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Article ; Online: Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.

Seillier, Alexandre / Martinez, Alex A / Giuffrida, Andrea

PloS one

2020 Volume 15, Issue 3, Page(s) e0230238

Abstract: Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively the ... ...

Abstract	Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively the course and expression of psychosis, we tested whether the beneficial effects of endocannabinoid-mediated CB1 activation on social withdrawal in PCP-treated rats (5 mg/kg, twice daily for 7 days)also occurred after administration of Δ9-tetrahydrocannabinol (THC; 0.1, 0.3, 1.0 mg/kg, i.p.). In addition, we assessed whether THC affected two correlates of positive symptoms: 1) motor activity induced by d-amphetamine (0.5 mg/kg, i.p.), and 2) dopamine neuron population activity in the ventral tegmental area (VTA). After the motor activity test, the brains from d-amphetamine-treated animals were collected and processed for measurements of endocannabinoids and activation of Akt/GSK3β, two molecular markers involved in the pathophysiology of schizophrenia. In control rats, THC dose-dependently produced social interaction deficits and aberrant VTA dopamine neuron population activity similar to those observed in PCP-treated animals. In PCP-treated rats, only the lowest dose of THC reversed PCP-induced deficits, as well as PCP-induced elevation of the endocannabinoid anandamide (AEA) in the nucleus accumbens. Last, THC activated the Akt/GSK3β pathway dose-dependently in both control and PCP-treated animals. Taken together, these data suggest that only low doses of THC have beneficial effects on behavioral, neurochemical and electrophysiological correlates of schizophrenia symptoms. This observation may shed some light on the controversial hypothesis of marijuana use as self-medication in schizophrenic patients.
MeSH term(s)	Animals ; Arachidonic Acids/pharmacology ; Disease Models, Animal ; Dronabinol/administration & dosage ; Endocannabinoids/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Male ; Motor Activity/drug effects ; Neurons/drug effects ; Phencyclidine/pharmacology ; Polyunsaturated Alkamides/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Wistar ; Schizophrenia/chemically induced ; Schizophrenia/drug therapy ; Signal Transduction/drug effects ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/metabolism
Chemical Substances	Arachidonic Acids ; Endocannabinoids ; Polyunsaturated Alkamides ; Dronabinol (7J8897W37S) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phencyclidine (J1DOI7UV76) ; anandamide (UR5G69TJKH)
Language	English
Publishing date	2020-03-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0230238
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Article ; Online: Delaying anti-VEGF therapy during the COVID-19 pandemic: long-term impact on visual outcomes in patients with neovascular age-related macular degeneration.

Nassisi, Marco / Pozzo Giuffrida, Francesco / Milella, Paolo / Ganci, Simone / Aretti, Andrea / Mainetti, Claudia / Dell'Arti, Laura / Mapelli, Chiara / Viola, Francesco

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 156

Abstract: Objectives: To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD).: Methods: nAMD patients with scheduled ...

Abstract	Objectives: To evaluate the outcomes of delayed intravitreal injections (IVIs) caused by the outbreak of coronavirus disease 2019 (COVID-19), in patients with neovascular age-related macular degeneration (nAMD). Methods: nAMD patients with scheduled IVIs between March 1 Results: Two hundred fifteen patients (132 females, mean age: 81.89 ± 5.98 years) delayed their scheduled IVI while 83 (53 females, mean age: 77.92 ± 6.06 years) adhered to their protocol. For both groups, BCVA at v Conclusions: A risk-based selection strategy and a rescue therapy may limit the long-term outcomes of an interruption of the treatment protocol in patients with nAMD.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Angiogenesis Inhibitors/therapeutic use ; Communicable Disease Control ; COVID-19 ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Pandemics ; Ranibizumab/therapeutic use ; Treatment Outcome ; Wet Macular Degeneration/drug therapy ; Male
Chemical Substances	Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-02864-x
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Article: Handheld Ultrasound or Conventional Ultrasound Devices in Patients Undergoing HCT: A Validation Study.

