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Article ; Online: Symptoms of gait and coordination impairment in a patient with COVID-19 interstitial pneumonia.

Pistoia, Francesca / Ornello, Raffaele / Sucapane, Patrizia / Marini, Carmine / Sacco, Simona

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 42, Issue 8, Page(s) 3083–3086

MeSH term(s)	Ataxia ; COVID-19 ; Gait ; Humans ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/diagnostic imaging ; SARS-CoV-2
Language	English
Publishing date	2021-05-22
Publishing country	Italy
Document type	Letter
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05341-9
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Article ; Online: Hyperkalaemia in Cardiological Patients: New Solutions for an Old Problem.

Abrignani, Maurizio Giuseppe / Gronda, Edoardo / Marini, Marco / Gori, Mauro / Iacoviello, Massimo / Temporelli, Pier Luigi / Benvenuto, Manuela / Binaghi, Giulio / Cesaro, Arturo / Maloberti, Alessandro / Tinti, Maria Denitza / Riccio, Carmine / Colivicchi, Furio / Grimaldi, Massimo / Gabrielli, Domenico / Oliva, Fabrizio

Cardiovascular drugs and therapy

2024

Abstract: Hyperkalaemia is one of the most common electrolyte disorders in patients with cardiovascular disease (CVD). The true burden of hyperkalaemia in the real-world setting can be difficult to assess, but in population-based cohort studies up to 4 in 10 ... ...

Abstract	Hyperkalaemia is one of the most common electrolyte disorders in patients with cardiovascular disease (CVD). The true burden of hyperkalaemia in the real-world setting can be difficult to assess, but in population-based cohort studies up to 4 in 10 patients developed hyperkalaemia. In addition to drugs interfering with potassium metabolism and food intake, several conditions can cause or worsen hyperkalaemia, such as advanced age, diabetes, and chronic kidney disease. Mortality, cardiovascular morbidity, and hospitalisation are higher in patients with hyperkalaemia. Hyperkalaemia represents a major contraindication or a withholding cause for disease-modifying therapies like renin-angiotensin-aldosterone inhibitors (RAASi), mainly mineralocorticoid receptor antagonists. Hyperkalaemia can be also classified as acute and chronic, according to the onset. Acute hyperkalaemia is often a life-threatening emergency requiring immediate treatment to avoid lethal arrhythmias. Therapy goal is cell membrane stabilisation by calcium administration, cellular intake, shift of extracellular potassium to the intracellular space (insulin, beta-adrenergic agents, sodium bicarbonate), and increased elimination with diuretics or dialysis. Chronic hyperkalaemia was often managed with dietary counselling to prevent potassium-rich food intake and tapering of potassium-increasing drugs, mostly RAASi. Sodium polystyrene sulphonate, a potassium binder, was the only therapeutic option. Recently, new drugs such as patiromer and sodium zirconium cyclosilicate give new opportunities for the treatment of hyperkalaemia, as they proved to be safe, well tolerated, and effective. Aim of this review is to describe the burden of hyperkalaemia in cardiovascular patients, its direct and indirect effects, and the therapeutic options now available in the acute and chronic setting.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-024-07551-7
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Article: Multiple sclerosis--new treatment modalities.

Totaro, Rocco / Di Carmine, Caterina / Marini, Carmine / Carolei, Antonio

The Indian journal of medical research

2016 Volume 142, Issue 6, Page(s) 647–654

Abstract: Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate ...

Abstract	Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate treatment to the right patient at the right time. The purpose of this review is to describe novel agents recently approved for multiple sclerosis treatment, namely teriflunomide, alemtuzumab and dimethylfumarate, focusing on mechanism of action, efficacy data in experimental setting, safety and tolerability. The place in therapy of newer treatment implies careful balancing of risk-benefit profile as well as accurate patient selection. Hence the widening of therapeutic arsenal provides greater opportunity for personalized therapy but also entails a complex trade-off between efficacy, tolerability, safety and eventually patient preference.
MeSH term(s)	Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials as Topic ; Humans ; Multiple Sclerosis/drug therapy
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2016-02-01
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
DOI	10.4103/0971-5916.174543
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Article ; Online: Advanced argillic alteration at Cave di Caolino, Lipari, Aeolian Islands (Italy): Implications for the mitigation of volcanic risks and the exploitation of geothermal resources.

