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Article: The role of gel-infused translabial ultrasound as a new modality in evaluation of female urethral stricture.

Mahmoudnejad, Nastaran / Abrishami, Alireza / Sharifiaghdas, Farzaneh / Borabadi, Ramin / Dadpour, Mehdi / Nayebzade, Amirhossein / Khazaei, Mehdi

Central European journal of urology

2024 Volume 77, Issue 1, Page(s) 152–156

Abstract: Introduction: To investigate the role of trans-labial ultrasound study in detection of female urethral stenosis (FUS) compared to former cysto-urethroscopy as the currently available definitive diagnostic modality.: Material and methods: In this ... ...

Abstract	Introduction: To investigate the role of trans-labial ultrasound study in detection of female urethral stenosis (FUS) compared to former cysto-urethroscopy as the currently available definitive diagnostic modality. Material and methods: In this cross-sectional study, 60 consecutive patients with bladder outlet obstruction diagnosed by clinical symptoms and urodynamic study, were included from 2019 to 2022. For additional assessment, all these patients underwent gel-Infused trans-labial ultrasound (GITLUS) and cystourethroscopy. Trans-labial real-time ultrasonography was performed following the insertion of 20 ml steady stream viscous jelly into the urethral meatus to assess the length of the urethra and exact location and length of the probable narrowing, as well as the presence of peri-urethral fibrosis (PUF). Results: In GITLUS evaluation, urethral stricture was found in 27 patients. Mean urethral length and stricture length were 35.63 ±4.78 and 17.04 ±10.59, respectively. All these stenosis were confirmed via cysto-urethroscopy. PUF was found in 20 of 27 patients. In cysto-urethroscopy, urethral stricture was confirmed in 40 patients: 13 in urethral meatus and 27 in other parts or pan-urethra. GITLUS could not reveal urethral stricture in 13 patients with meatal stenosis, confirmed with cystoscopy. GITLUS detected FUS less accurately when it involves pure distal urethra compared to other parts of urethra or pan-urethral stenosis (p value = 0.002). Conclusions: GITLUS is a safe, non-invasive, and valuable technique for detecting FUS. The location and the length of the stricture and probable peri-urethral fibrosis can be identified by this method. However, in meatal or pure short-length distal urethral strictures, this method should be used with caution.
Language	English
Publishing date	2024-01-31
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2024.168
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Article ; Online: Evaluation of Corneal Aberrometry Parameters Before and After Cross-Linking in Patients with Keratoconus

Mehdi Alizadeh / Salman Khazaei / Mones Bahramian

پزشکی بالینی ابن سینا, Vol 29, Iss 4, Pp 225-

2023 Volume 231

Abstract: Background and Objective: In the last decade, cross-linking (CXL) has been widely used for treating people with progressive keratoconus. The present study aimed to compare corneal aberrometry parameters before and after CXL in patients with keratoconus. ... ...

Abstract	Background and Objective: In the last decade, cross-linking (CXL) has been widely used for treating people with progressive keratoconus. The present study aimed to compare corneal aberrometry parameters before and after CXL in patients with keratoconus. Materials and Methods: In this cross-sectional study, 67 patients with keratoconus referred to Farshchian Sina Medical Education Center, Hamadan, Iran, who underwent CXL surgery at Mahdia Surgery Center, were selected. The results of refractometry and aberrometry before the surgery and six months after the CXL, were examined and compared. Data were extracted from patients’ medical records and analyzed in SPSS software (version 26). A P-valuec less than 0.05 was considered statistically significant. Results: The mean age of patients was 22.28 ± 5.03 years, and 65.7% were male. Mean aberrometry parameters before and six months after the treatment for K1: 44.33 and 44.04 (P=0.003), K2: 48.01 and 47.91 (P<0.001), Km: 46.27, and 45.86 (P<0.001), Kmax: 51.72 and 51.34 (P<0.001), astigmatism: 3.59 and 3.93 (P<0.001), Thanet Local: 472.76 and 462.37 (P<0.001) and CDVA: 6.41 and 8.25 (P<0.001). No significant difference was oberved between CCT, Rms Total, Rms LDA, Coma, and sphere parameters before and after the CXl. Conclusion: Cross-linking is an effective method for treating keratoconus in adults, leading to the correction of most corneal aberrometry parameters, including K1, K2, Km, Kmax, astigmatism, thinnest location, and CDVA within six months.
Keywords	corneal aberrometry ; cross-linking ; keratoconus ; Medicine ; R
Subject code	616
Language	Persian
Publishing date	2023-03-01T00:00:00Z
Publisher	Hamadan University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Attitudes of Practicing Radiologists Toward the Management of Palpable Circumscribed Breast Masses.

