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  1. Article ; Online: ECMO for all? Challenging traditional ECMO contraindications.

    Zakhary, Bishoy / Oppenheimer, Beno W

    Journal of critical care

    2018  Volume 48, Page(s) 451–452

    MeSH term(s) Contraindications ; Extracorporeal Membrane Oxygenation ; Humans ; Obesity ; Pneumonia ; Registries
    Language English
    Publishing date 2018-09-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2018.09.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2152: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Response.

    Berger, Kenneth I / Goldring, Roberta M / Oppenheimer, Beno W

    Neuromuscular disorders : NMD

    2016  Volume 27, Issue 2, Page(s) 202

    MeSH term(s) Disease Progression ; Glycogen Storage Disease Type II ; Humans ; Respiration Disorders
    Language English
    Publishing date 2016-12-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1077681-3
    ISSN 1873-2364 ; 0960-8966
    ISSN (online) 1873-2364
    ISSN 0960-8966
    DOI 10.1016/j.nmd.2016.12.016
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    Zs.A 3258: Show issues Location:
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  3. Article: Role of small airway dysfunction in unexplained exertional dyspnoea.

    Sharpe, Alexis L / Reibman, Joan / Oppenheimer, Beno W / Goldring, Roberta M / Liu, Mengling / Shao, Yongzhao / Bohart, Isaac / Kwok, Benjamin / Weinstein, Tatiana / Addrizzo-Harris, Doreen / Sterman, Daniel H / Berger, Kenneth I

    ERJ open research

    2023  Volume 9, Issue 3

    Abstract: Background: Isolated small airway abnormalities may be demonstrable at rest in patients with normal spirometry; however, the relationship of these abnormalities to exertional symptoms remains uncertain. This study uses an augmented cardiopulmonary ... ...

    Abstract Background: Isolated small airway abnormalities may be demonstrable at rest in patients with normal spirometry; however, the relationship of these abnormalities to exertional symptoms remains uncertain. This study uses an augmented cardiopulmonary exercise test (CPET) to include evaluation of small airway function during and following exercise to unmask abnormalities not evident with standard testing in individuals with dyspnoea and normal spirometry.
    Methods: Three groups of subjects were studied: 1) World Trade Center (WTC) dust exposure (n=20); 2) Clinical Referral (n=15); and Control (n=13). Baseline evaluation included respiratory oscillometry. Airway function during an incremental workload CPET was assessed by: 1) tidal flow
    Results: All subjects demonstrated normal baseline forced expiratory volume in 1 s (FEV
    Conclusions: We uncovered mechanisms for exertional dyspnoea in subject with normal spirometry that was attributable to either small airway dysfunction during exercise and/or small airway hyperreactivity following exercise. The similarity of findings in WTC environmentally exposed and clinically referred cohorts suggests broad relevance for these evaluations.
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00603-2022
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  4. Article: Small airway function in obese individuals with self-reported asthma.

    Oppenheimer, Beno W / Goldring, Roberta M / Soghier, Israa / Smith, David / Parikh, Manish / Berger, Kenneth I

    ERJ open research

    2020  Volume 6, Issue 2

    Abstract: Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical ... ...

    Abstract Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical characteristics, metabolic comorbidities and enhanced small airway dysfunction as compared with healthy obese subjects. Spirometry, plethysmography and oscillometry data pre/post-bronchodilator were obtained in 357 obese subjects in three groups as follows: no asthma group (n=180), self-reported asthma normal spirometry group (n=126), and asthma obstructed spirometry group (n=51). To assess the effects of obesity related to reduced lung volume, oscillometry measurements were repeated during a voluntary inflation to predicted functional residual capacity (FRC). Dyspnoea was equally prevalent in all groups. In contrast, cough, wheeze and metabolic comorbidities were more frequent in the asthma normal spirometry and asthma obstructed spirometry groups
    Language English
    Publishing date 2020-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00371-2019
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  5. Article ; Online: Rebuttal From Dr Berger et al.

