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  1. Article ; Online: [Tissue specific distribution of terpenoid biosynthesis in

    Wu, Di / Zhang, Yanyan / Lin, Nan / Wei, Yicong

    Sheng wu gong cheng xue bao = Chinese journal of biotechnology

    2024  Volume 40, Issue 2, Page(s) 542–561

    Abstract: The leaves and roots ... ...

    Abstract The leaves and roots of
    MeSH term(s) Transcriptome ; Terpenes/metabolism ; Metabolome ; Gene Expression Profiling ; Metabolomics
    Chemical Substances Terpenes
    Language Chinese
    Publishing date 2024-02-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1042206-7
    ISSN 1872-2075 ; 1042-749X
    ISSN (online) 1872-2075
    ISSN 1042-749X
    DOI 10.13345/j.cjb.230371
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3505: Show issues Location:
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  2. Article ; Online: Postoperation nursing care of enteral nutrition support in infants with congenital heart disease.

    Wu, Xi E / Song, Yanyan

    Asian journal of surgery

    2023  Volume 46, Issue 11, Page(s) 5397–5398

    MeSH term(s) Infant ; Humans ; Enteral Nutrition ; Nutritional Support ; Heart Defects, Congenital/surgery
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.07.120
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  3. Article: Refinement of Specialized Nursing Intervention in Elderly Patients with Diabetes Complicated by Pulmonary Infection and the Impact on the Patient's Condition and Prognosis.

    Zhang, Wenqing / Wu, Yanyan

    Alternative therapies in health and medicine

    2024  

    Abstract: Objective: Our aim was to analyze the effect of refined specialized nursing intervention in elderly patients with diabetes and concurrent pulmonary infection and the impact on patients' conditions and outcomes.: Methods: Clinical data from 87 elderly ...

    Abstract Objective: Our aim was to analyze the effect of refined specialized nursing intervention in elderly patients with diabetes and concurrent pulmonary infection and the impact on patients' conditions and outcomes.
    Methods: Clinical data from 87 elderly patients with type 2 diabetes (T2D) complicated by pulmonary infection treated in Lishui Municipal Central Hospital in China from February 2021 to February 2023 were retrospectively analyzed. All patients conformed to complete inclusion and exclusion criteria. Patients were divided into a control group (n=43) and an observation group (n=44) based on the nursing intervention they received. The control group received routine nursing intervention, while the observation group received refined specialized nursing intervention. The nursing intervention effects, hospitalization duration, disease knowledge acquisition, blood glucose indicators (fasting plasma glucose [FPG], 2-hour postprandial glucose [2hPG]), inflammatory marker indicators (C-reactive protein [CRP], heparin-binding protein [HBP]) levels, comfort levels and nursing satisfaction were compared between the 2 groups.
    Results: (1) Nursing intervention effect and hospitalization duration: The observation group showed significantly higher overall intervention effectiveness and notably shorter hospital stays compared with the control group (P < .05). (2) Disease knowledge acquisition and blood glucose indicator levels: Before the intervention, there were no significant differences in disease knowledge acquisition, FPG or 2hPG levels between the 2 groups (P > .05); after the intervention, the observation group exhibited significantly higher disease knowledge acquisition and lower FPG and 2hPG levels than the control group (P < .05). (3) Inflammatory marker indicator levels: Prior to the intervention, there were no significant differences in CRP or HBP levels between the 2 groups (P > .05); post-intervention, the observation group showed markedly lower CRP and HBP levels compared with the control group (P < .05). (4) Comfort levels: Prior to the intervention, there were no significant differences in physiological, psychological, environmental or social comfort scores between the 2 groups (P > .05); after the intervention, the observation group exhibited significantly higher scores in all comfort aspects compared with the control group (P < .05). (5) Nursing satisfaction: Nursing satisfaction in the control group was 74.42%, while in the observation group it was 90.91%, indicating significantly higher nursing satisfaction in the observation group (P < .05).
    Conclusion: Refined specialized nursing intervention significantly improved outcomes in elderly patients with diabetes and concurrent pulmonary infection. Compared with routine nursing intervention, refined specialized nursing intervention remarkably enhanced patient comfort during hospitalization, improved disease knowledge acquisition, rapidly adjusted blood glucose levels and reduced systemic inflammatory response, facilitating better patient recovery. Moreover, it moderately enhanced satisfaction for patients and their families, holding significant implications for promoting harmonious doctor-patient relationships, hence advocating for its clinical dissemination.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4504: Show issues Location:
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  4. Article ; Online: Neuroprotective effect of Kurarinone against corticosterone-induced cytotoxicity on rat hippocampal neurons by targeting BACE1 to activate P13K-AKT signaling - A potential treatment in insomnia disorder.

