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  1. Article ; Online: Apolipoprotein 1 amyloidosis cardiomyopathy and the grey zone of non-invasive diagnostic algorithms: Red flags to reach the diagnosis.

    Plard, Louise / Pallardy, Amandine / Trochu, Jean-Noël / Piriou, Nicolas

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2021  Volume 28, Issue 2, Page(s) 436–440

    MeSH term(s) Adult ; Algorithms ; Amyloidosis/diagnosis ; Amyloidosis/genetics ; Apolipoprotein A-I/genetics ; Cardiomyopathies/diagnosis ; Cardiomyopathies/genetics ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Retrospective Studies
    Chemical Substances Apolipoprotein A-I
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-021-02547-4
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    Zs.A 4121: Show issues Location:
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  2. Article ; Online: Down syndrome with posterior cortical atrophy.

    Boutoleau-Bretonnière, Claire / Pallardy, Amandine

    BMJ case reports

    2018  Volume 2018

    Abstract: Down syndrome (DS) is caused by trisomy of chromosome 21. The average age of onset of Alzheimer's disease (AD) ranged from 50 to 55 years in DS, with early symptoms usually characterised by changes in behaviour and executive dysfunction. On the other ... ...

    Abstract Down syndrome (DS) is caused by trisomy of chromosome 21. The average age of onset of Alzheimer's disease (AD) ranged from 50 to 55 years in DS, with early symptoms usually characterised by changes in behaviour and executive dysfunction. On the other hand, posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome characterised by progressive impairment of visual functions in the absence of visual deficits and a pattern of atrophy involving posterior cortex. This syndrome is mostly caused by AD pathology. We report the case of patient with DS who developed PCA. While atypical variants of AD are commonly associated with an early age at onset, all focal forms of AD may potentially appear in DS. Specifying the phenotype has an impact on the care of DS patients and could help us to know the evolution. It could also provide a better understanding of the underlying mechanisms of focal forms.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/etiology ; Atrophy/diagnostic imaging ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Cognitive Dysfunction/therapy ; Down Syndrome/complications ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography
    Language English
    Publishing date 2018-02-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2017-223108
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  3. Article ; Online: 18

    Godefroy, Thomas / Frécon, Gauthier / Asquier-Khati, Antoine / Mateus, Diana / Lecomte, Raphaël / Rizkallah, Mira / Piriou, Nicolas / Jamet, Bastien / Le Tourneau, Thierry / Pallardy, Amandine / Boutoille, David / Eugène, Thomas / Carlier, Thomas

    JACC. Cardiovascular imaging

    2023  Volume 16, Issue 7, Page(s) 951–961

    Abstract: Background: Fluorine-18 fluorodeoxyglucose (: Objectives: The primary objective of this study was to evaluate the performance of a radiomics and machine learning-based analysis of : Methods: All : Results: A total of 108 patients were included, ...

    Abstract Background: Fluorine-18 fluorodeoxyglucose (
    Objectives: The primary objective of this study was to evaluate the performance of a radiomics and machine learning-based analysis of
    Methods: All
    Results: A total of 108 patients were included, regardless of myocardial uptake, and were divided into training (n = 68) and test (n = 40) cohorts. Considering the latter, PET-ML findings were positive for 13 of 22 definite PVE cases and 3 of 18 rejected PVE cases (59% sensitivity, 83% specificity), thus leading to an ESC-ML sensitivity of 72% and a specificity of 83%.
    Conclusions: The use of ML for analyzing
    MeSH term(s) Humans ; Endocarditis, Bacterial ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Heart Valve Prosthesis ; Predictive Value of Tests ; Endocarditis/diagnostic imaging ; Endocarditis/etiology ; Machine Learning ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2023.01.020
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    Zs.A 6846: Show issues Location:
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  4. Article ; Online: Idiopathic normal pressure hydrocephalus and frontotemporal dementia: an unexpected association.

    de Guilhem de Lataillade, Adrien / Boutoleau-Bretonnière, Claire / Aguilar-Garcia, Jesus / Pallardy, Amandine / Bigot-Corbel, Edith / Roualdes, Vincent / Leroy, Julie / Damier, Philippe / Pouclet-Courtemanche, Hélène

    Brain communications

    2022  Volume 4, Issue 6, Page(s) fcac319

    Abstract: Idiopathic normal pressure hydrocephalus has a complex multifactorial pathogenesis and is associated with Alzheimer's disease in many patients. To date, it is not well known if a similar association exists with behavioural variant of frontotemporal lobar ...

