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Article ; Online: Myocardial ischaemia and valve insufficiency caused by a dysplastic aortic valve cusp: a previously unreported unique morphologic anomaly - CORRIGENDUM.

Samuel, Sharmeen / Dhanantwari, Preeta / Misra, Nilanjana / Meyer, David B

2020 Volume 30, Issue 9, Page(s) 1380

Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951120002218
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Article ; Online: Myocardial ischaemia and valve insufficiency caused by a dysplastic aortic valve cusp: a previously unreported unique morphologic anomaly.

Samuel, Sharmeen / Dhanantwari, Preeta / Meyer, David B

Cardiology in the young

2020 Volume 30, Issue 7, Page(s) 1046–1049

Abstract: Isolated aortic regurgitation and myocardial infarction are a rare congenital defect among neonatal patients. We present a case of a neonate with an unusual aortic valve morphology causing both regurgitation and obstruction of the left coronary artery ... ...

Abstract	Isolated aortic regurgitation and myocardial infarction are a rare congenital defect among neonatal patients. We present a case of a neonate with an unusual aortic valve morphology causing both regurgitation and obstruction of the left coronary artery ostium. Despite both non-invasive and invasive imaging modalities, accurate diagnosis of the valve morphology was only determined by direct visualisation at the time of surgical repair. To the knowledge of authors, this particular aortic valve morphology in neonatal population has not been previously reported in the literature.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnosis ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Coronary Artery Disease ; Humans ; Infant, Newborn ; Myocardial Ischemia ; Sinus of Valsalva
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951120001377
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Article ; Online: Comparison of C-Reactive Protein and White Blood Cell Count as Predictors of Infectious Complications after Colorectal Surgery: A Single-Center Experience.

Kim, Samuel / Husain, Sharmeen / Boustany, Marc

The American surgeon

2018 Volume 84, Issue 8, Page(s) e337–e339

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; C-Reactive Protein/analysis ; Colectomy/adverse effects ; Colorectal Neoplasms/surgery ; Female ; Humans ; Laparoscopy/adverse effects ; Laparotomy/adverse effects ; Length of Stay/statistics & numerical data ; Leukocyte Count/methods ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/epidemiology
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2018-11-19
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
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Article: Pharmacologic management of attention deficit hyperactivity disorder in children and adolescents: a review for practitioners.

Brown, Kelly A / Samuel, Sharmeen / Patel, Dilip R

Translational pediatrics

2018 Volume 7, Issue 1, Page(s) 36–47

Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children and adolescents. ADHD affects multiple aspects of an individual's life and functioning in family, social, and academic realms. Effective management of ADHD ... ...

Abstract	Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder in children and adolescents. ADHD affects multiple aspects of an individual's life and functioning in family, social, and academic realms. Effective management of ADHD is necessary for children and adolescents and may include non-pharmacologic treatments, pharmacologic therapy including use of stimulant and non-stimulant medications, or a combination of the different treatment modalities. In general, medications used to treat ADHD are safe and effective. Medical practitioners can follow a step-wise approach in the selection and adjustment of pharmacologic agents to treat ADHD, while working closely with families, caregivers, and other medical and educational professionals to form appropriate treatment plans. This article reviews practical aspects of pharmacological treatment of ADHD in children and adolescents.
Language	English
Publishing date	2018-01-26
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp.2017.08.02
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Unique Case of Sudden Cardiac Death in an Infant.

Samuel, Sharmeen / Fountain, Robin / Start, David / Karpawich, Peter P

Clinical pediatrics

2018 Volume 58, Issue 2, Page(s) 253–256

MeSH term(s)	Cardiomyopathies/complications ; Cardiomyopathies/congenital ; Cardiomyopathies/diagnosis ; Death, Sudden, Cardiac/etiology ; Diagnosis, Differential ; Electrocardiography/methods ; Electrocardiography, Ambulatory ; Electron Transport Complex III/deficiency ; Fatal Outcome ; Female ; Humans ; Infant ; Wolff-Parkinson-White Syndrome/complications ; Wolff-Parkinson-White Syndrome/diagnosis
Chemical Substances	Electron Transport Complex III (EC 1.10.2.2)
Language	English
Publishing date	2018-11-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/0009922818812477
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Zs.A 454: Show issues

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Article ; Online: Determinants of hypertension among adults in Bangladesh as per the Joint National Committee 7 and 2017 American College of Cardiology/American Hypertension Association hypertension guidelines.

