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  1. Article: Genotypes of ESBL producing Escherichia coli and Klebsiella pneumoniae in relation to resistance to antimicrobial drugs.

    Kaftandzieva, Ana / Trajkovska-Dokic, Elena / Kotevska, Vesna / Cekovska, Zaklina / Jankoska, Gordana

    Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)

    2014  Volume 35, Issue 2, Page(s) 31–38

    Abstract: Unlabelled: The aim of the study was to evaluate the association of drug resistance with β-lactamase gene types in ESBL positive E. coli and Klebsiella pneumoniae-Kp.: Material and methods: A total of 251 ESBL-positive E. coli and Kp isolates ... ...

    Abstract Unlabelled: The aim of the study was to evaluate the association of drug resistance with β-lactamase gene types in ESBL positive E. coli and Klebsiella pneumoniae-Kp.
    Material and methods: A total of 251 ESBL-positive E. coli and Kp isolates obtained from urine, tracheal aspirate, wound swab and blood from patients hospitalised at the University Clinics in Skopje were detected using the ESBL set and automated Vitek 2 system. Vitek was also used for susceptibility testing (determination of MIC of 17 antimicrobial agents). Multiplex PCR was used to identify genes for different types of ESBLs in a 100 randomly selected, ESBL positive strains.
    Results: More of the 87 ESBL typeable isolates (61%) harbour two or more bla genes and the frequency of antibiotic resistance was high in these isolates, compared to those with a single gene. Isolates with ≥ 3 genes were highly resistant to beta-lactams and non-beta lactams used. The degree of resistance to 3 rd generation cephalosporins was also high in these isolates (MIC ≥ 64). More of the ESBL-positive isolates showed higher resistance to cefotaxime than to ceftazidime.
    Conclusion: Identification of the genes is necessary for the surveillance of their transmission in hospitals. Surveillance of antibiotic resistance patterns are crucial to overcome the problems associated with ESBLs.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Genotype ; Humans ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology ; Microbial Sensitivity Tests ; beta-Lactam Resistance ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2014-12-11
    Publishing country North Macedonia
    Document type Journal Article
    ZDB-ID 2743787-5
    ISSN 1857-8985 ; 1857-9345
    ISSN (online) 1857-8985
    ISSN 1857-9345
    DOI 10.2478/prilozi-2014-0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6857: Show issues Location:
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  2. Article ; Online: Osteoarticular involvement in childhood brucellosis: experience with 133 cases in an endemic region.

    Bosilkovski, Mile / Kirova-Urosevic, Valerija / Cekovska, Zaklina / Labacevski, Nikola / Cvetanovska, Marija / Rangelov, Goran / Cana, Fadilj / Bogoeva-Tasevska, Suncica

    The Pediatric infectious disease journal

    2013  Volume 32, Issue 8, Page(s) 815–819

    Abstract: Aim: To describe the main clinical and laboratory characteristics, frequency and distribution of osteoarticular involvement, therapeutic options and outcome in children with osteoarticular brucellosis.: Methods: This descriptive study includes 133 ... ...

    Abstract Aim: To describe the main clinical and laboratory characteristics, frequency and distribution of osteoarticular involvement, therapeutic options and outcome in children with osteoarticular brucellosis.
    Methods: This descriptive study includes 133 pediatric patients with osteoarticular brucellosis who were treated at the University Clinic for Infectious Diseases and Febrile Conditions in Skopje, Republic of Macedonia, during the period between 1989 and 2011. Brucellosis was presumptively diagnosed on the basis of clinical signs and confirmed by the detection of specific antibodies at significant titers.
    Results: The median age of patients was 9 years (range, 2-14 years) and 63.9% were males. Family history of brucellosis was present in 54.1%. The dominant clinical symptoms were arthralgia and fever in 77.4% and 73.7%, respectively, and the dominant sign was hepatomegaly in 73.7% of patients. The main laboratory abnormalities were elevated C-reactive protein (81.0%) and circulating immunocomplexes (80.7%). In 71.4% of patients, the osteoarticular involvement was monoarticular. Hip arthritis was present in 49.6%, followed by the knee in 30.1%. Various therapeutic regimens with a duration of 6 weeks were used. In 87 patients during a follow-up of at least 6 months, relapse occurred in 13.8%.
    Conclusions: Osteoarticular involvement is frequent in children with brucellosis. It is most often manifested with monoarthritis of the large weight-bearing joints. Brucellosis should be included in the differential diagnosis of childhood arthritis in endemic countries, especially in the presence of family history, contact with infected animals or ingestion of unpasteurized food products, fever and hepatomegaly.
    MeSH term(s) Adolescent ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/pathology ; Brucellosis/drug therapy ; Brucellosis/microbiology ; Brucellosis/pathology ; Child ; Child, Preschool ; Endemic Diseases ; Female ; Humans ; Incidence ; Infant ; Macedonia (Republic)/epidemiology ; Male ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0b013e31828e9d15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1852: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The first survey about the antibiotic usage in the Republic of Macedonia.

    Bosevska, Golubinka / Panovski, Nikola / Kuzmanovska, Gordana / Coneva, Elizabeta / Memeti, Shaban / Cekovska, Zaklina / Celevska, Biljana / Zahariev, Ilco / Mikik, Vladimir

    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

    2012  Volume 9, Issue 2, Page(s) 393–396

    Abstract: Development of antibiotic resistance represents a major global and Macedonian public health problem. To assess the opinion and knowledge of the citizens of Macedonia about the usage of antibiotics, voluntary and anonymous survey was realized. A total of ... ...

