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Article ; Online: Comparative Genomics of Borderline Oxacillin-Resistant Staphylococcus aureus Detected during a Pseudo-outbreak of Methicillin-Resistant S. aureus in a Neonatal Intensive Care Unit.

Sawhney, Sanjam S / Ransom, Eric M / Wallace, Meghan A / Reich, Patrick J / Dantas, Gautam / Burnham, Carey-Ann D

2022 Volume 13, Issue 1, Page(s) e0319621

Abstract: Active surveillance for methicillin-resistant Staphylococcus aureus (MRSA) is a component of our neonatal intensive care unit (NICU) infection prevention efforts. Recent atypical trends prompted review of 42 suspected MRSA isolates. Species ... ...

Abstract	Active surveillance for methicillin-resistant Staphylococcus aureus (MRSA) is a component of our neonatal intensive care unit (NICU) infection prevention efforts. Recent atypical trends prompted review of 42 suspected MRSA isolates. Species identification was confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and methicillin resistance was reevaluated by PBP2a lateral flow assay, cefoxitin/oxacillin susceptibility testing,
MeSH term(s)	Humans ; Infant, Newborn ; Methicillin-Resistant Staphylococcus aureus/genetics ; Staphylococcus aureus/genetics ; Anti-Bacterial Agents/pharmacology ; Methicillin Resistance ; Cefoxitin/therapeutic use ; Intensive Care Units, Neonatal ; Bacterial Proteins/metabolism ; Penicillin-Binding Proteins/genetics ; Oxacillin ; Staphylococcal Infections/microbiology ; Genomics ; beta-Lactamases ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Cefoxitin (6OEV9DX57Y) ; Bacterial Proteins ; Penicillin-Binding Proteins ; Oxacillin (UH95VD7V76) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.03196-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute Lymphoblastic Leukemia as Secondary Malignancy in a Case of Ewing’s Sarcoma on Treatment

Satyarth, Satyam / Parikh, Sonia / Anand, Asha / Sawhney, Jyoti / Panchal, Harsha / Patel, Apurva / Shah, Sandeep

Indian Journal of Medical and Paediatric Oncology

2017 Volume 38, Issue 03, Page(s) 354–356

Abstract: The survival of Ewing's sarcoma (ES) has improved due to advances in both local and systemic therapy. This has given rise to an increased detection of second malignant neoplasms which can be in the form of solid tumors and hematological malignancies. The ...

Abstract	The survival of Ewing's sarcoma (ES) has improved due to advances in both local and systemic therapy. This has given rise to an increased detection of second malignant neoplasms which can be in the form of solid tumors and hematological malignancies. The most common hematological malignancies are acute myeloid leukemia/myelodysplastic syndrome. Acute lymphoblastic leukemia (ALL) is relatively uncommon in occurrence in this setting. Furthermore, the average refractory period for hematological malignancies varies from 3 to 5 years. We report a case of a young female who developed ALL while on adjuvant therapy for ES.
Keywords	Acute lymphoblastic leukemia ; Ewing's sarcoma ; secondary malignancy
Language	English
Publishing date	2017-07-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2181724-8
ISSN	0975-2129 ; 0971-5851 ; 0975-2129
ISSN (online)	0975-2129
ISSN	0971-5851 ; 0975-2129
DOI	10.4103/ijmpo.ijmpo_110_16
Database	Thieme publisher's database

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Article: Pilot Study Showing Feasibility of Phosphoproteomic Profiling of Pathway-Level Molecular Alterations in Barrett’s Esophagus

Moore, Jarrod / Hekman, Ryan / Blum, Benjamin C. / Lawton, Matthew / Lehoux, Sylvain / Stachler, Matthew / Pleskow, Douglas / Sawhney, Mandeep S. / Cummings, Richard D. / Emili, Andrew / Qureshi, Alia

Genes. 2022 July 07, v. 13, no. 7

2022

Abstract: 1) Background: Barrett’s esophagus is a major risk factor for esophageal adenocarcinoma ... in Barrett’s esophagus lesions and adjacent normal tissue to glean insights into disease progression. (2) Methods ... Barrett’s esophagus samples and adjacent matched (normal) tissues from patients with known pathology, while specimens ...

