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Article ; Online: Early Extubation After Elective Infratentorial Craniotomy: Results of the International PRICE Survey.

Gaudet, John G / Levy, Camille S / Jakus, Lien / Goettel, Nicolai / Meling, Torstein R / Quintard, Hervé

2022 Volume 36, Issue 1, Page(s) 69–73

Abstract: Background: Early extubation, defined as removal of the endotracheal tube at the end of surgery before transfer to a designated postoperative care area, is associated with better outcomes after elective infratentorial craniotomy. The Predicting ... ...

Abstract	Background: Early extubation, defined as removal of the endotracheal tube at the end of surgery before transfer to a designated postoperative care area, is associated with better outcomes after elective infratentorial craniotomy. The Predicting Infratentorial Craniotomy Extubation (PRICE) project was an international survey designed to estimate the rate of early extubation after elective infratentorial craniotomy, as reported by neuroanesthesiologists, neurosurgeons, and neurocritical care specialists. Methods: Following research ethics board waiver, the 15-question online PRICE survey was circulated to the members of 5 international medical societies over a 15-week period. Results: One hundred and ninety of 5453 society members completed the survey (3.5% response rate). Respondents represented a total of 99 institutions from 92 cities, in 27 countries. While 84 of 188 (44.7%) respondents reported achieving early extubation in more than 95% of cases, 43 of 188 (22.9%) reported extubating fewer than 75% of cases early. The proportion of physicians who reported extubating at least 75% of cases early was greater in high-volume compared with low-volume institutions (73.5% vs. 50.9%, respectively; P =0.003) and among anesthesiologists compared with other specialties (75.6% vs. 45.6%, respectively; P <0.001). Preoperative bulbar dysfunction, preoperative altered consciousness and the course of surgery were the 3 factors with the biggest impact on the decision to extubate early versus late among respondents. Conclusions: The reported rate of early extubation after elective infratentorial craniotomy varies widely between institutions, with respondents from high-volume institutions reporting greater rates of early extubation than those from lower-volume centers. The course of surgery, evidence of bulbar dysfunction, and altered consciousness, appear to affect the decision to extubate early more than other predictors.
MeSH term(s)	Humans ; Craniotomy/methods ; Airway Extubation/methods ; Neurosurgeons ; Postoperative Care ; Surveys and Questionnaires
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1018119-2
ISSN	1537-1921 ; 0898-4921
ISSN (online)	1537-1921
ISSN	0898-4921
DOI	10.1097/ANA.0000000000000894
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Article ; Online: The Enhanced Recovery After Surgery protocol for the perioperative management of pituitary neuroendocrine tumors/pituitary adenomas.

Cossu, Giulia / Belouaer, Amani / Kloeckner, Julie / Caliman, Catalina / Agri, Fabio / Daniel, Roy Thomas / Gaudet, John G / Papadakis, Georgios E / Messerer, Mahmoud

Neurosurgical focus

2023 Volume 55, Issue 6, Page(s) E9

Abstract: Objective: Enhanced Recovery After Surgery (ERAS) is a multimodal perioperative care pathway that has radically modified the management of patients in multiple surgical specialties. Until now, no ERAS Society guidelines have been formulated for the ... ...

