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Article: Editorial: Extracellular matrix in development and disorders of the nervous system.

Jakovcevski, Igor / Andjus, Pavle R / Förster, Eckart

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1153484

Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1153484
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: National Brain Councils - common challenges and regional cooperation.

Andjus, Pavle R

Croatian medical journal

2019 Volume 60, Issue 4, Page(s) 385–387

Language	English
Publishing date	2019-09-02
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1157623-6
ISSN	1332-8166 ; 0353-9504
ISSN (online)	1332-8166
ISSN	0353-9504
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial

Igor Jakovcevski / Pavle R. Andjus / Eckart Förster

Frontiers in Cell and Developmental Biology, Vol

Extracellular matrix in development and disorders of the nervous system

2023 Volume 11

Keywords	extracellular matrix (ECM) ; nervous system ; regeneration ; perineuronal nets (PNNs) ; synapses ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Primary Cultures of Rat Astrocytes and Microglia and Their Use in the Study of Amyotrophic Lateral Sclerosis.

Milićević, Katarina / Korenić, Andrej / Milošević, Milena / Andjus, Pavle R

Journal of visualized experiments : JoVE

2022 , Issue 184

Abstract: This protocol demonstrates how to prepare primary cultures of glial cells, astrocytes, and microglia from the cortices of Sprague Dawley rats and how to use these cells for the purpose of studying the pathophysiology of amyotrophic lateral sclerosis (ALS) ...

Abstract	This protocol demonstrates how to prepare primary cultures of glial cells, astrocytes, and microglia from the cortices of Sprague Dawley rats and how to use these cells for the purpose of studying the pathophysiology of amyotrophic lateral sclerosis (ALS) in the rat hSOD1
MeSH term(s)	Adenosine Triphosphate/metabolism ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Astrocytes/metabolism ; Calcium/metabolism ; Cells, Cultured ; Immunoglobulin G/metabolism ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase
Chemical Substances	Immunoglobulin G ; Adenosine Triphosphate (8L70Q75FXE) ; Superoxide Dismutase (EC 1.15.1.1) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/63483
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Article: Immunology of amyotrophic lateral sclerosis - role of the innate and adaptive immunity.

Mimic, Stefan / Aru, Başak / Pehlivanoğlu, Cemil / Sleiman, Hadi / Andjus, Pavle R / Yanıkkaya Demirel, Gülderen

Frontiers in neuroscience

2023 Volume 17, Page(s) 1277399

Abstract: This review aims to summarize the latest evidence about the role of innate and adaptive immunity in Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease affecting upper and lower motor neurons, which involves essential ... ...

Abstract	This review aims to summarize the latest evidence about the role of innate and adaptive immunity in Amyotrophic Lateral Sclerosis (ALS). ALS is a devastating neurodegenerative disease affecting upper and lower motor neurons, which involves essential cells of the immune system that play a basic role in innate or adaptive immunity, that can be neurotoxic or neuroprotective for neurons. However, distinguishing between the sole neurotoxic or neuroprotective function of certain cells such as astrocytes can be challenging due to intricate nature of these cells, the complexity of the microenvironment and the contextual factors. In this review, in regard to innate immunity we focus on the involvement of monocytes/macrophages, microglia, the complement, NK cells, neutrophils, mast cells, and astrocytes, while regarding adaptive immunity, in addition to humoral immunity the most important features and roles of T and B cells are highlighted, specifically different subsets of CD4
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1277399
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Article ; Online: Astroglial Cell-to-Cell Interaction with Autoreactive Immune Cells in Experimental Autoimmune Encephalomyelitis Involves P2X7 Receptor, β

Milicevic, Katarina D / Bataveljic, Danijela B / Bogdanovic Pristov, Jelena J / Andjus, Pavle R / Nikolic, Ljiljana M

Cells

2023 Volume 12, Issue 13

Abstract: In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells that attack the central nervous system (CNS), which causes and sustains neuroinflammation. However, little is known about the direct interaction between these ... ...

Abstract	In multiple sclerosis (MS), glial cells astrocytes interact with the autoreactive immune cells that attack the central nervous system (CNS), which causes and sustains neuroinflammation. However, little is known about the direct interaction between these cells when they are in close proximity in the inflamed CNS. By using an experimental autoimmune encephalomyelitis (EAE) model of MS, we previously found that in the proximity of autoreactive CNS-infiltrated immune cells (CNS-IICs), astrocytes respond with a rapid calcium increase that is mediated by the autocrine P2X7 receptor (P2X7R) activation. We now reveal that the mechanisms regulating this direct interaction of astrocytes and CNS-IICs involve the coupling between P2X7R, connexin-43, and β
MeSH term(s)	Animals ; Encephalomyelitis, Autoimmune, Experimental ; Astrocytes ; Receptors, Purinergic P2X7 ; Integrin beta3 ; Calcium ; Multiple Sclerosis ; Cell Communication
Chemical Substances	Receptors, Purinergic P2X7 ; Integrin beta3 ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12131786
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Article ; Online: The Role of Tenascin-C on the Structural Plasticity of Perineuronal Nets and Synaptic Expression in the Hippocampus of Male Mice.