Abstract	(1) Background: Barrett’s esophagus is a major risk factor for esophageal adenocarcinoma. In this pilot study, we employed precision mass spectrometry to map global (phospho)protein perturbations in Barrett’s esophagus lesions and adjacent normal tissue to glean insights into disease progression. (2) Methods: Biopsies were collected from two small but independent cohorts. Comparative analyses were performed between Barrett’s esophagus samples and adjacent matched (normal) tissues from patients with known pathology, while specimens from healthy patients served as additional controls. (3) Results: We identified and quantified 6810 proteins and 6395 phosphosites in the discovery cohort, revealing hundreds of statistically significant differences in protein abundances and phosphorylation states. We identified a robust proteomic signature that accurately classified the disease status of samples from the independent patient cohorts. Pathway-level analysis of the phosphoproteomic profiles revealed the dysregulation of specific cellular processes, including DNA repair, in Barrett’s esophagus relative to paired controls. Comparative analysis with previously published transcriptomic profiles provided independent evidence in support of these preliminary findings. (4) Conclusions: This pilot study establishes the feasibility of using unbiased quantitative phosphoproteomics to identify molecular perturbations associated with disease progression in Barrett’s esophagus to define potentially clinically actionable targets warranting further assessment.
Keywords	DNA repair ; adenocarcinoma ; disease progression ; esophagus ; mass spectrometry ; patients ; phosphorylation ; proteomics ; risk factors ; transcriptomics
Language	English
Dates of publication	2022-0707
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13071215
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults.

Case, Stephanie M / Sawhney, Manisha / Stewart, Jesse C

Depression and anxiety

2017 Volume 35, Issue 1, Page(s) 10–17

Abstract: ... of U.S. adults.: Methods: Prospective data from 28,726 adults initially free of CVD who participated ...

Abstract	Background: Although depression is a risk factor for cardiovascular disease (CVD), it is unknown whether this risk varies across depressive disorder subtypes. Thus, we investigated atypical major depressive disorder (MDD) and double depression as predictors of new-onset CVD in a nationally representative sample of U.S. adults. Methods: Prospective data from 28,726 adults initially free of CVD who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Lifetime depressive disorder subtypes (Wave 1) and incident CVD (Wave 2) were determined by structured interviews. Results: We identified 1,116 incident CVD cases. In demographics adjusted models, the atypical MDD group had a higher odds of incident CVD than the no depression history (OR = 2.19, 95% CI: 1.71-2.81, P < .001), dysthymic disorder only (OR = 1.61, 95% CI: 1.08-2.39, P = .019), and nonatypical MDD (OR = 1.46, 95% CI: 1.11-1.91, P = .006) groups. Likewise, the double depression group had a higher odds of incident CVD than the no depression history (OR = 2.17, 95% CI: 1.92-2.45, P < .001), dysthymic disorder only (OR = 1.59, 95% CI: 1.16-2.19, P = .004), and MDD only (OR = 1.46, 95% CI: 1.20-1.77, P < .001) groups. Relationships were similar but attenuated after adjustment for CVD risk factors and anxiety disorders. Conclusions: Adults with atypical MDD or double depression may be subgroups of the depressed population at particularly high risk of new-onset CVD. Thus, these subgroups may (a) be driving the overall depression-CVD relationship and (b) be in need of earlier and/or more intense CVD primary prevention efforts to reduce their excess CVD burden.
MeSH term(s)	Adult ; Cardiovascular Diseases/epidemiology ; Depressive Disorder, Major/epidemiology ; Dysthymic Disorder/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; United States/epidemiology
Language	English
Publishing date	2017-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1378635-0
ISSN	1520-6394 ; 1091-4269
ISSN (online)	1520-6394
ISSN	1091-4269
DOI	10.1002/da.22666
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Zs.A 3823: Show issues

