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Article ; Online: Patterns of HPV vaccine hesitancy among catch-up generations in Japan: A descriptive study.

Machida, Masaki / Inoue, Shigeru

2023 Volume 41, Issue 18, Page(s) 2956–2960

Abstract: Background: Cervical cancer is a preventable disease caused by human papillomavirus (HPV). The HPV vaccine uptake in Japan has been slow since the Ministry of Health, Labour and Welfare suspended the recommendation for proactive HPV vaccination in 2013. ...

Abstract	Background: Cervical cancer is a preventable disease caused by human papillomavirus (HPV). The HPV vaccine uptake in Japan has been slow since the Ministry of Health, Labour and Welfare suspended the recommendation for proactive HPV vaccination in 2013. In April 2022, Japan initiated catch-up vaccinations for women who missed the opportunity to receive the HPV vaccine. However, as of September 2022, very few women had received catch-up vaccination, raising concerns about vaccine hesitancy in the target population. It is necessary to understand the thinking and motivation of the target population to develop effective strategies to improve vaccination rates. Therefore, using cluster analysis, this study aimed to clarify the pattern of HPV vaccine hesitancy among the catch-up generations in Japan. Methods: This descriptive study was based on an Internet survey completed by 3,790 women in Japan aged over 18 years who were eligible for catch-up vaccination and had not yet received an HPV vaccine. Participants were asked about their intention and thinking about the HPV vaccine and descriptive norms on vaccination intention. Cluster analysis using k-means clustering was performed to clarify these patterns. Results: Cluster analysis revealed three hesitancy patterns: acceptance, neutral and refusal. The acceptance group, with high intention, comprised 28.2% of the participants, and students and a high-income level mainly dominated this group. The refusal group, with negative thinking and low intention, accounted for 20.1% and was more prevalent among workers and the unemployed. The neutral group, with neutral thinking and intention, accounted for 51.6%. The perceived effect of descriptive norms on vaccination intention was large in the acceptance group but small in the refusal group. Conclusion: HPV vaccine awareness promotion strategies must be based on the characteristics of each group and the different distributions of sociodemographic factors.
MeSH term(s)	Humans ; Female ; Adult ; Middle Aged ; Papillomavirus Vaccines ; Papillomavirus Infections/prevention & control ; Japan ; Vaccination Hesitancy ; Vaccination ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/epidemiology ; Health Knowledge, Attitudes, Practice ; Patient Acceptance of Health Care
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2023-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.03.061
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Article: [Vaccine hesitancy: current status, associated factors, measurement, and approach].

Machida, Masaki / Inoue, Shigeru

Nihon koshu eisei zasshi] Japanese journal of public health

2023 Volume 70, Issue 8, Page(s) 474–482

Abstract: Definition and present status　Vaccine hesitancy, defined as "delay in acceptance or refusal of vaccination despite availability of vaccination services," is a global public health concern. Specifically, COVID-19 and human papillomavirus (HPV) vaccine ... ...