Abstract	Objective: Enhanced Recovery After Surgery (ERAS) is a multimodal perioperative care pathway that has radically modified the management of patients in multiple surgical specialties. Until now, no ERAS Society guidelines have been formulated for the management of cranial pathologies. During the process of ERAS certification for their neurosurgical department, the authors formulated an ERAS protocol for the perioperative care of patients with pituitary neuroendocrine tumors (PitNET), along with a compliance checklist to monitor the adherence to it and its feasibility. The authors describe the protocol and checklist and report the results, including a cost-minimization analysis, with the application of the ERAS philosophy. Methods: The steps that led to the development of this ERAS protocol, including items concerning the preoperative, intraoperative, and postoperative period, are detailed. The authors report their preliminary results through the comparison of the care practice of a historical cohort with a consecutive surgical cohort of patients with PitNET who underwent operation after the implementation of this ERAS protocol. A compliance checklist with key performance indicators was useful to monitor the adherence to the protocol and the changes in the perioperative management. Results: Following the introduction of this ERAS protocol, the authors significantly shortened the duration of the antibiotic therapy (p < 0.00001) and increased the use of mechanical (p < 0.00001) and pharmacological measures to prevent deep venous thrombosis (p = 0.002). The median length of hospital stay was significantly shorter for the ERAS group (p = 0.00014), and there was no increase in readmission rate or postoperative complications. The documentation and data tracking strongly improved in the ERAS cohort and the authors were more attentive in pain evaluation (p = 0.001), postoperative hormonal supplementation (p = 0.001) and early feeding and mobilization (p = 0.0008 and p < 0.00001, respectively). More patients were discharged on day 3 after surgery in the ERAS group (p < 0.00001). The compliance to the whole process increased from 64.2% to 89.5% (p = 0.016), and the compliance per patient was also found to have significantly increased (p < 0.00001). Conclusions: The introduction of a standardized ERAS protocol for the perioperative management of patients with PitNET allowed the authors to improve the multidisciplinary management of these patients. With the application of simple cost-effective interventions and with the avoidance of unnecessary measures, gains were made in terms of early mobilization and feeding, thereby resulting in a shorter in-hospital stay.
MeSH term(s)	Humans ; Enhanced Recovery After Surgery ; Pituitary Neoplasms/surgery ; Neuroendocrine Tumors/surgery ; Perioperative Care ; Postoperative Complications/prevention & control ; Length of Stay
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2023.9.FOCUS23529
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Article ; Online: Evolocumab in paediatric heterozygous familial hypercholesterolaemia: cognitive function during 80 weeks of open-label extension treatment.

Santos, Raul D / Ruzza, Andrea / Wang, Bei / Maruff, Paul / Schembri, Adrian / Bhatia, Ajay K / Mach, François / Bergeron, Jean / Gaudet, Isabelle / St Pierre, Julie / Kastelein, John J P / Hovingh, G Kees / Wiegman, Albert / Gaudet, Daniel / Raal, Frederick J

European journal of preventive cardiology

2023 Volume 31, Issue 3, Page(s) 302–310

Abstract: Aims: PCSK9 inhibition intensively lowers low density lipoprotein cholesterol and is well tolerated in adults and paediatric patients with familial hypercholesterolaemia (FH). HAUSER-RCT showed that 24 weeks of treatment with evolocumab in paediatric ... ...

Abstract	Aims: PCSK9 inhibition intensively lowers low density lipoprotein cholesterol and is well tolerated in adults and paediatric patients with familial hypercholesterolaemia (FH). HAUSER-RCT showed that 24 weeks of treatment with evolocumab in paediatric patients did not affect cognitive function. This study determined the effects of 80 additional weeks of evolocumab treatment on cognitive function in paediatric patients with heterozygous FH. Methods and results: HAUSER-OLE was an 80-week open-label extension of HAUSER-RCT, a randomized, double-blind, 24-week trial evaluating the efficacy and safety of evolocumab in paediatric patients (ages 10-17 years) with FH. During the OLE, all patients received monthly 420 mg subcutaneous evolocumab injections. Tests of psychomotor function, attention, visual learning, and executive function were administered at baseline and Weeks 24 and 80 of the OLE. Changes over time were analysed descriptively and using analysis of covariance. Cohen's d statistic was used to evaluate the magnitude of treatment effects. Analysis of covariance results indicated no decrease in performance across visits during 80 weeks of evolocumab treatment for Groton Maze Learning, One Card Learning accuracy, Identification speed, or Detection speed (all P > 0.05). Performance on all tasks was similar for those who received placebo or evolocumab in the RCT (all P > 0.05). For all tests, the least square mean differences between patients who received placebo vs. evolocumab in the parent study were trivial (all Cohen's d magnitude < 0.2). Conclusion: In paediatric patients with FH, 80 weeks of open-label evolocumab treatment had no negative impact on cognitive function. Registration: ClinicalTrials.gov identifier: NCT02624869.
MeSH term(s)	Adult ; Humans ; Child ; Proprotein Convertase 9 ; Anticholesteremic Agents/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/drug therapy ; Cognition ; Treatment Outcome ; Double-Blind Method ; Antibodies, Monoclonal, Humanized
Chemical Substances	evolocumab (LKC0U3A8NJ) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Anticholesteremic Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-10-17
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwad332
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Article ; Online: Implementation of the Enhanced Recovery After Surgery (ERAS®) program in neurosurgery.

