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  1. Article ; Online: Endo- and Exo-Functionalized Tetraphenylethylene M

    Yan, Xuzhou / Wei, Peifa / Liu, Yuhang / Wang, Ming / Chen, Chuanshuang / Zhao, Jun / Li, Guangfeng / Saha, Manik Lal / Zhou, Zhixuan / An, Zhe / Li, Xiaopeng / Stang, Peter J

    Journal of the American Chemical Society

    2019  Volume 141, Issue 24, Page(s) 9673–9679

    Abstract: ... functionalized tetraphenylethylene (TPE)-based M ...

    Abstract The intrinsic relationship between the properties of green fluorescent protein (GFP) and its encapsulated small molecular light machine has spurred many biomimicking studies, aiming at revealing the detailed mechanism and further promoting its wide applications in different disciplines. However, how to build a similar confined microenvironment to mimic the cavity of a β-barrel and the fluorescence turn-on process is a fundamental challenge for both chemists and biologists. Herein, two distinct exo- and endo-functionalized tetraphenylethylene (TPE)-based M
    MeSH term(s) Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/radiation effects ; Fluorescence ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/radiation effects ; Green Fluorescent Proteins/chemistry ; Ligands ; Nanospheres/chemistry ; Nanospheres/radiation effects ; Stilbenes/chemical synthesis ; Stilbenes/chemistry ; Stilbenes/radiation effects ; Ultraviolet Rays
    Chemical Substances Fluorescent Dyes ; Ligands ; Stilbenes ; tetraphenylethylene ; Green Fluorescent Proteins (147336-22-9)
    Language English
    Publishing date 2019-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.9b03885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prospective comparison of CT and 18F-FDG PET/MRI in N and M staging of primary breast cancer patients: Initial results.

    Bruckmann, Nils Martin / Kirchner, Julian / Morawitz, Janna / Umutlu, Lale / Herrmann, Ken / Bittner, Ann-Kathrin / Hoffmann, Oliver / Mohrmann, Svjetlana / Ingenwerth, Marc / Schaarschmidt, Benedikt M / Li, Yan / Stang, Andreas / Antoch, Gerald / Sawicki, Lino M / Buchbender, Christian

    PloS one

    2021  Volume 16, Issue 12, Page(s) e0260804

    Abstract: ... tomography and whole-body 18F-FDG PET/MRI in N and M staging in newly diagnosed, histopathological proven ... diagnostic potential and outperforms CT in assessing the N and M stage in patients with primary breast cancer. ...

    Abstract Objectives: To compare the diagnostic accuracy of contrast-enhanced thoraco-abdominal computed tomography and whole-body 18F-FDG PET/MRI in N and M staging in newly diagnosed, histopathological proven breast cancer.
    Material and methods: A total of 80 consecutive women with newly diagnosed and histopathologically confirmed breast cancer were enrolled in this prospective study. Following inclusion criteria had to be fulfilled: (1) newly diagnosed, treatment-naive T2-tumor or higher T-stage or (2) newly diagnosed, treatment-naive triple-negative tumor of every size or (3) newly diagnosed, treatment-naive tumor with molecular high risk (T1c, Ki67 >14%, HER2neu over-expression, G3). All patients underwent a thoraco-abdominal ceCT and a whole-body 18F-FDG PET/MRI. All datasets were evaluated by two experienced radiologists in hybrid imaging regarding suspect lesion count, localization, categorization and diagnostic confidence. Images were interpreted in random order with a reading gap of at least 4 weeks to avoid recognition bias. Histopathological results as well as follow-up imaging served as reference standard. Differences in staging accuracy were assessed using Mc Nemars chi2 test.
    Results: CT rated the N stage correctly in 64 of 80 (80%, 95% CI:70.0-87.3) patients with a sensitivity of 61.5% (CI:45.9-75.1), a specificity of 97.6% (CI:87.4-99.6), a PPV of 96% (CI:80.5-99.3), and a NPV of 72.7% (CI:59.8-82.7). Compared to this, 18F-FDG PET/MRI determined the N stage correctly in 71 of 80 (88.75%, CI:80.0-94.0) patients with a sensitivity of 82.1% (CI:67.3-91.0), a specificity of 95.1% (CI:83.9-98.7), a PPV of 94.1% (CI:80.9-98.4) and a NPV of 84.8% (CI:71.8-92.4). Differences in sensitivities were statistically significant (difference 20.6%, CI:-0.02-40.9; p = 0.008). Distant metastases were present in 7/80 patients (8.75%). 18 F-FDG PET/MRI detected all of the histopathological proven metastases without any false-positive findings, while 3 patients with bone metastases were missed in CT (sensitivity 57.1%, specificity 95.9%). Additionally, CT presented false-positive findings in 3 patients.
    Conclusion: 18F-FDG PET/MRI has a high diagnostic potential and outperforms CT in assessing the N and M stage in patients with primary breast cancer.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18/metabolism ; Humans ; Magnetic Resonance Imaging/methods ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography/methods ; Prospective Studies ; ROC Curve ; Radiopharmaceuticals/metabolism ; Tomography, X-Ray Computed/methods
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2021-12-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0260804
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  3. Article ; Online: Prospective comparison of CT and 18F-FDG PET/MRI in N and M staging of primary breast cancer patients

