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  1. Article ; Online: Coverage of HIV pre-exposure prophylaxis (PrEP) within the active duty U.S. military, 2023.

    Mancuso, James D / Ahmed, Anwar E

    MSMR

    2024  Volume 31, Issue 3, Page(s) 13–16

    Abstract: Estimates of HIV pre-exposure prophylaxis (PrEP) coverage in the U.S. military, defined as the proportion of the persons taking HIV PrEP out of the estimated number of persons who had indications for it, have never been published. The objective of this ... ...

    Abstract Estimates of HIV pre-exposure prophylaxis (PrEP) coverage in the U.S. military, defined as the proportion of the persons taking HIV PrEP out of the estimated number of persons who had indications for it, have never been published. The objective of this study was to provide an estimate of HIV PrEP coverage comparable to U.S. civilian estimates. The population with indications for HIV PrEP was obtained from the Department of Defense 2018 Health Related Behaviors Survey, a stratified random sample of members of all military service branches. The military PrEP coverage estimate of 31.6% in 2023 was lower than the national U.S. estimate of 36.0% in 2022. Among the military population of men who have sex with men (MSM), an estimated 24.6% of service members had indications for PrEP, similar to the national estimate of 24.7%. MSM comprised 66% of all military service members with HIV PrEP indications, compared to 40% in the U.S. general population. The U.S. military should continue deliberate, sustained, and effective actions to address sexual health inequities among MSM, aligned and coordinated with societal efforts including improved coverage of HIV PrEP to prevent HIV transmission.
    MeSH term(s) Male ; Humans ; Homosexuality, Male ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Pre-Exposure Prophylaxis ; Military Personnel ; Sexual and Gender Minorities
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623409-9
    ISSN 2152-8217 ; 2152-8217
    ISSN (online) 2152-8217
    ISSN 2152-8217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to 'Race, ethnicity, F8 variants and inhibitor risk: Analysis of the "My Life Our Future" Hemophilia A database' [Journal of Thrombosis and Haemostasis Volume 21, Issue 4, April 2023, Pages 800-813].

    Ahmed, Anwar E / Pratt, Kathleen P

    Journal of thrombosis and haemostasis : JTH

    2023  Volume 21, Issue 6, Page(s) 1684–1685

    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tobacco and nicotine use among active component U.S. military service members: a comparison of 2018 estimates from the Health Related Behaviors Survey and the Periodic Health Assessment.

    Mancuso, James D / Ahmed, Anwar E / Rossi, Kristen R

    MSMR

    2024  Volume 31, Issue 3, Page(s) 2–12

    Abstract: ... to the HRBS: cigarettes (11.1% vs. 18.4%), e-cigarettes (7.3% vs. 16.2%), chewing tobacco (9.7% vs. 13.4 ...

    Abstract This study compared estimates of the prevalence of and risk factors for tobacco and nicotine use obtained from the 2018 Health Related Behaviors Survey (HRBS) and Periodic Health Assessment (PHA) survey. The HRBS and the PHA are important Department of Defense sources of data on health behavior collected from U.S. military service members. While their collection methods differ, some survey questions are similar, which provides an opportunity to compare survey estimates. Active duty service members consistently reported a much lower prevalence of all types of tobacco and nicotine use on the PHA compared to the HRBS: cigarettes (11.1% vs. 18.4%), e-cigarettes (7.3% vs. 16.2%), chewing tobacco (9.7% vs. 13.4%), any tobacco or nicotine use (25.3% vs. 37.8%), and use of 2 or more tobacco or nicotine products (5.8% vs. 17.4%). Associations between tobacco and nicotine use as well as demographic and other behavioral variables were fairly similar, including age, sex, education, race and ethnicity, rank, and alcohol use. The associations with service branch, body mass index, and sleep were inconsistent. This results of this study suggest that the PHA can provide timely information on trends in military tobacco and nicotine use over time, but much higher estimates from the confidential, voluntary HRBS reported in this study suggest that the command-directed PHA may substantially underestimate the prevalence of all types of tobacco and nicotine use.
    MeSH term(s) Humans ; United States/epidemiology ; Nicotine ; Military Personnel ; Electronic Nicotine Delivery Systems ; Tobacco, Smokeless ; Health Behavior
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623409-9
    ISSN 2152-8217 ; 2152-8217
    ISSN (online) 2152-8217
    ISSN 2152-8217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Limited transmissibility of coronavirus (SARS-1, MERS, and SARS-2) in certain regions of Africa.