    Berger, Kenneth I / Goldring, Roberta M / Oppenheimer, Beno W

    Chest

    2015  Volume 148, Issue 5, Page(s) 1137–1138

    MeSH term(s) Forced Expiratory Volume/physiology ; Humans ; Oscillometry/methods ; Respiratory Tract Diseases/diagnosis
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.15-1037
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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  6. Article ; Online: Increased Dead Space Ventilation and Refractory Hypercapnia in Patients With Coronavirus Disease 2019: A Potential Marker of Thrombosis in the Pulmonary Vasculature.

    Oppenheimer, Beno W / Bakker, Jan / Goldring, Roberta M / Teter, Katherine / Green, David L / Berger, Kenneth I

    Critical care explorations

    2020  Volume 2, Issue 9, Page(s) e0208

    Abstract: Objectives: Mortality rates in intubated coronavirus disease 2019 patients remain markedly elevated. Some patients develop sudden refractory hypercapnia and hypoxemia not explained by worsening pulmonary parenchymal disease. This case series highlights ... ...

    Abstract Objectives: Mortality rates in intubated coronavirus disease 2019 patients remain markedly elevated. Some patients develop sudden refractory hypercapnia and hypoxemia not explained by worsening pulmonary parenchymal disease. This case series highlights clinical findings and management of coronavirus disease 2019 patients with refractory hypercapnia despite maximal/optimal ventilatory support. Hypercapnia could not be explained by worsening lung disease or other common factors, and thus, a pulmonary vascular etiology was suggested. The pillars of management were targeted to improve pulmonary vascular patency via aggressive anticoagulation and support right ventricular function.
    Data sources: Four consecutive patients with confirmed coronavirus disease 2019 infection with sudden hypercapnia and hypoxemia were included.
    Data synthesis: There was sequential development of: 1) severe hypercapnia attributable to marked elevation of dead space without radiographic changes; 2) concomitant coagulopathy manifest by an increase in d-dimer levels; 3) progressive shunt with consequent hypoxemia; and 4) right ventricular dysfunction. Management included extracorporeal Co
    Conclusions: We speculate that thromboinflammation with pulmonary microvasculature occlusion leads to a sudden increase in dead space and shunt resulting in severe hypercapnia and hypoxemia in coronavirus disease 2019 patients. Early identification of these physiologic and clinical biomarkers could trigger the institution of therapies aiming to reverse the hypercoagulable state and support right ventricular function.
    Keywords covid19
    Language English
    Publishing date 2020-09-17
    Publishing country United States
    Document type Case Reports
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000208
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  7. Article ; Online: POINT: Should Oscillometry Be Used to Screen for Airway Disease? Yes.

    Berger, Kenneth I / Goldring, Roberta M / Oppenheimer, Beno W

    Chest

    2015  Volume 148, Issue 5, Page(s) 1131–1135

    MeSH term(s) Airway Resistance/physiology ; Humans ; Oscillometry/methods ; Respiratory Tract Diseases/diagnosis ; Respiratory Tract Diseases/physiopathology
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.15-0106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  8. Article ; Online: Small airway function in obese individuals with self-reported asthma

    Beno W. Oppenheimer / Roberta M. Goldring / Israa Soghier / David Smith / Manish Parikh / Kenneth I. Berger

    ERJ Open Research, Vol 6, Iss

    2020  Volume 2

    Abstract: Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical ... ...

