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  1. Article ; Online: Increase in urolithiasis prevalence due to vitamins C and D supplementation during the COVID-19 pandemic.

    Karam, Aya / Mjaess, Georges / Younes, Hadi / Aoun, Fouad

    Journal of public health (Oxford, England)

    2021  Volume 44, Issue 4, Page(s) e625–e626

    MeSH term(s) Humans ; Ascorbic Acid/therapeutic use ; COVID-19 ; Dietary Supplements ; Pandemics ; Prevalence ; Urolithiasis ; Vitamins/therapeutic use ; Vitamin D/therapeutic use
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdab328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2186: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: A 1-year analysis of adverse events following COVID-19 vaccination in Lebanon: a retrospective study.

    Zeitoun, Abeer / Hallit, Souheil / Chehade, Sirine / Ibrahim, Aya / Helali, Maya / Allam, Carla / Karam, Rita

    Journal of pharmaceutical policy and practice

    2023  Volume 16, Issue 1, Page(s) 24

    Abstract: Background: Since the deployment of Coronavirus Disease 2019 (COVID-19) vaccines, skepticism about the safety, incidence, and severity of Adverse Events Following Immunization (AEFI) was a concern. The study has two main objectives. First, to analyze ... ...

    Abstract Background: Since the deployment of Coronavirus Disease 2019 (COVID-19) vaccines, skepticism about the safety, incidence, and severity of Adverse Events Following Immunization (AEFI) was a concern. The study has two main objectives. First, to analyze AEFIs following COVID-19 vaccines (Pfizer-BioNTech, AstraZeneca, Sputnik, and Sinopharm) during the vaccination campaign in Lebanon and correlate them with age and gender. Second, to correlate Pfizer-BioNTech and AstraZeneca vaccines' AEFI with the dose administered.
    Methods: A retrospective study was carried out between February 14th, 2021, and February 14th, 2022. AEFI case reports received to the Lebanese Pharmacovigilance (PV) Program were cleaned, validated, and analyzed using SPSS software.
    Results: A total of 6808 AEFI case reports were received to the Lebanese PV Program during the period of this study. Case reports were mostly received from females (60.7%) and from vaccine recipients aged 18-44 years. As for the vaccine type, AEFIs occurred more frequently with the AstraZeneca vaccine compared to the Pfizer-BioNTech vaccine. The latter had AEFIs mainly following dose 2, whereas AEFIs with the AstraZeneca vaccine were more frequently reported after dose 1, with general body pain being the most reported systemic AEFI with PZ (34.6%), while fatigue was the most reported AEFI with AZ vaccine (56.5%).
    Conclusions: The AEFI reported with COVID-19 vaccines in Lebanon were aligned with those reported worldwide. The incidence of rare serious AEFIs should not discourage the public from getting vaccinated. Further studies are needed to evaluate their long-term potential risk.
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1186/s40545-023-00528-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Fecal microbiota transplantation for immunotherapy-resistant urological tumors: Is it time? An update of the recent literature.

    Mjaess, Georges / Karam, Aya / Aoun, Fouad / Albisinni, Simone / Roumeguère, Thierry

    Cancer

    2021  Volume 128, Issue 1, Page(s) 14–19

    MeSH term(s) Carcinoma, Renal Cell ; Fecal Microbiota Transplantation ; Humans ; Immunotherapy ; Kidney Neoplasms ; Urologic Neoplasms/therapy
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33893
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.146: Show issues Location:
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  4. Article: GAN-based semi-automated augmentation online tool for agricultural pest detection: A case study on whiteflies.

    Karam, Christophe / Awad, Mariette / Abou Jawdah, Yusuf / Ezzeddine, Nour / Fardoun, Aya

    Frontiers in plant science

    2022  Volume 13, Page(s) 813050

    Abstract: Deep neural networks can be used to diagnose and detect plant diseases, helping to avoid the plant health-related crop production losses ranging from 20 to 50% annually. However, the data collection and annotation required to achieve high accuracies can ... ...

