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  1. Article ; Online: Indicators of hypercoagulability and recurrent venous thromboembolism in the elderly: rethinking age and thrombophilia.

    Middeldorp, Saskia

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 1, Page(s) 100056

    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.100056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Aspirin as Thromboprophylaxis in Orthopedic Surgery: A Matter of Perspective.

    Schutgens, Roger E G / Middeldorp, Saskia

    HemaSphere

    2023  Volume 7, Issue 8, Page(s) e933

    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Editorial
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Concerns about the ALIFE2 trial - Authors' reply.

    Quenby, Siobhan / Ewington, Lauren / Hamulyák, Eva / Scheres, Luuk J / Goddijn, Mariëtte / Middeldorp, Saskia

    Lancet (London, England)

    2024  Volume 403, Issue 10423, Page(s) 248

    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02336-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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  4. Article ; Online: Veneuze trombo-embolie bij antifosfolipidensyndroom.

    van Mens, Thijs E / Middeldorp, Saskia / Coppens, Michiel

    Nederlands tijdschrift voor geneeskunde

    2023  Volume 167

    Abstract: Antiphospholipid syndrome (APS) is an auto-immune syndrome defined by thrombosis and/or pregnancy morbidity in the persistent presence of antiphospholipid antibodies. Antiphospholipid antibodies are a group of antibodies predominantly directed at ... ...

    Title translation Venous thromboembolism and antiphospholipid syndrome - considerations on diagnosis and treatment.
    Abstract Antiphospholipid syndrome (APS) is an auto-immune syndrome defined by thrombosis and/or pregnancy morbidity in the persistent presence of antiphospholipid antibodies. Antiphospholipid antibodies are a group of antibodies predominantly directed at phospholipid-bound plasma proteins. The more antibodies a patient has the higher the risk of thrombosis. The origin of the antibodies and the precise prothrombotic mechanism are incompletely understood. A diagnosis of APS can in certain clinical scenarios implicate a longer treatment with anticoagulants after a venous thromboembolism. High level evidence is absent. In addition, APS patients with a high risk antibody profile had a higher risk of arterial thrombosis in randomized trials when treated with direct oral anticoagulants compared to vitamin K antagonists. The number needed to screen in light of these possible consequences of an APS diagnosis for treatment, appears to high to justify routine screening. In this review we suggest indications for APS testing in the context of venous thromboembolism.
    MeSH term(s) Pregnancy ; Female ; Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/drug therapy ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology ; Anticoagulants/therapeutic use ; Antibodies, Antiphospholipid/therapeutic use ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Antibodies, Antiphospholipid
    Language Dutch
    Publishing date 2023-03-16
    Publishing country Netherlands
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.18: Show issues Location:
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  5. Article ; Online: Thromboprophylaxis in critical care.

    Helms, Julie / Middeldorp, Saskia / Spyropoulos, Alex C

    Intensive care medicine

    2022  Volume 49, Issue 1, Page(s) 75–78

    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/drug therapy ; Palliative Care ; Critical Care
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06850-7
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    Zs.A 1089: Show issues Location:
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  6. Article ; Online: Transgender health and haematology-a matter of respect.

    Connors, Jean M / Middeldorp, Saskia

    The Lancet. Haematology

    2020  Volume 7, Issue 5, Page(s) e367

    MeSH term(s) Hematology ; Humans ; Transgender Persons
    Language English
    Publishing date 2020-03-30
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30107-1
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  7. Article ; Online: VTE Risk Assessment and Prevention in Pregnancy.

    O'Rourke, Ellen / Faryal, Rehman / Blondon, Marc / Middeldorp, Saskia / Ní Áinle, Fionnuala

    Hamostaseologie

    2024  

    Abstract: Venous thromboembolism (VTE) remains the leading cause of maternal mortality in pregnancy and the postpartum period. In addition to the higher pregnancy-associated baseline VTE risk, there are several well-established risk factors that can further ... ...

    Abstract Venous thromboembolism (VTE) remains the leading cause of maternal mortality in pregnancy and the postpartum period. In addition to the higher pregnancy-associated baseline VTE risk, there are several well-established risk factors that can further increase the risk of VTE. At present, a thorough interrogation of these risk factors remains our only tool for estimating which pregnant people may be at an increased risk of VTE, and thus potentially benefit from thromboprophylaxis. However, an important knowledge gap still exists surrounding the duration of increased risk and the interaction of risk factors with each other. Furthermore, up to now, once significant risk has been established, prevention strategies have been largely based on expert opinion rather than high-quality data. Recent trials have successfully bridged a proportion of this knowledge gap; however, the challenge of conducting high-quality clinical trials with pregnant people remains. In this article, we provide an update on the recent evidence surrounding VTE risk factors in pregnancy while concurrently outlining knowledge gaps and current approaches to VTE prevention.
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-2238-4681
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    Zs.A 1631: Show issues Location:
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  8. Article ; Online: Inherited thrombophilia: a double-edged sword.

