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Article ; Online: SGLT2 inhibition could potentially impact inflammation in acute myocardial infarction.

Sourij, Harald / Aziz, Faisal / Mangge, Harald / von Lewinski, Dirk

2023 Volume 44, Issue 38, Page(s) 3931

MeSH term(s)	Humans ; Inflammation ; Myocardial Infarction/complications ; Myocardial Infarction/drug therapy ; Sodium-Glucose Transporter 2
Chemical Substances	Sodium-Glucose Transporter 2
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad404
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article ; Online: One sip of water with LT-4 supplementation-a key to euthyroidism in Hashimoto's thyroiditis.

Schnedl, Wolfgang J / Michaelis, Simon / Mangge, Harald / Enko, Dietmar

Endocrine

2024

Abstract: Purpose: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication.: ...

Abstract	Purpose: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication. Patients and methods: We report on 35 HT patients with LT-4 therapy in this retrospective evaluation. In general, we recommend that a maximum of two sips of water, which would then amount to < 50 mL, be ingested at the same time as LT-4. We report on follow up examinations measuring TSH and antibodies against thyroid peroxidase (TPOAb) after 6 months to five years. Results: After median time of 643 days (range 98-1825) we found in 35 HT patients a statistical significant reduction of serum TSH (p < 0.001) and TPOAb (p = 0.006). The patients median body weight was 71 kg (range 48-98) and a daily LT-4 dosage was used with median 69.1 µg (range 25-150). This results in a daily LT-4 dose of median 1.01 µg/kg bodyweight (range 0.3-2.3). Conclusions: The reduction of water ingestion to a maximum of two sips, which is <50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-024-03829-w
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Article ; Online: Fecal Calprotectin Elevations Associated with Food Intolerance/Malabsorption Are Significantly Reduced with Targeted Diets.

Schnedl, Wolfgang J / Michaelis, Simon / Enko, Dietmar / Mangge, Harald

Nutrients

2023 Volume 15, Issue 5

Abstract: Inflammatory bowel disease (IBD) involves two clinically defined entities, namely Crohn's disease and ulcerative colitis. Fecal calprotectin (FCAL) is used as a marker to distinguish between organic IBD and functional bowel disease in disorders of the ... ...

Abstract	Inflammatory bowel disease (IBD) involves two clinically defined entities, namely Crohn's disease and ulcerative colitis. Fecal calprotectin (FCAL) is used as a marker to distinguish between organic IBD and functional bowel disease in disorders of the irritable bowel syndrome (IBS) spectrum. Food components may affect digestion and cause functional abdominal disorders of the IBS spectrum. In this retrospective study, we report on FCAL testing to search for IBD in 228 patients with disorders of the IBS spectrum caused by food intolerances/malabsorption. Included were patients with fructose malabsorption (FM), histamine intolerance (HIT), lactose intolerance (LIT), and
MeSH term(s)	Humans ; Irritable Bowel Syndrome/diagnosis ; Food Intolerance ; Leukocyte L1 Antigen Complex ; Retrospective Studies ; Histamine ; Malabsorption Syndromes ; Inflammatory Bowel Diseases/diagnosis ; Lactose Intolerance/diagnosis ; Fructose Intolerance/diagnosis ; Diet ; Fructose ; Feces
Chemical Substances	Leukocyte L1 Antigen Complex ; Histamine (820484N8I3) ; Fructose (30237-26-4)
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15051179
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Article ; Online: Beyond Cholesterol - New Cardiovascular Biomarkers.

Mangge, Harald

Nestle Nutrition Institute workshop series

2016 Volume 84, Page(s) 81–88

Abstract: Atherosclerosis (AS) is the primary pathological result of obesity. Vulnerable AS plaques cause fatal clinical end points such as myocardial infarction and stroke. To prevent this, improvements in early diagnosis and treatment are essential. Because ... ...

