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Article ; Online: Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies.

Canet, Geoffrey / Rocaboy, Emma / Diego-Diàz, Sofia / Whittington, Robert A / Julien, Carl / Planel, Emmanuel

Methods in molecular biology (Clifton, N.J.)

2024 Volume 2754, Page(s) 323–341

Abstract: The intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including Alzheimer's disease. Formation of insoluble tau aggregates is initiated by the abnormal ... ...

Abstract	The intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including Alzheimer's disease. Formation of insoluble tau aggregates is initiated by the abnormal hyperphosphorylation and oligomerization of tau. Over the past decades, multiple transgenic rodent models mimicking tauopathies have been develop, showcasing this neuropathological hallmark. The biochemical analysis of insoluble tau in these models has served as a valuable tool to understand the progression of tau-related pathology. In this chapter, we provide a comprehensive review of the two primary methods for isolating insoluble tau, namely, sarkosyl and formic acid extraction (and their variants), which are employed for biochemical analysis in transgenic mouse models of tauopathy. We also analyze the strengths and limitations of these methods.
MeSH term(s)	Mice ; Animals ; Rodentia/metabolism ; Disease Models, Animal ; Tauopathies/metabolism ; tau Proteins/genetics ; tau Proteins/metabolism ; Alzheimer Disease/metabolism ; Mice, Transgenic ; Brain/metabolism
Chemical Substances	tau Proteins
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Review ; Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3629-9_17
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adult Gastroenterology Trainees' Experience of Receiving Feedback on Their Performance of Endoscopy in the Workplace.

Phaneuf, Julien-Carl / Wood, Dawn

Journal of the Canadian Association of Gastroenterology

2021 Volume 5, Issue 1, Page(s) 18–24

Abstract: Background: Competency-based gastrointestinal endoscopy training is concerned with outcomes of the learning experience. Feedback allows for trainees to achieve the expected outcomes. However, little is known about trainees' experience of receiving ... ...

Abstract	Background: Competency-based gastrointestinal endoscopy training is concerned with outcomes of the learning experience. Feedback allows for trainees to achieve the expected outcomes. However, little is known about trainees' experience of receiving feedback. Gaining understanding of their experience could help improve feedback practices. The study was conducted to explore what it means for adult gastroenterology trainees to receive feedback on their performance of endoscopy in the workplace. Methods: An interpretative phenomenological approach was used. Individual semi-structured interviews were conducted with six trainees from three Canadian adult gastroenterology residency programs. Interviews were audio-recorded and transcribed verbatim for analysis. Analysis was conducted to identify the phenomenological themes across participants' accounts of lived experience to provide an insight into the meaning of experiencing the studied phenomenon. Findings: Three phenomenological themes of experience were identified: Discussion: The study has captured the uniqueness and the complexity of the lived experience of receiving feedback on the performance of endoscopy in the workplace from the perspective of study participants. The gained understanding of this experience has enabled the authors to suggest how attending gastroenterologists' feedback practices may be improved.
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2940642-0
ISSN	2515-2092 ; 2515-2084
ISSN (online)	2515-2092
ISSN	2515-2084
DOI	10.1093/jcag/gwab011
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Article ; Online: Valorisation of multiple components from residual biomass for food and biofuel applications: A virtual biorefinery evaluation

Voogt, Juliën / Hua, Nam-Phuong / Geerdink, Peter / Beelen, Brigit / Mulder, Wim / Safi, Carl

Food and Bioproducts Processing.

2023

Abstract: A conceptual biorefinery process has been designed for the integration of the protein extraction and the ethanol production from brewers' spent grain (BSG) and palm kernel meal (PKM). The conceptual process is designed for an industrial scale biorefinery ...