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Article ; Online: Assessment of a Chronic Pain Clinic’s Compliance with Guidelines on Intrathecal Therapy for the Management of Pain

Monakshi Sawhney / Katie Root-Clarke / Elizabeth Brown / Scott Duggan / Mary Anne Good

Canadian Journal of Pain, Vol 0, Iss

2019

Abstract: Introduction/Aim: Intrathecal therapy (IT) is accepted as an effective way of treating chronic or cancer pain. The Polyanalgesic Consensus Conference (PACC, 2017) guidelines provide recommendations for: patient selection; assessment and psychological ... ...

Abstract	Introduction/Aim: Intrathecal therapy (IT) is accepted as an effective way of treating chronic or cancer pain. The Polyanalgesic Consensus Conference (PACC, 2017) guidelines provide recommendations for: patient selection; assessment and psychological considerations; medication selection and starting doses; and educational requirements for implanting and managing IT. This study examined the PACC recommendations regarding IT delivery and evaluated if these recommendations are being followed in a tertiary chronic pain setting. Method: This study utilized a retrospective chart audit. A checklist was created using the PACC guideline consensus points to assess for compliance with the recommendations. Results: Charts from patients (n = 8 eligible; n = 7 with consent) were reviewed in the clinic. The majority of PACC recommendations were met. Patients had a diagnosis of either palliative cancer pain (n = 2) or a chronic non-cancer pain (n = 5) including failed back syndrome (n = 4), and radicular extremity pain (n = 1). There were 5 different drug combinations administered to patients: morphine + bupivacaine (n = 2); hydromorphone (n = 2); morphine (n = 1); baclofen + morphine (n = 1); baclofen + bupivacaine (n = 1). Patients’ original opioids were weaned after the 1st year of IT. Psychological screening was only conducted for the cancer patients. All health care professionals who refilled pumps had the appropriate training and all programming was conducted using an independent double check. Discussion/Conclusions: Chronic non-cancer pain was the main reason for IT delivery at our clinic. Although the majority of PACC recommendations were met there is room for improvement, for example psychological screening is not routinely done but should be considered for current and future patients.
Keywords	Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exercise and lipids.

Madan, Kushal / Sawhney, J P S

Indian heart journal

2024 Volume 76 Suppl 1, Page(s) S73–S74

Abstract: Evidence from the existing literature suggests that exercise has positive effects for prevention and treatment of cardiovascular diseases by reducing risk factors such as elevated blood lipids. Based on clinical and observational clinical trials, it is ... ...

Abstract	Evidence from the existing literature suggests that exercise has positive effects for prevention and treatment of cardiovascular diseases by reducing risk factors such as elevated blood lipids. Based on clinical and observational clinical trials, it is well established that increased physical activity and regular exercise has a favourable impact on blood lipids and lipoprotein profiles. Exercise training significantly decreases blood triglycerides concentration and increases high density lipoprotein cholesterol levels. Though the Indian data depicting the effect of exercise on lipids is scarce, exercise directly improves "atherogenic dyslipidaemia" which is frequently present among Indians i.e. HDL-C is increased, TG is reduced and LDL-C particle size is improved. While drug therapy is key to the treatment of dyslipidaemia, lifestyle alterations such as exercise should continue to be actively promoted and encouraged by clinicians. Exercise is a low cost, non pharmacological therapeutic lifestyle change that is of value to lipid metabolism and cardiovascular fitness.
MeSH term(s)	Humans ; Cholesterol, HDL ; Dyslipidemias/therapy ; Exercise ; Lipids ; Lipoproteins ; Triglycerides ; Clinical Trials as Topic ; Observational Studies as Topic
Chemical Substances	Cholesterol, HDL ; Lipids ; Lipoproteins ; Triglycerides
Language	English
Publishing date	2024-04-08
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2023.11.270
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Zs.A 616: Show issues

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Article ; Online: Familial hypercholesterolemia.