Abstract	Definition and present status　Vaccine hesitancy, defined as "delay in acceptance or refusal of vaccination despite availability of vaccination services," is a global public health concern. Specifically, COVID-19 and human papillomavirus (HPV) vaccine hesitancy remains a major social challenge in Japan, and effective preventive strategies are urgently required. In this review, we discuss previous studies that have described vaccine hesitancy.Associated factors　Vaccine hesitancy is affected by several factors, primarily psychological variables (referred to as the "3Cs" comprising confidence, complacency, and convenience regarding individuals' perceptions of vaccination) and sociodemographic variables (age, sex, socioeconomic status, race, and social capital). "Behavioral and Social Drivers of Vaccination Framework", developed recently by the World Health Organization, has focused on vaccination-specific beliefs and reports that programs may affect and are likely to have wide applicability in the development of effective interventions.Measurement　Identification of psychological factors associated with vaccination hesitancy is important to establish strategies to increase vaccine uptake. Many scales are available to measure vaccine hesitancy and psychological factors that affect vaccine hesitancy. These scales include different evaluation items, validity, reliability, and availability of validated Japanese versions. Therefore, careful selection of scales based on their intended purpose and the target population in whom the desired intervention is intended are important. A representative 7C scale is widely used globally. It has been translated into more than 10 languages, including Japanese.Approach　Several studies and articles, mainly developed for the European and American populations provide guidelines for selection of evidence-based strategies and interventions to increase vaccine uptake. Evidence-based strategies may be broadly classified into the following categories: (1) Strengthening the healthcare system through implementation of the principles of behavioral science. (2) Development of tailored approaches using systematic listening activities. (3) Provision of evidence-based resources to support healthcare personnel. (4) Utilization of media. Based on findings described by previous studies discussed in this report, it may be important to plan strategies to improve the uptake of each vaccine in Japan, such as those for COVID-19, HPV, and also childhood vaccines.
MeSH term(s)	Humans ; Child ; Vaccination Hesitancy ; Papillomavirus Infections ; Reproducibility of Results ; Patient Acceptance of Health Care ; COVID-19/prevention & control ; Vaccination/psychology ; Vaccines
Chemical Substances	Vaccines
Language	Japanese
Publishing date	2023-05-10
Publishing country	Japan
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	45044-3
ISSN	0546-1766
ISSN	0546-1766
DOI	10.11236/jph.23-004
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Article ; Online: Psychological determinants of COVID-19 vaccine acceptance: A comparison between immigrants and the host population in Japan.

Teng, Yuanyuan / Hanibuchi, Tomoya / Machida, Masaki / Nakaya, Tomoki

Vaccine

2023 Volume 41, Issue 8, Page(s) 1426–1430

Abstract: This study explored the differences in COVID-19 vaccination readiness based on the 7C model and its association with vaccine acceptance among foreign-born immigrants, Japan-born immigrants, and locals in Japan. A cross-sectional survey was conducted in ... ...

Abstract	This study explored the differences in COVID-19 vaccination readiness based on the 7C model and its association with vaccine acceptance among foreign-born immigrants, Japan-born immigrants, and locals in Japan. A cross-sectional survey was conducted in October 2021 (n = 3,690). Our results show that COVID-19 vaccination readiness, acceptance, and their relationship differ according to migratory status and nativity. Immigrant participants reported higher general vaccination readiness and acceptability for vaccination against COVID-19 than the Japanese participants, but had lower vaccination coverage, particularly among those born in Japan. The psychological determinants of Japan-born immigrants were more similar to those of Japanese participants than those of foreign-born immigrants. The effects of confidence, complacency, and constraints on COVID-19 vaccine acceptance were strong among all three groups. However, the role of collective responsibility and conspiracy varied by migratory status. This study highlighted the importance of culturally tailored interventions in vaccine delivery to immigrants.
MeSH term(s)	Humans ; COVID-19 Vaccines ; Cross-Sectional Studies ; Japan ; COVID-19/prevention & control ; Emigrants and Immigrants ; Vaccination ; Vaccines
Chemical Substances	COVID-19 Vaccines ; Vaccines
Language	English
Publishing date	2023-01-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.01.037
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Article ; Online: General Vaccination Readiness in Japan: Results from the JASTIS 2023 Study.

Machida, Masaki / Inoue, Shigeru / Tabuchi, Takahiro

Japanese journal of infectious diseases

2023 Volume 77, Issue 1, Page(s) 34–39

Abstract: General vaccine hesitancy is a global concern. Clarifying general vaccination readiness and the psychological factors comprising it is important. Previous studies reported that Japan has one of the lowest vaccine confidence levels worldwide. However, the ...

