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Article: The dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals.

Sato, Yukiko / Matsumoto, Shigekiyo / Ogata, Kazue / Bacal, Kira / Nakatake, Misato / Kitano, Takaaki / Tokumaru, Osamu

Journal of clinical biochemistry and nutrition

2023 Volume 73, Issue 1, Page(s) 16–23

Abstract: This study aimed to illustrate the dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free ... ...

Abstract	This study aimed to illustrate the dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals
Language	English
Publishing date	2023-05-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.22-131
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Article: Age- and Sex-Related Differences in Morbidities of Sexually Transmitted Diseases in Children.

Hino, Yumika / Eshima, Nobuoki / Bacal, Kira / Tokumaru, Osamu

Children (Basel, Switzerland)

2021 Volume 8, Issue 1

Abstract: Sexually transmitted diseases (STDs) are causes of public health burden globally. The purpose of this study is to document age-specific and sex-related changes in the morbidity of four representative STDs in children. Japanese national surveillance data ... ...

Abstract	Sexually transmitted diseases (STDs) are causes of public health burden globally. The purpose of this study is to document age-specific and sex-related changes in the morbidity of four representative STDs in children. Japanese national surveillance data from 1999 to 2017 on morbidities of the following four STDs were analyzed by age and sex:
Language	English
Publishing date	2021-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children8010040
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Article ; Online: Medical Problems and Concerns with Temporary Evacuation Shelters after Great Earthquake Disasters in Japan: A Systematic Review.

Tokumaru, Osamu / Fujita, Masanori / Nagai, Saeko / Minamikawa, Yoko / Kumatani, Junnosuke

Disaster medicine and public health preparedness

2021 Volume 16, Issue 4, Page(s) 1645–1652

Abstract: Japan has repeatedly suffered from natural disasters. A number of temporary evacuation shelters have been opened for the benefit of evacuees. Although the operation of such evacuation shelters has improved after the Great Hanshin-Awaji Earthquake (1995), ...

Abstract	Japan has repeatedly suffered from natural disasters. A number of temporary evacuation shelters have been opened for the benefit of evacuees. Although the operation of such evacuation shelters has improved after the Great Hanshin-Awaji Earthquake (1995), a number of operational difficulties were encountered during the Great East Japan Earthquake in 2011 and the Kumamoto Earthquake in 2016. A systematic literature review was conducted to identify the medical concerns encountered in temporary evacuation shelters by focusing on unsanitary environment, food and nutrition, and shortage of medication. Actual sanitary conditions have been found to be below the standards stipulated by the Japanese government as per international guidelines. Food aid in evacuation shelters was neither nutritionally balanced, nor was the distribution to different shelters balanced. Furthermore, evacuees with chronic diseases feared that there may be a shortage of medication. Crowding in evacuation shelters increased the risk of outbreaks of infectious diseases (e.g., tuberculosis). Malnutrition and shortage of medication exacerbated the risk of deterioration of chronic diseases (e.g., diabetes mellitus, hypertension) among evacuees. Therefore, it is recommended that healthcare professionals should be promptly deployed to evacuation shelters, to promote sanitary control and education, as well as address limited space availability, and food and medication shortage.
MeSH term(s)	Humans ; Earthquakes ; Emergency Shelter ; Japan/epidemiology ; Disasters ; Communicable Diseases/epidemiology
Language	English
Publishing date	2021-06-09
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2021.99
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Article ; Online: Influence of aging on the color visual field in humans: A cross-sectional study.

Yada, Takeshi / Tokumaru, Osamu / Eshima, Nobuoki / Kitano, Takaaki / Yokoi, Isao

Medicine

2021 Volume 100, Issue 50, Page(s) e28230

Abstract: Abstract: Age-related narrowing of the visual field is observed in the elderly, which leads to reduced cognitive and psychomotor functions. The aim of the present cross-sectional study was to determine the influence of aging on the visual field for ... ...

Abstract	Abstract: Age-related narrowing of the visual field is observed in the elderly, which leads to reduced cognitive and psychomotor functions. The aim of the present cross-sectional study was to determine the influence of aging on the visual field for color vision in humans, with respect to angular thresholds for object detection and color detection.The subjects were divided into the elderly group (mean 76.1-year-old [70-89]) and the control group (25.2 [18-47]). Visual fields for different colors (blue, green, yellow, and red) were measured by manual kinetic perimetry and evaluated in terms of 2 measures of visual-field width: angular thresholds for object detection and those for color detection.While angular thresholds for object detection were significantly wider than those for color detection in the control group (P < .001), there was no difference in the elderly group (P = .06). Moreover, angular thresholds for object detection were significantly wider in the control group than in the elderly group (P = .019), but angular thresholds for color detection were not significantly different between the 2 groups (P = .903).The observed age-related changes in angular thresholds for object detection in color vision may reflect an age-related reduction in rod function. Stable cone function might explain the preserved angular thresholds for color detection in the elderly.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging ; Color Perception Tests/methods ; Color Vision ; Cross-Sectional Studies ; Female ; Humans ; Male ; Visual Field Tests ; Visual Fields
Language	English
Publishing date	2021-12-16
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000028230
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Article ; Online: A change in the timing of the Bacillus Calmette-Guérin vaccination in 2013 was associated with an increase in the incidence rate of infants with latent tuberculosis infection.