Sawhney, J P S / Madan, Kushal

Indian heart journal

2024 Volume 76 Suppl 1, Page(s) S108–S112

Abstract: Familial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India. The prevalence of ... ...

Abstract	Familial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India. The prevalence of FH is higher in young CAD patients (<55 years in men; <60 years in women). FH is underdiagnosed and undertreated. Screening during childhood and Cascade screening of family members of known FH patients is of utmost importance in order to prevent the burden of CAD. Early identification of FH patients and early initiation of the lifelong lipid lowering therapy is the most effective strategy for managing FH. FH management includes pharmaceutical agents (statins and non statin drugs) and lifestyle modification. Inspite of maximum dose of statin with or without Ezetimibe, if target levels of LDL-C are not achieved, Bempedoic acid, proprotein convertase subtilisin/kexin type 9 (PCSK9) Inhibitors/Inclisiran can be added.
MeSH term(s)	Male ; Humans ; Female ; Proprotein Convertase 9/therapeutic use ; Anticholesteremic Agents/therapeutic use ; Cholesterol, LDL ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Chemical Substances	PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Anticholesteremic Agents ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2024-04-08
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2023.12.002
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Zs.A 616: Show issues

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Article ; Online: Behçet’s Disease

Rajeev Jain / Samir S Hussein / Sukhpal Sawhney

Sultan Qaboos University Medical Journal, Vol 6, Iss 2, Pp 91-

Bilateral Pulmonary Arterial Aneurysms Presenting as Pulmonary Embolism

2006 Volume 92

Abstract: ... ...

Abstract	NA
Keywords	na ; Medicine ; R
Language	English
Publishing date	2006-12-01T00:00:00Z
Publisher	Sultan Qaboos University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatosplenic Alpha-Beta T-Cell Lymphoma: A Challenging Diagnostic Entity.

Gabra, Abanoub / Polanco, Joanna / Thapa, Shrija / Sawhney, Sumit / Glazyrin, Alexey

Journal of hematology

2024 Volume 13, Issue 1-2, Page(s) 29–33

Abstract: Hepatosplenic T-cell lymphoma (HSTCL) is rare and clinically very aggressive T-cell lymphoma. The majority of cases harbor γδ T-cell receptors (TCRs); however, in some even rarer cases, tumor cells harbor αβ TCR. Recent studies suggest that αβ cases may ... ...

Abstract	Hepatosplenic T-cell lymphoma (HSTCL) is rare and clinically very aggressive T-cell lymphoma. The majority of cases harbor γδ T-cell receptors (TCRs); however, in some even rarer cases, tumor cells harbor αβ TCR. Recent studies suggest that αβ cases may have distinct morphological characteristics and demonstrate an even more aggressive course. In this case report, we demonstrated that in line with previous findings, αβ case of HSTCL had hemolytic presentation, demonstrated a very aggressive clinical course, and was unrelated to immunosuppression. Morphologically, tumor cells demonstrated diffuse growth pattern, blastoid morphology, and were CD8
Language	English
Publishing date	2024-04-09
Publishing country	Canada
Document type	Case Reports
ZDB-ID	2662519-2
ISSN	1927-1220 ; 1927-1220
ISSN (online)	1927-1220
ISSN	1927-1220
DOI	10.14740/jh1203
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Article ; Online: Biomarkers to Predict CKD After Acute Kidney Injury: News or Noise?

Silver, Samuel A / Sawhney, Simon

American journal of kidney diseases : the official journal of the National Kidney Foundation

2022 Volume 79, Issue 5, Page(s) 620–622

MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Biomarkers ; Female ; Humans ; Male ; Renal Insufficiency, Chronic/diagnosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2021.09.023
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 468: Show issues

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