    Abstract Development of antibiotic resistance represents a major global and Macedonian public health problem. To assess the opinion and knowledge of the citizens of Macedonia about the usage of antibiotics, voluntary and anonymous survey was realized. A total of 239 persons (age 10-67 years) were interviewed. Following information was obtained: 73.64% get antibiotics with a medical prescription; and 87.03% receiving the antibiotic on time, dosage and prescribed duration. When asked about knowledge about antibiotics, 38% of the interviewed persons gave the right answer, 43.1% of respondents made false statements that antibiotics are effective against viral infections and 25.52% did not express any opinion.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Child ; Data Collection ; Drug Utilization ; Female ; Humans ; Macedonia (Republic) ; Male ; Middle Aged ; Young Adult
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2012-08
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2378942-6
    ISSN 1840-2445 ; 1840-0132
    ISSN (online) 1840-2445
    ISSN 1840-0132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Incidence of Staphylococcus aureus isolated from patients treated at the Clinical Center of Skopje, Macedonia, with special attention to MRSA.

    Cekovska, Zaklina / Panovski, Nikola / Petrovska, Milena / Kristóf, Katalin / Rozgonyi, F

    Acta microbiologica et immunologica Hungarica

    2005  Volume 52, Issue 3-4, Page(s) 373–384

    Abstract: The distribution of 3497 Staphylococcus aureus strains according to methicillin resistance, specimens, departmental profession and antibiotic resistance patterns was analysed. The strains were cultured from the patients of the Clinical Center of Skopje, ... ...

    Abstract The distribution of 3497 Staphylococcus aureus strains according to methicillin resistance, specimens, departmental profession and antibiotic resistance patterns was analysed. The strains were cultured from the patients of the Clinical Center of Skopje, Macedonia, between 1 January 2002 and 31 December 2004. The majority of the isolates was obtained from suppurated wounds (28.5%), nares (21%), intratracheal tubes (13%) and blood cultures (11.8%). Overall 1100 (31.4%) of the isolates was methicillin-resistant with 1 microg oxacillin disc. Of these 35.5%, 30.5% and 10.4% were cultured from wounds, intratracheal tubes and blood samples, respectively. The prevalence of MRSA strains was 78.6%, 75%, 44.2% and 37.3% in specimens of ICU, Coma Center, General Surgery and Haematology patients. There were extremely big differences in the frequency of MRSA between departments with particular specialisation. The 2397 MSSA isolates belonged to practically one antibiotic resistance pattern characterised with penicillin resistance and susceptibility to other antistaphylococcal drugs. The 1100 MRSA isolates distributed to four antibiotic resistance patterns on the basis of their resistance to oxacillin, penicillin, amoxicillin+clavulanic acid, azithromycin, clindamycin, amikacin, gentamicin, ciprofloxacin, trimethoprim+sulphamethoxasole, vancomycin and teicoplanin. All the MRSA isolates were multidrug resistant but sensitive to glycopeptides.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Drug Resistance, Bacterial ; Humans ; Incidence ; Macedonia (Republic)/epidemiology ; Methicillin Resistance ; Microbial Sensitivity Tests ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2005
    Publishing country Hungary
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/AMicr.52.2005.3-4.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 618: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Comparison of Austrian, Hungarian and Macedonian methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains in relation to prevalence of cytotoxin genes.

    Kocsis, Erika / Lagler, Heimo / Pesti, Natasa / Stich, Karin / Kristóf, Katalin / Nagy, Károly / Hermann, Péter / Komka, Kinga / Cekovska, Zaklina / Graninger, Wolfgang / Rozgonyi, Ferenc

    Microbial pathogenesis

    2009  Volume 46, Issue 6, Page(s) 328–336

    Abstract: Cytotoxin genes in 128 Austrian (AT) MSSA, 48 MRSA, 94 Hungarian (HU) MSSA, 110 MRSA and 67 Macedonian (MK) MSSA, 81 MRSA strains were examined. The presence of alfa-haemolysin gene (hla) was more common in HU MSSA strains compared to AT and MK (99%, 86%, ...

    Abstract Cytotoxin genes in 128 Austrian (AT) MSSA, 48 MRSA, 94 Hungarian (HU) MSSA, 110 MRSA and 67 Macedonian (MK) MSSA, 81 MRSA strains were examined. The presence of alfa-haemolysin gene (hla) was more common in HU MSSA strains compared to AT and MK (99%, 86%, 72%: p<0.001). AT and MK MRSA harboured hlb genes more frequently compared to HU (60%, 62%, 33%: p<0.001). HU and MK MRSA strains carried gamma-haemolysin gene (hlg) in higher percentage in contrast to AT (88%, 83%, 69%: p=0.01). Haemolysin gamma-variant gene (hlgv) was more prevalent in HU MSSA compared to AT and MK (84%, 56%, 69%: p<0.001). Panton-Valentine leukocidin genes were found only in AT, HU, MK MSSA and MK MRSA in 2.3%, 4%, 1.5% (p=0.53) and 1% (p=0.38), respectively. The 3-gene combination pattern comprising of hla, hlg and hld genes showed increased prevalence among AT MSSA compared to HU (27%, 11%: p<0.001). The 4-gene pattern composed of hla, hlg, hlgv and hld genes was significantly characteristic for HU MRSA in contrast to AT and MK MRSA (56%, 12.5%, 27%: p<0.001). Frequency of certain cytotoxin genes and combinations differed significantly in Staphylococcus aureus strains according to geographical origin and methicillin-resistance.
    MeSH term(s) Austria ; Cytotoxins/genetics ; Hemolysin Proteins/genetics ; Humans ; Hungary ; Leukocidins/genetics ; Macedonia (Republic) ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification
    Chemical Substances Cytotoxins ; Hemolysin Proteins ; Leukocidins
    Language English
    Publishing date 2009-06
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2009.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
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