Hino, Yumika / Eshima, Nobuoki / Tokumaru, Osamu / Bacal, Kira / Tanaka, Yuhei / Karukaya, Shigeru / Yamashita, Yushiro

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2022 Volume 28, Issue 7, Page(s) 929–933

Abstract: Background: A change in the timing of the Bacillus Calmette-Guérin (BCG) vaccination among infants in Japan appears to be associated with an increase in the incidence rate of latent tuberculosis infection (LTBI).: Methods: Data on both active and ... ...

Abstract	Background: A change in the timing of the Bacillus Calmette-Guérin (BCG) vaccination among infants in Japan appears to be associated with an increase in the incidence rate of latent tuberculosis infection (LTBI). Methods: Data on both active and latent tuberculosis (TB) infections from 2007 to 2019, which were reported by the Japan Anti-Tuberculosis Association, were statistically analyzed by comparing TB incidence rates in 2007-2012 and 2013-2019. Results: Although the incidence rate for active TB disease did not statistically increase nor decrease in the infant age group for either sex (and in fact decreased for some of the other age groups), the incidence rates of LTBI for both sexes were increased in the infant age group, while the incidence rates decreased in the other age groups. Between 2007 and 2012, the incidence rate of LTBI in females was statistically greater than those of males in the 1-4-year-old age group. From 2013 to 2019, the incidence rates of females were greater than those of males in both the infant and 1-4-year-old age groups, suggesting a growing preponderance of infections among female children in the youngest age groups. Conclusion: It may be that the change of BCG vaccination timing in Japan which took place in 2013 affected the infant incidence rate of LTBI, with a more prominent effect on females than males. In order to control TB infection, the ramifications of a change in vaccination timing therefore need careful exploration, as one such change appears associated with increased numbers of infants with LTBI, with disproportionate effects on females.
MeSH term(s)	BCG Vaccine ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Latent Tuberculosis/epidemiology ; Male ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control ; Vaccination
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2022-04-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2022.03.018
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Zs.A 5236: Show issues

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Article: Dose-dependent scavenging activity of the ultra-short-acting β1-blocker landiolol against specific free radicals.

Matsumoto, Shigekiyo / Tokumaru, Osamu / Ogata, Kazue / Kuribayashi, Yoshihide / Oyama, Yoshimasa / Shingu, Chihiro / Yokoi, Isao / Kitano, Takaaki

Journal of clinical biochemistry and nutrition

2022 Volume 71, Issue 3, Page(s) 185–190

Abstract: Landiolol, a highly cardioselective ultra-short-acting β1-blocker, prevents perioperative atrial fibrillation associated with systemic inflammation and oxidative stress. We evaluated the direct scavenging activity of landiolol against multiple free ... ...

Abstract	Landiolol, a highly cardioselective ultra-short-acting β1-blocker, prevents perioperative atrial fibrillation associated with systemic inflammation and oxidative stress. We evaluated the direct scavenging activity of landiolol against multiple free radical species. Nine free radical species (hydroxyl, superoxide anion, ascorbyl,
Language	English
Publishing date	2022-07-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.21-157
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Article ; Online: Clinical results of carbon-ion radiotherapy for stage I non-small cell lung cancer with concomitant interstitial lung disease: a Japanese national registry study (J-CROS-LUNG).

Okano, Naoko / Suefuji, Hiroaki / Nakajima, Mio / Tokumaru, Sunao / Kubo, Nobuteru / Yoshida, Daisaku / Suzuki, Osamu / Ishikawa, Hitoshi / Satouchi, Miyako / Nakayama, Haruhiko / Shioyama, Yoshiyuki

Journal of radiation research

2023 Volume 64, Issue Supplement_1, Page(s) i2–i7

Abstract: Anti-cancer treatments for lung cancer patients with interstitial lung disease (ILD) are challenging. The treatment options for ILD are often limited because of concerns that treatments can cause acute exacerbation (AE) of ILD. This study aimed to ... ...

