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  1. Book ; Online: Heme Oxygenase (HO)-1 as an Immunoregulator in Health and Disease

    Lianos, Elias / Detsika, Maria G

    2023  

    Keywords Medicine ; heme oxygenase 1 ; immune response ; inflammation ; immune-mediated injury ;
    Language English
    Size 1 electronic resource (220 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030382194
    ISBN 9783036581378 ; 3036581375
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Immune-Related Functions of Heme Oxygenase-1.

    Lianos, Elias A / Detsika, Maria G

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [ ... ]. ...

    Abstract Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...].
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury.

    Lianos, Elias A / Detsika, Maria G

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Renal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic ... ...

    Abstract Renal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic immunosuppression. Small molecules, naturally occurring biologic agents, show considerable promise in acting as disease modifiers and may provide novel therapeutic leads. Certain naturally occurring or synthetic Metalloporphyrins (Mps) can act as disease modifiers by increasing heme oxygenase (HO) enzymatic activity and/or synthesis of the inducible HO isoform (HO-1). Depending on the metal moiety of the Mp employed, these effects may occur in tandem or can be discordant (increased HO-1 synthesis but inhibition of enzyme activity). This review discusses effects of Mps, with varying redox-active transitional metals and cyclic porphyrin cores, on mechanisms underlying pathogenesis and outcomes of renal immune injury.
    MeSH term(s) Heme Oxygenase (Decyclizing) ; Metalloporphyrins/pharmacology ; Metalloporphyrins/therapeutic use ; Heme Oxygenase-1 ; Kidney
    Chemical Substances Heme Oxygenase (Decyclizing) (EC 1.14.14.18) ; Metalloporphyrins ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury.

    Detsika, Maria G / Lianos, Elias A

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 1

    Abstract: Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ... ...

    Abstract Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of carbon monoxide (CO). Recent studies uncovered a new cytoprotective role for heme oxygenase-1 (HO-1) by identifying a regulatory role on the complement control protein decay-accelerating factor. This is a key complement regulatory protein preventing dysregulation or overactivation of complement cascades that can cause kidney injury. Cell-specific targeting of HO-1 induction may, therefore, be a novel approach to attenuate complement-dependent forms of kidney disease.
    Language English
    Publishing date 2021-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10010060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.

    Detsika, Maria G / Lianos, Elias A

    Current issues in molecular biology

    2021  Volume 43, Issue 2, Page(s) 1081–1089

    Abstract: In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to ... ...

    Abstract In systemic hemolysis and in hematuric forms of kidney injury, the major heme scavenging protein, hemopexin (HPX), becomes depleted, and the glomerular microvasculature (glomeruli) is exposed to high concentrations of unbound heme, which, in addition to causing oxidative injury, can activate complement cascades; thus, compounding extent of injury. It is unknown whether unbound heme can also activate specific complement regulatory proteins that could defend against complement-dependent injury. Isolated rat glomeruli were incubated in media supplemented with HPX-deficient (HPX
    MeSH term(s) Animals ; Antigens, Surface/genetics ; Antigens, Surface/metabolism ; CD55 Antigens/genetics ; CD55 Antigens/metabolism ; Complement Activation ; Hemopexin/genetics ; Hemopexin/metabolism ; Rats ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism
    Chemical Substances Antigens, Surface ; CD55 Antigens ; Cr1l protein, rat ; Receptors, Cell Surface ; Hemopexin (9013-71-2)
    Language English
    Publishing date 2021-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb43020077
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Metalloporphyrins as Tools for Deciphering the Role of Heme Oxygenase in Renal Immune Injury

    Elias A. Lianos / Maria G. Detsika

    International Journal of Molecular Sciences, Vol 24, Iss 6815, p

    2023  Volume 6815

    Abstract: Renal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic ... ...

