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Article ; Online: Information bias for case definitions and mortality between and within studies over time undermines our understanding of COVID-19 transmission and disease severity.

Pan, Daniel / Nishimura, Hidekazu / Tang, Julian W

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2024

Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2024.02.002
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Nitrergic inhibition of sympathetic arteriolar constrictions in the female rodent urethra.

Hashitani, Hikaru / Mitsui, Retsu / Hirai, Yuuna / Tanaka, Hidekazu / Miwa-Nishimura, Kyoko

The Journal of physiology

2024

Abstract: During the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, ... ...

Abstract	During the urine storage phase, tonically contracting urethral musculature would have a higher energy consumption than bladder muscle that develops phasic contractions. However, ischaemic dysfunction is less prevalent in the urethra than in the bladder, suggesting that urethral vasculature has intrinsic properties ensuring an adequate blood supply. Diameter changes in rat or mouse urethral arterioles were measured using a video-tracking system. Intercellular Ca
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP285583
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Article ; Online: Analysis of Cooperative Perception in Ant Traffic and Its Effects on Transportation System by Using a Congestion-Free Ant-Trail Model.

Kasture, Prafull / Nishimura, Hidekazu

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 7

Abstract: We investigated agent-based model simulations that mimic an ant transportation system to analyze the cooperative perception and communication in the system. On a trail, ants use cooperative perception through chemotaxis to maintain a constant average ... ...

Abstract	We investigated agent-based model simulations that mimic an ant transportation system to analyze the cooperative perception and communication in the system. On a trail, ants use cooperative perception through chemotaxis to maintain a constant average velocity irrespective of their density, thereby avoiding traffic jams. Using model simulations and approximate mathematical representations, we analyzed various aspects of the communication system and their effects on cooperative perception in ant traffic. Based on the analysis, insights about the cooperative perception of ants which facilitate decentralized self-organization is presented. We also present values of communication-parameters in ant traffic, where the system conveys traffic conditions to individual ants, which ants use to self-organize and avoid traffic-jams. The mathematical analysis also verifies our findings and provides a better understanding of various model parameters leading to model improvements.
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21072393
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Article ; Online: Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner.

Takami, Mariko / Aoki, Takahiro / Nishimura, Katsuhiro / Tanaka, Hidekazu / Onodera, Atsushi / Motohashi, Shinichiro

Cancer research communications

2024 Volume 4, Issue 2, Page(s) 446–459

Abstract: Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT cells express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens ... ...

Abstract	Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT cells express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d. We recently reported that iNKT cells recognize CD1d-negative leukemia cell line K562 in a TCR-dependent manner. However, it remains controversial how iNKT cells use TCRs to recognize and exhibit cytotoxic activity toward CD1d-negative tumors cells without CD1d restriction. Here, we report that iNKT cells exerted cytotoxicity toward K562 cells via a carried over anti-Vα24 TCR mAb from positive selection by magnetic bead sorting. We found that addition of the anti-Vα24Jα18 TCR mAb (6B11 mAb) rendered iNKT cells cytotoxic to K562 cells in an FcγRII (CD32)-dependent manner. Moreover, iNKT cells treated with 6B11 mAb became cytotoxic to other CD32+ cell lines (U937 and Daudi). In addition, iNKT cells treated with 6B11 mAb suppressed K562 cell growth in a murine xenograft model in vivo. These data suggest that anti-iNKT TCR mAb treatment of iNKT cells can be applied as a therapeutic strategy to treat CD32+ cancers such as leukemia, lymphoma, and lung cancer. Significance: Our findings unveiled that iNKT cells recognize and kill CD1d-negative target tumors via the anti-iNKT TCR mAb bound to CD32 at the tumor site, thereby bridging iNKT cells and CD1d-negative tumors. These findings shed light on the therapeutic potential of anti-iNKT TCR mAbs in NKT cell-based immunotherapy to treat CD1d-negative CD32+ cancers.
MeSH term(s)	Humans ; Mice ; Animals ; Natural Killer T-Cells ; Receptors, Antigen, T-Cell/metabolism ; Cell Line ; Cytokines/metabolism ; Leukemia/metabolism
Chemical Substances	Receptors, Antigen, T-Cell ; Cytokines
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-23-0203
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Article ; Online: Techno-Economic Performance Analysis of a 40.1 kWp Grid-Connected Photovoltaic (GCPV) System after Eight Years of Energy Generation

Ghoname Abdullah / Hidekazu Nishimura

Sustainability, Vol 13, Iss 7680, p

A Case Study for Tochigi, Japan

2021 Volume 7680

Abstract: In this paper, the grid-connected photovoltaic system in Tochigi prefecture, Japan, is presented, and its technical and economic performance after eight years is evaluated. The system has a peak power of 40.1 kWp and has been in operation since 2012. The ...