Kibria, Gulam Muhammed Al / Swasey, Krystal / Hasan, Md Zabir / Choudhury, Allysha / Gupta, Rajat Das / Abariga, Samuel A / Sharmeen, Atia / Burrowes, Vanessa

Journal of the American Society of Hypertension : JASH

2018 Volume 12, Issue 11, Page(s) e45–e55

Abstract: We investigated determinants of hypertension in Bangladesh using both Joint National Committee 7 (JNC7) and 2017 American College of Cardiology/American Hypertension Association (2017 ACC/AHA) guidelines. After reporting background characteristics, odds ... ...

Abstract	We investigated determinants of hypertension in Bangladesh using both Joint National Committee 7 (JNC7) and 2017 American College of Cardiology/American Hypertension Association (2017 ACC/AHA) guidelines. After reporting background characteristics, odds ratios (ORs) were obtained by multilevel logistic regression. Among 7839 respondents aged ≥35 years, 25.7% (n = 2016) and 48.0% (n = 3767) respondents had hypertension as per the JNC7 and 2017 ACC/AHA guidelines, respectively. The following factors were significant according to the 2017 ACC/AHA guideline: ≥65 years (adjusted OR [AOR]: 2.4, 95% confidence interval [CI]: 2.2-3.0), 55-64 years (AOR: 1.6, 95% CI: 1.4-1.9), and 45-54 years (AOR: 1.4, 95% CI: 1.3-1.6) age groups, females (AOR: 2.0, 95% CI: 1.7-2.2), overweight/obesity (AOR: 2.4, 95% CI: 2.0-2.8), diabetes (AOR: 1.4, 95% CI: 1.2-1.6), secondary (AOR: 1.2, 95% CI: 1.1-1.4), or college education level (AOR: 1.8, 95% CI: 1.4-2.3), middle (AOR: 1.3, 95% CI: 1.1-1.6), richer (AOR: 1.5, 95% CI: 1.2-1.8) or richest (AOR: 2.0, 95% CI: 1.6-2.4) wealth quintiles, residence in Khulna (AOR: 1.5, 95% CI: 1.2-1.9), and Rangpur (AOR: 1.7, 95% CI: 1.3-2.2) divisions. All factors were significant as per the JNC7 guideline too. Both guidelines found similar determinants. Prevention and control programs should prioritize increasing awareness among people with higher likelihood of hypertension.
Language	English
Publishing date	2018-10-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2276144-5
ISSN	1878-7436 ; 1933-1711
ISSN (online)	1878-7436
ISSN	1933-1711
DOI	10.1016/j.jash.2018.10.004
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Article ; Online: Ten-Year Clinical Experience with the Lumenless, Catheter-Delivered, 4.1-Fr Diameter Pacing Lead in Patients with and without Congenital Heart.

Bansal, Neha / Samuel, Sharmeen / Zelin, Kathleen / Karpawich, Peter P

Pacing and clinical electrophysiology : PACE

2017 Volume 40, Issue 1, Page(s) 17–25

Abstract: Background: Patients with congenital heart defects (CHD) often present more challenges to pacing therapy due to anatomy than those without CHD. The lumenless, 4.1Fr diameter M3830 pacing lead (Medtronic, Inc., Minneapolis, MN, USA), approved for use in ... ...

Abstract	Background: Patients with congenital heart defects (CHD) often present more challenges to pacing therapy due to anatomy than those without CHD. The lumenless, 4.1Fr diameter M3830 pacing lead (Medtronic, Inc., Minneapolis, MN, USA), approved for use in 2005, has, to date, reported to have excellent short-term (<6 years) lead performance. Unfortunately, very long-term performance is unknown, especially among CHD patients and with implants at alternate pacing (AP) sites. This study reports a 10-year clinical experience with the M3830 lead. Methods: Records of patients who received the M3830 lead were reviewed: patient demographics, implant techniques and locations, sensing and pacing characteristics, impedances (Imp), and any complications at implant and follow-up. Results: From 2005 to 2015, 141 patients (ages 2-50, mean 20.1 years, 57% males) received 212 leads: atrial 115; ventricle 97. CHD was present in 62% of patients. Leads were inserted at AP sites in 96% of patients. Postimplant follow-up was from 3 months to 10 years (mean 56.3 months). Comparative implant versus follow-up values (mean ± standard deviation) were available on 196 leads (92.5%), showing persistently low (<1 v @ 0.4-0.5 ms) pacing thresholds (P = 0.57). Sensing was also comparable (atrial leads, P = 0.41; ventricular leads, P = 0.9). Impedances differed (P < 0.05) but remained within the normal range. Two A leads became dislodged and one was repositioned while two other leads (1 A, 1 V) were extracted. There are no differences observed in the pacing characteristics between the CHD and non-CHD groups on follow-up. Conclusions: The 4.1Fr lumenless pacing lead shows ease of implant regardless of CHD or AP site, excellent very long-term (10 years) stability, and performance indices with a very low rate of complications.
MeSH term(s)	Adolescent ; Adult ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/prevention & control ; Cardiac Catheterization/statistics & numerical data ; Cardiac Pacing, Artificial/statistics & numerical data ; Child ; Child, Preschool ; Equipment Design ; Equipment Failure/statistics & numerical data ; Equipment Failure Analysis ; Female ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/therapy ; Humans ; Longitudinal Studies ; Male ; Michigan/epidemiology ; Pacemaker, Artificial/statistics & numerical data ; Prevalence ; Prosthesis Implantation/methods ; Prosthesis Implantation/statistics & numerical data ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.12995
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval.