Belouaer, Amani / Cossu, Giulia / Papadakis, Georgios E / Gaudet, John G / Perez, Maria-Helena / Chanez, Vivianne / Boegli, Yann / Mury, Caroline / Peters, David / Addor, Valérie / Levivier, Marc / Daniel, Roy Thomas / Demartines, Nicolas / Messerer, Mahmoud

Acta neurochirurgica

2023 Volume 165, Issue 11, Page(s) 3137–3145

Abstract: Background: Over the past decade, Enhanced Recovery After Surgery (ERAS®) guidelines have been proven to simplify postoperative care and improve recovery in several surgical disciplines. The authors set out to create and launch an ERAS® program for ... ...

Abstract	Background: Over the past decade, Enhanced Recovery After Surgery (ERAS®) guidelines have been proven to simplify postoperative care and improve recovery in several surgical disciplines. The authors set out to create and launch an ERAS® program for cranial neurosurgery that meets official ERAS® Society standards. The authors summarize the successive steps taken to achieve this goal in two specific neurosurgical conditions and describe the challenges they faced. Methods: Pituitary neuroendocrine tumors (Pit-NET) resected by a transsphenoidal approach and craniosynostosis (Cs) repair were selected as appropriate targets for the implementation of ERAS® program in the Department of Neurosurgery. A multidisciplinary team with experience in managing these pathologies was created. A specialized ERAS® nurse coordinator was hired. An ERAS® certification process was performed involving 4 seminars separated by 3 active phases under the supervision of an ERAS® coach. Results: The ERAS® Pit-NET team included 8 active members. The ERAS® Cs team included 12 active members. Through the ERAS® certification process, areas for improvement were identified, local protocols were written, and the ERAS® program was implemented. Patient-centered strategies were developed to increase compliance with the ERAS® protocols. A prospective database was designed for ongoing program evaluation. Certification was achieved in 18 months. Direct costs and time requirements are reported. Conclusion: Successful ERAS® certification requires a committed multidisciplinary team, an ERAS® coach, and a dedicated nurse coordinator.
MeSH term(s)	Humans ; Enhanced Recovery After Surgery ; Neurosurgery ; Postoperative Care ; Neurosurgical Procedures ; Recovery of Function ; Length of Stay ; Postoperative Complications
Language	English
Publishing date	2023-09-09
Publishing country	Austria
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05789-y
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Article: Cognitive function with evolocumab in pediatric heterozygous familial hypercholesterolemia.

Gaudet, Daniel / Ruzza, Andrea / Bridges, Ian / Maruff, Paul / Schembri, Adrian / Hamer, Andrew / Mach, François / Bergeron, Jean / Gaudet, Isabelle / Pierre, Julie St / Kastelein, John J P / Hovingh, G Kees / Wiegman, Albert / Raal, Frederick J / Santos, Raul D

Journal of clinical lipidology

2022 Volume 16, Issue 5, Page(s) 676–684

Abstract: Background: Evolocumab is a fully human monoclonal antibody inhibitor of PCSK9 approved for lowering low-density lipoprotein cholesterol in adults and pediatric patients with familial hypercholesterolemia (FH). The cognitive safety of evolocumab has ... ...