Abstract	A conceptual biorefinery process has been designed for the integration of the protein extraction and the ethanol production from brewers' spent grain (BSG) and palm kernel meal (PKM). The conceptual process is designed for an industrial scale biorefinery annually processing 20 kton dry weight BSG and 50 kton dry weight PKM with 8000 production hours per year and is used to techno-economically analyse the performance. The techno-economic analysis showed that the biorefinery of BSG has a high economic potential with an internal rate of return of 24%. However, despite the high raw material costs, the biorefinery of PKM still has a positive internal rate of return of 12%. The presented virtual biorefinery demonstrated the economic potential of integrating the production of a valuable product, like protein powder for food applications, with the production of biofuel, like ethanol, from the remaining biomass, thereby valorising a larger portion of the biomass with the same raw material costs.
Keywords	biofuels ; biomass ; biorefining ; ethanol ; ethanol production ; palm kernel meal ; raw materials ; spent grains ; Proteins ; biorefinery ; techno-economic analysis ; brewers' spent grain
Language	English
Size	p. 1-10.
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2008001-3
ISSN	0960-3085
ISSN	0960-3085
DOI	10.1016/j.fbp.2023.02.002
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Is there a right time for dairy Alpine goat kid weaning: How does the weaning age of dairy Alpine goat kids affect their growth and behavior?

Bélanger-Naud, Stéphanie / Wolfe, Tania / Zambelis, Athena / Lévesque, Janie / Julien, Carl / Vasseur, Elsa

Journal of animal science

2023 Volume 102

Abstract: In dairy goat kids, weaning is often associated with poor growth leading to a decline in welfare and performance; however, little is known about optimal weaning practices. This study aimed to determine the optimal weaning age for dairy goat kids to ... ...

Abstract	In dairy goat kids, weaning is often associated with poor growth leading to a decline in welfare and performance; however, little is known about optimal weaning practices. This study aimed to determine the optimal weaning age for dairy goat kids to maximize outcome measures of welfare related to growth, feed intake, and behavior. Thirty-six newborn female Alpine kids were blocked by weight and birth date, paired with a similar male companion and randomly allocated to one of the three weaning age treatments: 6 (6W), 8 (8W), and 10 wk (10W). Kids had ad libitum access to acidified milk replacer refilled twice daily, concentrates, hay, and water. Milk consumption was measured daily, and concentrate consumption, weekly. Ten behaviors were live observed on days -8, -4, 0, 6, and 12 relative to weaning (i.e., weaning day = 0). Kruskal-Wallis tests were used to assess differences from baseline between the 6W, 8W, and 10W treatments. Post hoc analysis using the Dwass, Steel, Critchlow-Fligner (DSCF) multiple comparison analysis was used to evaluate pairwise treatment differences based on two-sample Wilcoxon comparisons. Kids weaned at 10 wk had the greatest increase compared to baseline in concentrate consumption (P = 0.0160), and greatest decrease compared to baseline in vocalization (P = 0.0008) while both 8- and 10- wk kid's groups had the greatest increase compared to baseline in self-grooming time (P < 0.0001), and cross-sucking time (P = 0.0006). Kids weaned at 6 wk of age were found to have the smallest increase compared to baseline in concentrate consumption (P = 0.0160) and self-grooming time (P < 0.0001), and the greatest increase compared to baseline in allogrooming time (P = 0.0032) and in redirected behaviors aimed towards the environment (biting and licking time [P = 0.0173]; displacement at the nipple frequency [P = 0.0236]). No negative impact of weaning on growth of either group was identified. Overall, our results tend towards a higher degree of discomfort behaviors (allogrooming, biting/licking, displacement, and vocalizations) in kids weaned earlier compared to later weaning, while kids weaned later showed higher levels of positive behaviors (lying time and self-grooming).
MeSH term(s)	Female ; Male ; Animals ; Weaning ; Diet/veterinary ; Animal Feed/analysis ; Eating ; Milk ; Goats
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Randomized Controlled Trial, Veterinary ; Journal Article
ZDB-ID	390959-1
ISSN	1525-3163 ; 0021-8812
ISSN (online)	1525-3163
ISSN	0021-8812
DOI	10.1093/jas/skad413
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Article ; Online: Diagnosis Accuracy for Compartment Syndrome: A Systematic Review and Meta-Analysis.

