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Article ; Online: "A new order of poisonous substances": revisiting Robert M. Glover's dissertation on the physiological effects of bromine, chlorine, and iodine compounds.

Perkins-McVey, Matthew

Naunyn-Schmiedeberg's archives of pharmacology

2023

Abstract: Robert Mortimer Glover's contribution as the first to identify the anaesthetic effects ...

Abstract	Robert Mortimer Glover's contribution as the first to identify the anaesthetic effects of chloroform went unrecognized for over 130 years. Posterity now remembers Glover as the first to experimentally demonstrate the effects of chloroform, and yet, the scope and impact of the work for which he is remembered remains largely undiscussed. This historical article returns to Glover's dissertation, for which he won the Harveian Prize in 1842, and examines its experimental findings in their historical context. Departing from the body of literature which emphasizes the clinical orientation of early anaesthesiological research, it revisits the theoretical and methodological foundations of Glover's study, which, first and foremost, sought to examine the possibility of an analogy between chemical structure and physiological effect. In doing so, it establishes that Glover was not merely the first to realize the physiological effects of chloroform or even merely the earliest figure to recognize the effects of bromoform, potassium bromide, and "bromide of mercury," over two decades before Henry Behrend's or Protheroe Smith's classic papers. My examination concludes that Glover may have been the first to propose the existence of a unique class of anaesthetic compounds, establishing Glover as an early representative of anaesthetic pharmacology as a collective body of research and clinical practice.
Language	English
Publishing date	2023-11-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02820-y
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Article ; Online: Dermatology in the urgent care setting: A retrospective review of patients seen in an urgent access dermatology clinic.

Wintringham, Jennifer A / Strock, Daniel M / Perkins-Holtsclaw, Kala / Smith, Robert J

Journal of the American Academy of Dermatology

2023 Volume 89, Issue 6, Page(s) 1271–1273

MeSH term(s)	Humans ; Dermatology ; Retrospective Studies ; Ambulatory Care ; Ambulatory Care Facilities ; Patients
Language	English
Publishing date	2023-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.08.006
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Zs.A 1540: Show issues

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Article: Long-term outcome of progressive multifocal leukoencephalopathy with recombinant interleukin-2 treatment and an associated increase in the number of HPyV-2-specific T-cells: a case report.

Hoff, Fieke W / Rolwes, John / Hardeman, Paula A / Perkins, Molly / Major, Eugene O / Douek, Daniel / Collins, Robert H / Greenberg, Benjamin M

Therapeutic advances in hematology

2023 Volume 14, Page(s) 20406207231201721

Abstract: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of the human polyomavirus 2 (HPyV-2). PML is associated with a high morbidity and mortality rate and there is currently no standard curative therapy. We ... ...

Abstract	Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of the human polyomavirus 2 (HPyV-2). PML is associated with a high morbidity and mortality rate and there is currently no standard curative therapy. We report short-term immunologic response and long-term clinical outcomes in a patient diagnosed with follicular lymphoma (FL) who developed PML. Diagnosis of PML was established conclusively based on findings from a brain biopsy. The patient was treated with recombinant interleukin 2 (IL-2) and showed rapid clinical improvement. HPyV-2-specific T-cells were tracked longitudinally and correlation with clinical status, viral load, and radiographic imaging was documented. After the progression of the patient's FL, which required an allogeneic bone marrow transplant, the patient prophylactically received human leukocyte antigen-matched donor-derived HPyV-2 T-cells to prevent the recurrence of the PML as part of a clinical trial. Twelve years after the initial diagnosis of PML, he did not develop a relapse of his PML, supporting data that therapies that increase HPyV-2-specific T-cells, including IL-2, may be effective in the management of PML.
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Case Reports
ZDB-ID	2585183-4
ISSN	2040-6215 ; 2040-6207
ISSN (online)	2040-6215
ISSN	2040-6207
DOI	10.1177/20406207231201721
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Article: AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease.

Kim, Yi Sak / Choi, Soo-Ho / Kim, Keun-Young / Navia-Pelaez, Juliana M / Perkins, Guy A / Choi, Seunghwan / Kim, Jungsu / Nazarenkov, Nicolaus / Rissman, Robert A / Ju, Won-Kyu / Ellisman, Mark H / Miller, Yury I

bioRxiv : the preprint server for biology

2024

Abstract: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer's disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid ... ...

