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  1. Article ; Online: A Burning Success: Ganglionated Plexus Ablation for Paroxysmal Atrial Fibrillation.

    Amin, Reshma / Sorgente, Antonio

    JACC. Case reports

    2020  Volume 2, Issue 12, Page(s) 2010–2012

    Language English
    Publishing date 2020-10-21
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2020.09.005
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  2. Article ; Online: Long-term mechanical ventilation and transitions in care: A narrative review.

    Xiao, Lena / Amin, Reshma / Nonoyama, Mika Laura

    Chronic respiratory disease

    2023  Volume 20, Page(s) 14799731231176301

    Abstract: Objectives: Individuals dependent on long-term mechanical ventilation (LTMV) for their day-to-day living are a heterogenous population who go through several transitions over their lifetime. This paper describes three transitions: 1) institution/ ... ...

    Abstract Objectives: Individuals dependent on long-term mechanical ventilation (LTMV) for their day-to-day living are a heterogenous population who go through several transitions over their lifetime. This paper describes three transitions: 1) institution/hospital to community/home, 2) pediatric to adult care, and 3) active treatment to end-of-life for ventilator-assisted individuals (VAIs).
    Methods: A narrative review based on literature and the author's collective practical and research experience. Four online databases were searched for relevant articles. A manual search for additional articles was completed and the results are summarized.
    Results: Transitions from hospital to home, pediatric to adult care, and to end-of-life for VAIs are complex and challenging processes. Although there are several LTMV clinical practice guidelines highlighting key components for successful transition, there still exists gaps and inconsistencies in care. Most of the literature and experiences reported to date have been in developed countries or geographic areas with funded healthcare systems.
    Conclusions: For successful transitions, the VAIs and their support network must be front-and-center. There should be a coordinated, systematic, and holistic plan (including a multi-disciplinary team), life-time follow-up, with bespoke consideration of jurisdiction and individual circumstances.
    MeSH term(s) Adult ; Humans ; Child ; Respiration, Artificial ; Transition to Adult Care ; Home Care Services ; Hospitals
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2211488-9
    ISSN 1479-9731 ; 1479-9723
    ISSN (online) 1479-9731
    ISSN 1479-9723
    DOI 10.1177/14799731231176301
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  3. Article ; Online: Volume assured pressure support mode use for non-invasive ventilation in pediatrics.

    Cithiravel, Nisha / Xiao, Lena / Shi, Jenny / Chiang, Jackie / Amin, Reshma

    Pediatric pulmonology

    2023  Volume 59, Issue 1, Page(s) 7–18

    Abstract: There has been increasing interest in utilizing volume assured pressure support (VAPS) modes of ventilation for children, which historically had only been favored in adult populations. In addition to patients with obesity hypoventilation syndrome, newer ... ...

    Abstract There has been increasing interest in utilizing volume assured pressure support (VAPS) modes of ventilation for children, which historically had only been favored in adult populations. In addition to patients with obesity hypoventilation syndrome, newer pediatric populations for which it has recently been prescribed include congenital central hypoventilation syndrome and children with neuromuscular disease such as Duchenne muscular dystrophy and spinal muscular atrophy. Given its expanding use in pediatrics, greater familiarity with VAPS is essential for pediatric pulmonologists and sleep physicians. This review article will highlight methods of initiation for this mode, specific ventilator settings, discussion of suitable pediatric patient populations, ventilator titrations via formal polysomnograms and detailed ventilator data downloads specific interpretation. Finally, common challenges to be aware of and how to troubleshoot relevant machine alarms will be reviewed.
    MeSH term(s) Adult ; Humans ; Child ; Noninvasive Ventilation ; Respiration, Artificial ; Positive-Pressure Respiration ; Hypoventilation/congenital ; Sleep Apnea, Central
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26721
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  4. Article ; Online: 14 and 6 Hz like spike wave activity is a common finding in in young patients with Prader-Willi syndrome.

    Alzaid, Mohammed / Sunkonkit, Kanokkarn / Massicotte, Colin / Otsubo, Hiroshi / Amin, Reshma / Al-Saleh, Suhail

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2024  

    Abstract: Study objectives: Our aim was to characterize the 14 and 6 like spike wave activity seen on electroencephalogram (EEG) in children with Prader-Willi syndrome (PWS) undergoing polysomnogram (PSG).: Methods: We performed a retrospective review of ... ...

    Abstract Study objectives: Our aim was to characterize the 14 and 6 like spike wave activity seen on electroencephalogram (EEG) in children with Prader-Willi syndrome (PWS) undergoing polysomnogram (PSG).
    Methods: We performed a retrospective review of children with PWS and healthy controls who underwent diagnostic PSGs between January 1, 2007 to December 31, 2020 at SickKids, Toronto, Canada. EEGs from the PSGs were reviewed for the presence of the 14 and 6 like spike wave activity and its characteristics. Clinical correlation of the EEG variant with sleep disordered breathing indices from the PSG was also evaluated.
    Results: 94 children with PWS and 50 healthy controls were included. The age, median (IQR) for the cohort was 1.42 (0.6, 4.2) years. There were 50 (53.2%) males in the PWS cohort. The EEG variant prevalence in this cohort was 51.0% (n=48) in children with PWS and 0% for the healthy controls. 14 and 6 Hz like spike wave activity was bilateral in 52% (25/48) children with PWS. The waves had a negative deflection in almost all patients 44/48 (92%) with PWS. It was predominantly located in the frontal leads for children with PWS, 23/48 (47.9%). It most frequently occurred during NREM stage 2 sleep for children with PWS, 25/48 (52.0%). The mean (SD) frequency was 6.8 (0.97) Hz. The median (IQR) length of the waves was 1.1 (0.8, 1.4) seconds in children with PWS. There was no correlation between the presence of the EEG variant and sleep disordered breathing indices in children with PWS.
    Conclusions: 14 and 6 Hz like spike wave activity EEG variant was present in more than 50% of a pediatric cohort of PWS as compared to 0% in healthy children. This EEG variant did not appear to be associated with sleep disordered breathing indices in children with PWS and is of unknown clinical significance.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.11078
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  5. Article ; Online: Clinical pearls for COVID-19 in children: what do pediatricians need to know?