    Abstract Idiopathic normal pressure hydrocephalus has a complex multifactorial pathogenesis and is associated with Alzheimer's disease in many patients. To date, it is not well known if a similar association exists with behavioural variant of frontotemporal lobar degeneration. In a first step, we compare the prevalence of idiopathic normal pressure hydrocephalus in two groups of patients, one with behavioural variant of frontotemporal lobar degeneration (
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcac319
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  5. Article ; Online: Incidental findings suggestive of COVID-19 in asymptomatic cancer patients undergoing 18F-FDG PET/CT in a low prevalence region.

    Pallardy, Amandine / Rousseau, Caroline / Labbe, Catherine / Liberge, Renan / Bodet-Milin, Caroline / Kraeber-Bodere, Françoise / Fleury, Vincent

    European journal of nuclear medicine and molecular imaging

    2020  Volume 48, Issue 1, Page(s) 287–292

    Abstract: Purpose: To assess the rate and pattern of incidental interstitial lung abnormalities suggestive of COVID-19 on 18F-FDG PET/CT in asymptomatic cancer patients during the period of active COVID-19 circulation between March and April 2020 in a geographic ... ...

    Abstract Purpose: To assess the rate and pattern of incidental interstitial lung abnormalities suggestive of COVID-19 on 18F-FDG PET/CT in asymptomatic cancer patients during the period of active COVID-19 circulation between March and April 2020 in a geographic area of low prevalence of the virus.
    Methods: 1396 18F-FDG PET/CT performed between January 1, 2020, and February 21, 2020, and between March 16, 2020, and April 17, 2020 for routine oncological indication were retrospectively analyzed. No patients had symptoms suggestive of COVID-19 at the time of the 18F-FDG PET/CT. Incidental interstitial pneumonias suggestive of COVID-19 were identified, and the 18F-FDG PET/CT patterns were described. We compared the incidence of these lesions in the pre-COVID and pandemic phases.
    Results: We observed a 1.6% increase in interstitial lung abnormalities during the period of COVID-19 circulation. All had < 50% lung involvement. We describe a case series with typical and atypical interstitial pneumonias suggestive of COVID-19 as unilateral or bilateral with ground-glass opacity, consolidation, or crazy-paving patterns.
    Conclusion: The relatively low increase in incidental findings suggestive of COVID-19 infection on 18F-FDG PET/CT in asymptomatic cancer patients was in accordance with the low COVID-19 transmission in our geographic region. Nevertheless, nuclear medicine physicians should familiarize themselves with typical and atypical 18F-FDG PET/CT patterns suggestive of COVID-19 pneumonia and initiate appropriate intervention where necessary.
    MeSH term(s) Aged ; Asymptomatic Infections/epidemiology ; COVID-19/complications ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Incidental Findings ; Lung/diagnostic imaging ; Male ; Middle Aged ; Neoplasms/complications ; Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Prevalence ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-05014-3
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    Zs.A 1227: Show issues Location:
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  6. Article ; Online: Functional Alterations Due to COVID-19 Lung Lesions-Lessons From a Multicenter V/Q Scan-Based Registry.

    Bonnefoy, Pierre-Benoît / Bahloul, Achraf / Denizot, Benoit / Barres, Bertrand / Moreau-Triby, Caroline / Girma, Astrid / Pallardy, Amandine / Ceyra, Quentin / Sarda-Mantel, Laure / Razzouk-Cadet, Micheline / Zsigmond, Reka / Cachin, Florent / Karcher, Gilles / Salaun, Pierre-Yves / Le Roux, Pierre-Yves

    Clinical nuclear medicine

    2022  Volume 47, Issue 8, Page(s) e540–e547

    Abstract: Purpose: In coronavirus disease 2019 (COVID-19) patients, clinical manifestations as well as chest CT lesions are variable. Lung scintigraphy allows to assess and compare the regional distribution of ventilation and perfusion throughout the lungs. Our ... ...