Abstract	In this paper, the grid-connected photovoltaic system in Tochigi prefecture, Japan, is presented, and its technical and economic performance after eight years is evaluated. The system has a peak power of 40.1 kWp and has been in operation since 2012. The entire electricity generated by the system was fed into the state grid. The system is suitably monitored for one year (2019) and analyzed using the parameters developed and defined in the standard IEC 61724-1 by the International Electrotechnical Commission. The system’s different parameters included array yield, final yield, capacity utilization factor, and performance ratio of the system. An analytical model with solar irradiation obtained from Power Data Access Viewer was developed to investigate and evaluate the efficiency of the system monthly and annual energy generation by comparing the simulated and measured energy acquired from the inverter. A positive linear relationship is observed between solar irradiation data obtained from Power Data Access Viewer and the grid-connected photovoltaic system energy injected into the utility grid. While an annual total of 48,521 kWh of energy was expected to be generated, 38,071 kWh was generated and injected into the utility in 2019. This study also introduces and explains the mechanism of the Feed-In-Tariff system in Japan. The performance of the grid-connected photovoltaic system under this study was compared with that of other systems installed across the globe.
Keywords	photovoltaic system ; solar energy in Japan ; Feed-In-Tariff (FIT) ; solar irradiation data ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-inflammatory effects of medications used for viral infection-induced respiratory diseases.

Yamaya, Mutsuo / Kikuchi, Akiko / Sugawara, Mitsuru / Nishimura, Hidekazu

Respiratory investigation

2022 Volume 61, Issue 2, Page(s) 270–283

Abstract: Respiratory viruses like rhinovirus, influenza virus, respiratory syncytial virus, and coronavirus cause several respiratory diseases, such as bronchitis, pneumonia, pulmonary fibrosis, and coronavirus disease 2019, and exacerbate bronchial asthma, ... ...

Abstract	Respiratory viruses like rhinovirus, influenza virus, respiratory syncytial virus, and coronavirus cause several respiratory diseases, such as bronchitis, pneumonia, pulmonary fibrosis, and coronavirus disease 2019, and exacerbate bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis, and diffuse panbronchiolitis. The production of inflammatory mediators and mucin and the accumulation of inflammatory cells have been reported in patients with viral infection-induced respiratory diseases. Interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α, granulocyte-macrophage colony-stimulating factor, and regulated on activation normal T-cell expressed and secreted are produced in the cells, including human airway and alveolar epithelial cells, partly through the activation of toll-like receptors, nuclear factor kappa B and p44/42 mitogen-activated protein kinase. These mediators are associated with the development of viral infection-induced respiratory diseases through the induction of inflammation and injury in the airway and lung, airway remodeling and hyperresponsiveness, and mucus secretion. Medications used to treat respiratory diseases, including corticosteroids, long-acting β
MeSH term(s)	Humans ; Quality of Life ; COVID-19 ; Asthma/drug therapy ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Virus Diseases/drug therapy ; Anti-Inflammatory Agents/therapeutic use ; Bronchiectasis ; Mucins/therapeutic use
Chemical Substances	Anti-Inflammatory Agents ; Mucins
Language	English
Publishing date	2022-12-19
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2022.11.002
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Article: Development of positive/negative pressure booth generating airflow for protection of medical staff from contagious respiratory pathogens.

Nishimura, Hidekazu / Sakata, Soichiro

Journal of thoracic disease

2020 Volume 12, Issue 9, Page(s) 4633–4642

Abstract: Background: The pandemic of COVID-19 caused confusion in medical settings because of increased patient load, and caused many infections among medical staff which occurred through exposure to bio-particles discharged from patients. The risk of exposure ... ...

Abstract	Background: The pandemic of COVID-19 caused confusion in medical settings because of increased patient load, and caused many infections among medical staff which occurred through exposure to bio-particles discharged from patients. The risk of exposure became maximum at the examination of patients, particularly in the collection of respiratory specimens. Effective interventions to reduce the risk are needed. Methods: A one-person booth consisting of curtain walls, frames, and fan-HEPA filter-unit (FFU) was designed. Using the airstream from/to FFU, it has dual functions as a positive/negative pressure machine to prevent pathogens in patient's cough to reach the medical staff inside/outside the booth, respectively. The curtain walls and positioning of the patient and staff were aerodynamically optimized for the best control of the airstream. Results: The positive pressure booth is to isolate a staff inside to safely deal with a surge in the number of patients in situations like influenza pandemics. The negative pressure booth is to isolate a patient inside to protect a staff outside from dangerous contagious respiratory infectious diseases including COVID-19. A calculated airflow of the positive pressure machine efficiently pushed back bio-particles discharged from a person outside the booth. The bio-particles of a cough from a person inside the negative pressure booth was sucked into the FFU for filtration immediately after the discharge. The booth needed a short front curtain of a stair-cut shape, and a patient and a staff facing each other needed to be positioned at an angle 45° to the airstream for optimization of the airflow. Conclusions: The booth named Barriflow
Keywords	covid19
Language	English
Publishing date	2020-10-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-20-1607
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Article: Development of a lightweight, 'on-bed', portable isolation hood to limit the spread of aerosolized influenza and other pathogens.