Duminuco, Andrea / Cupri, Alessandra / Massimino, Rosario / Leotta, Salvatore / Milone, Giulio Antonio / Garibaldi, Bruno / Giuffrida, Giulia / Garretto, Orazio / Milone, Giuseppe

Journal of clinical medicine

2023 Volume 12, Issue 2

Abstract: Abdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, ...

Abstract	Abdominal ultrasound exams play a major role in the diagnosis of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD). The development of portable hand-held ultrasound devices (HHUS) has been shown to facilitate the diagnosis of many diseases, but little data on the value of HHUS in the diagnosis of SOS/VOD are available. We performed a study aimed at validating portable ultrasound (US) devices in the setting of hematopoietic stem cell transplant (HCT). Sixteen evaluable patients undergoing allogeneic HCT were studied using conventional US and HHUS during the first 3 weeks after transplant. The results obtained demonstrate that there is a close correlation between conventional and handheld ultrasound examination in the measurement of the right hepatic lobe (r = 0.912, p < 0.0001), the left hepatic lobe (r = 0.843, p < 0.0001), the portal vein (PV) (r = 0.724, p < 0.0001), and the spleen (r = 0.983, p < 0.0001) based on Pearson’s correlation. The same data, analyzed through Lin’s concordance correlation coefficient, evidenced a substantial level of agreement in the comparison of the spleen and right hepatic lobe, while a lower grade of agreement in the measurement of the portal vein and left hepatic lobe. Moreover, there was good agreement between results obtained by the two types of ultrasound devices in assessing ascites (p < 0.0001), gallbladder thickening (p < 0.0001), and the direction of PV flow (p < 0.0001). HHUS device allows the study of HokUs-10 parameters with an excellent agreement with conventional US, and may contribute to SOS/VOD diagnosis.
Language	English
Publishing date	2023-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12020520
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Article ; Online: Effectiveness and Safety of Eliglustat Treatment in Gaucher Disease: Real-life Unicentric Experience.

Duminuco, Andrea / Fazio, Manlio / Grasso, Stephanie / Gullo, Lara / Riccobene, Carla / Calafiore, Valeria / Markovic, Uros / Di Raimondo, Francesco / Giuffrida, Gaetano

Clinical therapeutics

2023 Volume 45, Issue 11, Page(s) 1105–1110

Abstract: Purpose: The therapy and management of Gaucher disease (GD) have radically changed with the use of substrate reduction therapy, of which eliglustat is the most widely known drug, allowing it to overcome the limits of enzyme replacement therapy (ERT). ... ...

Abstract	Purpose: The therapy and management of Gaucher disease (GD) have radically changed with the use of substrate reduction therapy, of which eliglustat is the most widely known drug, allowing it to overcome the limits of enzyme replacement therapy (ERT). The rarity of GD and the limited use of eliglustat outside clinical trials require further study of its strengths and weaknesses. Methods: In this study, we evaluated the effectiveness and safety of eliglustat in a cohort of 12 patients with GD followed up in our center, reporting a reduction in both chitotriosidase (394.3 vs 181.1 nmol/h/mL, P = 0.027) and glucosylsphingosine values (45.1 vs 18.9 ng/mL, P <0.001) after at least 12 months of therapy compared with baseline, regardless of patient demographic characteristics and GD characteristics. Findings: There were no drug-related serious adverse effects and no drug-related cardiac events. Most adverse events were mild and transient, mainly dyspepsia and abdominal pain. Of interest, we reported an absence of statistical difference in terms of response regarding glucosylsphingosine reduction in relation to naive or prior exposure to ERT (P = 0.296), which was confirmed also when patients were placed in naive and treated groups for <5 vs >5 years (P = 0.667). Implications: The use of eliglustat immediately after diagnosis may guarantee the best treatment for patients with milder phenotypes or with aggressive disease after an initial stabilization with ERT compared with ERT, which cannot adequately remove the disease burden despite the apparent response, thus potentially reducing future complications caused by substrate deposits.
MeSH term(s)	Humans ; Gaucher Disease/drug therapy ; Gaucher Disease/diagnosis ; Pyrrolidines/therapeutic use ; Psychosine/therapeutic use ; Enzyme Replacement Therapy/adverse effects
Chemical Substances	eliglustat (DR40J4WA67) ; sphingosyl beta-glucoside (52050-17-6) ; Pyrrolidines ; Psychosine (2238-90-6)
Language	English
Publishing date	2023-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	603113-4
ISSN	1879-114X ; 0149-2918
ISSN (online)	1879-114X
ISSN	0149-2918
DOI	10.1016/j.clinthera.2023.08.010
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Zs.A 1435: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The cannabinoid transporter inhibitor OMDM-2 reduces social interaction: Further evidence for transporter-mediated endocannabinoid release.