    Ahmed, Anwar E

    Journal of medical virology

    2020  Volume 92, Issue 10, Page(s) 1753–1754

    MeSH term(s) Africa ; COVID-19/transmission ; COVID-19/virology ; Coronavirus Infections/transmission ; Female ; Humans ; Male ; Middle East Respiratory Syndrome Coronavirus/pathogenicity ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS Virus/pathogenicity ; SARS-CoV-2/pathogenicity ; Severe Acute Respiratory Syndrome/transmission ; Severe Acute Respiratory Syndrome/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  5. Article ; Online: Incidence of coronavirus disease (COVID-19) and countries affected by malarial infections.

    Ahmed, Anwar E

    Travel medicine and infectious disease

    2020  Volume 37, Page(s) 101693

    MeSH term(s) Antimalarials/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Incidence ; Malaria/drug therapy ; Malaria/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Chemical Substances Antimalarials
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  6. Article: Impact of Sleep Profiles on Multimorbidity Among US Active-Duty Service Members in the 2018 Health-Related Behaviors Survey.

    Weinberger, Marina / Ahmed, Anwar E / Singer, Darrell E

    Nature and science of sleep

    2023  Volume 15, Page(s) 1019–1032

    Abstract: Purpose: Sleep is a modifiable factor affecting chronic diseases and conditions in the Active-Duty (AD) United States (US) military population. This study assesses the impact of reported sleep health behaviors and sleep profiles on reported ... ...

    Abstract Purpose: Sleep is a modifiable factor affecting chronic diseases and conditions in the Active-Duty (AD) United States (US) military population. This study assesses the impact of reported sleep health behaviors and sleep profiles on reported multimorbidity in active-duty service members (ADSMs).
    Participants and methods: The study used a military representative sample of 17,166 active duty SMs from the 2018 Department of Defense
    Results: Sleep-related health behaviors were associated with increased odds of obesity, hypertension, and hyperlipidemia. We found higher odds of reported multimorbidity in SMs who reported lack of energy due to poor sleep (adjusted odds ratio [aOR] = 2.35, 95% CI:1.88-2.93), sleep 6 hours or less per night (aOR = 1.95, 95% CI:1.53-2.50), trouble sleeping (aOR = 2.19, 95% CI:1.76-2.72), and use of sleep medications (aOR = 2.10, 95% CI:1.64-2.68). Latent class analysis (LCA) identified three unobservable sleep profiles in SMs: minimal or low-risk sleep patterns (37.43%), moderate-risk sleep patterns (31.11%), and high-risk sleep patterns (31.46%). SMs with high-risk sleep patterns were significantly associated with reported multimorbidity (adjusted odds ratio [aOR] = 3.54, 95% CI:2.75-4.56).
    Conclusion: We found a strong association between sleep-related health behaviors and their unobservable sleep profiles with multimorbidity in this AD population. Future studies should investigate whether other chronic diseases may be influenced by sleep impairment in the US military population.
    Language English
    Publishing date 2023-12-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2587468-8
    ISSN 1179-1608
    ISSN 1179-1608
    DOI 10.2147/NSS.S434813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Race, ethnicity, F8 variants, and inhibitor risk: analysis of the "My Life Our Future" hemophilia A database.

    Ahmed, Anwar E / Pratt, Kathleen P

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 21, Issue 4, Page(s) 800–813

    Abstract: Background: Several studies have suggested Black and Hispanic hemophilia A (HA) patients in the United States suffer higher incidences of neutralizing anti-FVIII antibodies (inhibitors) than their White counterparts. The possible influence of ... ...