    Abstract Diagnosis of asthma in obese individuals frequently relies on clinical history, as airflow by spirometry may remain normal. This study hypothesised that obese subjects with self-reported asthma and normal spirometry will demonstrate distinct clinical characteristics, metabolic comorbidities and enhanced small airway dysfunction as compared with healthy obese subjects. Spirometry, plethysmography and oscillometry data pre/post-bronchodilator were obtained in 357 obese subjects in three groups as follows: no asthma group (n=180), self-reported asthma normal spirometry group (n=126), and asthma obstructed spirometry group (n=51). To assess the effects of obesity related to reduced lung volume, oscillometry measurements were repeated during a voluntary inflation to predicted functional residual capacity (FRC). Dyspnoea was equally prevalent in all groups. In contrast, cough, wheeze and metabolic comorbidities were more frequent in the asthma normal spirometry and asthma obstructed spirometry groups versus the no asthma group (p<0.05). Despite similar body size, oscillometry measurements demonstrated elevated R5–20 (difference between resistance at 5 and 20 Hz) in the no asthma and asthma normal spirometry groups (0.19±0.12; 0.23±0.13 kPa/(L·s−1), p<0.05) but to a lesser degree than the asthma obstructed spirometry group (0.34±0.20 kPa/(L·s−1), p<0.05). Differences between groups persisted post-bronchodilator (p<0.05). Following voluntary inflation to predicted FRC, R5–20 in the no asthma and asthma normal spirometry groups fell to similar values, indicating a reversible process (0.11±0.07; 0.12±0.08 kPa/(L·s−1), p=NS). Persistently elevated R5–20 was seen in the asthma obstructed spirometry group, suggesting chronic inflammation and/or remodelling (0.17±0.11 kPa/(L·s−1), p<0.05). Thus, small airway abnormalities of greater magnitude than observations in healthy obese people may be an early marker of asthma in obese subjects with self-reported disease despite normal airflow. Increased metabolic ...
    Keywords Medicine ; R
    Subject code 610 ; 150
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease.

    Sulaiman, Imran / Wu, Benjamin G / Chung, Matthew / Isaacs, Bradley / Tsay, Jun-Chieh J / Holub, Meredith / Barnett, Clea R / Kwok, Benjamin / Kugler, Matthias C / Natalini, Jake G / Singh, Shivani / Li, Yonghua / Schluger, Rosemary / Carpenito, Joseph / Collazo, Destiny / Perez, Luisanny / Kyeremateng, Yaa / Chang, Miao / Campbell, Christina D /
    Hansbro, Philip M / Oppenheimer, Beno W / Berger, Kenneth I / Goldring, Roberta M / Koralov, Sergei B / Weiden, Michael D / Xiao, Rui / D'Armiento, Jeanine / Clemente, Jose C / Ghedin, Elodie / Segal, Leopoldo N

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 10, Page(s) 1101–1114

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Animals ; Mice ; Dysbiosis/complications ; RNA, Ribosomal, 16S ; Pulmonary Disease, Chronic Obstructive/genetics ; Inflammation/complications ; Lung Injury/complications ; Lung/pathology
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1865OC
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  10. Article: Respiratory impedance measured using impulse oscillometry in a healthy urban population.

    Berger, Kenneth I / Wohlleber, Margaret / Goldring, Roberta M / Reibman, Joan / Farfel, Mark R / Friedman, Stephen M / Oppenheimer, Beno W / Stellman, Steven D / Cone, James E / Shao, Yongzhao

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: This study derives normative prediction equations for respiratory impedance in a healthy asymptomatic urban population using an impulse oscillation system (IOS). In addition, this study uses body mass index (BMI) in the equations to describe the effect ... ...

    Abstract This study derives normative prediction equations for respiratory impedance in a healthy asymptomatic urban population using an impulse oscillation system (IOS). In addition, this study uses body mass index (BMI) in the equations to describe the effect of obesity on respiratory impedance. Data from an urban population comprising 472 healthy asymptomatic subjects that resided or worked in lower Manhattan, New York City were retrospectively analysed. This population was the control group from a previously completed case-control study of the health effects of exposure to World Trade Center dust. Since all subjects underwent spirometry and oscillometry, these previously collected data allowed a unique opportunity to derive normative prediction equations for oscillometry in an urban, lifetime non-smoking, asymptomatic population without underlying respiratory disease. Normative prediction equations for men and women were successfully developed for a broad range of respiratory oscillometry variables with narrow confidence bands. Models that used BMI as an independent predictor of oscillometry variables (in addition to age and height) demonstrated equivalent or better fit when compared with models that used weight. With increasing BMI, resistance and reactance increased compatible with lung and airway compression from mass loading. This study represents the largest cohort of healthy urban subjects assessed with an IOS device. Normative prediction equations were derived that should facilitate application of IOS in the clinical setting. In addition, the data suggest that modelling of lung function may be best performed using height and BMI as independent variables rather than the traditional approach of using height and weight.
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00560-2020
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