Mahboubi-Fooladi, Zahra / Sabahi, Marjaan / Astani, Seyed Amin / Khazaei, Mehdi / Ghomi, Zahra

Journal of breast imaging

2024 Volume 5, Issue 3, Page(s) 297–305

Abstract: Objective: To investigate the attitudes of radiologists toward palpable breast masses with benign features on US and to determine the factors influencing their decision.: Methods: A 20-question online questionnaire was sent to radiologists with ... ...

Abstract	Objective: To investigate the attitudes of radiologists toward palpable breast masses with benign features on US and to determine the factors influencing their decision. Methods: A 20-question online questionnaire was sent to radiologists with membership of the Iranian Society of Radiology and included questions regarding demographics, practice experience, and management approach to palpable circumscribed breast masses based on patient age and risk factors. Radiologists' management choice for masses in themselves or close relatives/friends was also queried. Results: In total, 151 radiologists participated (response rate 16%). For palpable breast masses with benign imaging features in women at high risk, the majority of radiologists selected MRI (95/151, 62.9%) and core-needle biopsy (110/151, 72.8%). In average-risk patients, radiologists with >5 years of practice experience selected biopsy more frequently (33/79, 41.8%) than less experienced radiologists (17/79, 23.6%) for patients ≥40 years old (P < 0.001) and patients <40 years old (20/79, 25.3%; 11/72, 15.3%, respectively) (P = 0.014). Similarly, selecting biopsy was more common in radiologists who completed a breast imaging fellowship for patients ≥40 years old (23/45, 51.1% vs 27/106, 25.5%) (P = 0.04), as well as for patients <40 years old (18/45, 40% vs 13/106, 12.3%) (P = 0.02). Radiologists who were <40 years old selected biopsy more frequently if evaluating a mass in themselves (22/86, 25.6%) compared to patients (15/86, 17.4%) (P < 0.001). Conclusion: Radiologist experience and educational background, as well as patient baseline breast cancer risk, can predispose radiologists to choose biopsy for palpable breast masses despite a benign appearance on imaging.
MeSH term(s)	Female ; Humans ; Adult ; Mammography ; Iran ; Ultrasonography, Mammary ; Breast/diagnostic imaging ; Breast Neoplasms/diagnosis ; Radiologists
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbad002
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Article ; Online: tDCS efficacy and utility of anhedonia and rumination as clinical predictors of response to tDCS in major depressive disorder (MDD).

Rezaei, Mehdi / Shariat Bagheri, Mohammad Mahdi / Khazaei, Samaneh / Garavand, Houshang

Journal of affective disorders

2023 Volume 339, Page(s) 756–762

Abstract: Background: Anhedonia and rumination are mental disorders' transdiagnostic features but remain difficult to treat. Transcranial direct current stimulation (tDCS) is a proven treatment for depression, but its effects on anhedonia and rumination and ... ...

