LIVIVO - Search results -

Search results

Result 1 - 10 of total 20194

Article ; Online: H

Takahari, Kosuke / Hidaka, Takayuki / Ueda, Yusuke / Izumi, Kanako / Harada, Yu / Susawa, Hitoshi / Kinoshita, Mirai / Itakura, Kiho / Utsunomiya, Hiroto / Kihara, Yasuki

Circulation journal : official journal of the Japanese Circulation Society

2019 Volume 83, Issue 12, Page(s) 2487–2493

Abstract: Background: Both the H: Conclusions: The H ...

Abstract	Background: Both the H Conclusions: The H
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Early Diagnosis ; Echocardiography, Stress ; Exercise Test ; Exercise Tolerance ; Female ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Hemodynamics ; Humans ; Japan ; Male ; Middle Aged ; Nomograms ; Oxygen Consumption ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2019-11-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2068090-9
ISSN	1347-4820 ; 1346-9843
ISSN (online)	1347-4820
ISSN	1346-9843
DOI	10.1253/circj.CJ-19-0699
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.74: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Utility of the H

Hirano, Reina / Ikemura, Nobuhiro / Nguyen, Dan D / Jones, Philip G / Kimura, Takehiro / Katsumata, Yoshinori / Ueda, Ikuko / Takatsuki, Seiji / Spertus, John A / Kohsaka, Shun

JACC. Heart failure

2024

Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Letter
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2023.12.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Manipulating Parallel and Perpendicular Multiphoton Transitions in H_{2} Molecules.

Pan, Shengzhe / Zhang, Zhaohan / Xu, Liang / Zhang, Wenbin / Lu, Peifen / Ji, Qinying / Lin, Kang / Zhou, Lianrong / Lu, Chenxu / Ni, Hongcheng / Ruiz, Camilo / Ueda, Kiyoshi / He, Feng / Wu, Jian

Physical review letters

2023 Volume 130, Issue 14, Page(s) 143203

Abstract: We demonstrate that dissociative ionization of H_{2} can be fully manipulated in an angle-time ... sequentially, parallel and perpendicular transitions of stretching H_{2} molecules, respectively ...

Abstract	We demonstrate that dissociative ionization of H_{2} can be fully manipulated in an angle-time-resolved fashion, employing a polarization-skewed (PS) laser pulse in which the polarization vector rotates. The leading and falling edges of the PS laser pulse, characterized by unfolded field polarization, trigger, sequentially, parallel and perpendicular transitions of stretching H_{2} molecules, respectively. These transitions result in counterintuitive proton ejections that deviate significantly from the laser polarization directions. Our findings demonstrate that the reaction pathways can be controlled through fine-tuning the time-dependent polarization of the PS laser pulse. The experimental results are well reproduced using an intuitive wave-packet surface propagation simulation method. This research highlights the potential of PS laser pulses as powerful tweezers to resolve and manipulate complex laser-molecule interactions.
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.143203
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In vitro synthesis of oryzamutaic acid H using recombinant L-lysine ε-dehydrogenase from Agrobacterium tumefaciens.

Horie, Yuta / Uchikata, Makoto / Ueda, Sachie / Yamahira, Gai / Hashimoto, Masaru / Sakamoto, Kimitoshi / Ito, Hiroyuki / Hamada, Shigeki

Journal of biotechnology

2024 Volume 385, Page(s) 42–48

Abstract: ... the synthesis of oryzamutaic acid H at neutral pH in vitro. We synthesized 1.6 mg oryzamutaic acid H from 100 mg ... L-lysine. The synthesized oryzamutaic acid H exhibited UVA absorption, stability of temperature, and ... of oryzamutaic acid H in vitro and provides a basis for understanding the mechanisms of oryzamutaic acid ...

Abstract	Oryzamutaic acids, possessing a nitrogen-containing heterocyclic skeleton, have been isolated and identified from a rice mutant. Although oryzamutaic acids are expected to be functional ingredients, their functionality is difficult to evaluate, because of their wide variety and presence in trace amounts. Furthermore, how oryzamutaic acid is synthesized in vivo is unclear. Therefore, we developed a simple enzymatic synthesis method for these compounds in vitro. We focused on L-lysine ε-dehydrogenase (LysDH) from Agrobacterium tumefaciens, which synthesizes α-aminoadipate-δ-semialdehyde-a precursor of oryzamutaic acids. LysDH was cloned and expressed in Escherichia coli. Analysis of activity revealed that LysDH catalyzed the synthesis of oryzamutaic acid H at neutral pH in vitro. We synthesized 1.6 mg oryzamutaic acid H from 100 mg L-lysine. The synthesized oryzamutaic acid H exhibited UVA absorption, stability of temperature, and stability at a wide pH range. To our knowledge, this study is the first to report the enzymatic synthesis of oryzamutaic acid H in vitro and provides a basis for understanding the mechanisms of oryzamutaic acid synthesis in vivo.
MeSH term(s)	Agrobacterium tumefaciens/genetics ; Amino Acid Oxidoreductases ; Lysine ; Acids
Chemical Substances	lysine epsilon-dehydrogenase (EC 1.4.1.-) ; Amino Acid Oxidoreductases (EC 1.4.-) ; Lysine (K3Z4F929H6) ; Acids
Language	English
Publishing date	2024-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	843647-2
ISSN	1873-4863 ; 0168-1656 ; 1389-0352
ISSN (online)	1873-4863
ISSN	0168-1656 ; 1389-0352
DOI	10.1016/j.jbiotec.2024.03.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2299: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H

