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  1. Article ; Online: Optimizing Communication of Radiation Exposure in Medical Imaging, the Radiologist Challenge.

    Pozzessere, Chiara

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 2, Page(s) 717–720

    Abstract: Since I started my residency program in Radiology, I have been committed to promoting radiation protection, paying particular attention to the justification and optimization of the examinations [ ... ]. ...

    Abstract Since I started my residency program in Radiology, I have been committed to promoting radiation protection, paying particular attention to the justification and optimization of the examinations [...].
    MeSH term(s) Humans ; Tomography, X-Ray Computed/methods ; Radiation Exposure/prevention & control ; Radiation Protection/methods ; Communication ; Radiologists
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Editorial
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9020057
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  2. Article ; Online: Radiation Exposure to Low-Dose Computed Tomography for Lung Cancer Screening: Should We Be Concerned?

    Pozzessere, Chiara / von Garnier, Christophe / Beigelman-Aubry, Catherine

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 1, Page(s) 166–177

    Abstract: Lung cancer screening (LCS) programs through low-dose Computed Tomography (LDCT) are being implemented in several countries worldwide. Radiation exposure of healthy individuals due to prolonged CT screening rounds and, eventually, the additional ... ...

    Abstract Lung cancer screening (LCS) programs through low-dose Computed Tomography (LDCT) are being implemented in several countries worldwide. Radiation exposure of healthy individuals due to prolonged CT screening rounds and, eventually, the additional examinations required in case of suspicious findings may represent a concern, thus eventually reducing the participation in an LCS program. Therefore, the present review aims to assess the potential radiation risk from LDCT in this setting, providing estimates of cumulative dose and radiation-related risk in LCS in order to improve awareness for an informed and complete attendance to the program. After summarizing the results of the international trials on LCS to introduce the benefits coming from the implementation of a dedicated program, the screening-related and participant-related factors determining the radiation risk will be introduced and their burden assessed. Finally, future directions for a personalized screening program as well as technical improvements to reduce the delivered dose will be presented.
    MeSH term(s) Humans ; Radiation Dosage ; Early Detection of Cancer/methods ; Lung Neoplasms ; Tomography, X-Ray Computed/methods ; Radiation Exposure
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9010015
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  3. Article: Impact of COVID-19 pneumonia on pulmonary vascular volume.

    Fahrni, Guillaume / Rocha, Ana-Carolina / Gudmundsson, Louis / Pozzessere, Chiara / Qanadli, Salah D / Rotzinger, David C

    Frontiers in medicine

    2023  Volume 10, Page(s) 1117151

    Abstract: Background: Pulmonary manifestations of COVID-19 pneumonia are well known. However, COVID-19 is also associated with a range of vascular manifestations such as embolism, congestion, and perfusion changes. Regarding congestion, research from different ... ...

    Abstract Background: Pulmonary manifestations of COVID-19 pneumonia are well known. However, COVID-19 is also associated with a range of vascular manifestations such as embolism, congestion, and perfusion changes. Regarding congestion, research from different groups has suggested arteriovenous anastomosis dysregulation as a contributing factor. In this study, we aim to better describe the changes in vascular volume in affected lung zones and to relate them to pathophysiological hypotheses.
    Methods: We performed automatic vascular volume extraction in 10 chest CTs of patients, including 2 female and 8 male with a mean age of 63.5 ± 9.3 years, diagnosed with COVID-19 pneumonia. We compared the proportion of vascular volumes between manually segmented regions of lung parenchyma with and without signs of pneumonia.
    Results: The proportion of vascular volume was significantly higher in COVID (CVasc) compared to non-COVID (NCVasc) areas. We found a mean difference (DVasc) of 5% and a mean ratio (RVasc) of 3.7 between the two compartments (
    Conclusion: Vascular volume in COVID-19 affected lung parenchyma is augmented relative to normal lung parenchyma, indicating venous congestion and supporting the hypothesis of pre-existing intra-pulmonary arteriovenous shunts.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1117151
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  4. Article ; Online: Imaging of tumour response to immunotherapy.

    Dromain, Clarisse / Beigelman, Catherine / Pozzessere, Chiara / Duran, Rafael / Digklia, Antonia

    European radiology experimental

    2020  Volume 4, Issue 1, Page(s) 2

    Abstract: A wide range of cancer immunotherapy approaches has been developed including non-specific immune-stimulants such as cytokines, cancer vaccines, immune checkpoint inhibitors (ICIs), and adoptive T cell therapy. Among them, ICIs are the most commonly used ... ...

    Abstract A wide range of cancer immunotherapy approaches has been developed including non-specific immune-stimulants such as cytokines, cancer vaccines, immune checkpoint inhibitors (ICIs), and adoptive T cell therapy. Among them, ICIs are the most commonly used and intensively studied. Since 2011, these drugs have received marketing authorisation for melanoma, lung, bladder, renal, and head and neck cancers, with remarkable and long-lasting treatment response in some patients. The novel mechanism of action of ICIs, with immune and T cell activation, leads to unusual patterns of response on imaging, with the advent of so-called pseudoprogression being more pronounced and frequently observed when compared to other anticancer therapies. Pseudoprogression, described in about 2-10% of patients treated with ICIs, corresponds to an increase of tumour burden and/or the appearance of new lesions due to infiltration by activated T cells before the disease responds to therapy. To overcome the limitation of response evaluation criteria in solid tumors (RECIST) to assess these specific changes, new imaging criteria-so-called immune-related response criteria and then immune-related RECIST (irRECIST)-were proposed. The major modification involved the inclusion of the measurements of new target lesions into disease assessments and the need for a 4-week re-assessment to confirm or not confirm progression. The RECIST working group introduced the new concept of "unconfirmed progression", into the irRECIST. This paper reviews current immunotherapeutic approaches and summarises radiologic criteria to evaluate new patterns of response to immunotherapy. Furthermore, imaging features of immunotherapy-related adverse events and available predictive biomarkers of response are presented.
    MeSH term(s) Diagnostic Imaging ; Humans ; Immunotherapy ; Neoplasms/diagnostic imaging ; Neoplasms/immunology ; Neoplasms/therapy ; Response Evaluation Criteria in Solid Tumors
    Keywords covid19
    Language English
    Publishing date 2020-01-03
    Publishing country England
    Document type Journal Article ; Systematic Review
    ISSN 2509-9280
    ISSN (online) 2509-9280
    DOI 10.1186/s41747-019-0134-1
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  5. Article ; Online: Cross-sectional evaluation of FGD-avid polyostotic fibrous dysplasia: MRI, CT and PET/MRI findings.

    Pozzessere, Chiara / Cicone, Francesco / Barberio, Paolo / Papa, Annalisa / Coppolino, Giuseppe / Biagini, Roberto / Cascini, Giuseppe Lucio

    European journal of hybrid imaging

    2022  Volume 6, Issue 1, Page(s) 19

    Abstract: A 42-year-old male with left hip pain was diagnosed of several right femoral and tibial bone tumours. All lesions were osteolytic with sclerotic margins. The symptomatic lesion in the proximal femur also showed bone expansion and focal cortical thinning. ...

    Abstract A 42-year-old male with left hip pain was diagnosed of several right femoral and tibial bone tumours. All lesions were osteolytic with sclerotic margins. The symptomatic lesion in the proximal femur also showed bone expansion and focal cortical thinning. Whole-body [
    Language English
    Publishing date 2022-10-03
    Publishing country England
    Document type Journal Article
    ISSN 2510-3636
    ISSN (online) 2510-3636
    DOI 10.1186/s41824-022-00139-0
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  6. Article ; Online: Imaging Features of Pulmonary Immune-related Adverse Events.

    Pozzessere, Chiara / Lazor, Romain / Jumeau, Raphael / Peters, Solange / Prior, John O / Beigelman-Aubry, Catherine

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2021  Volume 16, Issue 9, Page(s) 1449–1460

    Abstract: Pulmonary immune-related adverse events represent rare but potentially severe side effects of immunotherapies. Diagnosis is often challenging, as symptoms and imaging features are not specific and may mimic other lung diseases, thus potentially delaying ... ...

    Abstract Pulmonary immune-related adverse events represent rare but potentially severe side effects of immunotherapies. Diagnosis is often challenging, as symptoms and imaging features are not specific and may mimic other lung diseases, thus potentially delaying appropriate patient management. In this setting, an accurate imaging evaluation is essential for a prompt detection and correct management of these drug-induced lung diseases. The purpose of this article is to review the different types of pulmonary immune-related adverse events, describe their imaging characteristics on both high-resolution computed tomography and positron emission tomography/computed tomography and stress their underlying diagnostic challenge by presenting the mimickers.
    MeSH term(s) CTLA-4 Antigen ; Humans ; Immunotherapy ; Lung ; Lung Neoplasms/diagnostic imaging ; Programmed Cell Death 1 Receptor
    Chemical Substances CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2021.05.017
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  7. Article ; Online: Incidentally discovered COVID-19 pneumonia: the role of diagnostic imaging.

    Pozzessere, Chiara / Rotzinger, David C / Ghaye, Benoit / Lamoth, Frédéric / Beigelman-Aubry, Catherine

    European radiology

    2020  Volume 30, Issue 9, Page(s) 5211–5213

    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country Germany
    Document type Letter
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-020-06914-6
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    Zs.A 3300: Show issues Location:
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  8. Article ; Online: MR-enterography: role in the assessment of suspected anastomotic recurrence of Crohn disease after ileocolic resection.

    Pozzessere, Chiara / Boudiaf, Mourad / Cirigliano, Alfredo / Dohan, Anthony / Mazzei, Maria Antonietta / Barat, Maxime / Volterrani, Luca / Soyer, Philippe

    La Radiologia medica

    2022  Volume 127, Issue 3, Page(s) 238–250

    Abstract: Purpose: To determine the potential of magnetic resonance-enterography (MRE) in the assessment of the anastomotic status in patients with Crohn disease and prior ileocolic resection.: Methods: A total of 62 MRE examinations obtained in 52 patients ... ...

    Abstract Purpose: To determine the potential of magnetic resonance-enterography (MRE) in the assessment of the anastomotic status in patients with Crohn disease and prior ileocolic resection.
    Methods: A total of 62 MRE examinations obtained in 52 patients with Crohn disease who had previously undergone ileocolic resection were retrospectively reviewed by two readers in consensus. MRE features (anastomotic wall thickening, wall stratification, wall enhancement pattern and degree, DWI signal intensity, ADC values, lymph nodes, comb sign and complications) were compared to clinical, endoscopic and histological findings that served as standard of reference. Sensitivity, specificity and accuracy of MRE were calculated.
    Results: At univariate analysis, anastomotic wall thickening, anastomotic wall stratification, segmental wall enhancement, moderate wall enhancement, early and mucosal enhancement, and moderate/marked hyperintensity on diffusion-weighed imaging (DWI) were the most discriminative MRE features for differentiating between normal and abnormal anastomoses (p < 0.001 for all variables). Anastomotic wall thickening and segmental anastomotic wall enhancement were the two most sensitive and accurate MRE variables for the diagnosis of abnormal anastomosis with sensitivities of 82% (95% CI: 67-92%) and accuracies of 84% (95% CI: 72-92%). At univariate analysis, hyperintensity on DWI of the anastomotic site was the most sensitive finding for distinguishing between inflammatory recurrence and fibrostenosis (sensitivity, 89%; 95% CI: 67-99%).
    Conclusions: MRE provides objective and relatively specific morphological criteria that help detect abnormal ileocolic anastomosis, but performances are lower when differentiating between inflammatory recurrence and fibrostenosis. DWI may be useful in identifying pathologic anastomosis and, in particular, in distinguishing between inflammatory recurrence and fibrostenosis.
    MeSH term(s) Anastomosis, Surgical ; Crohn Disease/complications ; Crohn Disease/diagnostic imaging ; Crohn Disease/surgery ; Humans ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-01-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-022-01452-1
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  9. Article ; Online: Not all that glitters is COVID! Differential diagnosis of FDG-avid interstitial lung disease in low-prevalence regions.

    Papa, Annalisa / Pozzessere, Chiara / Cicone, Francesco / Rizzuto, Fabiola / Cascini, Giuseppe Lucio

    European journal of hybrid imaging

    2020  Volume 4, Issue 1, Page(s) 19

    Abstract: Coronavirus disease-19 (COVID-19) is only one of the many possible infectious and non-infectious diseases that may occur with similar imaging features in patients undergoing [ ...

    Abstract Coronavirus disease-19 (COVID-19) is only one of the many possible infectious and non-infectious diseases that may occur with similar imaging features in patients undergoing [
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country England
    Document type Journal Article
    ISSN 2510-3636
    ISSN (online) 2510-3636
    DOI 10.1186/s41824-020-00088-6
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  10. Article: Dépistage du cancer pulmonaire : vers l’implémentation d’un projet pilote en Suisse.

    Bongard, Cédric / Rey Cobo, Juliana / Messe, Romain / Noirez, Leslie / Lovis, Alban / Krueger, Thorsten / Peters, Solange / Pozzessere, Chiara / Selby, Kevin / von Garnier, Christophe

    Revue medicale suisse

    2023  Volume 19, Issue 850, Page(s) 2165–2171

    Abstract: Lung cancer is responsible for one in five cancer-related deaths. Screening for lung cancer using low-dose chest CT (LDCT) is supported by several international studies targeting the at-risk population as part of an organised programme. Given the ... ...

    Title translation Lung cancer screening : towards the implementation of a pilot project in Switzerland.
    Abstract Lung cancer is responsible for one in five cancer-related deaths. Screening for lung cancer using low-dose chest CT (LDCT) is supported by several international studies targeting the at-risk population as part of an organised programme. Given the organisational challenges for the healthcare systems of the countries concerned, this involves setting up pilot screening projects. This requires close collaboration between the players involved, with a multidisciplinary approach structured around the participant, aiming to offer the expertise of the pulmonologist and the radiologist on the LDCT performed, interpreted with the help of artificial intelligence. Here we set out the elements needed to develop a screening programme, starting with the implementation of a pilot project.
    MeSH term(s) Humans ; Early Detection of Cancer ; Mass Screening ; Pilot Projects ; Switzerland/epidemiology ; Artificial Intelligence ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/epidemiology
    Language French
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2023.19.850.2165
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