Abstract	Background: Anhedonia and rumination are mental disorders' transdiagnostic features but remain difficult to treat. Transcranial direct current stimulation (tDCS) is a proven treatment for depression, but its effects on anhedonia and rumination and whether anhedonia and rumination can be used as a predictive biomarker of treatment response is not well known. This study aimed to investigate the tDCS efficacy and identify the predictive role of anhedonia and rumination in response to tDCS in patients with MDD. Methods: 182 patients received 10 tDCS sessions delivered at 2 mA to left (anode) dorsolateral prefrontal cortex (DLPFC). Hamilton Rating Scale for Depression (HRSD-17), Snaith-Hamilton Pleasure Scale (SHAPS), and the 10-item Ruminative Response Scale (RRS-10) was administered to patients with MDD before treatment, following it, and after two weeks of tDCS. Results: There was an overall significant improvement in anhedonia from pre- to post-treatment. Regression analyses revealed that responders had higher baseline anhedonia and rumination (reflective pondering) scores. We found that the reduction in HRSD scores after tDCS was significantly associated with anhedonia's baseline values while no relation was found between baseline rumination and tDCS treatment response. Conclusion: These results provide new evidence that pronounced anhedonia may be a significant clinical predictor of response to tDCS. Patients with severe or low baseline rumination had an equal chance of achieving clinical response. Prospective tDCS studies are necessary to validate the predictive value of the derived model.
Language	English
Publishing date	2023-07-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.07.065
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Article ; Online: Common imaging patterns of COVID-19 on spiral chest CT scan

Taraneh Faghihi Langroudi / Mehdi Khazaei

Journal of Cellular and Molecular Anesthesia, Vol 5, Iss 1, Pp 6-

a diagnostic approach for pulmonary involvement in ICU patients

2020 Volume 15

Abstract: COVID-19 is a newly emerged pandemic with great worldwide challenges. Imaging features are one of the most important aspects of the disease, both for screening, diagnosis, treatment assessment and follow-up. Here we review the imaging aspects of COVID-19 ...

Abstract	COVID-19 is a newly emerged pandemic with great worldwide challenges. Imaging features are one of the most important aspects of the disease, both for screening, diagnosis, treatment assessment and follow-up. Here we review the imaging aspects of COVID-19 with special focus on Critical Care patients.
Keywords	Anesthesiology ; RD78.3-87.3 ; covid19
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Shahid Beheshti University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Maternal risk factors for low birth weight infants: A nested case-control study of rural areas in Kurdistan (western of Iran).

Moradi, Ghobad / Zokaeii, Mehdi / Goodarzi, Elham / Khazaei, Zaher

Journal of preventive medicine and hygiene

2021 Volume 62, Issue 2, Page(s) E399–E406

Abstract: Infant mortality is among the most important indicators of health and development in global communities. One of the causes of neonatal mortality is low birth weight. This study aims at evaluating the risk factors for LBW in infants. This study was ... ...

Abstract	Infant mortality is among the most important indicators of health and development in global communities. One of the causes of neonatal mortality is low birth weight. This study aims at evaluating the risk factors for LBW in infants. This study was carried out using a nested case-control study in rural areas of Kurdistan province in Western Iran in 2015. The selection of case and control groups was based on the nesting using the risk set sampling approach. In total, 182 and 364 subjects were selected for the case group and the control group respectively. Data analysis was performed using the Stata-12 software with the point and spatial estimation of OR using the conditional logistic regression method. The multivariate logistic regression analysis performed shows that the maternal gestational age, the mother's health history during pregnancy, any medication abuses by the mother, any mental stress during pregnancy, are LBW risk factors (P < 0.05). Prevention of LBW is possible by identifying effective factors and performing appropriate interventions in infants with low birth weight.
MeSH term(s)	Adult ; Body Mass Index ; Case-Control Studies ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Iran/epidemiology ; Mental Disorders/epidemiology ; Mothers ; Nutritional Status ; Pregnancy ; Pregnancy Complications/epidemiology ; Premature Birth/epidemiology ; Premature Birth/etiology ; Prenatal Care ; Risk Factors ; Rural Population ; Socioeconomic Factors ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Substance-Related Disorders/epidemiology
Language	English
Publishing date	2021-07-30
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1102926-2
ISSN	2421-4248 ; 1121-2233
ISSN (online)	2421-4248
ISSN	1121-2233
DOI	10.15167/2421-4248/jpmh2021.62.2.1635
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Article ; Online: A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.