    Abstract Renal immune injury is a frequent cause of end-stage renal disease, and, despite the progress made in understanding underlying pathogenetic mechanisms, current treatments to preserve renal function continue to be based mainly on systemic immunosuppression. Small molecules, naturally occurring biologic agents, show considerable promise in acting as disease modifiers and may provide novel therapeutic leads. Certain naturally occurring or synthetic Metalloporphyrins (Mps) can act as disease modifiers by increasing heme oxygenase (HO) enzymatic activity and/or synthesis of the inducible HO isoform (HO-1). Depending on the metal moiety of the Mp employed, these effects may occur in tandem or can be discordant (increased HO-1 synthesis but inhibition of enzyme activity). This review discusses effects of Mps, with varying redox-active transitional metals and cyclic porphyrin cores, on mechanisms underlying pathogenesis and outcomes of renal immune injury.
    Keywords heme oxygenase ; immune mediated ; renal injury ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article ; Online: Immune-Related Functions of Heme Oxygenase-1

    Lianos, Elias A. / Detsika, Maria G.

    Antioxidants. 2023 June 22, v. 12, no. 7

    2023  

    Abstract: Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [ ... ] ...

    Abstract Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
    Keywords antioxidants ; bilirubin ; catalytic activity ; heme ; heme oxygenase (biliverdin-producing)
    Language English
    Dates of publication 2023-0622
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071322
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease.

    Athanassiadou, Virginia / Plavoukou, Stella / Grapsa, Eirini / Detsika, Maria G

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 12

    Abstract: The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. ...

    Abstract The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.
    Language English
    Publishing date 2022-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11122454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Constitutive HO-1 and CD55 (DAF) Expression and Regulatory Interaction in Cultured Podocytes.

    Lianos, Elias A / Wilson, Kelsey / Goudevenou, Katerina / Detsika, Maria G / Sharma, Mukut

    Biomedicines

    2023  Volume 11, Issue 12

    Abstract: Overexpression of the inducible heme oxygenase (HO-1) isoform in visceral renal glomerular epithelial cells (podocytes) using in vivo transgenesis methods was shown to increase glomerular expression of the complement regulatory protein decay-accelerating ...

    Abstract Overexpression of the inducible heme oxygenase (HO-1) isoform in visceral renal glomerular epithelial cells (podocytes) using in vivo transgenesis methods was shown to increase glomerular expression of the complement regulatory protein decay-accelerating factor (DAF, CD55) and reduce complement activation/deposition in a rat model of immune-mediated injury. In this preliminary study, we assessed whether constitutively expressed HO-1 regulates CD55 expression in cultured rat podocytes. We employed methods of flow cytometry, quantitative (q) RT-qPCR and post-transcriptional HO-1 gene silencing (HO-1 interfering RNA, RNAi), to assess changes in constitutive (basal) levels of podocyte HO-1 and CD55 mRNA in cultured rat podocytes. Additionally, the effect of the HO-1 inducer, heme, on HO-1 and CD55 expression was assessed. Results indicate that rat podocytes constitutively express HO-1 and DAF and that the HO-1 inducer, heme, increases both HO-1 and DAF expression. HO-1 gene silencing using RNA interference (RNAi) is feasible but the effect on constitutive CD55 transcription is inconsistent. These observations are relevant to conditions of podocyte exposure to heme that can activate the complementary cascade, as may occur in systemic or intraglomerular hemolysis.
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury

    Detsika, Maria G / Lianos, Elias A

    Antioxidants. 2021 Jan. 06, v. 10, no. 1

    2021  

    Abstract: Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ... ...

    Abstract Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of carbon monoxide (CO). Recent studies uncovered a new cytoprotective role for heme oxygenase-1 (HO-1) by identifying a regulatory role on the complement control protein decay-accelerating factor. This is a key complement regulatory protein preventing dysregulation or overactivation of complement cascades that can cause kidney injury. Cell-specific targeting of HO-1 induction may, therefore, be a novel approach to attenuate complement-dependent forms of kidney disease.
    Keywords antioxidants ; carbon monoxide ; complement ; degradation ; enzyme activity ; heme ; heme oxygenase (biliverdin-producing) ; kidney diseases ; kidneys ; regulatory proteins
    Language English
    Dates of publication 2021-0106
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10010060
    Database NAL-Catalogue (AGRICOLA)

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