Jakovljević, Ana / Stamenković, Vera / Poleksić, Joko / Hamad, Mohammad I K / Reiss, Gebhard / Jakovcevski, Igor / Andjus, Pavle R

Biomolecules

2024 Volume 14, Issue 4

Abstract: Neuronal plasticity is a crucial mechanism for an adapting nervous system to change. It is shown to be regulated by perineuronal nets (PNNs), the condensed forms of the extracellular matrix (ECM) around neuronal bodies. By assessing the changes in the ... ...

Abstract	Neuronal plasticity is a crucial mechanism for an adapting nervous system to change. It is shown to be regulated by perineuronal nets (PNNs), the condensed forms of the extracellular matrix (ECM) around neuronal bodies. By assessing the changes in the number, intensity, and structure of PNNs, the ultrastructure of the PNN mesh, and the expression of inhibitory and excitatory synaptic inputs on these neurons, we aimed to clarify the role of an ECM glycoprotein, tenascin-C (TnC), in the dorsal hippocampus. To enhance neuronal plasticity, TnC-deficient (TnC-/-) and wild-type (TnC+/+) young adult male mice were reared in an enriched environment (EE) for 8 weeks. Deletion of TnC in TnC-/- mice showed an ultrastructural reduction of the PNN mesh and an increased inhibitory input in the dentate gyrus (DG), and an increase in the number of PNNs with a rise in the inhibitory input in the CA2 region. EE induced an increased inhibitory input in the CA2, CA3, and DG regions; in DG, the change was also followed by an increased intensity of PNNs. No changes in PNNs or synaptic expression were found in the CA1 region. We conclude that the DG and CA2 regions emerged as focal points of alterations in PNNs and synaptogenesis with EE as mediated by TnC.
MeSH term(s)	Animals ; Tenascin/metabolism ; Tenascin/genetics ; Male ; Neuronal Plasticity ; Mice ; Hippocampus/metabolism ; Extracellular Matrix/metabolism ; Synapses/metabolism ; Mice, Knockout ; Neurons/metabolism ; Mice, Inbred C57BL ; Dentate Gyrus/metabolism
Chemical Substances	Tenascin ; Tnc protein, mouse
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14040508
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Article ; Online: Dysfunction of oligodendrocyte inwardly rectifying potassium channel in a rat model of amyotrophic lateral sclerosis.

Peric, Mina / Nikolic, Ljiljana / Andjus, Pavle R / Bataveljic, Danijela

The European journal of neuroscience

2021 Volume 54, Issue 7, Page(s) 6339–6354

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the death of motor neurons in the spinal cord and the brain. Although this disease is characterized by motoneuron degeneration, non-neuronal cells such as oligodendrocytes ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the death of motor neurons in the spinal cord and the brain. Although this disease is characterized by motoneuron degeneration, non-neuronal cells such as oligodendrocytes play an important role in the disease onset and progression. The aim of our study was to examine functional properties of oligodendrocytes in the SOD1
MeSH term(s)	Amyotrophic Lateral Sclerosis ; Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Motor Neurons ; Neurodegenerative Diseases ; Oligodendroglia ; Potassium Channels, Inwardly Rectifying/genetics ; Rats ; Spinal Cord
Chemical Substances	Kcnj10 (channel) ; Potassium Channels, Inwardly Rectifying
Language	English
Publishing date	2021-09-22
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15451
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Article: Emerging Roles for Phase Separation of RNA-Binding Proteins in Cellular Pathology of ALS.

Milicevic, Katarina / Rankovic, Branislava / Andjus, Pavle R / Bataveljic, Danijela / Milovanovic, Dragomir

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 840256

Abstract: Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in ... ...

Abstract	Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in metabolic activities and signaling. Nowhere is this regulation more important than in neurons and glia, where cellular physiology occurs simultaneously on a range of time- and length-scales. In a number of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), misregulation of biomolecular condensates leads to the formation of insoluble aggregates-a pathological hallmark of both sporadic and familial ALS. Here, we summarize how the emerging knowledge about the LLPS of ALS-related proteins corroborates with their aggregation. Understanding the mechanisms that lead to protein aggregation in ALS and how cells respond to these aggregates promises to open new directions for drug development.
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.840256
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Article ; Online: Emerging Roles for Phase Separation of RNA-Binding Proteins in Cellular Pathology of ALS

Katarina Milicevic / Branislava Rankovic / Pavle R. Andjus / Danijela Bataveljic / Dragomir Milovanovic

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract	Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in metabolic activities and signaling. Nowhere is this regulation more important than in neurons and glia, where cellular physiology occurs simultaneously on a range of time- and length-scales. In a number of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), misregulation of biomolecular condensates leads to the formation of insoluble aggregates—a pathological hallmark of both sporadic and familial ALS. Here, we summarize how the emerging knowledge about the LLPS of ALS-related proteins corroborates with their aggregation. Understanding the mechanisms that lead to protein aggregation in ALS and how cells respond to these aggregates promises to open new directions for drug development.
Keywords	liquid-liquid phase separation ; FUS ; TDP-43 ; RNP aggregates ; stress granule ; neurons ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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