Abstract	Microglia-driven neuroinflammation plays an important role in the development of Alzheimer's disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform for TLR4 dimers and complexes of other inflammatory receptors. The secreted apoA-I binding protein (APOA1BP or AIBP) binds TLR4 and selectively targets cholesterol depletion machinery to TLR4 inflammaraft expressing inflammatory, but not homeostatic microglia. Here we demonstrated that amyloid-beta (Aβ) induced formation of TLR4 inflammarafts in microglia in vitro and in the brain of APP/PS1 mice. Mitochondria in
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.16.580751
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Article ; Online: The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss.

Nobles, Carrie J / Mendola, Pauline / Mumford, Sunni L / Silver, Robert M / Kim, Keewan / Perkins, Neil J / Schisterman, Enrique F

Epidemiology (Cambridge, Mass.)

2023 Volume 34, Issue 5, Page(s) 759–766

Abstract: Background: Although redox stress likely plays an important role in reproductive health, the utility of peripheral biomarkers of oxidative stress, such as isoprostanes, during the periconception period remains underexplored. We evaluated the ... ...

Abstract	Background: Although redox stress likely plays an important role in reproductive health, the utility of peripheral biomarkers of oxidative stress, such as isoprostanes, during the periconception period remains underexplored. We evaluated the relationship between isoprostanes during preconception and gestational week 4 and women's reproductive health outcomes. Methods: The Effects of Aspirin in Gestation and Reproduction trial (2007-2011) enrolled 1228 women attempting pregnancy and followed them for up to 6 menstrual cycles and throughout pregnancy if they became pregnant. We measured creatinine-adjusted, log-transformed isoprostanes 8-iso-prostaglandin F 2α (8-iso-PGF2α), its metabolite 2,3-dinor-iPF2α-III, and stereoisomers 5-iso-PGF2α-VI and 8,12-iso-iPF2α-VI in urine during preconception and 4 weeks gestation. We evaluated pregnancy among participants in each menstrual cycle using human chorionic gonadotropin (hCG) and defined pregnancy loss as observed loss following positive hCG. We calculated fecundability odds ratios (FOR) and 95% confidence intervals (CI) using discrete-time Cox proportional hazards models and relative risk of pregnancy loss using adjusted log-binomial models. Results: Higher preconception isoprostane levels were associated with lower fecundability [e.g., FOR = 0.89; 95% CI = 0.81, 0.97 per interquartile range (IQR) increase in 8-iso-PGF2α]. Among 797 pregnancies, isoprostane levels increased from preconception to 4 weeks gestation (e.g., mean difference = 0.12; 95% CI = 0.10, 0.14 ng/mL for 8-iso-PGF2α) and higher isoprostanes at 4 weeks gestation were associated with lower risk of pregnancy loss (e.g., RR = 0.79; 95% CI = 0.62, 1.00 per IQR increase in 8-iso-PGF2α). Conclusions: Preconception urinary isoprostanes may identify redox stress pathways associated with lower fecundability. However, the increase in isoprostanes into gestational week 4 and the associated lower risk of pregnancy loss may suggest confounding by latent factors in early pregnancy.
MeSH term(s)	Pregnancy ; Humans ; Female ; Isoprostanes ; Abortion, Spontaneous/epidemiology ; Fertility ; Aspirin
Chemical Substances	Isoprostanes ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0000000000001631
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Zs.A 3121: Show issues

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Article ; Online: Preconception Phthalate Exposure and Women's Reproductive Health: Pregnancy, Pregnancy Loss, and Underlying Mechanisms.

Nobles, Carrie J / Mendola, Pauline / Kim, Keewan / Pollack, Anna Z / Mumford, Sunni L / Perkins, Neil J / Silver, Robert M / Schisterman, Enrique F

Environmental health perspectives

2023 Volume 131, Issue 12, Page(s) 127013

Abstract: Background: Phthalates are endocrine-disrupting chemicals linked to adverse pregnancy outcomes. Despite the sensitivity of female reproductive processes to oxidation-reduction reaction stress and endocrine disruption, evidence for the impact of women's ... ...