Ueda, Ayaka / Aihara, Yusuke / Sato, Shinya / Kano, Keiko / Mishiro-Sato, Emi / Kitano, Hiroyuki / Sato, Ayato / Fujimoto, Kazuhiro J / Yanai, Takeshi / Amaike, Kazuma / Kinoshita, Toshinori / Itami, Kenichiro

ACS chemical biology

2023 Volume 18, Issue 2, Page(s) 347–355

Abstract: ... their mechanistic study. Based on biological assays, AUs may involve in the pathway related with plasma membrane H ...

Abstract	Stomata are pores in the leaf epidermis of plants and their opening and closing regulate gas exchange and water transpiration. Stomatal movements play key roles in both plant growth and stress responses. In recent years, small molecules regulating stomatal movements have been used as a powerful tool in mechanistic studies, as well as key players for agricultural applications. Therefore, the development of new molecules regulating stomatal movement and the elucidation of their mechanisms have attracted much attention. We herein describe the discovery of 2,6-dihalopurines, AUs, as a new stomatal opening inhibitor, and their mechanistic study. Based on biological assays, AUs may involve in the pathway related with plasma membrane H
MeSH term(s)	Phosphorylation ; Plant Stomata ; Cell Membrane/metabolism ; Cell Wall/metabolism ; Proton-Translocating ATPases ; Arabidopsis Proteins/metabolism
Chemical Substances	Proton-Translocating ATPases (EC 3.6.3.14) ; Arabidopsis Proteins
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.2c00771
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study.

Kusumoto, Tatsuya / Chubachi, Shotaro / Namkoong, Ho / Tanaka, Hiromu / Lee, Ho / Otake, Shiro / Nakagawara, Kensuke / Fukushima, Takahiro / Morita, Atsuho / Watase, Mayuko / Asakura, Takanori / Masaki, Katsunori / Kamata, Hirofumi / Ishii, Makoto / Hasegawa, Naoki / Harada, Norihiro / Ueda, Tetsuya / Ueda, Soichiro / Ishiguro, Takashi /

Arimura, Ken / Saito, Fukuki / Yoshiyama, Takashi / Nakano, Yasushi / Mutoh, Yoshikazu / Suzuki, Yusuke / Edahiro, Ryuya / Murakami, Koji / Sato, Yasunori / Okada, Yukinori / Koike, Ryuji / Kitagawa, Yuko / Tokunaga, Katsushi / Kimura, Akinori / Imoto, Seiya / Miyano, Satoru / Ogawa, Seishi / Kanai, Takanori / Fukunaga, Koichi

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22054

Abstract: ... within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most ...

Abstract	The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.
MeSH term(s)	Humans ; COVID-19 ; Retrospective Studies ; X-Rays ; Radiography, Thoracic ; Lung
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49340-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Development of multiple AI pipelines that predict neoadjuvant chemotherapy response of breast cancer using H&E-stained tissues.

Shen, Bin / Saito, Akira / Ueda, Ai / Fujita, Koji / Nagamatsu, Yui / Hashimoto, Mikihiro / Kobayashi, Masaharu / Mirza, Aashiq H / Graf, Hans Peter / Cosatto, Eric / Hazama, Shoichi / Nagano, Hiroaki / Sato, Eiichi / Matsubayashi, Jun / Nagao, Toshitaka / Cheng, Esther / Hoda, Syed Af / Ishikawa, Takashi / Kuroda, Masahiko

The journal of pathology. Clinical research

2023 Volume 9, Issue 3, Page(s) 182–194

Abstract: In recent years, the treatment of breast cancer has advanced dramatically and neoadjuvant chemotherapy (NAC) has become a common treatment method, especially for locally advanced breast cancer. However, other than the subtype of breast cancer, no clear ... ...