Seillier, Alexandre / Giuffrida, Andrea

Neuropharmacology

2017 Volume 130, Page(s) 1–9

Abstract: Experimental evidence suggests that the transport of endocannabinoids might work bi-directionally. Accordingly, it is possible that pharmacological blockade of the latter affects not only the re-uptake, but also the release of endocannabinoids, thus ... ...

Abstract	Experimental evidence suggests that the transport of endocannabinoids might work bi-directionally. Accordingly, it is possible that pharmacological blockade of the latter affects not only the re-uptake, but also the release of endocannabinoids, thus preventing them from stimulating CB
MeSH term(s)	Amidohydrolases/antagonists & inhibitors ; Amidohydrolases/metabolism ; Amygdala/drug effects ; Amygdala/metabolism ; Animals ; Arachidonic Acids/pharmacology ; Behavior, Animal/drug effects ; Benzamides/pharmacology ; Benzodioxoles/pharmacology ; Benzyl Compounds/pharmacology ; Cannabinoid Receptor Modulators/pharmacology ; Carbamates/pharmacology ; Endocannabinoids/antagonists & inhibitors ; Endocannabinoids/metabolism ; Male ; Piperidines/pharmacology ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Social Behavior
Chemical Substances	Arachidonic Acids ; Benzamides ; Benzodioxoles ; Benzyl Compounds ; Cannabinoid Receptor Modulators ; Carbamates ; Endocannabinoids ; JZL 184 ; OMDM-2 cpd ; Piperidines ; Receptor, Cannabinoid, CB1 ; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-)
Language	English
Publishing date	2017-11-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2017.11.032
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Article ; Online: Efficacy and safety of endoscopic ultrasound-guided hepatico-gastrostomy: a meta-regression analysis.

Binda, Cecilia / Dajti, Elton / Giuffrida, Paolo / Trebbi, Margherita / Coluccio, Chiara / Cucchetti, Alessandro / Fugazza, Alessandro / Perini, Barbara / Gibiino, Giulia / Anderloni, Andrea / Repici, Alessandro / Fabbri, Carlo

Endoscopy

2024

Abstract: Background and study aim: EUS-guided hepaticogastrostomy (EUS-HGS) is a valid option for EUS-guided biliary drainage that has been increasingly used in the last decade. The aims of the study were to provide a systematic review with meta-analysis and ... ...

Abstract	Background and study aim: EUS-guided hepaticogastrostomy (EUS-HGS) is a valid option for EUS-guided biliary drainage that has been increasingly used in the last decade. The aims of the study were to provide a systematic review with meta-analysis and meta-regression of features and outcomes of this procedure. Methods: MEDLINE, Scopus, Web-of-Science, and Cochrane databases were searched for literature pertinent to EUS-HGS. Meta-analysis of proportions and meta-regression of potential modifiers of the main outcome measures were applied. The main outcome was technical success. Secondary outcomes were clinical success and procedure-related adverse events (AEs). Results: Thirty-three studies including 1644 patients were included in the meta-analysis. Malignant biliary obstruction was the underlying cause in almost all (99.6%) cases; the main indications for EUS-HGS were duodenal/papillary invasion (34.8%), surgical altered anatomy (18.4%) and hilar stenosis (16%). Pooled technical success of EUS-HGS was 97.7% (95%-CI: 96.1-99%, I2=0%), the intention to treat (ITT) clinical success was 88.1% (95%-CI: 84.7-91.2%, I2=33.9%) and procedure-related AEs occurred in 12% (95%-CI: 9.8-14.5%, I2=20.4%), being cholangitis/sepsis (2.8%) and bleeding (2.3%) the most frequent. The rate of procedure related AEs was reduced with the use of dedicated stents at the univariable meta regression analysis. Meta-regression showed that technical success and clinical success rates were modified by centers' experience (>4/year). Conclusions: EUS-HGS represents an effective and safe procedure for EUS-guided biliary drainage in patients with malignant biliary obstruction. Future studies should address the impact of center experience, patient selection, and use of dedicated stents to improve this technique's performance.
Language	English
Publishing date	2024-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2282-3350
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Article ; Online: Anxiety does not contribute to social withdrawal in the subchronic phencyclidine rat model of schizophrenia.