Abstract	Background: Phthalates are endocrine-disrupting chemicals linked to adverse pregnancy outcomes. Despite the sensitivity of female reproductive processes to oxidation-reduction reaction stress and endocrine disruption, evidence for the impact of women's phthalate exposure on the ability to establish and maintain pregnancy has been inconclusive. Objectives: We aimed to determine the relationship of preconception phthalate metabolite exposure with Methods: Data were collected from the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial, a preconception study following 1,228 women who were attempting pregnancy, for up to six menstrual cycles and throughout pregnancy if they became pregnant. Twenty phthalate metabolites were measured in a consecutive 3-d pooled urine sample at enrollment. Pregnancy was determined through urinary human chorionic gonadotropin (hCG) at the expected date of menses during each cycle and pregnancy loss as an observed loss following positive hCG. Highly sensitive C-reactive protein (hsCRP) and isoprostanes were measured at enrollment, and reproductive hormones were measured during the follicular phase, ovulation, and luteal phase. Discrete-time Cox proportional hazards models evaluated the relationship of phthalate metabolites with fecundability and weighted Poisson models with robust variance evaluated the risk of pregnancy loss. Results: An interquartile range (IQR) higher mono-(2-ethylhexyl) phthalate [ Discussion: Women's preconception exposure to phthalates was associated with lower fecundability, changes in reproductive hormones, and increased inflammation and oxidative stress. The pre- and periconception periods may represent sensitive windows for intervening to limit the reproductive toxicity of phthalate exposure. https://doi.org/10.1289/EHP12287.
MeSH term(s)	Pregnancy ; Humans ; Female ; Reproductive Health ; C-Reactive Protein ; Abortion, Spontaneous/chemically induced ; Abortion, Spontaneous/epidemiology ; Phthalic Acids/toxicity ; Phthalic Acids/urine ; Pregnancy Outcome/epidemiology ; Hormones ; Inflammation ; Isoprostanes ; Environmental Pollutants/toxicity ; Environmental Pollutants/urine
Chemical Substances	phthalic acid (6O7F7IX66E) ; C-Reactive Protein (9007-41-4) ; Phthalic Acids ; Hormones ; Isoprostanes ; Environmental Pollutants
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP12287
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Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

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Article ; Online: Control of contextual memory through interneuronal α5-GABA

Zhu, Mengwen / Abdulzahir, Alifayaz / Perkins, Mark G / Chu, Chan C / Krause, Bryan M / Casey, Cameron / Lennertz, Richard / Ruhl, David / Hentschke, Harald / Nagarajan, Rajasekar / Chapman, Edwin R / Rudolph, Uwe / Fanselow, Michael S / Pearce, Robert A

PNAS nexus

2023 Volume 2, Issue 4, Page(s) pgad065

Abstract: γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5- ... ...

Abstract	γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABA
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgad065
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Article ; Online: Calculating real-world travel routes instead of straight-line distance in the community response to out-of-hospital cardiac arrest.

Smith, Christopher M / Lall, Ranjit / Spaight, Robert / Fothergill, Rachael T / Brown, Terry / Perkins, Gavin D

Resuscitation plus

2021 Volume 8, Page(s) 100176

Abstract: ... Results: Real-world travel routes to the nearest AED were (median) 219 m longer (623 m vs 406 m ... than straight-line estimates in London, and 211 m longer (568 m vs 357 m) in East Midlands. The identity ... responders' real-world travel routes were (median) 222 m longer (601 m vs 379 m) in London, and 291 m longer ...

Abstract	Background: Using straight-line distance to estimate the proximity of public-access Automated External Defibrillators (AEDs) or volunteer first-responders to potential out-of-hospital cardiac arrests (OHCAs) does not reflect real-world travel distance. The difference between estimates may be an important consideration for bystanders and first-responders responding to OHCAs and may potentially impact patient outcome. Objectives: To explore how calculating real-world travel routes instead of using straight-line distance estimates might impact the community response to OHCA. Methods: We mapped 4355 OHCA (01/04/2016-31/03/2017) and 2677 AEDs in London (UK), and 1263 OHCA (18/06/2017-17/06/2018) and 4704 AEDs in East Midlands (UK) using ArcGIS mapping software. We determined the distance from OHCAs to the nearest AED using straight-line estimates and real-world travel routes. We mapped locations of potential OHCAs (London: n = 9065, 20/09/2019-22/03/2020; East Midlands: n = 7637, 20/09/2019-17/03/2020) for which volunteer first-responders were alerted by the GoodSAM mobile-phone app, and calculated response distance using straight-line estimates and real-world travel routes. We created Receiver Operating Characteristic (ROC) curves and calculated the Area Under the Curve (AUC) to determine if travel distance predicted whether or not a responder accepted an alert. Results: Real-world travel routes to the nearest AED were (median) 219 m longer (623 m vs 406 m) than straight-line estimates in London, and 211 m longer (568 m vs 357 m) in East Midlands. The identity of the nearest AED changed on 26% occasions in both areas when calculating real-world travel routes. GoodSAM responders' real-world travel routes were (median) 222 m longer (601 m vs 379 m) in London, and 291 m longer (814 m vs 523 m) in East Midlands. AUC statistics for both areas demonstrated that neither straight-line nor real-world travel distance predicted whether or not a responder accepted an alert. Conclusions: Calculating real-world travel routes increases the estimated travel distance and time for those responding to OHCAs. Calculating straight-line distance may overestimate the benefit of the community response to OHCA.
Language	English
Publishing date	2021-11-09
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2021.100176
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Article ; Online: Symptom Association for Gastroesophageal Reflux Disease by pH Monitoring After Peroral Endoscopic Myotomy.