    Wu, Guoqing / Wu, Yanyan

    Pharmacology research & perspectives

    2023  Volume 11, Issue 5, Page(s) e01132

    Abstract: The hippocampus has been implicated in the pathogenesis of insomnia disorder (ID) and the purpose of this study was to investigate the neuroprotective mechanism of the natural flavone Kurarinone (Kur) on hippocampal neurotoxicity as a potential treatment ...

    Abstract The hippocampus has been implicated in the pathogenesis of insomnia disorder (ID) and the purpose of this study was to investigate the neuroprotective mechanism of the natural flavone Kurarinone (Kur) on hippocampal neurotoxicity as a potential treatment of ID. The effect of Kur on hippocampal neuronal cell (HNC) viability and apoptosis were assessed by Cell counting kit-8 (CCK-8) assay and flow cytometry, respectively. Then, the effect of Kur on β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), brain-derived neurotrophic factor (BDNF), and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) phosphorylation level were measured by Western blot. Further, SwissTargetPrediction analysis and molecular docking experiments were used to detect a potential target of Kur. Then, the p-chlorophenylalanine (PCPA) model was established in vivo to further study the effect of BACE1 expression on Kur and HNC. As a result, HNC viability was only significantly decreased by 2 μM of Kur. Kur reversed the impacts of corticosterone upon inhibiting viability (0.25-1 μM), PI3K (0.5-1 μM)/AKT phosphorylation, and BDNF (1 μM) level, and enhancing the apoptosis (0.25-1 μM) and BACE1 expression (1 μM) in HNCs. BACE1 was a potential target of Kur. Notably, Kur (150 mg/kg) attenuated PCPA-induced upregulation of BACE1 expression in rat hippocampal tissues as ZRAS (0.8 g/kg). The effects of Kur (1 μM) on corticosterone-treated HNCs were reversed by BACE1 overexpression. Collectively, Kur downregulates BACE1 level to activate PI3K/AKT, thereby attenuating corticosterone-induced toxicity in HNCs, indicating that Kur possibly exerted a neuroprotective effect, which providing a new perspective for the treatment of insomnia disorders.
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1132
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  5. Article ; Online: The health of the elderly and social security in the context of digital financial inclusion in China.

    Xiao, Lei / Wu, Yanyan / Cao, Xin

    Frontiers in public health

    2023  Volume 10, Page(s) 1079436

    MeSH term(s) Humans ; Aged ; Social Security ; China ; Demography
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1079436
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  6. Article ; Online: Sophora flavescens alcohol extract ameliorates insomnia and promotes PI3K/AKT/BDNF signaling transduction in insomnia model rats.

    Wu, Yanyan / Yao, Chenhang / Zhang, Lan / Wu, Guoqing

    Neuroreport

    2024  Volume 35, Issue 5, Page(s) 275–282

    Abstract: Active ingredient of Sophora flavescens is reported to promote non-rapid eye movement (NREM) sleep. However, the role of Sophora flavescens alcohol extract in insomnia is elusive, which is addressed in this study, together with the exploration on its ... ...

    Abstract Active ingredient of Sophora flavescens is reported to promote non-rapid eye movement (NREM) sleep. However, the role of Sophora flavescens alcohol extract in insomnia is elusive, which is addressed in this study, together with the exploration on its potential mechanism. An insomnia model of rats was established by para-chlorophenylalanine induction and further treated with SFAE or Zaoren Anshen capsule (ZRAS; positive control drug). Sleep quality and sleep architecture of rats were evaluated by the sleep test, electroencephalogram and electromyogram. The levels of monoamine neurotransmitters in rat hypothalamus were determined using ELISA, and the transduction of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/brain-derived neurotrophic factor (BDNF) signaling in the brain tissues of rats was examined by Western blot. SFAE and ZRAS increased the sleeping time and decreased the sleep latency of insomnia rats. SFAE reduced waking time and increased NREM and REM time, while changing power density of wakefulness, NREM sleep, and REM sleep in insomnia rats. SFAE and ZRAS upregulated levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid, and downregulated those of norepinephrine and dopamine in insomnia rats. Besides, SFAE and ZRAS elevated BDNF expression as well as the ratios of phosphorylated (p)-PI3K/PI3K and p-AKT/AKT. The role of SFAE in insomnia model rats was similar with that of ZRAS. SFAE reduces insomnia and enhances the PI3K/AKT/BDNF signaling transduction in insomnia model rats, which can function as a drug candidate for insomnia.
    MeSH term(s) Rats ; Animals ; Proto-Oncogene Proteins c-akt ; Sleep Initiation and Maintenance Disorders/drug therapy ; Sophora flavescens ; Brain-Derived Neurotrophic Factor/metabolism ; Phosphatidylinositol 3-Kinases ; Ethanol
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Brain-Derived Neurotrophic Factor ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001999
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Iris neovascularization and neurotrophic keratopathy following ultrasound cycloplasty in refractory glaucoma: case series.