Seillier, Alexandre / Giuffrida, Andrea

Behavioural pharmacology

2017 Volume 28, Issue 7, Page(s) 512–520

Abstract: Social withdrawal should not be considered a direct measure of the negative symptoms of schizophrenia as it may result not only from asociality (primary negative symptom) but also from other altered processes such as anxiety. To understand the ... ...

Abstract	Social withdrawal should not be considered a direct measure of the negative symptoms of schizophrenia as it may result not only from asociality (primary negative symptom) but also from other altered processes such as anxiety. To understand the contribution of these two factors to social deficit, we investigated whether the social withdrawal observed in the subchronic phencyclidine (PCP) rat model of schizophrenia could be attributed to increased anxiety. Compared to saline controls, PCP-treated rats (5 mg/kg, twice daily for 7 days, followed by a washout period) spent significantly less time in social interaction, but did not show anxiety-like behaviors in different relevant behavioral paradigms. In addition, their social deficit was not affected by a behavioral procedure known to reduce anxiety-like behavior (repeated exposure to the same partner) nor by systemic administration of the classical anxiolytic diazepam. In contrast, PCP-induced social withdrawal was reversed by the cannabinoid agonist CP55,940, a drug with known anxiogenic properties. Furthermore, when using the social approach task, PCP-treated animals performed similarly to control animals treated with diazepam, but not to those treated with the anxiogenic compound pentylenetetrazole. Taken together, our results indicate that PCP-induced social withdrawal cannot be attributed to increased anxiety. These data are discussed in the context of primary versus secondary negative symptoms and the deficit syndrome of schizophrenia.
MeSH term(s)	Animals ; Anti-Anxiety Agents/pharmacology ; Anxiety/physiopathology ; Anxiety Disorders/drug therapy ; Behavior, Animal/drug effects ; Cannabinoids ; Carbamates/pharmacology ; Disease Models, Animal ; Exploratory Behavior/drug effects ; Interpersonal Relations ; Male ; Phencyclidine/pharmacology ; Piperidines/pharmacology ; Rats ; Rats, Wistar ; Schizophrenia/chemically induced ; Schizophrenia/physiopathology ; Schizophrenic Psychology ; Social Behavior
Chemical Substances	Anti-Anxiety Agents ; Cannabinoids ; Carbamates ; Piperidines ; Phencyclidine (J1DOI7UV76)
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1027374-8
ISSN	1473-5849 ; 0955-8810
ISSN (online)	1473-5849
ISSN	0955-8810
DOI	10.1097/FBP.0000000000000325
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Article ; Online: Interstitial pneumonia associated with autoimmune diseases: a possible mimicker of SARS-CoV-2 pneumonia.

Pozzi, Maria Rosa / Faverio, Paola / Varisco, Valentina / D'Andrea, Gabriele / Giuffrida, Angela Concetta / Luppi, Fabrizio

Internal and emergency medicine

2021 Volume 17, Issue 2, Page(s) 577–581

MeSH term(s)	Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; COVID-19/complications ; COVID-19/diagnosis ; Humans ; Lung Diseases, Interstitial/diagnosis ; Pneumonia ; SARS-CoV-2
Language	English
Publishing date	2021-10-12
Publishing country	Italy
Document type	Letter
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-021-02844-3
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Article ; Online: One Health approach to Coxiella burnetii in Brazilian indigenous communities.