Nishimura, Hidekazu / Sakata, Soichiro

Journal of thoracic disease

2020 Volume 12, Issue 7, Page(s) 3682–3687

Abstract: Background: The annual seasonal influenza epidemics in the winter season lead to many hospital admissions, increasing risks of nosocomial infections. Infectious diseases caused by contagious respiratory pathogens also pose a great risk to hospitals as ... ...

Abstract	Background: The annual seasonal influenza epidemics in the winter season lead to many hospital admissions, increasing risks of nosocomial infections. Infectious diseases caused by contagious respiratory pathogens also pose a great risk to hospitals as has been seen in the current epidemic by a novel coronavirus infection. Such risk occurs in high density patient settings with few or no partitions, since the pathogens are transmitted by aerosols discharged from the patients. Possible interventions against the transmission are needed. Methods: We developed a compact, lightweight, and portable hood designed to cover just the top half of a patient sitting or lying in bed, to limit the dissemination of infectious aerosols, constructed out of lightweight pipes, transparent plastic curtains, and a fan-filter-unit (FFU). The containment efficacy of the product was tested using an aerosolized cultured influenza virus tracer and an optimal airflow rate was determined according to the test results. It was tested for use in hospital wards during the 2016-2018 influenza seasons. Results: The hood, named as Barrihood Conclusions: With the use of the hood, secondary influenza infection cases significantly decreased, compared to previous influenza seasons. It may be suited to hospitals with not enough/no negative pressure facilities, or without enough number of individual patient isolation rooms, and could contribute to decrease the risk of nosocomial infections.
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-20-1072
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Article: Volumetric Modulated Arc Therapy Planning for Craniospinal Irradiation With a New O-ring Linac.

Matsumoto, Kenji / Monzen, Hajime / Kubo, Kazuki / Otsuka, Masakazu / Nambu, Hidekazu / Nishimura, Yasumasa

Cureus

2023 Volume 15, Issue 3, Page(s) e36493

Abstract: This study aims to determine the feasibility of using a new O-ring linear accelerator (Halcyon, Varian Medical Systems, CA, USA) to perform treatment planning using volumetric modulated arc therapy (VMAT) for craniospinal irradiation (CSI). A 20-year-old ...

Abstract	This study aims to determine the feasibility of using a new O-ring linear accelerator (Halcyon, Varian Medical Systems, CA, USA) to perform treatment planning using volumetric modulated arc therapy (VMAT) for craniospinal irradiation (CSI). A 20-year-old male patient with leukemia was selected. The planning target volume (PTV) was contoured to include the entire contents of the brain and spinal canal. The PTV margin was 10 mm applied to the clinical target volume (CTV). VMAT (RapidArc, Varian Medical Systems, CA, USA) planning was performed using four isocenter with five arcs, two full rotation arcs to cover the brain and upper part of the spinal cord, and one full rotation arc for the lower part of the spinal cord. The plan was created using the auto-feathering photon optimizer calculation of the planning system. The conformity index (CI) and heterogeneity index (HI) as well as dose-volume histograms of organs at risk (OAR) were evaluated. The patient position of ±3.0 mm in the craniocaudal direction was moved in to simulate the effect of treatment inaccuracy. The total treatment time was also measured. The CI and HI were 1.09 and 8.44, respectively. The mean dose (PTV) was 105.5%, and the mean dose (OARs) was lower than the planning dose constraints. Simulations with a patient position shift of ±3.0 mm resulted in an error of less than ±10.0% of the planned dose to the spinal cord. The total treatment time was within 15 minutes. VMAT planning for CSI with Halcyon achieved high conformality, uniform dose distribution, low dose to the surrounding normal tissues, and reduced treatment time.
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36493
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Article ; Online: Congestion-Free Ant Traffic

Prafull Kasture / Hidekazu Nishimura

Applied Sciences, Vol 9, Iss 14, p

Jam Absorption Mechanism in Multiple Platoons

2019 Volume 2918

Abstract: In this paper, an agent-based model of ant traffic on a unidirectional single-lane ant trail is presented to provide better understanding of the jam-free traffic of an ant colony. On a trail, the average velocity of ants remains approximately constant ... ...

Abstract	In this paper, an agent-based model of ant traffic on a unidirectional single-lane ant trail is presented to provide better understanding of the jam-free traffic of an ant colony. On a trail, the average velocity of ants remains approximately constant irrespective of density, thereby avoiding jamming. Assuming chemotaxis, we analyze platoon-related scenarios to assess the marching-platoon hypothesis, which claims that ants on a trail form a single platoon in which they march synchronously, thereby reducing hindrances due to increasing density. Contrary to that hypothesis, our findings show that ants on a trail do not march synchronously and do experience stop-and-go motion. However, more interestingly, our study also indicates that the ants’ chemotaxis behavior leads to a peculiar jam absorption mechanism, which helps to maintain free flow on a trail and avoids jamming. Again, contrary to the marching-platoon hypothesis, our findings also indicate that, rather than assisting traffic flow, forming a single cluster actually triggers jamming.
Keywords	ant-trail ; self-organization ; swarming ; jam-free traffic ; intelligent transportation system ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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