered, close to the
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ISSN	2329-7670
ISSN (online)	2329-7670
DOI	10.1089/3dp.2021.0052
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Article: Dysphagia secondary to neuroendocrine carcinoma: a rare esophageal tumor.

López García, María Luisa / Bravo Rodriguez, María Teresa / Castro Zavaleta, Aldo / Calderon García, Ángel José

Revista espanola de enfermedades digestivas

2023 Volume 116, Issue 1, Page(s) 35–36

Abstract: We present two clinical cases, a 68-year-old male and a 55-year-old female, who are being studied for progressive solid food dysphagia. The initial gastroscopy revealed a polypoid lesion in the first case and a partially stenosing lesion in the second ... ...

Abstract	We present two clinical cases, a 68-year-old male and a 55-year-old female, who are being studied for progressive solid food dysphagia. The initial gastroscopy revealed a polypoid lesion in the first case and a partially stenosing lesion in the second case. Both lesions were located in the mid-esophagus and presented a normal mucosa. Histological diagnosis confirmed an esophageal neuroendocrine carcinoma (NEC) of large cell and small cell types, respectively.
MeSH term(s)	Male ; Female ; Humans ; Middle Aged ; Aged ; Deglutition Disorders/complications ; Carcinoma, Neuroendocrine/complications ; Carcinoma, Neuroendocrine/diagnostic imaging ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/diagnostic imaging ; Esophageal Neoplasms/pathology
Language	English
Publishing date	2023-10-26
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2023.9951/2023
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Article ; Online: In vivo induction of immune responses to pathogens by conventional dendritic cells.

López-Bravo, María / Ardavín, Carlos

Immunity

2008 Volume 29, Issue 3, Page(s) 343–351

Abstract: Specific defense mechanisms against pathogens are fulfilled by different subsets of nonmucosal conventional dendritic cells (DCs), including migratory Langerhans cells (LCs), dermal DCs, and resident CD8(+) and CD8(-) DCs found in lymphoid organs. Dermal ...

Abstract	Specific defense mechanisms against pathogens are fulfilled by different subsets of nonmucosal conventional dendritic cells (DCs), including migratory Langerhans cells (LCs), dermal DCs, and resident CD8(+) and CD8(-) DCs found in lymphoid organs. Dermal DCs capture antigens in the skin and migrate to lymph nodes, where they can transfer the antigens to CD8(+) DCs and activate CD4(+) T cells. Differential antigen-processing machinery grants CD8(+) DCs a high efficiency in activating CD8(+) T cells through crosspresentation, whereas CD8(-) DCs preferentially trigger CD4(+) T cell responses. Recent findings have revealed the important role played by monocyte-derived DCs (mo-DCs), newly formed during infection, in activating CD4(+) and CD8(+) T cells, regulating immunoglobulin production, and killing pathogens. However, a number of controversial issues regarding the function of different DC subsets during viral, bacterial, and parasitic infections remain to be resolved.
MeSH term(s)	Animals ; Antigen Presentation ; Cell Movement ; Cytokines/immunology ; Cytokines/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Humans ; Infection/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Lymphocyte Subsets/immunology ; Lymphocyte Subsets/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Cytokines
Language	English
Publishing date	2008-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2008.08.008
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Article ; Online: Cognitive Performance in Episodic Cluster Headache.

Santos-Lasaosa, Sonia / Bellosta-Diago, Elena / López-Bravo, Alba / Viloria-Alebesque, Alejandro / Garrido-Fernández, Alberto / Pilar Navarro-Pérez, María

Pain medicine (Malden, Mass.)

2018 Volume 20, Issue 5, Page(s) 1032–1037

Abstract: Background: Cluster headache is one of the most disabling of all headache conditions. Although some studies have investigated the psychological profile of patients with cluster headache, research on its impact on cognitive function in patients with ... ...

Abstract	Background: Cluster headache is one of the most disabling of all headache conditions. Although some studies have investigated the psychological profile of patients with cluster headache, research on its impact on cognitive function in patients with episodic cluster headache outside the cluster bout is scant. Methods: Cross-sectional study to evaluate various aspects of neuropsychological assessment and cognitive function including working memory, selective attention, verbal fluency, and executive function in 40 patients with episodic cluster headache. The patients were compared with 40 age-, gender-, and level of education-matched healthy controls. Results: Episodic cluster headache patients performed significantly worse than healthy controls on all cognitive tests, except for the Interference Score (P = 0.281). They had significantly higher Hospital Anxiety Scale scores (P = 0.002). However, we found no significant association between cognitive performance, anxiety, sleep quality, and disease duration. Conclusions: Patients with episodic cluster headache outside the bout showed worse executive functioning, working memory, language, and selective attention compared with healthy controls, regardless of the duration of disease or sleep quality.
MeSH term(s)	Adult ; Aged ; Cluster Headache ; Cognition ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2018-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2015903-1
ISSN	1526-4637 ; 1526-2375
ISSN (online)	1526-4637
ISSN	1526-2375
DOI	10.1093/pm/pny238
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