    Abstract Purpose: In coronavirus disease 2019 (COVID-19) patients, clinical manifestations as well as chest CT lesions are variable. Lung scintigraphy allows to assess and compare the regional distribution of ventilation and perfusion throughout the lungs. Our main objective was to describe ventilation and perfusion injury by type of chest CT lesions of COVID-19 infection using V/Q SPECT/CT imaging.
    Patients and methods: We explored a national registry including V/Q SPECT/CT performed during a proven acute SARS-CoV-2 infection. Chest CT findings of COVID-19 disease were classified in 3 elementary lesions: ground-glass opacities, crazy-paving (CP), and consolidation. For each type of chest CT lesions, a semiquantitative evaluation of ventilation and perfusion was visually performed using a 5-point scale score (0 = normal to 4 = absent function).
    Results: V/Q SPECT/CT was performed in 145 patients recruited in 9 nuclear medicine departments. Parenchymal lesions were visible in 126 patients (86.9%). Ground-glass opacities were visible in 33 patients (22.8%) and were responsible for minimal perfusion impairment (perfusion score [mean ± SD], 0.9 ± 0.6) and moderate ventilation impairment (ventilation score, 1.7 ± 1); CP was visible in 43 patients (29.7%) and caused moderate perfusion impairment (2.1 ± 1.1) and moderate-to-severe ventilation impairment (2.5 ± 1.1); consolidation was visible in 89 patients (61.4%) and was associated with moderate perfusion impairment (2.1 ± 1) and severe ventilation impairment (3.0 ± 0.9).
    Conclusions: In COVID-19 patients assessed with V/Q SPECT/CT, a large proportion demonstrated parenchymal lung lesions on CT, responsible for ventilation and perfusion injury. COVID-19-related pulmonary lesions were, in order of frequency and functional impairment, consolidations, CP, and ground-glass opacity, with typically a reverse mismatched or matched pattern.
    MeSH term(s) COVID-19/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Registries ; SARS-CoV-2 ; Ventilation-Perfusion Scan
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004261
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    Zs.A 1276: Show issues Location:
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  7. Article ; Online: LeSCoD: a new clinical scale for the detection of Lewy body disease in neurocognitive disorders.

    Olivieri, Pauline / Lebouvier, Thibaud / Hardouin, Jean-Benoît / Courtemanche, Hélène / Le Dily, Séverine / Barbin, Laëtitia / Pallardy, Amandine / Derkinderen, Pascal / Boutoleau-Bretonnière, Claire

    Journal of neurology

    2021  Volume 268, Issue 10, Page(s) 3886–3896

    Abstract: Background: Dementia with Lewy bodies remains underdiagnosed in clinical practice mainly because of the low sensitivity of existing diagnostic criteria and a strong overlap with Alzheimer's pathology that can mask the Lewy phenotype.: Objective: The ... ...

    Abstract Background: Dementia with Lewy bodies remains underdiagnosed in clinical practice mainly because of the low sensitivity of existing diagnostic criteria and a strong overlap with Alzheimer's pathology that can mask the Lewy phenotype.
    Objective: The objective of this study was therefore to develop and validate a new clinical scale designed to detect signs of Lewy body disease, called LeSCoD for Lewy body Screening scale in Cognitive Disorders.
    Methods: 128 patients who fulfilled the clinical criteria of dementia with Lewy bodies (DLB; n = 32), Alzheimer's disease (AD; n = 77) or both (n = 19) was prospectively enrolled.
    Results: LeSCoD scale showed robust internal and external validity. We determined a cut-off of 10 above which the sensitivity and specificity for Lewy body disease diagnosis were 86% and 95%, respectively. The LeSCoD scale correlated with striatal dopamine uptake in
    Conclusion: LeSCoD scale is a simple and reliable tool for the evaluation of Lewy body disease in routine clinical practice, with a higher sensitivity and specificity than the existing criteria. It might be an alternative to the use of dopamine-specific imaging.
    MeSH term(s) Alzheimer Disease ; Humans ; Lewy Bodies ; Lewy Body Disease/diagnostic imaging ; Positron-Emission Tomography ; Sensitivity and Specificity
    Language English
    Publishing date 2021-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10539-0
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  8. Article ; Online: Incidental findings suggestive of COVID-19 in asymptomatic cancer patients undergoing 18F-FDG PET/CT in a low prevalence region