Farinhas, João Henrique / de França, Danilo Alves / Serpa, Maria Carolina / Biondo, Leandro Meneguelli / Doline, Fernando Rodrigo / Giuffrida, Rogério / Santarém, Vamilton Alvares / Dos Santos, Andrea Pires / Labruna, Marcelo B / Kmetiuk, Louise Bach / Biondo, Alexander Welker

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10142

Abstract: Indigenous health has posted complex challenges worldwide, particularly due to historical economic, territorial, social and environmental processes, which may lead to emergence and reemergence of pathogens. In addition to few Coxiella burnetii ... ...

Abstract	Indigenous health has posted complex challenges worldwide, particularly due to historical economic, territorial, social and environmental processes, which may lead to emergence and reemergence of pathogens. In addition to few Coxiella burnetii serosurveys in vulnerable populations, especially in developing tropical countries, no comprehensive One Health approach has focused on human-animal infection along with potential environmental determinants. Accordingly, this study aimed to assess the seroprevalence of anti-C. burnetii antibodies in indigenous populations and their dogs from 10 indigenous communities distributed in southern and southeastern Brazil, along with the correspondent healthcare professionals. In overall, 8/893 (0.90%; 95% CI 0.45-1.76) indigenous and 1/406 (0.25%) dog samples were seropositive, with 7/343 (2.04%) individuals the 1/144 (0.69%) dog from the Ocoy community, located in the city of São Miguel do Iguaçu, bordering Argentina at south, and far 10 km at west from Paraguay. All 84 healthcare professionals tested seronegative.
MeSH term(s)	Brazil/epidemiology ; Coxiella burnetii/immunology ; Animals ; Humans ; Q Fever/epidemiology ; Q Fever/microbiology ; One Health ; Seroepidemiologic Studies ; Dogs ; Male ; Female ; Adult ; Antibodies, Bacterial/blood ; Adolescent ; Indigenous Peoples ; Middle Aged ; Young Adult ; Child ; Dog Diseases/epidemiology ; Dog Diseases/microbiology ; Child, Preschool ; Aged
Chemical Substances	Antibodies, Bacterial
Language	English
Publishing date	2024-05-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60850-9
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Article ; Online: Fibroelastoma papillare della valvola aortica e origine anomala dell’arteria coronaria destra.

Arena, Giorgio Maria / Pappalardo, Andrea / Garretto, Valeria / Giuffrida, Angelo

Giornale italiano di cardiologia (2006)

2020 Volume 21, Issue 9, Page(s) 675–677

Abstract: We report a case of a 48-year-old man who complained episodes of angina at rest. Instrumental investigation demonstrated a mass involving the ventricular side of the aortic valve suggestive for papillary fibroelastoma; an anomalous origin of the right ... ...

Title translation	Aortic valve papillary fibroelastoma and anomalous origin of the right coronary artery.
Abstract	We report a case of a 48-year-old man who complained episodes of angina at rest. Instrumental investigation demonstrated a mass involving the ventricular side of the aortic valve suggestive for papillary fibroelastoma; an anomalous origin of the right coronary artery from the left sinus of Valsalva and no significant coronary artery disease were shown as well. The patient underwent open heart surgery, the tumor was excised and the aortic valve was spared. Pathological examination confirmed the diagnostic hypothesis of papillary fibroelastoma. The resolution of anginal symptoms after surgery suggests the possibility of papillary fibroelastoma causing these symptoms.
MeSH term(s)	Angina Pectoris ; Aortic Valve/diagnostic imaging ; Cardiac Papillary Fibroelastoma/diagnostic imaging ; Cardiac Papillary Fibroelastoma/surgery ; Coronary Vessel Anomalies/diagnostic imaging ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/surgery ; Humans ; Male ; Middle Aged ; Tomography, X-Ray Computed
Language	Italian
Publishing date	2020-10-22
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3413.33963
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