Abstract	Background: Evolocumab is a fully human monoclonal antibody inhibitor of PCSK9 approved for lowering low-density lipoprotein cholesterol in adults and pediatric patients with familial hypercholesterolemia (FH). The cognitive safety of evolocumab has been established in adults but has not yet been described in pediatric patients. Objective: To determine the effects of evolocumab on cognitive function in pediatric heterozygous FH. Methods: Cognitive function was assessed during a 24-week, randomized, double-blind, placebo-controlled study (HAUSER-RCT) evaluating the efficacy, safety, and tolerability of 24 weeks of monthly subcutaneous injections of evolocumab in pediatric patients with FH. Cognitive safety endpoints included changes from baseline to week 24 in test scores in domains of psychomotor function, attention, visual learning, and executive function. Between-group differences in age-standardized mean test score changes were analyzed using analysis of covariance models and point estimates with 95% confidence interval (CI). Magnitudes of difference between treatment groups (Cohen's d) and reliable change indices were calculated for each cognitive function test. Results: At week 24, changes from baseline in age-standardized cognitive test scores were similar between the treatment groups. Differences (95% CI) between the evolocumab and placebo groups in mean test score changes for the Groton Maze Learning, One-Card Learning, Identification, and Detection tests were 0.1 (-0.2, 0.4), -0.1 (-0.5, 0.4), 0.3 (0.0, 0.7), 0.3 (-0.1, 0.8), respectively. For all tests, abnormal and clinically important cognitive decline occurred with lesser frequency in the evolocumab group. Conclusion: In pediatric patients with FH, 24-week treatment with evolocumab did not negatively influence cognition. Funding: This study was funded and designed by Amgen.
MeSH term(s)	Adult ; Humans ; Child ; Proprotein Convertase 9 ; Hyperlipoproteinemia Type II/drug therapy ; Cognition ; Anticholesteremic Agents/therapeutic use ; Treatment Outcome
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; evolocumab (LKC0U3A8NJ) ; Anticholesteremic Agents
Language	English
Publishing date	2022-07-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2022.07.005
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Article ; Online: Three-Minute Diagnostic Assessment for Delirium using the Confusion Assessment Method (3D-CAM): French translation and cultural adaptation.

Gaudet, John G / Kull, Corey / Eskenazi, Marc L / Diaper, John / Maillard, Julien / Mollard, Florence / Marti, Christophe / Marcantonio, Edward R / Courvoisier, Delphine S / Walder, Bernhard

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2022 Volume 69, Issue 6, Page(s) 726–735

Abstract: Purpose: The routine use of validated diagnostic instruments is key to identifying delirious patients early and expediting care. The 3-Minute Diagnostic Assessment for Delirium using the Confusion Assessment Method (3D-CAM) instrument is a brief, easy ... ...

Title translation	Évaluation diagnostique de l'état confusionnel de l'instrument 3D-CAM: traduction française et adaptation culturelle.
Abstract	Purpose: The routine use of validated diagnostic instruments is key to identifying delirious patients early and expediting care. The 3-Minute Diagnostic Assessment for Delirium using the Confusion Assessment Method (3D-CAM) instrument is a brief, easy to use, sensitive, and specific delirium assessment tool for hospitalized patients. We aimed to translate the original English version into French, and then adapt it to older high-risk patients. Methods: Translation and adaptation of the questionnaire were guided by an expert committee and the 3D-CAM instrument developer. During the translation phase, we achieved semantic and conceptual equivalence of the instrument by conducting forward and backward translations. During the adaptation phase, we assessed the face validity, clarity of wording, and ease of use of the translated questionnaire by administering it to 30 patients and their caregivers in peri-interventional and medical intermediate care units. During both phases, we used qualitative (goal and adequacy of the questionnaire) and quantitative (Sperber score, clarity score) criteria. Results: Translation: four items were judged inadequate and were revised until all reached a Sperber score of < 3/7. Face validity: 91% of patients thought the questionnaire was designed to assess memory, thoughts, or reasoning. Clarity: eight items required adjustments until all scored ≥ 9/10 for clarity. Ease of use: all bedside caregivers reported that the questionnaire was easy to complete after receiving brief instructions. Conclusions: We produced a culturally adapted French version of the 3D-CAM instrument that is well understood and well-received by older high-risk patients and their caregivers.
MeSH term(s)	Delirium/diagnosis ; Humans ; Reproducibility of Results ; Surveys and Questionnaires ; Translations
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-022-02232-1
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Article: Sex differences in the presentation, treatment and outcomes of patients with homozygous familial hypercholesterolemia.

