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  1. Article: FLT3 Mutated Acute Myeloid Leukemia after CD19 CAR-t Cells.

    Galli, Eugenio / Frioni, Filippo / Malara, Tanja / Attardi, Enrico / Bellesi, Silvia / Hohaus, Stefan / Sica, Simona / Sorà, Federica / Chiusolo, Patrizia

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024029

    Language English
    Publishing date 2024-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unlocking Predictive Power: Quantitative Assessment of CAR-T Expansion with Digital Droplet Polymerase Chain Reaction (ddPCR).

    Galli, Eugenio / Viscovo, Marcello / Fosso, Federica / Pansini, Ilaria / Di Cesare, Giacomo / Iacovelli, Camilla / Maiolo, Elena / Sorà, Federica / Hohaus, Stefan / Sica, Simona / Bellesi, Silvia / Chiusolo, Patrizia

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Flow cytometry (FCM) and quantitative PCR (qPCR) are conventional methods for assessing CAR-T expansion, while digital droplet PCR (ddPCR) is emerging as a promising alternative. We monitored CAR-T transcript expansion in 40 B-NHL patients post-infusion ... ...

    Abstract Flow cytometry (FCM) and quantitative PCR (qPCR) are conventional methods for assessing CAR-T expansion, while digital droplet PCR (ddPCR) is emerging as a promising alternative. We monitored CAR-T transcript expansion in 40 B-NHL patients post-infusion of CAR-T products (axi-cel; tisa-cel; and brexu-cel) with both His-Tag FCM and ddPCR techniques. Sensitivity and predictive capacity for efficacy and safety outcomes of ddPCR were analyzed and compared with FCM. A significant correlation between CAR-T counts determined by FCM and CAR transcripts assessed by ddPCR (
    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; Polymerase Chain Reaction/methods ; Treatment Outcome ; Progression-Free Survival ; Immunotherapy, Adoptive ; Lymphoma, Large B-Cell, Diffuse/therapy
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Morphological anomalies of circulating blood cells in COVID-19.

    Zini, Gina / Bellesi, Silvia / Ramundo, Francesco / d'Onofrio, Giuseppe

    American journal of hematology

    2020  Volume 95, Issue 7, Page(s) 870–872

    MeSH term(s) Apoptosis ; Betacoronavirus ; Blood Cells/pathology ; Blood Cells/ultrastructure ; COVID-19 ; Cell Nucleus/ultrastructure ; Cell Shape ; Chromatin/ultrastructure ; Convalescence ; Coronavirus Infections/blood ; Coronavirus Infections/therapy ; Cytoplasmic Granules/ultrastructure ; Disease Progression ; Humans ; Myelopoiesis ; Neutrophils/enzymology ; Neutrophils/ultrastructure ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Chemical Substances Chromatin
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
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  4. Article ; Online: The CD4/CD8 ratio of infused CD19-CAR-T is a prognostic factor for efficacy and toxicity.

    Galli, Eugenio / Bellesi, Silvia / Pansini, Ilaria / Di Cesare, Giacomo / Iacovelli, Camilla / Malafronte, Rosalia / Maiolo, Elena / Chiusolo, Patrizia / Sica, Simona / Sorà, Federica / Hohaus, Stefan

    British journal of haematology

    2023  Volume 203, Issue 4, Page(s) 564–570

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; Immunotherapy, Adoptive/adverse effects ; Prognosis ; CD4-CD8 Ratio ; CD8-Positive T-Lymphocytes ; Antigens, CD19 ; Lymphoma, Large B-Cell, Diffuse/pathology
    Chemical Substances Receptors, Chimeric Antigen ; Antigens, CD19
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management.

    Marra, John Donald / Frioni, Filippo / Minnella, Gessica / Rossi, Monica / Malara, Tanja / Bellesi, Silvia / Maiolo, Elena / Orteschi, Daniela / Galli, Eugenio / Bacigalupo, Andrea / Pagano, Livio / Sica, Simona / Zini, Gina / Chiusolo, Patrizia

    Annals of hematology

    2023  Volume 103, Issue 3, Page(s) 1013–1014

    MeSH term(s) Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Mutation ; Leukemia, Erythroblastic, Acute/diagnosis ; Leukemia, Erythroblastic, Acute/genetics ; Leukemia, Erythroblastic, Acute/therapy ; Fusion Proteins, bcr-abl/genetics ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Fusion Proteins, bcr-abl (EC 2.7.10.2) ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-11-29
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05561-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.181: Show issues Location:
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  6. Article: Severe CMV Infection after Chemo-Immunotherapy with Dose-Reduced Bendamustine and Rituximab in a Mantle Cell Lymphoma Old Patient.