Apollaro, Carmine / Fuoco, Ilaria / Gennaro, Emanuela / Giuliani, Letizia / Iezzi, Gianluca / Marini, Luigi / Radica, Francesco / Di Luccio, Francesca / Ventura, Guido / Vespasiano, Giovanni

The Science of the total environment

2023 Volume 889, Page(s) 164333

Abstract: Four sites in the western sector of Lipari Island with still active hydrothermal activity are here considered. The petrography (mesoscopic observations and XRPD) and geochemistry (major, minor and trace elements chemistry) of ten representative and ... ...

Abstract	Four sites in the western sector of Lipari Island with still active hydrothermal activity are here considered. The petrography (mesoscopic observations and XRPD) and geochemistry (major, minor and trace elements chemistry) of ten representative and extremely altered volcanic rocks were characterized. Two types of parageneses of altered rocks are discriminable, one rich in silicate phases (opal/cristobalite, montmorillonite, kaolinite, alunite and hematite) and one in sulphates (gypsum, plus minor amounts of anhydrite or bassanite). The altered silicate-rich rocks are rich in SiO
MeSH term(s)	Calcium Sulfate ; Kaolin ; Silicon Dioxide ; Steam ; Islands ; Silicates/chemistry ; Minerals/analysis ; Sulfates
Chemical Substances	alunite ; Calcium Sulfate (WAT0DDB505) ; Kaolin (24H4NWX5CO) ; Silicon Dioxide (7631-86-9) ; Steam ; Silicates ; Minerals ; Sulfates
Language	English
Publishing date	2023-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164333
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Article ; Online: Long-Term Clinical and Radiographic Analysis of Platform Matching and Platform Switching Implants in the Esthetic Zone

Andrea Raco / Bianca Di Murro / Pier Carmine Passarelli / Antonio D’Addona / Andrea Pilloni / Lorenzo Marini / Piero Papi

Applied Sciences, Vol 13, Iss 1, p

A Retrospective Cohort Study

2023 Volume 661

Abstract: Background: The aims of this study are to retrospectively compare the clinical, radiographic and esthetic outcomes of platform switching (PS) and platform matching (PM) dental implants in the anterior maxilla after ≥ 10 years of functional loading. ... ...

Abstract	Background: The aims of this study are to retrospectively compare the clinical, radiographic and esthetic outcomes of platform switching (PS) and platform matching (PM) dental implants in the anterior maxilla after ≥ 10 years of functional loading. Methods: Marginal bone loss (MBL) levels were recorded; furthermore, peri-implant clinical parameters (PPD, BOP, PI) were collected and the Pink and White Esthetic scores (PES/WES) were used to evaluate the esthetic outcomes. Wilcoxon signed rank tests were performed to compare collected parameters among the two groups, with a p -value < 0.05. Results: A final sample of 58 patients was enrolled in this study (PM implants = 29; PS implants = 29). PS implants showed lower MBL levels (1.02 ± 0.81 mm vs. 1.67 ± 0.99 mm, p = 0.028) and PPD values (3.69 ± 1.1 vs. 5.16 ± 1.09 mm, p < 0.001) compared to PM implants. Mean PES values were higher in the PS group compared to the PM group (8.46 ± 0.69 vs. 7.89 ± 0.78, p < 0.005), while there were no differences for WES values (7.82 ± 1.09 vs. 7.71 ± 0.85, p > 0.05) and peri-implant diseases’ prevalence ( p > 0.05). Conclusions: After 10 years, PS implants showed statistically significant lower MBL and PPD values and higher PES values compared to PM implants.
Keywords	dental implants ; esthetics ; implant-supported crown ; platform matching implants ; platform switching implants ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Point-Of-Care low-field MRI in acute Stroke (POCS): protocol for a multicentric prospective open-label study evaluating diagnostic accuracy.