Al-Baldawi, Zobaida / Brown, Leslie / Ruel, Isabelle / Baass, Alexis / Bergeron, Jean / Cermakova, Lubomira / Couture, Patrick / Gaudet, Daniel / Francis, Gordon A / Hegele, Robert A / Iatan, Iulia / Mancini, G B John / McCrindle, Brian W / Ransom, Thomas / Sherman, Mark H / McPherson, Ruth / Genest, Jacques / Brunham, Liam R

Journal of clinical lipidology

2024

Abstract: Background: Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal semi-dominant lipid metabolism disorder characterized by extremely high LDL-C levels and premature cardiovascular disease. The objective of this study was to investigate ... ...

Abstract	Background: Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal semi-dominant lipid metabolism disorder characterized by extremely high LDL-C levels and premature cardiovascular disease. The objective of this study was to investigate sex-differences in the treatment and outcomes of patients with HoFH. Methods: We examined clinical characteristics, lipid-lowering therapy (LLT), and cardiovascular events using descriptive statistics of patients in the Canadian HoFH registry. Major adverse cardiovascular events (MACE) were defined as the composite of cardiovascular death, non-fatal myocardial infarction, and stroke. Sex differences between continuous and categorical variables were analyzed using Mann-Whitney U test and Fisher's Exact test, respectively. Results: This study included 48 patients (27 (56%) female). The median age at diagnosis in females was 14.0 (IQR 9.0-30.0) and in males was 8.0 (IQR 2.0-23.0) (p = 0.07). Baseline clinical characteristics were comparable between both sexes. The median baseline LDL-C was 12.7 (10.0-18.3) in females and 15.3 (10.5-20.0) in males (p = 0.51). Follow up LDL-C levels was 7.6 mmol/L (IQR 4.8-11.0) in females and 6.3 (IQR 4.6-7.5) in males (p = 0.1). Most patients were taking 3 or more LLTs, with comparable proportions in both sexes (p = 0.26). Apheresis was similar in both sexes, 14 (51.8%) vs. 10 (47.6%), p = 0.2. Over a mean of 10 years of follow-up, MACE occurred in 3 females (11.1%) and 4 males (19.1%) (p = 0.2). Conclusion: Lipid levels and treatment were similar between sexes. MACE occurred in similar proportions between sexes, indicating that HoFH offsets the inherently lower cardiovascular risk in pre-menopausal females. Further investigation into sex-differences in HoFH in larger sample sizes is warranted.
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2365061-8
ISSN	1876-4789 ; 1933-2874
ISSN (online)	1876-4789
ISSN	1933-2874
DOI	10.1016/j.jacl.2024.01.003
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Article ; Online: Comparison of two simple models for prediction of short term mortality in patients after severe traumatic brain injury.

Rached, Mohamed A K B / Gaudet, John G / Delhumeau, Cecile / Walder, Bernhard

Injury

2018 Volume 50, Issue 1, Page(s) 65–72

Abstract: Introduction: The subscale motor score of Glasgow Coma Scale (msGCS) and the Abbreviated Injury Score of head region (HAIS) are validated prognostic factors in traumatic brain injury (TBI). The aim was to compare the prognostic performance of a HAIS- ... ...