    Abstract Deep neural networks can be used to diagnose and detect plant diseases, helping to avoid the plant health-related crop production losses ranging from 20 to 50% annually. However, the data collection and annotation required to achieve high accuracies can be expensive and sometimes very difficult to obtain in specific use-cases. To this end, this work proposes a synthetic data generation pipeline based on generative adversarial networks (GANs), allowing users to artificially generate images to augment their small datasets through its web interface. The image-generation pipeline is tested on a home-collected dataset of whitefly pests,
    Language English
    Publishing date 2022-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.813050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Myths, Superstitions, and Popular Beliefs: Do They Still Impact Our Practice?

    Mjaess, Georges / Aoun, Fouad / Kazzi, Hanane / Karam, Aya / Albisinni, Simone / Roumeguère, Thierry

    Annals of surgery

    2021  Volume 274, Issue 6, Page(s) e641–e642

    MeSH term(s) Folklore ; Humans ; Mythology ; Superstitions ; Surgeons/psychology ; Symbolism
    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Does antibiotic use explain the discrepancy of urolithiasis prevalence between countries?

    Karam, Aya / Mjaess, Georges / Aoun, Fouad / Albisinni, Simone / Vafa, Haydeh / Roumeguere, Thierry

    Urolithiasis

    2020  Volume 49, Issue 2, Page(s) 181–182

    Language English
    Publishing date 2020-11-16
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-020-01229-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 928: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Journal ; Article ; Online: COVID-19, the economic crisis, and the Beirut blast

    Georges Mjaess / Aya Karam / Roy Chebel / Georges Abi Tayeh / Fouad Aoun

    what 2020 meant to the Lebanese health-care system

    2021  

    Abstract: ... 535 ... ...

    Abstract 535

    537
    Keywords Coronavirus Disease (COVID-19) ; COVID-19 ; Economic Recession ; Pandemics ; Delivery of Health Care ; economics
    Language English
    Publisher World Health Organization. Regional Office for the Eastern Mediterranean
    Document type Journal ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A dynamic online nomogram predicting severe vitamin D deficiency at ICU admission.

    Bou Kheir, George / Khaldi, Amina / Karam, Aya / Duquenne, Louis / Preiser, Jean-Charles

    Clinical nutrition (Edinburgh, Scotland)

    2021  Volume 40, Issue 10, Page(s) 5383–5390

    Abstract: Introduction: Although prevalent and associated with worsened outcomes, vitamin D severe deficiency is not systematically searched among intensive care unit (ICU) admissions and waiting time for measurement results range from hours to few days. Hence, ... ...

    Abstract Introduction: Although prevalent and associated with worsened outcomes, vitamin D severe deficiency is not systematically searched among intensive care unit (ICU) admissions and waiting time for measurement results range from hours to few days. Hence, we developed and internally validated a simple nomogram for predicting severe vitamin D deficiency at ICU admission.
    Patients and methods: Data of 3338 ICU admissions from an observational prospective cohort registered between January 2017 and December 2019 were analyzed. Demographic data as well as severity scores and season of admission were obtained. After splitting the population into training and test sets, a least absolute shrinkage (LASSO) regression model was used to select factors and construct the nomogram. Calibration and discrimination were used to assess the nomogram performance. Clinical use was evaluated by a decision curve analysis.
    Results: Age, gender, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score III (SAPS3) and season of admission were identified by the LASSO regression analysis as significant predictors of vitamin D severe deficiency at ICU admission. The nomogram model showed good discrimination with a 1000 bootstrap analysis and good calibration with a C-index of 0.64. The decision curve analysis showed that at a threshold probability between 30% and 50%, using the nomogram adds more benefit that considering that all patients are severely deficient or non-severely deficient.
    Conclusions: This easy-to-use dynamic nomogram can help physicians to select patients that could benefit the most from vitamin D supplementation at ICU admission. External validation is needed to verify the generalizability of this nomogram.
    MeSH term(s) Adult ; Aged ; Belgium/epidemiology ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Nomograms ; Organ Dysfunction Scores ; Patient Admission ; Predictive Value of Tests ; Regression Analysis ; Reproducibility of Results ; Seasons ; Simplified Acute Physiology Score ; Vitamin D Deficiency/diagnosis
    Language English
    Publishing date 2021-09-04
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2021.08.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1774: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: CAR-T Cell Therapy for Solid Tumors: Are we Still That Far? a Systematic Review of Literature.