Abstract	General vaccine hesitancy is a global concern. Clarifying general vaccination readiness and the psychological factors comprising it is important. Previous studies reported that Japan has one of the lowest vaccine confidence levels worldwide. However, the status of other psychological factors comprising general vaccination readiness in Japan remains unclear. Therefore, we aimed to clarify the status of seven psychological factors comprising general vaccination readiness and their patterns in Japan. This descriptive study utilized data from a large-scale nationwide internet survey (Japan Society and New Tobacco Internet Survey 2023 study, N = 31,037). Seven psychological factors were assessed using the 7C of vaccination readiness scale. Cluster analysis was performed using k-means++ clustering to clarify patterns. Of the seven factors, support for social monitoring of people refusing vaccination (e.g., vaccine passports) was very low among the participants. Cluster analysis showed that the participants' vaccination readiness could be classified into six patterns, of which the very low vaccination readiness cluster, with the lowest scores for most psychological factors, accounted for 11.1% and was more common among those aged 30-49 years (13.1-16.4%). Individuals in this cluster may refuse to receive recommended vaccines.
MeSH term(s)	Humans ; Japan ; Vaccination ; Vaccines ; Surveys and Questionnaires ; Cluster Analysis
Chemical Substances	Vaccines
Language	English
Publishing date	2023-10-31
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2023.261
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Article: Relationship between weight bearing ratio in sitting and physical function assessment in healthy adults.

Moriyama, Yoshinao / Shimamura, Ryota / Hirosawa, Masaki / Sakasai, Takayuki / Machida, Hayato

Journal of physical therapy science

2023 Volume 35, Issue 5, Page(s) 320–325

Abstract: Purpose] The weight-bearing ratio in sitting is a simple quantitative assessment using a body weight scale. Bilateral total weight bearing ratio in sitting is related to the ability to stand up, transfer, and walk; however, it has not been examined in ... ...

Abstract	[Purpose] The weight-bearing ratio in sitting is a simple quantitative assessment using a body weight scale. Bilateral total weight bearing ratio in sitting is related to the ability to stand up, transfer, and walk; however, it has not been examined in the performance test on just one side. Therefore, this study aimed to investigate the relationship between weight bearing ratio in sitting and performance tests on one side. [Participants and Methods] Thirty-two healthy adults were recruited (27.47 ± 4.06 years). Weight-bearing ratio in sitting, knee extensor muscle strength, lateral reach test, and one-leg stand-up test were measured. Correlation analysis between the measurement results was performed on the pivot and non-pivot sides and the total. [Results] Correlation analysis of the weight-bearing ratio in sitting showed a significant positive correlation (pivot/non-pivot/total) with knee extensor muscle strength (r=0.54/0.44/0.50), lateral reach test (r=0.42/0.44/0.48), and one-leg stand up test (r=0.44/0.52/0.51). [Conclusion] Weight-bearing ratio in sitting, both pivot, non-pivot, and total, reflected results of the performance tests. Weight bearing ratio in sitting would be a highly useful quantitative assessment for a wide range of individuals, from those with unstable standing to those with relatively high function.
Language	English
Publishing date	2023-05-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.35.320
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Article ; Online: Estimation of cutoff score for the 7C of vaccination readiness scale.

Machida, Masaki / Takamiya, Tomoko / Odagiri, Yuko / Fukushima, Noritoshi / Kikuchi, Hiroyuki / Inoue, Shigeru

Vaccine: X

2023 Volume 15, Page(s) 100394

Abstract: The 7C of the vaccination readiness scale provides a score to evaluate the willingness and readiness to get vaccinated (vaccination readiness). This cross-sectional study clarifies the cutoff vaccination readiness score to determine whether an individual ...

Abstract	The 7C of the vaccination readiness scale provides a score to evaluate the willingness and readiness to get vaccinated (vaccination readiness). This cross-sectional study clarifies the cutoff vaccination readiness score to determine whether an individual is willing to be vaccinated. We conducted an online survey of 774 participants. The vaccination readiness scores for the full and short survey versions were calculated. The coronavirus disease 2019 vaccination status was used to determine whether the participant was willing to be vaccinated. Receiver operating characteristic curve analysis was performed using the Youden index. The Youden Index was at its maximum when the cutoff score was 4.02 for the full version (area under the curve [AUC]:0.94) and 4.07 for the short version (AUC:0.90). Vaccination readiness scores greater than 4 on both the full and short version may indicate a willingness to be vaccinated. This cutoff value facilitates the interpretation of the 7C scale results.
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ISSN	2590-1362
ISSN (online)	2590-1362
DOI	10.1016/j.jvacx.2023.100394
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Article ; Online: Association between the decrease in medical visit frequency and chronic disease worsening in the early stages of COVID-19-A longitudinal study.