    Abstract Background: Several studies have suggested Black and Hispanic hemophilia A (HA) patients in the United States suffer higher incidences of neutralizing anti-FVIII antibodies (inhibitors) than their White counterparts. The possible influence of nonsynonymous single-nucleotide polymorphisms (ns-SNPs) in the F8 gene sequence has been proposed as a possible race-associated contributing factor. Some earlier studies indicated that intron-22 inversion mutations carry a lower inhibitor risk than other mutations resulting in large F8 gene disruptions.
    Objectives: The objectives of the study were to test the following hypotheses: (1) The risk of developing an inhibitor differs among racial/ethnic groups in the United States, (2) specific non-HA-causing ns-SNPs in the F8 gene are correlated with inhibitor risk, and (3) inhibitor risk associated with intron-22 inversions mutations is similar to that associated with other large structural changes in the F8 gene.
    Methods: Adjusted logistic regression analysis of the "My Life Our Future" database containing demographic, clinical, and F8 sequence data from >6000 mild, moderate, and severe HA participants.
    Results: Black and Hispanic severe HA subjects had a higher inhibitor risk than non-Hispanic Whites (adjusted odds ratio = 1.65, 95% CI: 1.22-2.21 and adjusted odds ratio = 1.88, 95% CI: 1.43-2.48), confirming this racial/ethnic/medical disparity; however, F8 ns-SNPs were not associated with inhibitor development. There was no difference in inhibitor risk among severe HA subjects with an intron-22 inversion vs other large structural changes in the F8 gene.
    Conclusions: Nonpathogenic ns-SNPs in the F8 gene are not correlated with inhibitor risk. Inhibitor risk associated with intron-22 inversion mutations is similar to that of other large structural changes in F8 that preclude intact FVIII expression.
    MeSH term(s) Humans ; Hemophilia A/diagnosis ; Hemophilia A/genetics ; Ethnicity ; Factor VIII/genetics ; Mutation ; Introns
    Chemical Substances Factor VIII (9001-27-8)
    Language English
    Publishing date 2022-12-26
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2022.12.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 295: Show issues

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  10. Article ; Online: Green UPLC method for estimation of ciprofloxacin, diclofenac sodium, and ibuprofen with application to pharmacokinetic study of human samples.

    Ahmed-Anwar, Alaa A / Mohamed, Mahmoud A / Farghali, Ahmed A / Mahmoud, Rehab / Hassouna, Mohamed E M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 17613

    Abstract: Investigation of a unique and fast method for the determination and separation of a mixture of three drugs viz., ciprofloxacin (CIP), Ibuprofen (IBU), and diclofenac sodium (DIC) in actual samples of human plasma. Also, the technique was used to look at ... ...

    Abstract Investigation of a unique and fast method for the determination and separation of a mixture of three drugs viz., ciprofloxacin (CIP), Ibuprofen (IBU), and diclofenac sodium (DIC) in actual samples of human plasma. Also, the technique was used to look at their pharmacokinetics study. Hydrocortisone was chosen as the internal standard (IS). The drugs were chromatographically separated using an Acquity ultra-performance liquid chromatography UPLC ® BEH C18 1.7 µm (2.1 × 150 mm) column with a mobile phase composed of acetonitrile: water (65:35, v/v) adjusted to pH 3 with diluted acetic acid. Plasma proteins were precipitated with acetonitrile. The separated drugs ranged from 0.3 to 10, 0.2-11, and 1-25 µg/mL for CIP, IBU, and DIC, respectively. Calibration curves were discovered to achieve linearity with acceptable correlation coefficients (0.99%). Examination of quality assurance samples showed exceptional precision and accuracy. Following the successful application of this improved technique to plasma samples, the pharmacokinetic characteristics of each selected drug were evaluated using (UPLC) with UV detection at 210 nm. Two green metrics were applied, the Analytical Eco-scale and the Analytical GREEnness Calculator (AGREE). Separation was achieved in only 4-min analysis time. The method's validation agreed with the requirements of the FDA, and the results were sufficient.
    MeSH term(s) Humans ; Diclofenac ; Ibuprofen ; Chromatography, High Pressure Liquid/methods ; Ciprofloxacin ; Tandem Mass Spectrometry/methods ; Reproducibility of Results ; Acetonitriles
    Chemical Substances Diclofenac (144O8QL0L1) ; Ibuprofen (WK2XYI10QM) ; Ciprofloxacin (5E8K9I0O4U) ; Acetonitriles
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44846-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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