    Verma, Rahul / Amin, Reshma

    Pediatric research

    2020  Volume 89, Issue 6, Page(s) 1328–1330

    MeSH term(s) COVID-19/diagnostic imaging ; COVID-19/physiopathology ; COVID-19/therapy ; COVID-19/virology ; Child ; England ; Humans ; Infant ; Infant, Newborn ; Pediatricians ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Letter
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-020-01123-9
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    Zs.A 564: Show issues Location:
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  6. Article ; Online: Paradigm shift in the era of disease-modifying therapies for Spinal Muscular Atrophy type 1: respiratory challenges and opportunities.

    Xiao, Lena / Chiang, Jackie / Amin, Reshma

    Sleep medicine

    2021  Volume 86, Page(s) 113–115

    MeSH term(s) Humans ; Muscular Atrophy, Spinal/therapy ; Spinal Muscular Atrophies of Childhood/therapy
    Language English
    Publishing date 2021-06-25
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2021.06.022
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  7. Article ; Online: Pediatric tracheostomy tube decannulation with or without polysomnography: A PRO-CON debate.

    Xiao, Lena / Kaspy, Kimberley / Zielinski, David / Amin, Reshma

    Pediatric pulmonology

    2022  Volume 57, Issue 3, Page(s) 609–615

    Abstract: Determining the timing for decannulation in children with a tracheostomy is a complex process, as the appropriate timing varies based on the initial indication for the tracheostomy tube as well as individual patient characteristics. The original ... ...

    Abstract Determining the timing for decannulation in children with a tracheostomy is a complex process, as the appropriate timing varies based on the initial indication for the tracheostomy tube as well as individual patient characteristics. The original condition for which a tracheostomy was created may improve over time with decannulation being a very important long-term goal for many families and multidisciplinary teams. However, decannulation is an inherently risky procedure associated with morbidity and mortality. Therefore, careful planning is required to ensure the safety of the procedure. Although routine airway endoscopy is an important component of decannulation protocols, guidelines are less prescriptive regarding the definition of a complete endoscopic airway evaluation and the routine use of polysomnography. This review will summarize the important PRO and CON arguments of integrating polysomnography into pediatric decannulation protocols.
    MeSH term(s) Child ; Device Removal/methods ; Endoscopy ; Humans ; Polysomnography ; Retrospective Studies ; Tracheostomy/methods
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25773
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  8. Article ; Online: Family Caregivers Facing the Decision of Long-Term Ventilation for Their Child: Mind the Gap.

    Chiang, Jackie / Amin, Reshma

    Annals of the American Thoracic Society

    2019  Volume 17, Issue 1, Page(s) 32–33

    MeSH term(s) Caregivers ; Child ; Decision Making ; Family ; Humans ; Respiration
    Language English
    Publishing date 2019-12-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201910-747ED
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    Zs.A 5828: Show issues Location:
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  9. Article: Factors Influencing the Aggressive Behavior of Odontogenic Keratocyst: A Narrative Review

    Amin, Reshma / Talwar, Avaneendra

    Journal of Health and Allied Sciences NU

    2022  Volume 13, Issue 03, Page(s) 332–336

    Abstract: During odontogenesis, the dental lamina disintegrates, leaving behind the remnants. Odontogenic pathologies such as cysts and tumors can arise from these remnants. The odontogenic keratocyte (OKC) arises from dental lamina remnants. Among the cysts, the ... ...

    Abstract During odontogenesis, the dental lamina disintegrates, leaving behind the remnants. Odontogenic pathologies such as cysts and tumors can arise from these remnants. The odontogenic keratocyte (OKC) arises from dental lamina remnants. Among the cysts, the odontogenic keratocyst is the most controversial. There is convincing evidence that inflammation plays a significant role in the pathogenesis and expansion of OKCs. Several factors mediate the proliferative capacity of the epithelial lining. The presence of mast cells close to the epithelial lining, cystic pressure build-up by vascular endothelial growth factors (VEGFs), and other cytokines contribute to the cystic expansion. Fibroblast activation by inflammation in the connective tissue stroma and changes in the epithelial lining are responsible for the aggressive nature of OKC. The use of molecular methodologies gives more profound insights into the factors influencing the progression of the lesion and helps develop newer treatment modalities for OKC. This review describes the characteristics that determine the aggressive behavior of this unique cyst.
    Keywords odontogenic keratocyst ; host response ; aggressiveness
    Language English
    Publishing date 2022-11-23
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2582-4953 ; 2582-4287
    ISSN (online) 2582-4953
    ISSN 2582-4287
    DOI 10.1055/s-0042-1758036
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  10. Article ; Online: [No title information]

    Amin, Reshma / Pizzuti, Regina / Buchanan, Francine / Rose, Louise

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Volume 193, Issue 27, Page(s) E1062–E1066

    Title translation Soins virtuels innovants pour la ventilation mécanique à domicile.
    MeSH term(s) Child ; Home Care Services/organization & administration ; Humans ; Long-Term Care ; Monitoring, Physiologic ; Ontario ; Oximetry ; Professional-Family Relations ; Program Development ; Remote Consultation/organization & administration ; Respiration, Artificial
    Language French
    Publishing date 2021-07-09
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.202584-f
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