DeWitt, John M / Kessler, William R / Wo, John M / Stainko, Sarah / Perkins, Anthony / Dickason, Destenee / Al-Haddad, Mohammad A / Siwiec, Robert

The American journal of gastroenterology

2022 Volume 117, Issue 8, Page(s) 1316–1319

Abstract: Introduction: There are limited data correlating symptoms with reflux episodes during pH studies after peroral endoscopic myotomy.: Methods: Consecutive patients who underwent POEM followed up ≥6 months later by 48-hour ambulatory wireless pH testing ...

Abstract	Introduction: There are limited data correlating symptoms with reflux episodes during pH studies after peroral endoscopic myotomy. Methods: Consecutive patients who underwent POEM followed up ≥6 months later by 48-hour ambulatory wireless pH testing off antisecretory therapy were identified. Reflux symptom association was defined as symptom association probability >95%. Results: The most frequent symptoms of heartburn (47.2%), cough (45.1%), and chest pain (39.6%) were associated with a positive reflux symptom association (symptom association probability >95%) in 20.9%, 17.1%, and 19.4%, respectively. Discussion: There is poor correlation between reported symptoms and esophageal acid exposure during pH testing after POEM.
MeSH term(s)	Esophageal Achalasia/complications ; Esophageal Achalasia/surgery ; Esophagitis, Peptic ; Esophagoscopy ; Gastroesophageal Reflux/complications ; Gastroesophageal Reflux/etiology ; Heartburn/etiology ; Humans ; Hydrogen-Ion Concentration ; Myotomy ; Natural Orifice Endoscopic Surgery ; Treatment Outcome
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000001801
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Ui V Zs.36: Show issues

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Article ; Online: Functional and recreational dog walking practices in the UK.

Westgarth, Carri / Christley, Robert M / Marvin, Garry / Perkins, Elizabeth

Health promotion international

2020 Volume 36, Issue 1, Page(s) 109–119

Abstract: Dog walking is a popular everyday activity known to contribute considerably to human health through motivating substantial additional physical activity. However, despite recognition that walking with a dog is substantially different from walking without ... ...

Abstract	Dog walking is a popular everyday activity known to contribute considerably to human health through motivating substantial additional physical activity. However, despite recognition that walking with a dog is substantially different from walking without a dog, little is known sociologically about the practices of dog walking. This study used in-depth interviews with 38 dog owners, combined with autoethnographical observation of dog walking. The aim was to investigate the types of dog walks that occur and the implications of this for the promotion of dog walking to increase human and animal wellbeing. Two distinct types of dog walking were found that had differing influencers and resulting experiences. Functional walks were purposed through feelings of guilt to provide the dog with a convenient form of exercise but were less pleasurable for the owner. In contrast, recreational walks provided significant owner stress-relief and were longer, typically during pleasant weather and at weekends, in less urban environments, and involved more members of the household. Limitations on time availability, conducive weather or accessibility of desirable physical environments for dog walking, generated functional rather than recreational dog walks. These findings have implications for interventions aiming to promote dog walking and for policy relating to the availability of safe and suitable green spaces for encouraging dog walking.
MeSH term(s)	Animals ; Dogs ; Physical Conditioning, Animal ; United Kingdom ; Walking
Language	English
Publishing date	2020-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1027448-0
ISSN	1460-2245 ; 0957-4824
ISSN (online)	1460-2245
ISSN	0957-4824
DOI	10.1093/heapro/daaa051
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