Abstract	Anti-cancer treatments for lung cancer patients with interstitial lung disease (ILD) are challenging. The treatment options for ILD are often limited because of concerns that treatments can cause acute exacerbation (AE) of ILD. This study aimed to analyze the outcomes of carbon-ion radiotherapy (CIRT) for stage I non-small cell lung cancer (NSCLC) with ILD, using a multi-institutional registry. Patients with ILD who received CIRT for stage I NSCLC in CIRT institutions in Japan were enrolled. The indication for CIRT was determined by an institutional multidisciplinary tumor board, and CIRT was performed in accordance with institutional protocols. Thirty patients were eligible. The median follow-up duration was 30.3 months (range, 2.5-58 months), and the total dose ranged from 50 Gy (relative biological effectiveness [RBE]) to 69.6 Gy (RBE), and five different patterns of fractionation were used. The beam delivery method was passive beam in 19 patients and scanning beam in 11 patients. The 3-year overall survival (OS), cause-specific survival, disease-free survival (DFS) and local control (LC) rates were 48.2%, 62.2%, 41.2% and 88.1%, respectively. Grade > 2 radiation pneumonitis occurred in one patient (3.3%). In conclusion, CIRT is a safe treatment modality for stage I NSCLC with concomitant ILD. CIRT is a safe and feasible treatment option for early lung cancer in ILD patients.
MeSH term(s)	Humans ; Carbon ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; East Asian People ; Heavy Ion Radiotherapy ; Lung/pathology ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/radiotherapy ; Lung Neoplasms/complications ; Lung Neoplasms/radiotherapy
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rrad008
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Article ; Online: Clinical results of carbon ion radiotherapy for inoperable stage I non-small cell lung cancer: A Japanese national registry study (J-CROS-LUNG).

Kubo, Nobuteru / Suefuji, Hiroaki / Nakajima, Mio / Tokumaru, Sunao / Okano, Naoko / Yoshida, Daisaku / Suzuki, Osamu / Ishikawa, Hitoshi / Satouchi, Miyako / Nakayama, Haruhiko / Shioyama, Yoshiyuki

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 183, Page(s) 109640

Abstract: Background and purpose: Radiotherapy is a standard treatment for inoperable stage I non-small cell lung cancer (NSCLC), and carbon-ion radiation therapy (CIRT) may be used for such treatment. Although CIRT for stage I NSCLC has demonstrated favorable ... ...

Abstract	Background and purpose: Radiotherapy is a standard treatment for inoperable stage I non-small cell lung cancer (NSCLC), and carbon-ion radiation therapy (CIRT) may be used for such treatment. Although CIRT for stage I NSCLC has demonstrated favorable outcomes in previous reports, the reports covered only single-institution studies. We conducted a prospective nationwide registry study including all CIRT institutions in Japan. Materials and methods: Ninety-five patients with inoperable stage I NSCLC were treated by CIRT between May 2016 and June 2018. The dose fractionations for CIRT were selected from several options approved by the Japanese Society for Radiation Oncology. Results: The median patient age was 77 years. Comorbidity rates for chronic obstructive pulmonary disease and interstitial pneumonia were 43% and 26%, respectively. The most common schedule for CIRT was 60 Gy (relative biological effectiveness (RBE)) in four fractions, and the second most common was 50 Gy (RBE) in one fraction. The 3-year overall survival, cause-specific survival, and local control rates were 59.3%, 77.1%, and 87.3%, respectively. Female sex and ECOG performance status of 0-1 were favorable prognostic factors for overall survival in a multivariate analysis. No grade 4 or higher adverse event was observed. The 3-year cumulative incidence of grade 2 or higher radiation pneumonitis was 3.2%. The risk factors for grade 2 or higher radiation pneumonitis were a force expiratory volume in 1 second (FEV1) of <0.9 L and a total does of ≥ 67 Gy(RBE). Conclusion: This study provides real-world treatment outcomes of CIRT for inoperable. stage I NSCLC in Japan.
MeSH term(s)	Aged ; Female ; Humans ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; East Asian People ; Heavy Ion Radiotherapy/adverse effects ; Lung ; Lung Neoplasms/radiotherapy ; Prospective Studies ; Radiation Pneumonitis/epidemiology ; Radiation Pneumonitis/etiology
Language	English
Publishing date	2023-03-27
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109640
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Zs.A 1926: Show issues

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Article ; Online: Five-Year Survival Outcomes After Carbon-Ion Radiotherapy for Operable Stage I NSCLC: A Japanese National Registry Study (J-CROS-LUNG).