    Nils Martin Bruckmann / Julian Kirchner / Janna Morawitz / Lale Umutlu / Ken Herrmann / Ann-Kathrin Bittner / Oliver Hoffmann / Svjetlana Mohrmann / Marc Ingenwerth / Benedikt M Schaarschmidt / Yan Li / Andreas Stang / Gerald Antoch / Lino M Sawicki / Christian Buchbender

    PLoS ONE, Vol 16, Iss 12, p e

    Initial results.

    2021  Volume 0260804

    Abstract: ... tomography and whole-body 18F-FDG PET/MRI in N and M staging in newly diagnosed, histopathological proven ...

    Abstract Objectives To compare the diagnostic accuracy of contrast-enhanced thoraco-abdominal computed tomography and whole-body 18F-FDG PET/MRI in N and M staging in newly diagnosed, histopathological proven breast cancer. Material and methods A total of 80 consecutive women with newly diagnosed and histopathologically confirmed breast cancer were enrolled in this prospective study. Following inclusion criteria had to be fulfilled: (1) newly diagnosed, treatment-naive T2-tumor or higher T-stage or (2) newly diagnosed, treatment-naive triple-negative tumor of every size or (3) newly diagnosed, treatment-naive tumor with molecular high risk (T1c, Ki67 >14%, HER2neu over-expression, G3). All patients underwent a thoraco-abdominal ceCT and a whole-body 18F-FDG PET/MRI. All datasets were evaluated by two experienced radiologists in hybrid imaging regarding suspect lesion count, localization, categorization and diagnostic confidence. Images were interpreted in random order with a reading gap of at least 4 weeks to avoid recognition bias. Histopathological results as well as follow-up imaging served as reference standard. Differences in staging accuracy were assessed using Mc Nemars chi2 test. Results CT rated the N stage correctly in 64 of 80 (80%, 95% CI:70.0-87.3) patients with a sensitivity of 61.5% (CI:45.9-75.1), a specificity of 97.6% (CI:87.4-99.6), a PPV of 96% (CI:80.5-99.3), and a NPV of 72.7% (CI:59.8-82.7). Compared to this, 18F-FDG PET/MRI determined the N stage correctly in 71 of 80 (88.75%, CI:80.0-94.0) patients with a sensitivity of 82.1% (CI:67.3-91.0), a specificity of 95.1% (CI:83.9-98.7), a PPV of 94.1% (CI:80.9-98.4) and a NPV of 84.8% (CI:71.8-92.4). Differences in sensitivities were statistically significant (difference 20.6%, CI:-0.02-40.9; p = 0.008). Distant metastases were present in 7/80 patients (8.75%). 18 F-FDG PET/MRI detected all of the histopathological proven metastases without any false-positive findings, while 3 patients with bone metastases were missed in CT (sensitivity 57.1%, ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Die M.-abductor-digiti-minimi-Lappenplastik zur Defektdeckung im Handbereich.

