Article ; Online: Is miR-223 Upregulation in Inflammatory Bowel Diseases a Protective Response?
Frontiers in bioscience (Elite edition)
2023 Volume 15, Issue 1, Page(s) 5
Abstract: Inflammatory bowel diseases (IBD) are characterized by chronic inflammation and damage of colonocytes with etiology of genetic, epigenetic and environmental factors. MicroRNA-223 (miR-223) has been found to be increased in both IBD patients and animal ... ...
Abstract | Inflammatory bowel diseases (IBD) are characterized by chronic inflammation and damage of colonocytes with etiology of genetic, epigenetic and environmental factors. MicroRNA-223 (miR-223) has been found to be increased in both IBD patients and animal colitis models. However, contentious opinions relevant to the roles of miR-223 in IBD have been reported. Notwithstading that most studies have described that miR-223 has anti-inflammatory effects, several reports have progressed a pro-inflammatory view. In this review, we summarise both the anti-inflammatory and pro-inflammatory effects of miR-223 on key molecules in inflammatory responses in both animal models and in patients diagnosed with IBD and objectively discuss the possible basis for the discrepancies. |
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MeSH term(s) | Animals ; Colitis/genetics ; Inflammation ; Inflammatory Bowel Diseases/genetics ; MicroRNAs/genetics ; Up-Regulation ; Humans |
Chemical Substances | MicroRNAs |
Language | English |
Publishing date | 2023-03-23 |
Publishing country | Singapore |
Document type | Journal Article ; Review |
ZDB-ID | 2565080-4 |
ISSN | 1945-0508 ; 1945-0494 |
ISSN (online) | 1945-0508 |
ISSN | 1945-0494 |
DOI | 10.31083/j.fbe1501005 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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