    Pallardy, Amandine / Rousseau, Caroline / Labbe, Catherine / Liberge, Renan / Bodet-Milin, Caroline / Kraeber-Bodere, Françoise / Fleury, Vincent

    European Journal of Nuclear Medicine and Molecular Imaging ; ISSN 1619-7070 1619-7089

    2020  

    Keywords Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00259-020-05014-3
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  9. Article ; Online: Brain Metabolic Profile in Presymptomatic

    Saracino, Dario / Sellami, Leila / Boniface, Hugo / Houot, Marion / Pélégrini-Issac, Mélanie / Funkiewiez, Aurélie / Rinaldi, Daisy / Locatelli, Maxime / Azuar, Carole / Causse-Lemercier, Valérie / Jaillard, Alice / Pasquier, Florence / Chastan, Mathieu / Wallon, David / Hitzel, Anne / Pariente, Jérémie / Pallardy, Amandine / Boutoleau-Bretonnière, Claire / Guedj, Eric /
    Didic, Mira / Migliaccio, Raffaella / Kas, Aurélie / Habert, Marie-Odile / Le Ber, Isabelle

    Neurology

    2022  Volume 100, Issue 4, Page(s) e396–e407

    Abstract: Background and objectives: GRN: Methods: Participants were longitudinally evaluated over 5 years in a prospective cohort study focused on : Results: Among the 80 individuals enrolled in the study, 58 (27 PS-: Discussion: This study detected ... ...

    Abstract Background and objectives: GRN
    Methods: Participants were longitudinally evaluated over 5 years in a prospective cohort study focused on
    Results: Among the 80 individuals enrolled in the study, 58 (27 PS-
    Discussion: This study detected brain metabolic changes in the STS region, preceding structural and cognitive alterations, thus contributing to the characterization of the pathochronology of preclinical
    MeSH term(s) Humans ; Frontotemporal Dementia/genetics ; Follow-Up Studies ; Progranulins/genetics ; Fluorodeoxyglucose F18 ; Prospective Studies ; Cross-Sectional Studies ; Mutation ; Brain/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Metabolome
    Chemical Substances Progranulins ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; GRN protein, human
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000201439
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    Zs.MO 374: Show issues

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  10. Article ; Online: Lung Scintigraphy for Pulmonary Embolism Diagnosis in COVID-19 Patients: A Multicenter Study.

    Roux, Pierre-Yves Le / Bonnefoy, Pierre-Benoit / Bahloul, Achraf / Denizot, Benoit / Barres, Bertrand / Moreau-Triby, Caroline / Girma, Astrid / Pallardy, Amandine / Ceyrat, Quentin / Sarda-Mantel, Laure / Razzouk-Cadet, Micheline / Zsigmond, Reka / Florent, Cachin / Karcher, Gilles / Salaun, Pierre-Yves

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 63, Issue 7, Page(s) 1070–1074

    Abstract: In patients with novel coronavirus disease 2019 (COVID-19) referred for lung scintigraphy because of suspected pulmonary embolism (PE), there has been an ongoing debate within the nuclear medicine community as to whether and when the ventilation imaging ... ...

    Abstract In patients with novel coronavirus disease 2019 (COVID-19) referred for lung scintigraphy because of suspected pulmonary embolism (PE), there has been an ongoing debate within the nuclear medicine community as to whether and when the ventilation imaging should be performed. Indeed, whereas PE diagnosis typically relies on the recognition of ventilation-perfusion (V/P) mismatched defects, the ventilation procedure potentially increases the risk of contamination to health-care workers. The primary aim of this study was to assess the role of ventilation imaging when lung scintigraphy is performed because of suspected PE in COVID-19 patients. The secondary aim was to describe practices and imaging findings in this specific population.
    MeSH term(s) COVID-19/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Pulmonary Embolism/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon/methods ; Ventilation-Perfusion Ratio
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.262955
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