Abstract	Introduction: The subscale motor score of Glasgow Coma Scale (msGCS) and the Abbreviated Injury Score of head region (HAIS) are validated prognostic factors in traumatic brain injury (TBI). The aim was to compare the prognostic performance of a HAIS-based prediction model including HAIS, pupil reactivity and age, and the reference prediction model including msGCS in emergency department (ED), pupil reactivity and age. Methods: Secondary analysis of a prospective epidemiological study including patients after severe TBI (HAIS > 3) with follow-up from the time of accident until 14 days or earlier death was performed in Switzerland. Performance of prediction, based on accuracy of discrimination [area under the receiver-operating curve (AUROC)], calibration (Hosmer-Lemeshow test) and validity (bootstrapping with 2000 repetitions to correct) for optimism of the two prediction models were investigated. A non-inferiority approach was performed and an a priori threshold for important differences was established. Results: The cohort included 808 patients [median age 56 {inter-quartile range (IQR) 33-71}, median motor part of GCS in ED 1 (1-6), abnormal pupil reactivity 29.0%] with a death rate of 29.7% at 14 days. The accuracy of discrimination was similar (AUROC HAIS-based prediction model: 0.839; AUROC msGCS-based prediction model: 0.826, difference of the 2 AUROC 0.013 (-0.007 to 0.037). A similar calibration was observed (Hosmer-Lemeshow X Conclusions: Performance of prediction for short-term mortality after severe TBI with HAIS-based prediction model was non-inferior to reference prediction model using msGCS as predictor.
MeSH term(s)	Adult ; Aged ; Area Under Curve ; Brain Injuries, Traumatic/mortality ; Female ; Glasgow Coma Scale ; Humans ; Injury Severity Score ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Reproducibility of Results
Language	English
Publishing date	2018-09-03
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2018.08.022
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Article ; Online: Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells.

Gaudet, Ryan G / Bradfield, Clinton J / MacMicking, John D

Microbiology spectrum

2017 Volume 4, Issue 6

Abstract: Specialized adaptations for killing microbes are synonymous with phagocytic cells including macrophages, monocytes, inflammatory neutrophils, and eosinophils. Recent genome sequencing of extant species, however, reveals that analogous antimicrobial ... ...

Abstract	Specialized adaptations for killing microbes are synonymous with phagocytic cells including macrophages, monocytes, inflammatory neutrophils, and eosinophils. Recent genome sequencing of extant species, however, reveals that analogous antimicrobial machineries exist in certain non-immune cells and also within species that ostensibly lack a well-defined immune system. Here we probe the evolutionary record for clues about the ancient and diverse phylogenetic origins of macrophage killing mechanisms and how some of their properties are shared with cells outside the traditional bounds of immunity in higher vertebrates such as mammals.
MeSH term(s)	Animals ; Biological Evolution ; Humans ; Macrophages/immunology ; Microbial Viability ; Phagocytosis
Language	English
Publishing date	2017-01-16
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2165-0497
ISSN (online)	2165-0497
DOI	10.1128/microbiolspec.MCHD-0050-2016
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Article ; Online: Prolonged Opioid Use and Pain Outcome and Associated Factors after Surgery under General Anesthesia: A Prospective Cohort Association Multicenter Study.

Kuck, Kai / Naik, Bhiken I / Domino, Karen B / Posner, Karen L / Saager, Leif / Stuart, Ami R / Johnson, Ken B / Alpert, Salome B / Durieux, Marcel E / Sinha, Anik K / Brummett, Chad M / Aziz, Michael F / Cummings, Kenneth C / Gaudet, John G / Kurz, Andrea / Rijsdijk, Mienke / Wanderer, Jonathan P / Pace, Nathan L

Anesthesiology

2023 Volume 138, Issue 5, Page(s) 462–476

MeSH term(s)	Humans ; Female ; Analgesics, Opioid/adverse effects ; Prospective Studies ; Breast Neoplasms ; Pain, Postoperative/drug therapy ; Mastectomy ; Opioid-Related Disorders/drug therapy ; Anesthesia, General
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004510
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