Khanmohammadi, Shaghayegh / Rezaei, Nima / Khazaei, Mehdi / Shirkani, Afshin

Journal of clinical immunology

2021 Volume 42, Issue 1, Page(s) 19–24

Abstract: Background: Interferons (IFNs) play a crucial role in antiviral immunity. Genetic defects in interferon receptors, IFNs, and auto-antibodies against IFNs can lead to the development of life-threatening forms of infectious diseases like a severe form of ... ...

Abstract	Background: Interferons (IFNs) play a crucial role in antiviral immunity. Genetic defects in interferon receptors, IFNs, and auto-antibodies against IFNs can lead to the development of life-threatening forms of infectious diseases like a severe form of COVID-19. Case presentation: A 13-year-old boy with a previously reported homozygous loss-of-function mutation in interferon alpha/beta receptor subunit 1 (IFNAR1) (c.674-2A > G) was diagnosed with severe COVID-19. He had cold symptoms and a high-grade fever at the time of admission. He was admitted to the pediatric intensive care unit after showing no response to favipiravir and being hypoxemic. High-resolution computed tomography (HRCT) scanning revealed lung involvement of 70% with extensive areas of consolidation in both lungs. Antibiotics, interferon gamma (IFN-γ), remdesivir, methylprednisolone pulse, and other medications were started in the patient. However, remdesivir and methylprednisolone pulse were discontinued because of their adverse side effects in the patient. His general condition improved, and a few days later was discharged from the hospital. Conclusion: We reported a patient with severe COVID-19 who had a mutation in IFNAR1. Our finding suggests that patients with IFNAR1 deficiency are prone to severe forms of COVID-19. Besides, IFN-γ therapy may be a potential drug to treat patients with defects in IFN-α/β signaling pathways which needs further investigations.
MeSH term(s)	Adolescent ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/genetics ; Humans ; Interferon-gamma/therapeutic use ; Male ; Receptor, Interferon alpha-beta/deficiency
Chemical Substances	Antiviral Agents ; IFNAR1 protein, human ; Receptor, Interferon alpha-beta (156986-95-7) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-10-28
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-021-01166-5
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Article ; Online: Novel Decentralized Peer-to-Peer Gas and Electricity Transaction Market between Prosumers and Retailers Considering Integrated Demand Response Programs

Hassan Khazaei / Hossein Aghamohammadloo / Milad Habibi / Mehdi Mehdinejad / Amin Mohammadpour Shotorbani

Sustainability, Vol 15, Iss 6165, p

2023 Volume 6165

Abstract: This paper proposes a novel peer-to-peer (P2P) decentralized energy market consisting of retailers and prosumers considering integrated demand response (IDR). Retailers can trade electrical energy and gas with prosumers in a P2P way to maximize their ... ...

Abstract	This paper proposes a novel peer-to-peer (P2P) decentralized energy market consisting of retailers and prosumers considering integrated demand response (IDR). Retailers can trade electrical energy and gas with prosumers in a P2P way to maximize their welfare. Since they are equipped with electrical storage and power self-generation units, they can benefit from selling power not only to the upstream network but also to prosumers. In peer-to-peer transactions, the prosumers purchase electricity as well as gas from retailers. Because of their access to the competitive retail market, including some retailers, they enjoy more freedom to reduce their energy supply cost. In addition, the prosumers are equipped with an energy hub consisting of combined heat and power (CHP) units and electric pumps, allowing them to change their energy supply according to price fluctuations. Furthermore, they have some changeable electrical and thermal load enabling them to change their load if needed. To clear the proposed P2P decentralized market, a fully decentralized approach called the fully decentralized alternating direction method of multipliers (ADMM) is applied. This method does not require a supervisory entity and, thus, preserves the players’ private information. The numerical studies performed on a system with two retailers and multiple prosumers demonstrate the feasibility and effectiveness of the proposed decentralized market. The results also show that the proposed decentralized algorithm achieves the optimal global solution, compared with the centralized approach.
Keywords	peer-to-peer electrical energy and gas trading ; energy hub ; decentralized optimization ; integrated demand response program ; alternating direction method of multipliers ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	620
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: GGE biplot vs. AMMI analysis of promising sorghum lines in the warm-temperate regions of Iran