Takakubo, Takeshi / Odagiri, Yuko / Machida, Masaki / Takamiya, Tomoko / Fukushima, Noritoshi / Kikuchi, Hiroyuki / Hayashi, Toshio / Amagasa, Shiho / Inoue, Shigeru

Internal medicine (Tokyo, Japan)

2024

Abstract: Background: This longitudinal study aimed to clarify the changes in the medical treatment behavior of Japanese patients with chronic diseases during the early phase of the COVID-19 pandemic and examine the factors associated with disease worsening.: ... ...

Abstract	Background: This longitudinal study aimed to clarify the changes in the medical treatment behavior of Japanese patients with chronic diseases during the early phase of the COVID-19 pandemic and examine the factors associated with disease worsening. Methods: Subjects with chronic diseases were selected from a panel survey that started at the beginning of the COVID-19 pandemic consists of 2,400 participants recruited via the Internet. Medical treatment behaviors (decrease in medical visit frequency, inability to take regular medications, and utilization of telephone/online medical care), psychological distress, and sociodemographic factors were evaluated at baseline (May 2020) and at the follow-up survey (February 2021). A worsening of chronic diseases was defined as those who answered yes to the question, "Has-the-condition-of-the-chronic-disease-worsened?". The factors related to the worsening of chronic diseases at follow-up were examined. Results: A total of 514 participants (mean age 61.6±12.9 years) were analyzed. The percentage of participants who reported decreasing medical visit frequency was 34% at the baseline and 16.5% at follow-up, and those who reported a worsening of chronic diseases was 5.1% and 5.1%, respectively. A worsening of chronic diseases at follow-up was significantly associated with a younger age, a decreased frequency of medical visits, unemployment, a history of smoking, and psychological distress. Conclusions: A decreased frequency of medical visits was observed among one-third of the participants with chronic disease in the early stage of the pandemic, and it reduced by half at follow-up. In the early stages of an emerging infectious disease pandemic, decreased regular hospital/clinic visits can lead to a worsening of chronic diseases. Those who had psychological distress, unemployment, and a history of smoking were vulnerable to a worsening chronic disease.
Language	English
Publishing date	2024-04-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2697-23
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Article ; Online: Tracking handgrip strength in Kendo athletes from university to middle and older adulthood.

Abe, Takashi / Machida, Shuichi / Nakamura, Mitsuru / Kohmura, Yoshimitsu / Suzuki, Koya / Abe, Akemi / Nakano, Masaki / Loenneke, Jeremy P / Naito, Hisashi

American journal of human biology : the official journal of the Human Biology Council

2024 , Page(s) e24082

Abstract: Objective: This study aimed to compare the current handgrip strength (HGS) of Kendo athletes with their HGS when they were in university (up to 50 years).: Methods: Eighty male graduates who were Kendo club members during their university days ... ...

Abstract	Objective: This study aimed to compare the current handgrip strength (HGS) of Kendo athletes with their HGS when they were in university (up to 50 years). Methods: Eighty male graduates who were Kendo club members during their university days performed anthropometric and HGS measurements, and these HGS were compared with those measured during their university days (mean age of 19.5 years old). Results: There was no evidence of a statistical difference in HGS between the current measurement and the measurement taken during university [-0.64 (-1.9, 0.67) kg, p = .336]. There was, however, evidence that the difference in HGS depended upon the current age of the individual (t = -6.43, p < .001). When probing the interaction, there were statistical differences between the ages of 24.6 and 38.2 years and between the ages of 47.4 and 69.9 years. Strength increased across time in the younger participants and decreased for those who were older. Between the ages of 38.9 and 46.1 years, there was no evidence of a statistical difference indicating a maintenance of strength. Conclusion: The HGS of Kendo club graduates, which they acquired during their formative years, continued to increase even after they graduated from university and entered their 30s. However, their HGS decreased from age 50, even though they practiced Kendo.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.24082
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Article ; Online: Prostatic stromal tumour of uncertain malignant potential in a dog.