    Chen, Zidong / Wu, Yanyan / Yu, Minbin

    BMC ophthalmology

    2024  Volume 24, Issue 1, Page(s) 188

    Abstract: Background: Ultrasound cycloplasty is a noninvasive surgery used to reduce intraocular pressure in patients with glaucoma, with fewer severe complications. This report presents several cases of iris neovascularization and neurotrophic keratopathy ... ...

    Abstract Background: Ultrasound cycloplasty is a noninvasive surgery used to reduce intraocular pressure in patients with glaucoma, with fewer severe complications. This report presents several cases of iris neovascularization and neurotrophic keratopathy following ultrasound cycloplasty.
    Case presentation: Six patients diagnosed with refractory glaucoma underwent ultrasound cycloplasty at our clinic. Three cases developed iris neovascularization at postoperative day 3, week 2 and week 4 respectively, with intraocular pressure ranging from 12 to 24 mmHg. The other three cases developed neurotrophic keratopathy at postoperative week 3, week 6 and week 8 which completely healed within 60 days.
    Conclusions: Iris neovascularization and neurotrophic keratopathy can be triggered after ultrasound cycloplasty, which are uncommon and self-limited but potentially vision-threatening. Preoperative risk assessment and regular postoperative follow-up are recommended to manage complications effectively.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Intraocular Pressure/physiology ; Iris/surgery ; Iris/blood supply ; Iris/diagnostic imaging ; Aged ; Glaucoma/surgery ; Neovascularization, Pathologic ; Corneal Diseases/surgery ; Corneal Diseases/etiology ; Postoperative Complications ; Adult
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article ; Case Reports
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-024-03460-3
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  8. Article ; Online: Influence of Perceived Value on Consumers’ Continuous Purchase Intention in Live-Streaming E-Commerce—Mediated by Consumer Trust

    Yanyan Wu / Hongqing Huang

    Sustainability, Vol 15, Iss 4432, p

    2023  Volume 4432

    Abstract: As an emerging e-commerce model that combines the convenience of traditional e-commerce with the real-time and interactive nature of live streaming, live-streaming (LS) e-commerce is loved and recognized by consumers. At the same time, LS e-commerce also ...

    Abstract As an emerging e-commerce model that combines the convenience of traditional e-commerce with the real-time and interactive nature of live streaming, live-streaming (LS) e-commerce is loved and recognized by consumers. At the same time, LS e-commerce also faces many difficulties such as homogenization of marketing content and consumers’ low willingness to repeat purchase. Therefore, how to better stimulate consumers’ continuous purchase willingness in LS has become a hot topic of current research. Based on the stimulus–organism–response (SOR) model, this paper constructs a model of consumers’ purchase intention mediated by consumers’ trust in LS e-commerce, measuring consumers’ perceived value in LS e-commerce in three dimensions: utilitarian value, hedonic value and social value, and using consumers’ trust in the streamer and trust in the product as mediators to investigate the influence of perceived value on consumers’ continuous purchase intention. Data of Chinese users were collected by questionnaire survey to prove the assumptions of this paper. The results show that consumers’ perceived utilitarian value, hedonic value and social value significantly and positively influence their trust in the streamer; consumers’ perceived utilitarian value and social value significantly and positively influence their trust in product; trust in streamer significantly and positively influences their trust in the product; and consumer trust partially mediates the relationship between perceived value and consumers’ willingness to continue to purchase.
    Keywords live-streaming (LS) e-commerce ; stimulus–organism–response (SOR) theory ; perceived value ; consumer trust ; continuous purchase intention ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 650
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Editorial: Prodrug design and therapeutic applications.

    Xiao, Qicai / Li, Zhengqiu / Miao, Yanyan / Xia, Jiang / Wu, Mingyue

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1280190

    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1280190
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  10. Article ; Online: Ultrasound-guided versus conventional lung recruitment manoeuvres in thoracic surgery: a randomised controlled study.

    Wu, Lei / Yang, Li / Yang, Yanyan / Wu, Xin / Zhang, Jun

    Journal of clinical monitoring and computing

    2024  

    Abstract: Lung recruitment manoeuvres (RMs) during mechanical ventilation may reduce atelectasis, however, the optimal recruitment strategy for patients undergoing thoracic surgery remains unknown. Our study was designed to investigate whether ultrasound-guided ... ...

    Abstract Lung recruitment manoeuvres (RMs) during mechanical ventilation may reduce atelectasis, however, the optimal recruitment strategy for patients undergoing thoracic surgery remains unknown. Our study was designed to investigate whether ultrasound-guided lung RMs is superior to conventional RMs in reducing perioperative atelectasis during thoracic surgery with one-lung ventilation. We conducted a randomised controlled clinical trial from August 2022 to September 2022. Sixty patients scheduled for video-assisted thoracoscopic surgery (VATS) under general anaesthesia were enrolled. Subjects were randomly divided into the ultrasound-guided RMs group (manual inflation guided by lung ultrasound) or conventional RMs group (manual inflation with 30 cmH
    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-024-01134-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2054: Show issues Location:
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