Khazaei, Azim / Golzardi, Farid / Torabi, Masoud / Feyzbakhsh, Mohammad Taghi / Azarinasrabad, Ali / Nazari, Leyla / Ghasemi, Ahmad / Mottaghi, Mehdi

Journal of Crop Improvement. 2023 July 04, v. 37, no. 4 p.506-522

2023

Abstract: Due to increasing farmers' attention to sorghum (Sorghum bicolor (L.) Moench) cultivation in arid and semi-arid regions, it is necessary to introduce new, suitable sorghum cultivars. The present study aimed to evaluate the yield stability of grain ... ...

Abstract	Due to increasing farmers' attention to sorghum (Sorghum bicolor (L.) Moench) cultivation in arid and semi-arid regions, it is necessary to introduce new, suitable sorghum cultivars. The present study aimed to evaluate the yield stability of grain sorghum genotypes via AMMI and GGE biplot analyses to identify high-yielding and best adapted genotypes for release in Iran's warm-temperate regions. Seven promising grain sorghum lines (KGS15, KGS19, KGS23, KGS25, KGS27, KGS32, and KGS36), along with three commercial cultivars (Kimiya, Payam, and Sepideh), were studied in seven regions of Iran (Karaj, Isfahan, Gorgan, Birjand, Shiraz, Zabol, and Hamedan) during the 2019 and 2020 growing seasons. AMMI analysis showed that genotypes G7, G3, and G6 had the lowest AMMI stability values (ASV). GGE biplot analysis showed that genotype G6 had the highest grain yield (GY) in most environments, whereas genotype G1 was specifically adapted to the Hamedan province. According to the average-environment coordination of the GGE biplot, genotype G6 was the most desirable genotype, significantly better than the second and third best genotypes G4 and G3 (G4 was missed by AMMI). This study also indicated that the GGE biplot method was more effective than the AMMI method in analyzing genotype by environment and identifying superior genotypes. Overall, G6 can be introduced as the superior-most genotype for cultivation in Iran's warm-temperate regions.
Keywords	Sorghum bicolor ; cultivars ; genotype ; genotype-environment interaction ; grain sorghum ; grain yield ; Iran ; Adaptability ; genotype-by-environment interaction ; ideal genotype ; multi-environment trials ; sorghum ; stability
Language	English
Dates of publication	2023-0704
Size	p. 506-522.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2163790-8
ISSN	1542-7536 ; 1542-7528
ISSN (online)	1542-7536
ISSN	1542-7528
DOI	10.1080/15427528.2022.2113488
Database	NAL-Catalogue (AGRICOLA)

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Article: The role of milk-derived exosomes in the treatment of diseases.

Rashidi, Mehdi / Bijari, Salar / Khazaei, Amir Hossein / Shojaei-Ghahrizjani, Fereshteh / Rezakhani, Leila

Frontiers in genetics

2022 Volume 13, Page(s) 1009338

Abstract: Exosomes (EXOs) are natural nanoparticles of endosome origin that are secreted by a variety of cells in the body. Exosomes have been found in bio-fluids such as urine, saliva, amniotic fluid, and ascites, among others. Milk is the only commercially ... ...

Abstract	Exosomes (EXOs) are natural nanoparticles of endosome origin that are secreted by a variety of cells in the body. Exosomes have been found in bio-fluids such as urine, saliva, amniotic fluid, and ascites, among others. Milk is the only commercially available biological liquid containing EXOs. Proof that exosomes are essential for cell-to-cell communication is increasingly being reported. Studies have shown that they migrate from the cell of origin to various bioactive substances, including membrane receptors, proteins, mRNAs, microRNAs, and organelles, or they can stimulate target cells directly through interactions with receptors. Because of the presence of specific proteins, lipids, and RNAs, exosomes act in physiological and pathological conditions
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.1009338
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