Abstract	Atherosclerosis (AS) is the primary pathological result of obesity. Vulnerable AS plaques cause fatal clinical end points such as myocardial infarction and stroke. To prevent this, improvements in early diagnosis and treatment are essential. Because vulnerable AS plaques are frequently nonstenotic, they are preclinically undetectable using conventional imaging. Levels of blood lipids, C-reactive protein, and interleukin-6 are increased, but are insufficient to indicate the process of critical perpetuation before the end points present. More specific biomarkers (e.g. troponin, copetin, natriuretic peptides, growth differentiation factor-15, or soluble ST2) indicate the acute coronary syndrome or cardiac insufficiency, but not a critical destabilization of AS lesions in coronary or carotid arteries. Thus, valuable time (months to years) that could be used to treat the patient is wasted. An improved management of this dilemma may involve better detection of variations in degrees of immune inflammation in plaques by using new biomarkers in blood and/or within the lesion (molecular imaging). Macrophage and T-cell polarization, and innate and adaptive immune responses (e.g. Toll-like receptors) are involved in this critical process. New biomarkers in these mechanisms include pentraxin 3, calprotectins S100A8/S100A9, myeloperoxidase, adiponectin, interleukins, and chemokines. These proteins may also be candidates for molecular imaging using nuclear (magnetic resonance) imaging tools. Nevertheless, the main challenge remains: which asymptomatic individual should be screened? At which time interval? Intense interdisciplinary research in laboratory medicine (biomarkers), nanomedicine (nanoparticle development), and radiology (molecular imaging) will hopefully address these questions.
MeSH term(s)	Adiponectin/blood ; Atherosclerosis/blood ; Atherosclerosis/complications ; Biomarkers/blood ; C-Reactive Protein/metabolism ; Cholesterol/blood ; Cytokines/blood ; Humans ; Inflammation/blood ; Inflammation Mediators/blood ; Leukocyte L1 Antigen Complex/blood ; Myocardial Infarction/blood ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Peroxidase/blood ; Risk Factors ; Serum Amyloid P-Component/metabolism ; Stroke/blood ; Stroke/etiology ; Stroke/prevention & control
Chemical Substances	Adiponectin ; Biomarkers ; Cytokines ; Inflammation Mediators ; Leukocyte L1 Antigen Complex ; Serum Amyloid P-Component ; PTX3 protein (148591-49-5) ; C-Reactive Protein (9007-41-4) ; Cholesterol (97C5T2UQ7J) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000436990
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Article ; Online: A personalized management approach in disorders of the irritable bowel syndrome spectrum.

Schnedl, Wolfgang J / Michaelis, Simon / Mangge, Harald / Enko, Dietmar

Clinical nutrition ESPEN

2023 Volume 57, Page(s) 96–105

Abstract: Symptoms of the disorders across the irritable bowel syndrome (IBS) spectrum include several different, usually postprandial, abdominal complaints. Up to date, dietary treatments of the IBS have neither been personalized nor diagnosed with sufficient ... ...

Abstract	Symptoms of the disorders across the irritable bowel syndrome (IBS) spectrum include several different, usually postprandial, abdominal complaints. Up to date, dietary treatments of the IBS have neither been personalized nor diagnosed with sufficient scientific evidence. They have mostly been treated using 'one-size-fits-all' approaches. Such include exclusion diets, a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols diet, and gluten-free diets, lactose-free diets, a diet recommended by the UK National Institute for Health and Care Excellence, and a wheat-free diet. The exact pathophysiology of IBS disorders across the spectrum is still unclear. However, the symptom profile of IBS spectrum disorders seems similar to that of food intolerance/malabsorption syndromes. Celiac disease, fructose malabsorption, histamine intolerance and lactose intolerance represent food intolerance/malabsorption disorders based on the indigestion of sugars and/or proteins. Helicobacter pylori infection may potentially promote the development of IBS and, when facing a case of IBS-like symptoms, a search for intolerance/malabsorption and H. pylori should be added to find the correct treatment for the respective patient. This review will discuss why the 'one-size-fits-all' dietary approach in the treatment of complaints across the IBS spectrum cannot be successful. Hence, it will provide an overview of the most common overall dietary approaches currently used, and why those should be discouraged. Alternatively, a noninvasive diagnostic workup of the pathophysiologic factors of food intolerance/malabsorption in each patient with symptoms of the IBS spectrum is suggested. Additionally, if H. pylori is found, eradication therapy is mandatory, and if food intolerance/malabsorption is detected, an individual and personalized dietary intervention by a registered dietician is recommended.
MeSH term(s)	Humans ; Irritable Bowel Syndrome/therapy ; Food Intolerance ; Helicobacter Infections ; Helicobacter pylori ; Malabsorption Syndromes
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.06.028
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Article: Comparison of Automated Procalcitonin Immunoassays under Routine Conditions.