    Magliano, Gabriele / Cuccaro, Annarosa / d'Alo', Francesco / Maiolo, Elena / Bellesi, Silvia / Hohaus, Stefan / Bacigalupo, Andrea / Pagano, Livio

    Mediterranean journal of hematology and infectious diseases

    2021  Volume 13, Issue 1, Page(s) e2021054

    Language English
    Publishing date 2021-09-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2021.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting.

    Metafuni, Elisabetta / Di Marino, Luca / Giammarco, Sabrina / Bellesi, Silvia / Limongiello, Maria Assunta / Sorà, Federica / Frioni, Filippo / Maggi, Roberto / Chiusolo, Patrizia / Sica, Simona

    Microorganisms

    2023  Volume 11, Issue 9

    Abstract: Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host ... ...

    Abstract Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy.
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11092182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Endoscopic Ultrasound-Guided Fine Needle Biopsy in the Diagnostic Work-Up of Deep-Seated Lymphadenopathies and Spleen Lesions: A Monocentric Experience.

    Bellisario, Flaminia / Attili, Fabia / Campana, Fabrizia / Borrelli de Andreis, Federica / Bellesi, Silvia / Maiolo, Elena / Alma, Eleonora / Malafronte, Rosalia / Macis, Giuseppe / Larocca, Luigi Maria / Annunziata, Salvatore / D'Alò, Francesco / Hohaus, Stefan

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 17

    Abstract: EUS-FNB has been introduced in clinical practice as a less invasive diagnostic approach with respect to surgery. We performed a single-center retrospective study on the diagnostic efficacy of EUS-guided FNB, including 171 patients with lymph nodes, ... ...

    Abstract EUS-FNB has been introduced in clinical practice as a less invasive diagnostic approach with respect to surgery. We performed a single-center retrospective study on the diagnostic efficacy of EUS-guided FNB, including 171 patients with lymph nodes, splenic, and extranodal lesions that underwent EUS for FNB at our institution. Excluding 12 patients who did not undergo FNB and 25 patients with a previous diagnosis of a solid tumor, we included 134 patients with clinical/radiological suspect of a lymphoproliferative disease, including 20 patients with a previous history of lymphoma. Out of the 134 biopsies, material of diagnostic quality was obtained in 111 procedures (84.3%). Histological examination of the EUS-FNB samples produced an actionable diagnosis in 100 cases (74.6%). Among the patients without an actionable diagnosis, a second, different diagnostic procedure produced a further eight diagnoses of lymphoma. Therefore, the sensitivity of EUS-FNB for diagnosing lymphomas was calculated to be 86.4% (51/59). Assignment of lymphomas to WHO classification subtypes was possible in 47/51 (92%) of the cases. In conclusion, EUS-FNB is an effective procedure for the histological characterization of lesions that are suspected to be lymphoproliferative disease, allowing for an actionable diagnosis in 75% of cases.
    Language English
    Publishing date 2023-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13172839
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  9. Article ; Online: Hematopoiesis and immune reconstitution after CD19 directed chimeric antigen receptor T-cells (CAR-T): A comprehensive review on incidence, risk factors and current management.

    Galli, Eugenio / Fresa, Alberto / Bellesi, Silvia / Metafuni, Elisabetta / Maiolo, Elena / Pansini, Ilaria / Frioni, Filippo / Autore, Francesco / Limongiello, Maria Assunta / Innocenti, Idanna / Giammarco, Sabrina / Chiusolo, Patrizia / Zini, Gina / Sorà, Federica

    European journal of haematology

    2023  Volume 112, Issue 2, Page(s) 184–196

    Abstract: Impaired function of hematopoiesis after treatment with chimeric antigen T-cells (CAR-T) is a frequent finding and can interest a wide range of patients, regardless of age and underlying disease. Trilinear cytopenias, as well as hypogammaglobulinemia, B- ... ...

    Abstract Impaired function of hematopoiesis after treatment with chimeric antigen T-cells (CAR-T) is a frequent finding and can interest a wide range of patients, regardless of age and underlying disease. Trilinear cytopenias, as well as hypogammaglobulinemia, B-cell aplasia, and T-cell impairment, can severely affect the infectious risk of CAR-T recipients, as well as their quality of life. In this review, we provide an overview of defects in hematopoiesis after CAR-T, starting with a summary of different definitions and thresholds. We then move to summarize the main pathogenetic mechanisms of cytopenias, and we offer insight into cytomorphological aspects, the role of clonal hematopoiesis, and the risk of secondary myeloid malignancies. Subsequently, we expose the major findings and reports on T-cell and B-cell quantitative and functional impairment after CAR-T. Finally, we provide an overview of current recommendations and leading experiences regarding the management of cytopenias and defective B- and T-cell function.
    MeSH term(s) Humans ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen/genetics ; Immunotherapy, Adoptive/adverse effects ; Immune Reconstitution ; Incidence ; Quality of Life ; T-Lymphocytes ; Antigens, CD19 ; Hematopoiesis ; Risk Factors
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen ; Antigens, CD19
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.14052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
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