BMJ open

2024 Volume 14, Issue 1, Page(s) e075614

Abstract: Introduction: Fast and accurate diagnosis of acute stroke is crucial to timely initiate reperfusion therapies. Conventional high-field (HF) MRI yields the highest accuracy in discriminating early ischaemia from haemorrhages and mimics. Rapid access to ... ...

Abstract	Introduction: Fast and accurate diagnosis of acute stroke is crucial to timely initiate reperfusion therapies. Conventional high-field (HF) MRI yields the highest accuracy in discriminating early ischaemia from haemorrhages and mimics. Rapid access to HF-MRI is often limited by contraindications or unavailability. Low-field (LF) MRI (<0.5T) can detect several types of brain injury, including ischaemic and haemorrhagic stroke. Implementing LF-MRI in acute stroke care may offer several advantages, including extended applicability, increased safety, faster administration, reduced staffing and costs. This multicentric prospective open-label trial aims to evaluate the diagnostic accuracy of LF-MRI, as a tool to guide treatment decision in acute stroke. Methods and analysis: Consecutive patients accessing the emergency department with suspected stroke dispatch will be recruited at three Italian study units: Azienda Sanitaria Locale (ASL) Abruzzo 1 and 2, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital. The estimated sample size is 300 patients. Anonymised clinical and LF-MRI data, along with conventional neuroimaging data, will be independently assessed by two external units: Marche Polytechnic University and 'G. Martino' Polyclinic University Hospital. Both units will independently adjudicate the best treatment option, while the latter will provide historical HF-MRI data to develop artificial intelligence algorithms for LF-MRI images interpretation (Free University of Bozen-Bolzano). Agreement with conventional neuroimaging will be evaluated at different time points: hyperacute, acute (24 hours), subacute (72 hours), at discharge and chronic (4 weeks). Further investigations will include feasibility study to develop a mobile stroke unit equipped with LF-MRI and cost-effectiveness analysis. This trial will provide necessary data to validate the use of LF-MRI in acute stroke care. Ethics and dissemination: The study was approved by the Research Ethics Committee of the Abruzzo Region (CEtRA) on 11 May 2023 (approval code: richyvgrg). Results will be disseminated in peer-reviewed journals and presented in academic conferences. Trial registration number: NCT05816213; Pre-Results.
MeSH term(s)	Humans ; Prospective Studies ; Artificial Intelligence ; Point-of-Care Systems ; Stroke/diagnostic imaging ; Stroke/therapy ; Magnetic Resonance Imaging ; Research Design ; Multicenter Studies as Topic
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075614
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Article ; Online: Real-world use of Safinamide in motor fluctuating Parkinson's disease patients in Italy.

Bovenzi, Roberta / Liguori, Claudio / Canesi, Margherita / D'Amelio, Marco / De Pandis, Maria Francesca / Marini, Carmine / Monge, Alessandra / Padovani, Alessandro / Tessitore, Alessandro / Stefani, Alessandro / Zappia, Mario

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 45, Issue 2, Page(s) 573–583

Abstract: Introduction: Safinamide is a recent antiparkinsonian drug that modulates both dopaminergic and glutamatergic systems with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). Here, we aimed to describe the efficacy and safety of ...