    Stang, F / Siemers, F / von Wild, T / Weyers, I / Mailänder, P / Stollwerck, P

    Operative Orthopadie und Traumatologie

    2013  Volume 25, Issue 4, Page(s) 372–380

    Abstract: Objective: Defect coverage of the ulnar aspect of the hand, wrist and hypothenar with an abductor digiti minimi muscle flap and split skin graft.: Indications: Soft tissue defects of the ulnar aspect of the hand, wrist and hypothenar. Osteomyelitis ... ...

    Title translation Abductor digiti minimi muscle flap for defect coverage of the hand.
    Abstract Objective: Defect coverage of the ulnar aspect of the hand, wrist and hypothenar with an abductor digiti minimi muscle flap and split skin graft.
    Indications: Soft tissue defects of the ulnar aspect of the hand, wrist and hypothenar. Osteomyelitis of the fifth metacarpal bone.
    Contraindications: Large defects > 3 × 5 cm, complex hand trauma, injuries of the ulnar artery or within the area of the pedicle.
    Surgical technique: Marking of the flap's rotational radius, using the pisiform bone as the center point. Ulnar skin incision and exposure and detachment of the distal flap pole, which is located at the level of the metacarpophalangeal (MCP) joint. Dissection of the abductor digiti minimi muscle flap up to the vascular pedicle in the area of the pisiform bone. Transposition and fixation of the flap onto the defect after opening of the tourniquet. Coverage of the muscle flap with a split skin graft. Wound closure of the donor side.
    Postoperative management: Palmar cast splinting in intrinsic-plus position for 10 days physiotherapy. Scar care and compression glove for 3 months.
    Results: In total, 9 patients showed good results with a reliable defect coverage due to a constant anatomy and easy preparation.
    MeSH term(s) Female ; Hand Injuries/diagnosis ; Hand Injuries/surgery ; Humans ; Male ; Middle Aged ; Myocutaneous Flap ; Reconstructive Surgical Procedures/instrumentation ; Reconstructive Surgical Procedures/methods ; Soft Tissue Injuries/diagnosis ; Soft Tissue Injuries/surgery ; Treatment Outcome
    Language German
    Publishing date 2013-07-25
    Publishing country Germany
    Document type Clinical Trial ; English Abstract ; Journal Article
    ZDB-ID 1007514-8
    ISSN 1439-0981 ; 0934-6694
    ISSN (online) 1439-0981
    ISSN 0934-6694
    DOI 10.1007/s00064-012-0201-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2846: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Exhaled nitric oxide after high-intensity exercise at 2800 m altitude.

    Stang, Julie / Bråten, Veslemøy / Caspersen, Cecilie / Thorsen, Einar / Stensrud, Trine

    Clinical physiology and functional imaging

    2015  Volume 35, Issue 5, Page(s) 338–343

    Abstract: ... intensity exercise at 2800 m and at 180 m altitude.: Methods: Twenty trained healthy volunteers (12 men ... at different altitudes, 2800 m and 180 m, in a randomized order. The fraction of NO in exhaled gas (FE(NO)) was ... of peak HR. Peak HR was assessed during a pretest at 180 m. Ambient temperature was 20.1°C (SD = 1.2) and ...