Lorange, Justin-Pierre / Laverdière, Carl / Corban, Jason / Montreuil, Julien / Harvey, Edward J

Journal of orthopaedic trauma

2023 Volume 37, Issue 8, Page(s) e319–e325

Abstract: Objective: To evaluate whether published studies support basing the diagnosis of compartment syndrome of the lower leg on clinical findings, intracompartmental pressure (ICP) monitoring, or both.: Data sources: A PubMed/MEDLINE, Web of Science, and ... ...

Abstract	Objective: To evaluate whether published studies support basing the diagnosis of compartment syndrome of the lower leg on clinical findings, intracompartmental pressure (ICP) monitoring, or both. Data sources: A PubMed/MEDLINE, Web of Science, and Embase search of the English literature from 1966 to February 2022 was performed. This used "lower extremity" or "leg" or "tibia" and "compartment syndrome" and "pressure" as the subjects. A manual search of the bibliographies was performed and cross-referenced with those used to formulate the American Academy of Orthopaedic Surgeons clinical practice guidelines. Study selection and extraction: Inclusion criteria were traumatic tibia injuries, presence of data to calculate the sensitivity, specificity, positive and negative predictive values of clinical findings and/or pressure monitoring, and the presence or absence of compartment syndrome as the outcome. A total of 2906 full articles were found, of which 63 were deemed relevant for a detailed review. Seven studies met all eligibility criteria. Data synthesis: The likelihood ratio form of Bayes theorem was used to assess the discriminatory ability of the clinical findings and ICP monitoring as tests for compartment syndrome. The predictive value for diagnosing acute compartment syndrome was 21% and 29% for the clinical signs and ICP, respectively. When combining both, the probability reached 68%. Conclusions: The use of ICP monitoring may be helpful when combined with a clinical assessment to increase the sensitivity and specificity of the overall diagnosis. Previously accepted individual inference values should be revisited with new prospective studies to further characterize the statistical value of each clinical finding. Level of evidence: Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Prospective Studies ; Bayes Theorem ; Compartment Syndromes/diagnosis ; Lower Extremity ; Leg
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	639099-7
ISSN	1531-2291 ; 0890-5339
ISSN (online)	1531-2291
ISSN	0890-5339
DOI	10.1097/BOT.0000000000002610
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Zs.A 2234: Show issues

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Article ; Online: Honeybees as a biomonitoring species to assess environmental airborne pollution in different socioeconomic city districts.

Grenier, Émilie / Giovenazzo, Pierre / Julien, Carl / Goupil-Sormany, Isabelle

Environmental monitoring and assessment

2021 Volume 193, Issue 11, Page(s) 740

Abstract: Honeybees have been used in Europe as environmental bioindicators for heavy metals and polycyclic aromatic hydrocarbons (PAHs). However, their potential has been little explored in North America, especially between environments which have similar ... ...