Abstract	Introduction: Safinamide is a recent antiparkinsonian drug that modulates both dopaminergic and glutamatergic systems with positive effects on motor and nonmotor symptoms of Parkinson's disease (PD). Here, we aimed to describe the efficacy and safety of safinamide in the Italian PD patients in real-life conditions. Methods: We performed a sub-analysis of the Italian cohort of the SYNAPSES study, a multi-country, multi-center, retrospective-prospective cohort observational study, designed to investigate the use of safinamide in routine clinical practice. Patients received for the first time a treatment with safinamide and were followed up for 12 months. The analysis was conducted on the overall population and in subgroups of interest: i) patients > 75 years, ii) patients with relevant comorbidities and iii) patients affected by psychiatric symptoms. Results: Italy enrolled 616/1610 patients in 52 centers, accounting for 38% of the entire SYNAPSES cohort. Of the patients enrolled, 86.0% were evaluable at 12 months, with 23.3% being > 75 years, 42.4% with psychiatric conditions and 67.7% with relevant comorbidities. Safinamide was effective on motor symptoms and fluctuations as measured through the Unified PD rating scale III and IV scores, and on the total score, without safety issues in none of the subgroups considered. Conclusion: The SYNAPSES data related to Italian patients confirms the good safety profile of safinamide even in special groups of patients. Motor fluctuations and motor impairment improved at the follow-up suggesting the significant role of safinamide in managing motor symptoms in PD patients.
MeSH term(s)	Humans ; Parkinson Disease/complications ; Parkinson Disease/drug therapy ; Retrospective Studies ; Prospective Studies ; Antiparkinson Agents/therapeutic use ; Alanine/adverse effects ; Levodopa/therapeutic use ; Benzylamines
Chemical Substances	safinamide (90ENL74SIG) ; Antiparkinson Agents ; Alanine (OF5P57N2ZX) ; Levodopa (46627O600J) ; Benzylamines
Language	English
Publishing date	2023-09-09
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-07001-6
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Article ; Online: Sialylation status in placentas from pregnancies with SARS-CoV-2 infection.

Perna, Angelica / Tani, Alessia / Sellitto, Carmine / Marini, Mirca / La Verde, Marco / De Luca, Antonio / Guerra, Germano / Lucariello, Angela / Manetti, Mirko / Sgambati, Eleonora

Tissue & cell

2023 Volume 82, Page(s) 102074

Abstract: Introduction: Recent investigations suggest the potential negative impact of SARS-CoV-2 infection on pregnant women and pregnancy outcome. In addition, some studies have described pathological changes in the placental tissue of SARS-CoV-2-positive ... ...

Abstract	Introduction: Recent investigations suggest the potential negative impact of SARS-CoV-2 infection on pregnant women and pregnancy outcome. In addition, some studies have described pathological changes in the placental tissue of SARS-CoV-2-positive mothers, which are related or not to the infection severity and/or infection trimester. Among the various molecules involved in the normal structure and functionality of the placenta, sialic acids (Sias) seem to play an important role. Hence, we aimed to investigate possible changes in the distribution and content of Sias with different glycosidic linkages, namely α2,3 and α2,6 Galactose- or N-acetyl-Galactosamine-linked Sias and polymeric Sia (PolySia), in placentas from pregnant women infected by SARS-CoV-2 during the three different pregnancy trimesters. Methods: α2,3 and α2,6 Galactose-linked Sias were evaluated by lectin histochemistry (Maackia amurensis agglutinin (MAA) and Sambucus nigra agglutinin (SNA), respectively), while immunohistochemistry was used for PolySia detection. Results: Data showed lower levels of α2,3 Galactose-linked Sias in the trophoblast and underlying basement membrane/basal plasma membrane in placentas from women infected during the second and third infection trimester compared with uninfected cases and those infected during first trimester. On the other hand, higher levels of PolySia were detected in the trophoblast during the second and third infection trimester. Conclusions: Our findings suggest that changes in the sialylation status of trophoblast and its basement membrane/basal plasma membrane, together with other concomitant factors, could be at the basis of the most common placental histopathological alterations and gestational complications found especially in pregnancies with SARS-CoV-2 infection during the second and third trimester.
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta/metabolism ; COVID-19/pathology ; SARS-CoV-2 ; Galactose/metabolism ; Agglutinins/metabolism
Chemical Substances	polysialic acid ; Galactose (X2RN3Q8DNE) ; Agglutinins
Language	English
Publishing date	2023-03-17
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102074
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Article ; Online: Advanced argillic alteration at Cave di Caolino, Lipari, Aeolian Islands (Italy): Implications for the mitigation of volcanic risks and the exploitation of geothermal resources