Samuel, Sharmeen / Friedman, Richard A / Sharma, Chetan / Ganigara, Madhusudan / Mitchell, Elizabeth / Schleien, Charles / Blaufox, Andrew D

Heart rhythm

2020 Volume 17, Issue 11, Page(s) 1960–1966

Abstract: Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN).: ... ...

Abstract	Background: There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN). Objectives: To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. Methods: A single-center retrospective chart review was undertaken and included all patients with (1) symptoms of COVID-19 and (2) PCR-positive nasopharyngeal swabs for SARS-CoV-2 who were placed on continuous telemetry for the duration of their hospitalization during March through May, 2020. Results: Thirty-six patients were included in the study. Significant arrhythmias were found in 6 (nonsustained ventricular tachycardia in 5 and sustained atrial tachycardia in 1). All were self-resolving and half prompted prophylactic antiarrhythmic therapy. Patients with significant arrhythmias were likely to have noncardiac comorbidities (4/6), but these were not more common than in patients without arrhythmias (20/30, P = 1). The use of HCQ was associated with statistically significant QTc prolongation (413 ± 19 ms vs 425 ± 16 ms, P =.005). QTc was not statistically different in patients with and without arrhythmias (425 ± 15 ms vs 425 ± 15 ms, P = 1). Conclusions: In pediatric patients with PCR-positive active COVID-19 infection, significant arrhythmias are infrequent, but are more common than expected in a general pediatric population. Comorbidities are not more common in patients with arrhythmias than in patients without arrhythmias. COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients.
MeSH term(s)	Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/adverse effects ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Azithromycin/administration & dosage ; Azithromycin/adverse effects ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Child ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Electrocardiography/methods ; Electrocardiography/statistics & numerical data ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Incidence ; Long QT Syndrome/chemically induced ; Long QT Syndrome/diagnosis ; Male ; New York City/epidemiology ; Outcome and Process Assessment, Health Care ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Chemical Substances	Anti-Infective Agents ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
Keywords	covid19
Language	English
Publishing date	2020-07-01
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2020.06.033
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Article ; Online: Human Metapneumovirus Infection in Immunocompromised Patients.

Samuel, Sharmeen / Nanjappa, Sowmya / Cooper, Christopher D / Greene, John N

Cancer control : journal of the Moffitt Cancer Center

2016 Volume 23, Issue 4, Page(s) 442–445

Abstract: Human metapneumovirus (HMPV) is a pathogen associated with respiratory tract infection and is related to avian pneumovirus. Typically, children, the elderly, and those who are immunocompromised are the most susceptible to HMPV infection; however, the ... ...

Abstract	Human metapneumovirus (HMPV) is a pathogen associated with respiratory tract infection and is related to avian pneumovirus. Typically, children, the elderly, and those who are immunocompromised are the most susceptible to HMPV infection; however, the virus can infect persons of all ages. In otherwise healthy individuals, HMPV infection is generally self-limiting, but immunocompromised individuals can develop fatal complications. We present a case series of 3 severely immunocompromised patients who were infected with HMPV and describe their clinical course. All 3 patients had acute myeloid leukemia, histories of neutropenic fever, and prolonged hospitalization stays. This case series highlights the severe sequelae observed in individuals infected with HMPV, particularly among those who are immunocompromised.
MeSH term(s)	Female ; Humans ; Immunocompromised Host ; Male ; Metapneumovirus/pathogenicity ; Middle Aged ; Respiratory Tract Infections/complications
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
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Article ; Online: Incidence of arrhythmias and electrocardiographic abnormalities in symptomatic pediatric patients with PCR-positive SARS-CoV-2 infection, including drug-induced changes in the corrected QT interval

Samuel, Sharmeen / Friedman, Richard A. / Sharma, Chetan / Ganigara, Madhusudan / Mitchell, Elizabeth / Schleien, Charles / Blaufox, Andrew D.

Heart Rhythm

2020 Volume 17, Issue 11, Page(s) 1960–1966

Keywords	Physiology (medical) ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2020.06.033
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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