Niedrist, Tobias / Mangge, Harald / Herrman, Markus

Clinical laboratory

2021 Volume 67, Issue 1

MeSH term(s)	Calcitonin ; Humans ; Immunoassay ; Procalcitonin
Chemical Substances	Procalcitonin ; Calcitonin (9007-12-9)
Language	English
Publishing date	2021-01-24
Publishing country	Germany
Document type	Letter
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2020.200457
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Ud II Zs.170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 25: Show issues

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Article: Functional Abdominal Pain Disorders in Children May Be Associated with Food Intolerance/Malabsorption.

Schnedl, Wolfgang J / Schenk, Michael / Michaelis, Simon / Enko, Dietmar / Mangge, Harald

Children (Basel, Switzerland)

2023 Volume 10, Issue 9

Abstract: Functional abdominal pain disorders (FAPDs) are among the most common types of chronic pain disorders in children. FAPD symptoms are characterized by chronic abdominal pain and changed bowel movements. The pathophysiology of FAPDs in children is unknown, ...

Abstract	Functional abdominal pain disorders (FAPDs) are among the most common types of chronic pain disorders in children. FAPD symptoms are characterized by chronic abdominal pain and changed bowel movements. The pathophysiology of FAPDs in children is unknown, but these conditions may have an imprecise clinical overlap to food intolerance/malabsorption. We report on 51 consecutive children (23/28 males/females; median age 15.3 years) with investigated FAPDs from 2017 to 2022 in this retrospective pilot study. Small intestinal biopsies in children demonstrated the association of lactase and diamine oxidase (DAO), which prompted us to perform hydrogen (H
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10091444
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Article ; Online: Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease.

Fitzinger, Julia / Rodriguez-Blanco, Giovanny / Herrmann, Markus / Borenich, Andrea / Stauber, Rudolf / Aigner, Elmar / Mangge, Harald

Nutrients

2024 Volume 16, Issue 2

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. A main cause is the obesogenic, so-called Western lifestyle. NAFLD follows a long, unperceived course, and ends potentially fatally. Early diagnosis of aggressive subtypes ... ...