Apollaro, Carmine / Fuoco, Ilaria / Gennaro, Emanuela / Giuliani, Letizia / Iezzi, Gianluca / Marini, Luigi / Radica, Francesco / Di Luccio, Francesca / Ventura, Guido / Vespasiano, Giovanni

Science of the Total Environment. 2023 Sept., v. 889 p.164333-

2023

Abstract	Four sites in the western sector of Lipari Island with still active hydrothermal activity are here considered. The petrography (mesoscopic observations and XRPD) and geochemistry (major, minor and trace elements chemistry) of ten representative and extremely altered volcanic rocks were characterized. Two types of parageneses of altered rocks are discriminable, one rich in silicate phases (opal/cristobalite, montmorillonite, kaolinite, alunite and hematite) and one in sulphates (gypsum, plus minor amounts of anhydrite or bassanite). The altered silicate-rich rocks are rich in SiO₂, Al₂O₃, Fe₂O₃ and H₂O, and depleted in CaO, MgO, K₂O and Na₂O, while the sulphate-rich ones are extremely enriched in CaO and SO₄ in comparison with local unaltered volcanic rocks. The content of many incompatible elements is similar in altered silicate-rich rocks and lower in sulphate-rich ones with respect to the pristine volcanic rocks; conversely, almost all REEs are markedly enriched in silicate-rich rocks and heavy REEs are enriched in sulphate-rich altered rocks compared to unaltered volcanic rocks. Reaction path modelling of basaltic andesite dissolution in local steam condensate predicts the production of amorphous-silica, anhydrite, goethite, and kaolinite (or smectites and saponites) as stable secondary minerals and alunite, jarosite, and jurbanite as ephemeral minerals. Considering possible post-depositional reactions and admitting that the presence of two distinct parageneses is apparent, since gypsum is prone to form large crystals, it can be concluded that there is an excellent agreement between the alteration minerals occurring in nature and those predicted by geochemical modelling. Consequently, the modelled process is the main responsible for the production of the advanced argillic alteration assemblage of “Cave di Caolino” on Lipari Island. Since rock alteration is sustained by the H₂SO₄ solution produced by hydrothermal steam condensation, there is no need to invoke the involvement of SO₂-HCl-HF-bearing magmatic fluids, in line with the absence of fluoride minerals.
Keywords	alunite ; andesite ; anhydrite ; calcium oxide ; condensates ; environment ; fluorides ; geochemistry ; goethite ; gypsum ; hematite ; jarosite ; kaolinite ; montmorillonite ; opal ; silica ; silicates ; steam ; Aeolian Islands ; Italy ; Lipari volcano (Aeolian Islands) ; Altered and hydrothermal rocks ; Mineralogy ; Fluid/rock interaction ; Advanced argillic alteration
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164333
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Article ; Online: Gene- and Gender-Related Decrease in Serum BDNF Levels in Alzheimer's Disease.

Piancatelli, Daniela / Aureli, Anna / Sebastiani, Pierluigi / Colanardi, Alessia / Del Beato, Tiziana / Del Cane, Lorenza / Sucapane, Patrizia / Marini, Carmine / Di Loreto, Silvia

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer's disease (AD). Oxidative stress and inflammatory cytokines are potentially implicated in AD risk. In this study, BDNF was detected in serum of AD and mild cognitive impairment ( ... ...

Abstract	Brain-derived neurotrophic factor (BDNF) has a protective role in Alzheimer's disease (AD). Oxidative stress and inflammatory cytokines are potentially implicated in AD risk. In this study, BDNF was detected in serum of AD and mild cognitive impairment (MCI) patients and investigated in association with gene polymorphisms of BDNF (Val66Met and C270T), of some oxidative stress-related genes (FOXO3A, SIRT3, GLO1, and SOD2), and of interleukin-1 family genes (IL-1α, IL-1β, and IL-38). The APOE status and mini-mental state examination (MMSE) score were also evaluated. Serum BDNF was significantly lower in AD (
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232314599
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