    Middeldorp, Saskia

    Hematology. American Society of Hematology. Education Program

    2016  Volume 2016, Issue 1, Page(s) 1–9

    Abstract: Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad ... ...

    Abstract Inherited thrombophilia is a blood coagulation disorder that increases the risk for venous thromboembolism (VTE). During the last decades, the practice of testing has evolved from testing selected populations, leading to high perceived risks, to broad testing for various conditions that included VTE, arterial thrombosis, and pregnancy complications. Because results of such tests usually do not guide treatment decisions, not testing patients with VTE for inherited thrombophilia is on the "Choosing Wisely" list endorsed by multiple specialty societies, including ASH. Inherited thrombophilia can be regarded a double-edged sword, as despite the rationale not to test, it is still being performed frequently. Another way of seeing inherited thrombophilia as a double-edged sword lies in its 2-sided association with reproduction, both in men and in women. Current areas of research are whether women with inherited thrombophilia and pregnancy complications benefit from anticoagulant therapy with regard to improving the chance of a successful pregnancy. Potential effects of inherited thrombophilia, most notably factor V Leiden, on improved embryo implantation in women and sperm counts in men are intriguing, but are currently poorly understood.
    MeSH term(s) Female ; Humans ; Male ; Pregnancy ; Pregnancy Complications, Hematologic/diagnosis ; Pregnancy Complications, Hematologic/etiology ; Pregnancy Complications, Hematologic/therapy ; Risk Factors ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Thrombophilia/therapy ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology ; Venous Thromboembolism/therapy
    Language English
    Publishing date 2016-12-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-4383
    ISSN (online) 1520-4383
    DOI 10.1182/asheducation-2016.1.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Thrombophilia, Thrombosis and Thromboprophylaxis in Pregnancy: For What and in Whom?

    Middeldorp, Saskia / Naue, Christiane / Köhler, Christina

    Hamostaseologie

    2022  Volume 42, Issue 1, Page(s) 54–64

    Abstract: Compared with nonpregnant women, pregnancy carries a four- to fivefold higher risk of venous thromboembolism (VTE). Despite increasing use of heparin prophylaxis in identified high-risk patients, pulmonary embolism still is the leading cause of maternal ... ...

    Abstract Compared with nonpregnant women, pregnancy carries a four- to fivefold higher risk of venous thromboembolism (VTE). Despite increasing use of heparin prophylaxis in identified high-risk patients, pulmonary embolism still is the leading cause of maternal mortality in the western world. However, evidence on optimal use of thromboprophylaxis is scarce. Thrombophilia, the hereditary or acquired tendency to develop VTE, is also thought to be associated with complications in pregnancy, such as recurrent miscarriage and preeclampsia. In this review, the current evidence on optimal thromboprophylaxis in pregnancy is discussed, focusing primarily on VTE prevention strategies but also discussing the potential to prevent recurrent pregnancy complications with heparin in pregnant women with thrombophilia.
    MeSH term(s) Anticoagulants/therapeutic use ; Female ; Heparin/therapeutic use ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Pregnancy ; Risk Factors ; Thrombophilia/complications ; Thrombophilia/diagnosis ; Thrombophilia/drug therapy ; Thrombosis/drug therapy ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants ; Heparin, Low-Molecular-Weight ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-02-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/a-1717-7663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1631: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Factor XI-remmers: de heilige graal voor antistolling?

    Harskamp, Ralf E / Middeldorp, Saskia / De Groot, Joris R

    Nederlands tijdschrift voor geneeskunde

    2022  Volume 166

    Abstract: Direct-acting oral anticoagulants (DOAC's) have surpassed vitamin K antagonists (VKAs) as the preferred anticoagulant therapy in patients with non-valvular atrial fibrillation or venous thromboembolism. In most patients, the benefits of anticoagulant ... ...

    Title translation Factor XI inhibitors: the holy grail of anticoagulant therapy?
    Abstract Direct-acting oral anticoagulants (DOAC's) have surpassed vitamin K antagonists (VKAs) as the preferred anticoagulant therapy in patients with non-valvular atrial fibrillation or venous thromboembolism. In most patients, the benefits of anticoagulant therapy, i.e. prevention of thromboembolism including stroke risk outweigh the risks of bleeding complications. However, in older and frail patients, uptake of DOAC's is limited by concerns of bleeding. Recent developments, with therapeutics that specifically target factor XI, carry a promise to be a game changer. Activated factor XI is thought to contribute to clot progression and thrombosis, but has only a minor effect on clot consolidation during hemostasis. In this paper we will discuss the latest findings of clinical studies on factor XI inhibitors and speculate on future perspectives, including the proposal to use consistent terminology for this emerging class of DOAC's.
    MeSH term(s) Aged ; Humans ; Administration, Oral ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/complications ; Factor XI/antagonists & inhibitors ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Stroke/etiology ; Thrombosis ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants ; Factor XI (9013-55-2)
    Language Dutch
    Publishing date 2022-11-30
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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