Abstract	Background: Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. A main cause is the obesogenic, so-called Western lifestyle. NAFLD follows a long, unperceived course, and ends potentially fatally. Early diagnosis of aggressive subtypes saves lives. So far, non-invasive means of detection are limited. A better understanding of the pathogenic interplay among insulin resistance, immune inflammation, microbiome, and genetic background is important. Metabolomics may give insight into these interlaced processes. Methods: In this study, we measured bile acids (BA) in the plasma of adult NAFLD and alcohol-associated liver disease (ALD) patients and healthy controls with targeted mass spectrometry. We focused on gender-related bile acid production pathology in NAFLD and ALD. Results: Compared to healthy controls, women with NAFLD had significantly higher concentrations of total BA, total primary BA, total cholic (CA), total chenodeoxycholic (CDCA), total glycine-conjugated, and total non-12-a-OH BA. Concerning subtypes, glycocholic (GCA) and glycochenodeoxycholic (GCDCA), BA were elevated in women with NAFLD. In contrast, men with NAFLD had no significantly altered total BA fractions. However, the subtypes GCA, glycodeoxycholic (GDCA), glycolithocholic (GLCA), lithocholic (LCA), taurolithocholic (TLCA), and tauroursodeoxycholic acid (TUDCA) were elevated, while CA was significantly decreased. In NAFLD, except ursodeoxycholic acid (UDC), all total BA correlated significantly positively in both sexes with the ELF score, while in ALD, only males showed significant correlations exceptive for total UDC BA. In NAFLD, total BA, total primary BA, total secondary BA, total free secondary BA, total CA, total CDCA, total taurine conjugated, total glycine conjugated, total 12-a-OH, and total non-12-a-OH were significantly higher in cases of a high enhanced liver fibrosis (ELF) score above 9.8. In ALD, total UDC was additionally elevated. Between NAFLD with and without NASH, we found no significant differences. Conclusion: Our data show gender-specific bile acid profiles in NAFLD and markedly different BA patterns in ALD. Women with NAFLD had more severe cholestasis. Men may better compensate fat storage-driven bile acid dynamics, indicated by higher levels of taurine-conjugated BA, which associate with beneficial metabolic functions.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Bile Acids and Salts ; Non-alcoholic Fatty Liver Disease ; Ursodeoxycholic Acid ; Fabaceae ; Glycine ; Liver Diseases, Alcoholic ; Taurine
Chemical Substances	Bile Acids and Salts ; Ursodeoxycholic Acid (724L30Y2QR) ; Glycine (TE7660XO1C) ; Taurine (1EQV5MLY3D)
Language	English
Publishing date	2024-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16020250
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Article ; Online: Immune-Mediated Inflammation in Vulnerable Atherosclerotic Plaques.

Mangge, Harald / Almer, Gunter

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 17

Abstract: Atherosclerosis is a chronic long-lasting vascular disease leading to myocardial infarction and stroke. Vulnerable atherosclerotic (AS) plaques are responsible for these life-threatening clinical endpoints. To more successfully work against ... ...

Abstract	Atherosclerosis is a chronic long-lasting vascular disease leading to myocardial infarction and stroke. Vulnerable atherosclerotic (AS) plaques are responsible for these life-threatening clinical endpoints. To more successfully work against atherosclerosis, improvements in early diagnosis and treatment of AS plaque lesions are required. Vulnerable AS plaques are frequently undetectable by conventional imaging because they are non-stenotic. Although blood biomarkers like lipids, C-reactive protein, interleukin-6, troponins, and natriuretic peptides are in pathological ranges, these markers are insufficient in detecting the critical perpetuation of AS anteceding endpoints. Thus, chances to treat the patient in a preventive way are wasted. It is now time to solve this dilemma because clear results indicate a benefit of anti-inflammatory therapy per se without modification of blood lipids (CANTOS Trial, NCT01327846). This fact identifies modulation of immune-mediated inflammation as a new promising point of action for the eradication of fatal atherosclerotic endpoints.
MeSH term(s)	Adaptive Immunity ; Animals ; Biomarkers ; Disease Susceptibility/immunology ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immunity, Innate ; Inflammation/complications ; Inflammation/immunology ; Inflammation/metabolism ; Matrix Metalloproteinases/metabolism ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/metabolism ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/etiology ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology
Chemical Substances	Biomarkers ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2019-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24173072
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Article ; Online: Procalcitonin measurement by Diazyme™ immunturbidimetric and Elecsys BRAHMS™ PCT assay on a Roche COBAS modular analyzer.

Jensch, Andreas / Mahla, Elisabeth / Toller, Wolfgang / Herrmann, Markus / Mangge, Harald

Clinical chemistry and laboratory medicine

2021 Volume 59, Issue 9, Page(s) e362–e366

MeSH term(s)	Biological Assay/instrumentation ; Humans ; Immunoassay ; Procalcitonin/analysis ; Sensitivity and Specificity
Chemical Substances	Procalcitonin
Language	English
Publishing date	2021-03-15
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-1541
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