Abstract	Honeybees have been used in Europe as environmental bioindicators for heavy metals and polycyclic aromatic hydrocarbons (PAHs). However, their potential has been little explored in North America, especially between environments which have similar pollution levels. Many urban residents and stakeholders are concerned with air quality, mainly in regard to gradients of exposure to industrial pollution between deprived and privileged subpopulation. Thus, the aim of this study was to evaluate the use of honeybees as bioindicators to assess exposure to heavy metals and PAHs in Québec City, Canada, in different socioeconomic districts of Quebec City (deprivation index). Honeybees were sampled over a 5-month period (May to September) at six locations distributed in two urban areas that are distinct geomorphologically and socioeconomically (lower town socio-economically deprived and upper town socioeconomically privileged) and two control rural locations. Six PAHs were analyzed by ultra-performance liquid chromatography (UPLC), while four heavy metals were analyzed by inductively coupled plasma mass spectrometry. Arsenic was the only measured pollutant that showed a significant gradient of exposure between rural and urban environments, but also between the two urban areas. Furthermore, we were able to detect significant differences at certain sampling times for heavy metals and PAHs. Overall, the results show that honeybees are sensitive enough to detect differences between the differential urban environments of a city presumed to have similar pollution levels and therefore could be used when potential socio-environmental inequalities are present.
MeSH term(s)	Animals ; Bees ; Biological Monitoring ; Cities ; Environmental Monitoring ; Polycyclic Aromatic Hydrocarbons/analysis ; Socioeconomic Factors
Chemical Substances	Polycyclic Aromatic Hydrocarbons
Language	English
Publishing date	2021-10-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-021-09485-1
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Article ; Online: A Changing Landscape for Lifelong Learning in Health Globally.

Mitchell, Sharon / Phaneuf, Julien-Carl / Astefanei, Silvia Matilda / Guttormsen, Sissel / Wolfe, Amy / de Groot, Esther / Sehlbach, Carolin

Journal of CME

2023 Volume 12, Issue 1, Page(s) 2154423

Abstract: On 25 July 2022, the Continuing Professional Development (CPD) Special Interest Group of the Association for Medical Education in Europe came together to open up discussions during a live webinar on ' ...

Abstract	On 25 July 2022, the Continuing Professional Development (CPD) Special Interest Group of the Association for Medical Education in Europe came together to open up discussions during a live webinar on '
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ISSN	2833-8073
ISSN (online)	2833-8073
DOI	10.1080/21614083.2022.2154423
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Article ; Online: Growth performance, organ weight, and plasma metabolites in broiler chickens fed corn-soybean meal diet containing berry pomaces and fed without or with multienzymes supplement.

Kithama, Munene / Hassan, Youssef I / Yin, Xianhua / Ross, Kelly / Julien, Carl / Kennes, Yan-Martel / Kiarie, Elijah G / Diarra, Moussa S

Poultry science

2023 Volume 102, Issue 4, Page(s) 102544

Abstract: This study evaluated effects of feeding low-bush wild blueberry (LBP) and organic American cranberry (CRP) pomaces without or with multienzyme supplement (ENZ) on growth performance, organ weight and plasma metabolites in broiler chickens. Nonenzyme-fed ( ...

Abstract	This study evaluated effects of feeding low-bush wild blueberry (LBP) and organic American cranberry (CRP) pomaces without or with multienzyme supplement (ENZ) on growth performance, organ weight and plasma metabolites in broiler chickens. Nonenzyme-fed (no-ENZ: n = 1,575) and enzyme-fed (ENZ: n = 1,575) day-old male Cobb500 broilers were placed in floor pens (45 chicks/pen) and allocated to five corn-soybean meal-based diets: a basal diet supplemented with either bacitracin methylene disalicylate (BMD, 55 mg/kg), 0.5 or 1% of CRP or LBP in a 2 × 5 factorial design for 35-day experiment. Body weight (BW), feed intake (FI) and mortality were recorded whereas BW gain (BWG) and feed conversion ratio (FCR) were calculated. Birds were sampled at days 21 and 35 for organ weights and plasma metabolites. There were no interactions between diet and ENZ on any parameter (P > 0.05) and no effect of ENZ on overall (d 0-35) growth performance and organ weights (P > 0.05). Birds fed BMD were heavier (P < 0.05) at d 35 and had better overall FCR than berry-supplemented birds. Birds fed 1% LBP had poor FCR than birds fed 0.5% CRP. Birds fed LBP exhibited heavier liver (P < 0.05) than birds fed BMD or 1% CRP. The highest plasma concentrations of aspartate transaminase (AST), creatine kinase (CK) at d 28 and gamma-glutamyl transferase (GGT) at d 35 were found in ENZ-fed birds (P < 0.05). At d 28, birds fed 0.5% LBP showed higher plasma AST and CK concentrations (P < 0.05). However, CRP feeding resulted in a lower plasma CK level compared with BMD feeding (P < 0.05). The lowest cholesterol level was detected in 1% CRP-fed birds. In conclusion, this study showed no ENZ effects to potentiate berry pomaces on the overall growth performance of broilers (P < 0.05. However, plasma profiles revealed the potential of ENZ to modulate the metabolism of pomace-fed broilers. LBP increased BW during the starter phase, while CRP increased BW during the grower phase.
MeSH term(s)	Animals ; Male ; Chickens ; Zea mays ; Fruit ; Organ Size ; Glycine max ; Flour ; Dietary Supplements/analysis ; Diet/veterinary ; Animal Feed/analysis ; Animal Nutritional Physiological Phenomena
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102544
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Article ; Online: Valorisation of multiple components from residual biomass for food and biofuel applications