Abstract	In recent years, the treatment of breast cancer has advanced dramatically and neoadjuvant chemotherapy (NAC) has become a common treatment method, especially for locally advanced breast cancer. However, other than the subtype of breast cancer, no clear factor indicating sensitivity to NAC has been identified. In this study, we attempted to use artificial intelligence (AI) to predict the effect of preoperative chemotherapy from hematoxylin and eosin images of pathological tissue obtained from needle biopsies prior to chemotherapy. Application of AI to pathological images typically uses a single machine-learning model such as support vector machines (SVMs) or deep convolutional neural networks (CNNs). However, cancer tissues are extremely diverse and learning with a realistic number of cases limits the prediction accuracy of a single model. In this study, we propose a novel pipeline system that uses three independent models each focusing on different characteristics of cancer atypia. Our system uses a CNN model to learn structural atypia from image patches and SVM and random forest models to learn nuclear atypia from fine-grained nuclear features extracted by image analysis methods. It was able to predict the NAC response with 95.15% accuracy on a test set of 103 unseen cases. We believe that this AI pipeline system will contribute to the adoption of personalized medicine in NAC therapy for breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Artificial Intelligence ; Neoadjuvant Therapy/methods ; Machine Learning ; Chemotherapy, Adjuvant
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814357-7
ISSN	2056-4538 ; 2056-4538
ISSN (online)	2056-4538
ISSN	2056-4538
DOI	10.1002/cjp2.314
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Development of serological assays to identify Helicobacter suis and H. pylori infections

Hidenori Matsui / Emiko Rimbara / Masato Suzuki / Kengo Tokunaga / Hidekazu Suzuki / Masaya Sano / Takashi Ueda / Hitoshi Tsugawa / Sohachi Nanjo / Akira Takeda / Makoto Sasaki / Shuichi Terao / Tsuyoshi Suda / Sae Aoki / Keigo Shibayama / Hiroyoshi Ota / Katsuhiro Mabe

iScience, Vol 26, Iss 4, Pp 106522- (2023)

2023

Abstract: ... Helicobacter species found in humans. Recent studies have suggested that H. suis infection has caused ... on H. suis urease activity often yield negative results, and there is no reliable method for diagnosing ... H. suis infection in clinical practice without gastric biopsy specimens. This study presents ...

Abstract	Summary: Helicobacter suis, hosted by hogs, is the most prevalent gastric non-Helicobacter pylori Helicobacter species found in humans. Recent studies have suggested that H. suis infection has caused many cases of gastric disease, but the transmission route from hogs remains unclear. Diagnostic methods based on H. suis urease activity often yield negative results, and there is no reliable method for diagnosing H. suis infection in clinical practice without gastric biopsy specimens. This study presents the world’s first use of whole-bacterial cell ELISA to simultaneously assess H. suis and H. pylori infections. The ELISAs showed high accuracy, with an area under the ROC curve of 0.96, 100% sensitivity, 92.6% specificity, 76.9% positive predictive value, and 100% negative predictive value for the H. suis test, and an area under the ROC curve of 0.92, 88.2% sensitivity, 87.5% specificity, 65.2% positive predictive value, and 96.6% negative predictive value for the H. pylori test.
Keywords	Diagnostic procedure ; Gastroenterology ; Virology ; Science ; Q
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Discovery of Plant Growth Stimulants by C-H Arylation of 2-Azahypoxanthine.

Kitano, Hiroyuki / Choi, Jae-Hoon / Ueda, Ayaka / Ito, Hideto / Hagihara, Shinya / Kan, Toshiyuki / Kawagishi, Hirokazu / Itami, Kenichiro

Organic letters

2018 Volume 20, Issue 18, Page(s) 5684–5687

Abstract: A series of new AHX derivatives were synthesized by Pd-catalyzed C-H arylation. Their rice-growth ... of C-H functionalization chemistry to rapidly transform biologically active natural products into more ...

Abstract	A series of new AHX derivatives were synthesized by Pd-catalyzed C-H arylation. Their rice-growth-promoting activity was evaluated in vivo. Among the synthesized compounds, C8 phenyl-substituted AHX showed remarkable growth-promoting activity on rice. The present study shows the power and significant opportunity of C-H functionalization chemistry to rapidly transform biologically active natural products into more active compounds.
Language	English
Publishing date	2018-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.8b02407
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Site-Selective Molecular Transformation: Acylation of Hydroxy Groups and C-H Amination.

Ueda, Yoshihiro

Chemical & pharmaceutical bulletin

2021 Volume 69, Issue 10, Page(s) 931–944

Abstract: ... the acylation of hydroxy groups and C-H amination, is summarized. Regarding the acylation of hydroxy groups ... syntheses of sugar-related natural and unnatural products. Regarding C-H amination, the discovery ...

Abstract	Control of site selectivity is an exciting direction for synthetic organic chemistry owing to the possibility of selective modification of multifunctionalized molecules, ultimately including biomacromolecules. In this review, our recent research related to site selectivity in two types of transformation, namely, the acylation of hydroxy groups and C-H amination, is summarized. Regarding the acylation of hydroxy groups, catalyst-controlled site selectivity enables unconventional retrosynthetic analysis, leading to efficient syntheses of sugar-related natural and unnatural products. Regarding C-H amination, the discovery of unprecedented reaction sites in intermolecular amination mediated by dirhodium nitrenes is described. The findings of this research demonstrate the power of site-selective transformation in the synthesis of a particular class of compounds.
MeSH term(s)	Acylation ; Amination ; Hydroxides/chemistry ; Molecular Structure
Chemical Substances	Hydroxides
Language	English
Publishing date	2021-10-02
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c21-00425
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 770: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito