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Article ; Online: Histopathologic features predictive of metastasis and survival in 230 patients with cutaneous squamous cell carcinoma of the head and neck and non-head and neck locations: a single-center retrospective study.

Farah, M / Milton, D R / Gross, N D / Nagarajan, P / Gu, J / Curry, J L / Ivan, D / Torres-Cabala, C A / Myers, J N / Prieto, V G / Aung, P P

Journal of the European Academy of Dermatology and Venereology : JEADV

2022 Volume 36, Issue 8, Page(s) 1246–1255

Abstract: Background: Staging systems for cutaneous squamous cell carcinoma (cSCC) produce inconsistent risk stratification.: Objective: The aim of this study was to identify further prognostic parameters for better stratification.: Methods: We ... ...

Abstract	Background: Staging systems for cutaneous squamous cell carcinoma (cSCC) produce inconsistent risk stratification. Objective: The aim of this study was to identify further prognostic parameters for better stratification. Methods: We retrospectively analysed the prognostic significance of clinicopathologic parameters of 230 patients who underwent primary excision of invasive cSCC of the head and neck (n = 115) and non-head and non-neck (n = 115) locations. In addition to known high-risk features, we analysed tumour nest shape, invasion pattern, lymphoid response pattern and tumour budding. Results: On multivariable analysis, lymphovascular invasion (LVI) and high tumour budding predicted worse disease-specific survival, and ulceration, LVI and high tumour budding predicted worse overall survival. Only ulceration was independently associated with risk of nodal metastasis. Conclusion: High tumour budding, LVI and ulceration are independently associated with poor outcome in cSCC and may be used to refine cSCC prognostic stratification, which is crucial to optimize clinical decision and to identify patients who are more likely to benefit from more aggressive interventions or clinical trials.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/pathology ; Humans ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Risk Factors ; Skin Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2022-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18147
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article: Efficacy of radioactive iodine treatment of graves' hyperthyroidism using a single calculated

Wong, Ka Kit / Shulkin, Barry L / Gross, Milton D / Avram, Anca M

Clinical diabetes and endocrinology

2018 Volume 4, Page(s) 20

Abstract: Objective: To evaluate the success rate of therapeutic administration of a single calculated : Methods and materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and ... ...

Abstract	Objective: To evaluate the success rate of therapeutic administration of a single calculated Methods and materials: Patients with Graves' hyperthyroidism underwent pinhole thyroid imaging, 24-h radioactive iodine uptake (RAIU) measurements and clinical examination and received a calculated Results: The study included 316 hyperthyroid patients with Graves' disease (F238:M78, mean age 42.1 ± 16 y, 4-94). 179 patients (56.6%) had no prior therapeutic intervention (treatment-naive patients), whereas 6 patients had prior thyroid surgery, and 131 (41.5%) had been treated with anti-thyroid medications.The mean estimated thyroid gland size was 50.2 g ± 18, range 15-100. Mean RAIU was 0.57 ± 0.17 (normal 0.07-0.30). RAI doses ranged from 5 to 70 mCi (mean dose = 18.1 mCi). Successful treatment of hyperthyroidism at our institution was obtained after a single therapeutic 131-I activity administration in 295 of 316 (93.3%) patients. Multivariate logistic regression analysis demonstrated that failure of Conclusion: Successful
Language	English
Publishing date	2018-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2834859-X
ISSN	2055-8260
ISSN	2055-8260
DOI	10.1186/s40842-018-0071-6
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Article ; Online: The impact of infection and inflammation in oncologic

Rahman, W Tania / Wale, Daniel J / Viglianti, Benjamin L / Townsend, Danyelle M / Manganaro, Matthew S / Gross, Milton D / Wong, Ka Kit / Rubello, Domenico

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019 Volume 117, Page(s) 109168

Abstract: Sites of infection and inflammation can be misleading in oncology PET/CT imaging because these areas commonly ... ...

Abstract	Sites of infection and inflammation can be misleading in oncology PET/CT imaging because these areas commonly show
MeSH term(s)	Animals ; Fluorodeoxyglucose F18/chemistry ; Fluorodeoxyglucose F18/metabolism ; Humans ; Infections/diagnostic imaging ; Inflammation/diagnostic imaging ; Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2019-07-01
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2019.109168
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Article ; Online: Synchronous Metastatic Breast Carcinoma and Parathyroid Adenoma on 18F-FDG PET/CT and 99mTc-Sestamibi Imaging.

Singh, Harkamal / Wale, Daniel J / Wong, Ka Kit / Gross, Milton D / Viglianti, Benjamin L

Clinical nuclear medicine

2018 Volume 44, Issue 2, Page(s) 148–149

Abstract: In addition to nuclear cardiac and breast imaging, Tc-sestamibi scintigraphy is often used to localize parathyroid adenomas. F- fluorodeoxyglucose (FDG) PET is heavily utilized in oncology, although its use in identifying parathyroid adenomas is limited. ...

Abstract	In addition to nuclear cardiac and breast imaging, Tc-sestamibi scintigraphy is often used to localize parathyroid adenomas. F- fluorodeoxyglucose (FDG) PET is heavily utilized in oncology, although its use in identifying parathyroid adenomas is limited. We describe a case of a 57-year-old woman who underwent parathyroid scintigraphy and F-FDG PET/CT in the same week due to hyperparathyroidism and an enlarging breast mass, respectively. A right paratracheal mediastinal mass that otherwise would be suspicious for nodal metastases by CT alone was correctly identified to be an ectopic parathyroid adenoma using a combination of the nuclear medicine studies performed.
MeSH term(s)	Adenoma/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasms, Multiple Primary/diagnostic imaging ; Parathyroid Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Technetium Tc 99m Sestamibi
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Technetium Tc 99m Sestamibi (971Z4W1S09)
Language	English
Publishing date	2018-11-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002380
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Zs.A 1276: Show issues

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Article ; Online: Nuclear Medicine Therapy With 223Radium-dichloride for Osseous Metastases in Prostate Carcinoma.

Wale, Daniel J / Viglianti, Benjamin L / Gross, Milton D / Ferretti, Alice / Rubello, Domenico / Wong, Ka Kit

American journal of clinical oncology

2018 Volume 42, Issue 1, Page(s) 99–106

Abstract: Painful osseous metastasis resulting from castration-resistant prostate carcinoma is a common clinical problem. Historically, nuclear medicine offered several palliative beta-emitting radiopharmaceuticals targeting the skeleton with the goal of ... ...

Abstract	Painful osseous metastasis resulting from castration-resistant prostate carcinoma is a common clinical problem. Historically, nuclear medicine offered several palliative beta-emitting radiopharmaceuticals targeting the skeleton with the goal of decreasing pain. However, these have largely been replaced by the alpha-emitting agent 223radium (Ra). 223Ra received Food and Drug Administration approval in 2013 for the treatment of metastatic castration-resistant prostate cancer with symptomatic bone metastases without visceral metastases. 223Ra offers an improved therapeutic profile due to its alpha-particle emissions resulting in a relatively higher linear energy transfer and lower particle range compared with beta-emitters. 223Ra also has demonstrated to increase overall survival in patients and to delay adverse skeletal events. Running a successful clinical nuclear therapy program with Ra requires a multidisciplinary team approach and this article suggests an implementation strategy from the authors' institution. Potential new nuclear radiopharmaceuticals still under investigation offering the future possibility of radioligand therapy are also discussed briefly.
MeSH term(s)	Bone Neoplasms/radiotherapy ; Bone Neoplasms/secondary ; Clinical Trials as Topic ; Humans ; Lutetium/therapeutic use ; Male ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/therapy ; Radioisotopes/adverse effects ; Radioisotopes/therapeutic use ; Radiopharmaceuticals/therapeutic use ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Radium/adverse effects ; Radium/therapeutic use
Chemical Substances	Radioisotopes ; Radiopharmaceuticals ; Lutetium (5H0DOZ21UJ) ; Lutetium-177 (BRH40Y9V1Q) ; radium Ra 223 dichloride (RJ00KV3VTG) ; Radium (W90AYD6R3Q)
Language	English
Publishing date	2018-09-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000000479
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Zs.A 1557: Show issues

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Article ; Online: Lingual Thyroid Ectopia: Diagnostic SPECT/CT Imaging and Radioactive Iodine Treatment.

Gandhi, Arpit / Wong, Ka Kit / Gross, Milton D / Avram, Anca M

Thyroid : official journal of the American Thyroid Association

2016 Volume 26, Issue 4, Page(s) 573–579

Abstract: Background: Lingual thyroid is a rare abnormality of thyroid development that is usually treated conservatively with levothyroxine replacement. Rarely, it becomes large enough to cause obstructive symptoms in the oral cavity, requiring definitive ... ...

Abstract	Background: Lingual thyroid is a rare abnormality of thyroid development that is usually treated conservatively with levothyroxine replacement. Rarely, it becomes large enough to cause obstructive symptoms in the oral cavity, requiring definitive treatment. Patient findings: This study reports on three patients with lingual thyroid treated with radioactive iodine-131 ((131)I) with successful radioablation of their ectopic thyroid tissues. Measurement of 24-hour radioactive iodine uptake within thyroidal tissues and hybrid single-photon emission computed tomography/computed tomography imaging using either iodine-123 or technetium-99m pertechnetate scans were performed in all patients demonstrating the location and size of lingual thyroid and absence of an orthotopic thyroid gland. Summary: The aim of this study was to describe nonsurgical management of obstructive lingual thyroid tissue with (131)I therapy for lingual thyroid radioablation. Patients were prepared with a low-iodine diet and levothyroxine withdrawal prior to radioablation for optimizing (131)I uptake in ectopic thyroid tissues. Hybrid single-photon emission computed tomography/computed tomography measurement of anatomic size of lingual thyroid tissue and radioactive iodine uptake guided the selection of therapeutic doses, resulting in administration of 10.7, 17.5, and 15.4 mCi of (131)I, respectively. There were no post-therapy complications, and clinical follow-up demonstrated resolution of obstructive oropharyngeal symptoms. Conclusions: Ectopic lingual thyroid tissue is rarely associated with obstructive oropharyngeal symptoms due to progressive enlargement. Radioiodine therapy with (131)I is an effective treatment modality for ablation of ectopic thyroid tissue as an alternative to surgery.
MeSH term(s)	Adult ; Female ; Humans ; Iodine Radioisotopes/chemistry ; Lingual Thyroid/diagnostic imaging ; Lingual Thyroid/etiology ; Lingual Thyroid/therapy ; Middle Aged ; Single Photon Emission Computed Tomography Computed Tomography ; Sodium Pertechnetate Tc 99m/chemistry ; Thyroid Dysgenesis/diagnostic imaging ; Thyroid Gland/diagnostic imaging ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/therapy ; Thyroxine/adverse effects ; Treatment Outcome ; Young Adult
Chemical Substances	Iodine Radioisotopes ; Sodium Pertechnetate Tc 99m (A0730CX801) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2015.0396
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Zs.A 3307: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 106: Show issues

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Article ; Online: Contemporary imaging of incidentally discovered adrenal masses.

Wale, Daniel J / Wong, Ka Kit / Viglianti, Benjamin L / Rubello, Domenico / Gross, Milton D

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Volume 87, Page(s) 256–262

Abstract: Adrenal lesions are routinely encountered incidentally in clinical practice. Although most of these lesions are benign, malignancy needs to be excluded. Therefore, the initial clinical workup is to exclude aggressive characteristics suggesting malignancy ...

Abstract	Adrenal lesions are routinely encountered incidentally in clinical practice. Although most of these lesions are benign, malignancy needs to be excluded. Therefore, the initial clinical workup is to exclude aggressive characteristics suggesting malignancy and to identify characteristics predictive of the most common benign lesion, an adrenal adenoma. Predicting a benign adenoma using a variety of imaging modalities has been widely studied using unenhanced computed tomography (CT), contrast enhanced CT, and magnetic resonance (MR) imaging. This review article describes the currently used imaging protocols and clinical interpretation criteria of common adrenal lesions. An adenoma can be predicted if a homogenous soft tissue adrenal mass demonstrates low attenuation (upper threshold value of 10 Hounsfield Units) on unenhanced CT, demonstrates an absolute enhancement washout of ≥ 60% and/or relative enhancement washout of ≥ 40% on adrenal washout contrast enhanced CT, or demonstrates signal loss in opposed-phased MR imaging. If an adrenal adenoma cannot be predicted based upon these criteria, the lesion should be evaluated for other imaging characteristics that suggest a specific pathology, such as an adrenal cyst or myelolipoma. Although nonspecific and with limitations, 18F-fluorodeoxyglucose (FDG) PET/CT has a potential role for differentiating benign from malignant lesions based upon the amount of radiopharmaceutical uptake with malignant lesions generally having greater uptake. If clinical and/or hormonal screening suggests a pheochromocytoma, consideration can be given to 18F-dihydroxyphenylalanine (DOPA) or 123I-metaiodobenzylguanidine (MIBG) in addition to CT and MR. Finally, this review proposes a diagnostic work-up strategy for routine use in clinical practice.
MeSH term(s)	Adrenal Gland Neoplasms/diagnostic imaging ; Animals ; Diagnostic Imaging/methods ; Humans ; Incidental Findings ; Magnetic Resonance Imaging/methods ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/administration & dosage ; Tomography, X-Ray Computed/methods
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2017-03
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2016.12.090
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Article ; Online: 99mTc MAG3 renography demonstrating return to normal renal function following resolution of renal vein thrombosis.

Leschied, Jessica R / Wong, Ka Kit / Gross, Milton D

Clinical nuclear medicine

2012 Volume 37, Issue 4, Page(s) 382–384

MeSH term(s)	Female ; Humans ; Kidney/blood supply ; Kidney/physiology ; Middle Aged ; Radioisotope Renography ; Recovery of Function ; Renal Veins/diagnostic imaging ; Technetium Tc 99m Mertiatide ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/physiopathology ; Venous Thrombosis/therapy
Chemical Substances	Technetium Tc 99m Mertiatide (36ITO9SKQJ)
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0b013e318239249f
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Zs.A 1276: Show issues

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Article: Something old, something new, PET in adrenal imaging.

Gross, Milton D / Rubello, Domenico

European journal of nuclear medicine and molecular imaging

2008 Volume 35, Issue 7, Page(s) 1233–1235

MeSH term(s)	Adrenal Glands/diagnostic imaging ; Adrenal Glands/metabolism ; Carbon Radioisotopes ; Etomidate/analogs & derivatives ; Fluorine Radioisotopes ; Humans ; Positron-Emission Tomography/methods ; Positron-Emission Tomography/trends ; Radiopharmaceuticals ; Steroid 11-beta-Hydroxylase/antagonists & inhibitors
Chemical Substances	Carbon Radioisotopes ; Fluorine Radioisotopes ; Radiopharmaceuticals ; Steroid 11-beta-Hydroxylase (EC 1.14.15.4) ; metomidate (Z18ZYL8Y51) ; Etomidate (Z22628B598)
Language	English
Publishing date	2008-03-13
Publishing country	Germany
Document type	Editorial
ZDB-ID	8236-3
ISSN	1619-7089 ; 1619-7070 ; 0340-6997
ISSN (online)	1619-7089
ISSN	1619-7070 ; 0340-6997
DOI	10.1007/s00259-008-0717-1
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Zs.A 1227: Show issues

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Article ; Online: Parathyroid adenoma localization with 99mTc-sestamibi SPECT/CT: a meta-analysis.

Wong, Ka Kit / Fig, Lorraine M / Gross, Milton D / Dwamena, Ben A

Nuclear medicine communications

2015 Volume 36, Issue 4, Page(s) 363–375

Abstract: Purpose: The aim of the study was to determine the diagnostic utility of parathyroid scintigraphy with technetium-99m (99mTc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) for localization of parathyroid adenoma.: ...

Abstract	Purpose: The aim of the study was to determine the diagnostic utility of parathyroid scintigraphy with technetium-99m (99mTc)-sestamibi single-photon emission computed tomography/computed tomography (SPECT/CT) for localization of parathyroid adenoma. Materials and methods: We performed a systematic search of medical databases PubMed and Medline/OVID for literature on 99mTc-sestamibi SPECT/CT parathyroid scintigraphy, using the search terms hyperparathyroidism, parathyroid adenoma/hyperplasia, SPECT/CT, and SPECT-CT. Citations for 981 articles and 128 abstracts of full articles were reviewed by two coauthors for relevance. Twenty-four peer-reviewed studies on SPECT/CT parathyroid scintigraphy qualified for inclusion. The Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality. Meta-analytical techniques were used to obtain pooled estimates of the parathyroid adenoma localization rate using a random-effects model. Results: A total of 24 studies published between January 2003 and March 2014 with 1276 patients (334 men, 762 women, and 180 of unspecified sex) met the inclusion criteria. Data on the test performance of dual-phase 99mTc-sestamibi SPECT/CT showed an estimated pooled sensitivity (per-patient analysis) of 0.86 [confidence interval (CI) 0.81-0.90]. Sensitivity of SPECT/CT was superior to that of SPECT (0.74; CI 0.66-0.82) and planar (0.70; CI 0.61-0.80) techniques. Heterogeneity was present in the reported literature (I2=80.3%). The rate of ectopic parathyroid adenomas ranged between 4 and 20% and SPECT/CT was superior to SPECT and planar imaging for localization of ectopic sites. Conclusion: Utilization of SPECT/CT fusion imaging for 99mTc-sestamibi parathyroid scintigraphy improves the test performance compared with planar and SPECT imaging; it assists preoperative planning for a minimally invasive surgical approach for the neck and is of value in subgroups with ectopic glands or coexisting nodular thyroid disease.
MeSH term(s)	Adenoma/diagnostic imaging ; Humans ; Multimodal Imaging ; Parathyroid Neoplasms/diagnostic imaging ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon/methods ; Tomography, X-Ray Computed/methods
Chemical Substances	Technetium Tc 99m Sestamibi (971Z4W1S09)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	758141-5
ISSN	1473-5628 ; 0143-3636
ISSN (online)	1473-5628
ISSN	0143-3636
DOI	10.1097/MNM.0000000000000262
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