Nagashima, Tomokazu / Kobayashi, Masanori / Kubo, Yoshiaki / Nagaho, Katsuya / Sugibayashi, Kayoko / Saito, Takahiro / Machida, Yukino / Michishita, Masaki

Journal of comparative pathology

2024 Volume 210, Page(s) 8–14

Abstract: An 11-year-old male Miniature Dachshund dog was presented with dyschezia. Computed tomography examination 35 days after the initial visit revealed a prostate mass (4.0 × 3.5 × 2.7 cm) and prostatectomy and orchiectomy were performed 13 days later. ... ...

Abstract	An 11-year-old male Miniature Dachshund dog was presented with dyschezia. Computed tomography examination 35 days after the initial visit revealed a prostate mass (4.0 × 3.5 × 2.7 cm) and prostatectomy and orchiectomy were performed 13 days later. Grossly, the prostate was rubbery and the cut surface of the mass was swollen. The mass was whitish and demarcated from the surrounding tissues. Microscopically, the mass had a capsulate consisting of atypical spindloid stromal cells arranged in a phyllode pattern and also in a fasciculated pattern admixed with acinar ductal cells. Atypical stromal cells contained round-to-oval finely hyperchromatic nuclei that had distinct nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, the atypical stromal cells were positive for vimentin, CD34, desmin, α-smooth muscle actin, progesterone receptor and androgen receptor but negative for cytokeratin AE1/AE3, p63, c-Kit, DOG-1 and SOX10. On the basis of these findings, the tumour was diagnosed as a prostatic stromal tumour of uncertain malignant potential.
MeSH term(s)	Male ; Animals ; Dogs ; Prostate/pathology ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/veterinary ; Proto-Oncogene Proteins c-kit ; Dog Diseases/pathology
Chemical Substances	Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2024.02.003
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Article ; Online: Childhood book availability helps to preserve cognitive function in older adults with low education: Results from the NEIGE study.

Tani, Yukako / Kawahara, Tomoki / Sugihara, Genichi / Machida, Masaki / Amagasa, Shiho / Murayama, Hiroshi / Inoue, Shigeru / Fujiwara, Takeo / Shobugawa, Yugo

The journals of gerontology. Series B, Psychological sciences and social sciences

2024

Abstract: Objectives: It is well-known that low educational attainment is associated with cognitive function decline in older age. Childhood book availability may help to preserve cognitive function in older adults with low education. The study objective was to ... ...

Abstract	Objectives: It is well-known that low educational attainment is associated with cognitive function decline in older age. Childhood book availability may help to preserve cognitive function in older adults with low education. The study objective was to examine the association between childhood book availability and cognitive function among older adults with low educational attainment, and to investigate the mediating effect of the volume of reading-related brain regions (e.g., superior temporal cortex). Methods: A cross-sectional study of community-dwelling older Japanese adults aged 65-84 years was conducted (n=474). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Childhood book availability was assessed using a retrospective questionnaire. Brain region volume was measured using magnetic resonance imaging. Multivariate regression modeling and structural equation modeling were used for analysis. Results: Both high educational attainment and childhood book availability were independently associated with high MMSE score. Stratification of educational level showed that childhood book availability was positively associated with MMSE score among participants with low educational attainment (coefficient=1.48, 95% confidence interval (CI): 0.31 to 2.66), but not among those with moderate or high educational attainment (coefficient=-0.01, 95% CI: -1.44 to 1.42 and -1.21, 95% CI: -3.85 to 1.42, respectively). Among participants with low educational attainment, left superior temporal cortex volume mediated the association between childhood book availability and MMSE score. Discussion: The availability of books in childhood helps to preserve cognitive function in older adults with low education via left superior temporal cortex volume. Further research is needed to replicate these findings.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223664-0
ISSN	1758-5368 ; 1079-5014
ISSN (online)	1758-5368
ISSN	1079-5014
DOI	10.1093/geronb/gbae052
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