    Abstract Background: Nitric oxide (NO) concentration in exhaled gas is a marker of some inflammatory processes in the lung, and endogenous NO plays a role in the physiological responses to exercise and altitude. The aim of this study was to compare changes in exhaled NO concentration 5-60 mins after high-intensity exercise at 2800 m and at 180 m altitude.
    Methods: Twenty trained healthy volunteers (12 men), aged 19-28 years, were included in this open, crossover study. Subjects performed two exercise tests at different altitudes, 2800 m and 180 m, in a randomized order. The fraction of NO in exhaled gas (FE(NO)) was measured 5 mins before and 5-60 mins after 8 mins of running on a treadmill at a heart rate (HR) of 90% of peak HR. Peak HR was assessed during a pretest at 180 m. Ambient temperature was 20.1°C (SD = 1.2) and relative humidity 40.2% (SD = 3.2). FE(NO) measurements were corrected for altitude gas density effects and converted to partial pressure of NO (PE(NOcorr)).
    Results: PE(NOcorr) was reduced from 1.47 (1.21, 1.73) millipascal (mPa) at baseline to 1.11 (0.87, 1.34) mPa 5 mins after exercise at 2800 m and from 1.54 (1.24, 1.84) to 1.04 (0.87, 1.22) mPa 5 mins after exercise at 180 m. There was no difference in PE(NOcorr) between exercise at 2800 m and 180 m, and PE(NOcorr) was normalized within 20 mins.
    Conclusions: Exercise at 2800 m induces a similar acute reduction in exhaled nitric oxide concentration as compared with 180 m in healthy subjects.
    MeSH term(s) Adult ; Altitude ; Breath Tests/methods ; Exercise/physiology ; Exhalation/physiology ; Female ; Humans ; Male ; Nitric Oxide/metabolism ; Physical Endurance/physiology ; Physical Exertion/physiology ; Pulmonary Gas Exchange/physiology ; Reproducibility of Results ; Sensitivity and Specificity ; Young Adult
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2071203-0
    ISSN 1475-097X ; 1475-0961
    ISSN (online) 1475-097X
    ISSN 1475-0961
    DOI 10.1111/cpf.12131
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    Zs.A 1650: Show issues Location:
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  6. Article ; Online: Staging colorectal cancer with the TNM 7(th): the presumption of innocence when applying the M category.

    Puppa, Giacomo / Poston, Graeme / Jess, Per / Nash, Guy F / Coenegrachts, Kenneth / Stang, Axel

    World journal of gastroenterology

    2012  Volume 19, Issue 8, Page(s) 1152–1157

    Abstract: One of the main changes of the current TNM-7 is the elimination of the category MX, since it has been a source of ambiguity and misinterpretation, especially by pathologists. Therefore the ultimate staging would be better performed by the patient's ... ...

    Abstract One of the main changes of the current TNM-7 is the elimination of the category MX, since it has been a source of ambiguity and misinterpretation, especially by pathologists. Therefore the ultimate staging would be better performed by the patient's clinician who can classify the disease M0 (no distant metastasis) or M1 (presence of distant metastasis), having access to the completeness of data resulting from clinical examination, imaging workup and pathology report. However this important change doesn't take into account the diagnostic value and the challenge of small indeterminate visceral lesions encountered, in particular, during radiological staging of patients with colorectal cancer. In this article the diagnosis of these lesions with multiple imaging modalities, their frequency, significance and relevance to staging and disease management are described in a multidisciplinary way. In particular the interplay between clinical, radiological and pathological staging, which are usually conducted independently, is discussed. The integrated approach shows that there are both advantages and disadvantages to abandoning the MX category. To avoid ambiguity arising both by applying and interpreting MX category for stage assigning, its abandoning seems reasonable. The recognition of the importance of small lesion characterization raises the need for applying a separate category; therefore a proposal for their categorization is put forward. By using the proposed categorization the lack of consideration for indeterminate visceral lesions with the current staging system will be overcome, also optimizing tailored follow-up.
    MeSH term(s) Colorectal Neoplasms/classification ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/secondary ; Colorectal Neoplasms/therapy ; Humans ; Magnetic Resonance Imaging ; Multimodal Imaging ; Neoplasm Invasiveness ; Neoplasm Staging/methods ; Positron-Emission Tomography ; Predictive Value of Tests ; Prognosis ; Terminology as Topic ; Tomography, X-Ray Computed ; Tumor Burden
    Language English
    Publishing date 2012-12-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v19.i8.1152
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    Zs.A 6039: Show issues Location:
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  7. Conference proceedings: Freie M. latissimus dorsi Lappenplastik zur Defektdeckung der unteren Extremität bei Kindern

    Namdar, Thomas / Stollwerck, Peter / Stang, Felix Hagen / Lange, Thomas / Mailänder, Peter / Siemers, Frank

    2010  , Page(s) 10dgch708

    Event/congress 127. Kongress der Deutschen Gesellschaft für Chirurgie; Berlin; Deutsche Gesellschaft für Chirurgie; 2010
    Keywords Medizin, Gesundheit
    Publishing date 2010-05-17
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/10dgch708
    Database German Medical Science

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  8. Article: Metal-directed formation of three-dimensional M(3)L(2) trigonal-bipyramidal cages.