    Karam, Aya / Mjaess, Georges / Martinez Chanza, Nieves / Aoun, Fouad / Bou Kheir, George / Younes, Hadi / Kazzi, Hanane / Albisinni, Simone / Roumeguère, Thierry

    Cancer investigation

    2022  Volume 40, Issue 10, Page(s) 923–937

    Abstract: This systematic review aims to assess all the prospective studies published to date on the efficacy of CAR-T cell therapy in solid tumors. Databases searched were PubMed and Google Scholar from inception through May 1st 2021. Search query was (Chimeric ... ...

    Abstract This systematic review aims to assess all the prospective studies published to date on the efficacy of CAR-T cell therapy in solid tumors. Databases searched were PubMed and Google Scholar from inception through May 1st 2021. Search query was (Chimeric antigen receptor) or (CAR-T) or (T-CAR). Twenty-nine prospective studies (265 patients) were included. Most published clinical trials are phase I. Clinical benefit was 100% in epithelial ovarian cancer, 70-82% in gastrointestinal tumors, 79% in mesothelioma, 63% in small-cell lung cancer, 24-67% in sarcoma, 50-62% in prostate cancer, and 45-50% in central nervous system tumors. No serious CAR-T cell specific serious toxicities were noted.
    MeSH term(s) Male ; Humans ; Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/therapeutic use ; Prospective Studies ; T-Lymphocytes ; Immunotherapy, Adoptive/adverse effects ; Gastrointestinal Neoplasms ; Cell- and Tissue-Based Therapy
    Chemical Substances Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-09-20
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2022.2125004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Vaccination process evaluation at COVID-19 vaccination centers in Lebanon: a national study.

    Zeitoun, Abeer / Hallit, Souheil / Helali, Maya / Chehade, Sirine / Allam, Carla / Ibrahim, Aya / Dimassi, Hani / Karam, Rita

    Journal of pharmaceutical policy and practice

    2022  Volume 15, Issue 1, Page(s) 63

    Abstract: Background: Upon the authorization of COVID-19 vaccines worldwide, national and international standards were developed to help integrate mass COVID-19 immunization campaigns into the healthcare network. The primary objective is to evaluate the overall ... ...

    Abstract Background: Upon the authorization of COVID-19 vaccines worldwide, national and international standards were developed to help integrate mass COVID-19 immunization campaigns into the healthcare network. The primary objective is to evaluate the overall COVID-19 vaccination process through on-site visits to vaccination centers all over Lebanon to assess whether these are abiding by the national and international requirements for both Pfizer-BioNTech and AstraZeneca vaccines. The secondary objective is to explore whether the type of the facility, private versus governmental, and educational versus non-education, affects the vaccination process in these centers.
    Methods: A convenient sample of 33 vaccination centers was selected from a list of all COVID-19 vaccination centers operating in Lebanon. Data were collected using a structured checklist developed following an extensive literature review of the national and international standards for Pfizer-BioNTech and AstraZeneca COVID-19 vaccines. A scoring system for the overall vaccination process was developed.
    Results: Quality deficiencies were identified in several steps of the immunization process; however, the international standards were followed in most vaccination centers visited despite their limited resources. It was noticed that there were no significant differences between private and governmental, between educational and non-educational, and between Pfizer and AstraZeneca vaccination centers; the 33 vaccination centers visited have scored above 75 on the entire process immunization against COVID-19 with P-values above 0.05 in all steps evaluated.
    Conclusion: An optimization of the immunization process should be performed to ensure that the practice is within international standards. This can be done by conducting periodic vaccination center visits, implementing clear guidelines, training staff involved in the vaccination process, and ensuring continuous support of the Lebanese Ministry of Public Health.
    Language English
    Publishing date 2022-10-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1186/s40545-022-00459-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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