Voogt, Juliën / Humblet-Hua, Nam Phuong / Geerdink, Peter / Beelen, Brigit / Mulder, Wim / Safi, Carl

Food and Bioproducts Processing

A virtual biorefinery evaluation

2023 Volume 139

Abstract: A conceptual biorefinery process has been designed for the integration of the protein extraction and the ethanol production from brewers’ spent grain (BSG) and palm kernel meal (PKM). The conceptual process is designed for an industrial scale biorefinery ...

Abstract	A conceptual biorefinery process has been designed for the integration of the protein extraction and the ethanol production from brewers’ spent grain (BSG) and palm kernel meal (PKM). The conceptual process is designed for an industrial scale biorefinery annually processing 20 kton dry weight BSG and 50 kton dry weight PKM with 8000 production hours per year and is used to techno-economically analyse the performance. The techno-economic analysis showed that the biorefinery of BSG has a high economic potential with an internal rate of return of 24 %. However, despite the high raw material costs, the biorefinery of PKM still has a positive internal rate of return of 12 %. The presented virtual biorefinery demonstrated the economic potential of integrating the production of a valuable product, like protein powder for food applications, with the production of biofuel, like ethanol, from the remaining biomass, thereby valorising a larger portion of the biomass with the same raw material costs.
Keywords	Biorefinery ; Brewers’ spent grain ; Ethanol ; Palm kernel meal ; Protein ; Techno-economic analysis
Subject code	660
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2008001-3
ISSN	0960-3085
ISSN	0960-3085
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Valorisation of proteins from palm kernel meal

Safi, Carl / Humblet, Nam-Phuong / Geerdink, Peter / Theunissen, Mira / Beelen, Brigit / Voogt, Juliën / Mulder, Wim

Bioresource technology reports. 2022 June, v. 18

2022

Abstract: A process to extract proteins from palm kernel meal was investigated. A sequence of unit operations was implemented and optimized in order to ensure an optimal process efficacy. It has been determined that among all the enzymes that were tested, Alcalase ...

Abstract	A process to extract proteins from palm kernel meal was investigated. A sequence of unit operations was implemented and optimized in order to ensure an optimal process efficacy. It has been determined that among all the enzymes that were tested, Alcalase had the highest capacity to hydrolyse proteins and solubilize them in solution, especially after using 5% dry matter of PKM as a starting material. Thus, 80% of the proteins were solubilized in the supernatant after Alcalase treatment, but only 60% of the proteins were recovered in the permeate after applying ultrafiltration (300 kDa), with a purity of 60%. Functionality tests revealed that the protein fraction obtained had a very high solubility and a mild foaming and emulsification capacity.
Keywords	emulsifying ; palm kernel meal ; solubility ; solubilization ; subtilisin ; ultrafiltration
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2589-014X
DOI	10.1016/j.biteb.2022.101050
Database	NAL-Catalogue (AGRICOLA)

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