    Radhakrishnan, U / Schweiger, M / Stang, P J

    Organic letters

    2001  Volume 3, Issue 20, Page(s) 3141–3143

    Abstract: ... quantitative formation of self-assembled M(3)L(2) trigonal-bipyramidal (TBP) supramolecular species. ...

    Abstract [reaction: see text] The simple combination of two angular tritopic pyridine donor linkers (109 degrees bond angle) with three ditopic platinum acceptors (90 degrees bond angle) leads to essentially quantitative formation of self-assembled M(3)L(2) trigonal-bipyramidal (TBP) supramolecular species.
    MeSH term(s) Adamantane/analogs & derivatives ; Adamantane/chemical synthesis ; Cross-Linking Reagents/chemistry ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Molecular Conformation ; Organoplatinum Compounds/chemical synthesis ; Organoplatinum Compounds/chemistry ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Spectrometry, Mass, Electrospray Ionization
    Chemical Substances Cross-Linking Reagents ; Organoplatinum Compounds ; Pyridines ; Adamantane (PJY633525U)
    Language English
    Publishing date 2001-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
    ISSN 1523-7060
    ISSN 1523-7060
    DOI 10.1021/ol0164684
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  9. Conference proceedings: Die M. abductor digiti minimi Lappenplastik, eine suffiziente Lösung bei ulnaren Handdefekten mit begleitender Osteomyelitis

    Bergmann, P. / Siemers, F. / von Wild, T. / Mailänder, P. / Stang, F.

    2012  , Page(s) FV09

    Event/congress 43. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); Bremen; ; Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen; 2012
    Keywords Medizin, Gesundheit
    Publishing date 2012-09-10
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/12dgpraec020
    Database German Medical Science

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  10. Book ; Online: Apophasis and Pseudonymity in Dionysius the Areopagite

    M. Stang, Charles

    2012  

    Abstract: This book argues that the pseudonym, Dionysius the Areopagite, and the influence of Paul together constitute the best interpretive lens for understanding the Corpus Dionysiacum [CD]. This book demonstrates how Paul in fact animates the entire corpus, ... ...

    Abstract This book argues that the pseudonym, Dionysius the Areopagite, and the influence of Paul together constitute the best interpretive lens for understanding the Corpus Dionysiacum [CD]. This book demonstrates how Paul in fact animates the entire corpus, that the influence of Paul illuminates such central themes of the CD as hierarchy, theurgy, deification, Christology, affirmation (kataphasis) and negation (apophasis), dissimilar similarities, and unknowing. Most importantly, Paul serves as a fulcrum for the expression of a new theological anthropology, an "apophatic anthropology." Dionysius figures Paul as the premier apostolic witness to this apophatic anthropology, as the ecstatic lover of the divine who confesses to the rupture of his self and the indwelling of the divine in Gal 2:20: "it is no longer I who live, but Christ who lives in me." Building on this notion of apophatic anthropology, the book forwards an explanation for why this sixth‐century author chose to write under an apostolic pseudonym. It argues that the very practice of pseudonymous writing itself serves as an ecstatic devotional exercise whereby the writer becomes split in two and thereby open to the indwelling of the divine. Pseudonymity is on this interpretation integral and internal to the aims of the wider mystical enterprise. Thus this book aims to question the distinction between "theory" and "practice" by demonstrating that negative theology-often figured as a speculative and rarefied theory regarding the transcendence of God-is in fact best understood as a kind of asceticism, a devotional practice aiming for the total transformation of the Christian subject
    Keywords Christianity
    Size 1 electronic resource (245 p.)
    Publisher Oxford University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020088061
    ISBN 9780199640423 ; 0199640424
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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