Kubo, Nobuteru / Suefuji, Hiroaki / Nakajima, Mio / Tokumaru, Sunao / Okano, Naoko / Yoshida, Daisaku / Suzuki, Osamu / Ishikawa, Hitoshi / Satouchi, Miyako / Nakayama, Haruhiko / Shimizu, Kimihiro / Shioyama, Yoshiyuki

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2023 Volume 19, Issue 3, Page(s) 491–499

Abstract: Introduction: The standard therapy for stage I NSCLC is surgery, but some operable patients refuse this option and instead undergo radiotherapy. Carbon-ion radiotherapy (CIRT) is a type of radiotherapy. The Japanese prospective nationwide registry study ...

Abstract	Introduction: The standard therapy for stage I NSCLC is surgery, but some operable patients refuse this option and instead undergo radiotherapy. Carbon-ion radiotherapy (CIRT) is a type of radiotherapy. The Japanese prospective nationwide registry study on CIRT began in 2016. Here, we analyzed real-world clinical outcomes of CIRT for operable patients with stage I NSCLC. Methods: All patients with operable stage I NSCLC treated with CIRT in Japan between 2016 and 2018 were enrolled. The dose fractionations for CIRT were selected from several options approved by the Japanese Society for Radiation Oncology. CIRT was delivered to the primary tumor, not to lymph nodes. Results: The median follow-up period was 56 months. Among 136 patients, 117 (86%) had clinical stage IA NSCLC and 19 (14%) had clinical stage IB NSCLC. There were 50 patients (37%) diagnosed clinically without having been diagnosed histologically. Most tumors (97%) were located in the periphery. The 5-year overall survival, cause-specific survival, progression-free survival, and local control rate were 81.8% (95% confidence interval [CI]: 75.1-89.2), 91.2% (95% CI: 86.0-96.8), 65.9% (95% CI: 58.2-74.6), and 95.8% (95% CI: 92.3-99.5), respectively. Multivariate analysis identified age as a significant factor for overall survival (p = 0.018), whereas age and consolidation/tumor ratio (p = 0.010 and p = 0.004) were significant factors for progression-free survival. There was no grade 4 or higher toxicity. Grade 3 radiation pneumonitis occurred in one patient. Conclusions: This study reports the long-term outcomes of CIRT for operable NSCLC in the real world. CIRT for operable patients has been found to have favorable outcomes, with tolerable toxicity.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Japan/epidemiology ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Carbon ; Lung/pathology
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2023.10.016
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Article ; Online: A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK-1654 in healthy Japanese adults.

Orito, Yuji / Otani, Naoyuki / Matsumoto, Yuki / Fujimoto, Katsukuni / Oshima, Nobuyuki / Maas, Brian M / Caro, Luzelena / Aliprantis, Antonios O / Cox, Kara S / Tokumaru, Osamu / Kodama, Masaaki / Kudo, Hideo / Imai, Hiromitsu / Uemura, Naoto

Clinical and translational science

2022 Volume 15, Issue 7, Page(s) 1753–1763

Abstract: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among all infants worldwide and remains a significant cause of morbidity and mortality. To address this unmet medical need, MK-1654, a half-life extended RSV ... ...

Abstract	Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among all infants worldwide and remains a significant cause of morbidity and mortality. To address this unmet medical need, MK-1654, a half-life extended RSV neutralizing monoclonal antibody, is in clinical development for the prevention of RSV disease in infants. This was a phase I, randomized, placebo-controlled, single-site, double-blind trial of MK-1654 in 44 healthy Japanese adults. The safety, tolerability, pharmacokinetics, antidrug antibodies (ADAs), and serum neutralizing antibody (SNA) titers against RSV were evaluated for 1 year after a single intramuscular (i.m.) or intravenous (i.v.) dose of MK-1654 or placebo in five groups (100 mg i.m., 300 mg i.m., 300 mg i.v., 1000 mg i.v., or placebo). MK-1654 was generally well-tolerated in Japanese adults. There were no serious drug-related adverse events (AEs) reported in any MK-1654 recipient and no discontinuations due to any AEs in the study. The half-life of MK-1654 ranged from 76 to 91 days across dosing groups. Estimated bioavailability was 86% for 100 mg i.m. and 77% for 300 mg i.m. One participant out of 33 (3.0%) developed detectable ADA with no apparent associated AEs. The RSV SNA titers increased in a dose-dependent manner among participants who received MK-1654. These data support the development of MK-1654 for use in Japanese infants.
MeSH term(s)	Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Humans ; Infant ; Japan ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus, Human
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2022-05-17
Publishing country	United States
Document type	Clinical Trial, Phase I ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13290
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