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  1. Book ; Online: Insights on Antimicrobial Peptides

    Enany, Shymaa / Masso-Silva, Jorge / Savitskaya, Anna

    2022  

    Keywords Biochemical immunology ; Biology, life sciences
    Language English
    Size 1 electronic resource (166 pages)
    Publisher IntechOpen
    Document type Book ; Online
    Note English
    HBZ-ID HT030377649
    ISBN 9781839697159 ; 1839697156
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Just When We Thought Nothing Could Be Worse Than Smoking Tobacco, Vaping e-Hookah Proves Us Wrong.

    Masso-Silva, Jorge A / Crotty Alexander, Laura E

    Chest

    2022  Volume 161, Issue 1, Page(s) 13–15

    MeSH term(s) Humans ; Smoking/adverse effects ; Smoking Water Pipes ; Nicotiana ; Tobacco Products ; Vaping/adverse effects
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.08.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring the arsenal of antimicrobial peptides: Mechanisms, diversity, and applications.

    Savitskaya, Anna / Masso-Silva, Jorge / Haddaoui, Imen / Enany, Shymaa

    Biochimie

    2023  Volume 214, Issue Pt B, Page(s) 216–227

    Abstract: Antimicrobial peptides (AMPs) are essential for defence against pathogens in all living organisms and possessed activities against bacteria, fungi, viruses, parasites and even cancer cells. AMPs are short peptides containing 12-100 amino acids conferring ...

    Abstract Antimicrobial peptides (AMPs) are essential for defence against pathogens in all living organisms and possessed activities against bacteria, fungi, viruses, parasites and even cancer cells. AMPs are short peptides containing 12-100 amino acids conferring a net positive charge and an amphiphilic property in most cases. Although, anionic AMPs also exist. AMPs can be classified based on the types of secondary structures, charge, hydrophobicity, amino acid composition, length, etc. Their mechanism of action usually includes a membrane disruption process through pore formation (three different models have been described, barrel-stave, toroidal or carpet model) but AMPs can also penetrate and impair intracellular functions. Besides their activity against pathogens, they have also shown immunomodulatory properties in complex scenarios through many different interactions. The aim of this review to summarize knowledge about AMP's and discuss the potential application of AMPs as therapeutics, the challenges due to their limitations, including their susceptibility to degradation, the potential generation of AMP resistance, cost, etc. We also discuss the current FDA-approved drugs based on AMPs and strategies to circumvent natural AMPs' limitations.
    MeSH term(s) Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/therapeutic use ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Peptides ; Fungi ; Bacteria/metabolism ; Anti-Bacterial Agents
    Chemical Substances Antimicrobial Cationic Peptides ; Antimicrobial Peptides ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-25
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 120345-9
    ISSN 1638-6183 ; 0300-9084
    ISSN (online) 1638-6183
    ISSN 0300-9084
    DOI 10.1016/j.biochi.2023.07.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Initiation of ECMO in patients with COVID-19- related ARDS does not increase blood markers of neutrophil extracellular traps (NETs) or IL-8.

    Odish, Mazen F / Masso-Silva, Jorge A / Pollema, Travis L / Owens, Robert L / Alexander, Laura E Crotty / Meier, Angela

    Journal of cardiothoracic and vascular anesthesia

    2024  Volume 38, Issue 5, Page(s) 1288–1289

    MeSH term(s) Humans ; Extracellular Traps ; COVID-19 ; Interleukin-8 ; Extracorporeal Membrane Oxygenation ; Respiratory Distress Syndrome/therapy
    Chemical Substances Interleukin-8
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2024.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute and chronic effects of vaping electronic devices on lung physiology and inflammation.

    Masso-Silva, Jorge A / Byun, Min Kwang / Alexander, Laura E Crotty

    Current opinion in physiology

    2021  Volume 22

    Abstract: The impact of e-cigarette use on the inflammatory state and function of the lungs is not well understood. Here we review the latest studies on the impact of short and long term e-cigarette aerosol inhalation on molecular pathways, cellular recruitment, ... ...

    Abstract The impact of e-cigarette use on the inflammatory state and function of the lungs is not well understood. Here we review the latest studies on the impact of short and long term e-cigarette aerosol inhalation on molecular pathways, cellular recruitment, gas exchange and airway physiology. Inflammatory cytokines IL-6 and IL-8 were increased by e-cigarette exposures, and a variety of immune cells were recruited to the parenchyma and airways across models. While there are few consistent signals across
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2918626-2
    ISSN 2468-8673 ; 2468-8681
    ISSN (online) 2468-8673
    ISSN 2468-8681
    DOI 10.1016/j.cophys.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulin.

    Masso-Silva, Jorge Adrian / Sakoulas, George / Olay, Jarod / Groysberg, Victoria / Geriak, Matthew / Nizet, Victor / Crotty Alexander, Laura E / Meier, Angela

    Frontiers in immunology

    2022  Volume 13, Page(s) 993720

    Abstract: Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 ... ...

    Abstract Pathogenesis of lung injury in COVID-19 is not completely understood, leaving gaps in understanding how current treatments modulate the course of COVID-19. Neutrophil numbers and activation state in circulation have been found to correlate with COVID-19 severity, and neutrophil extracellular traps (NETs) have been found in the lung parenchyma of patients with acute respiratory distress syndrome (ARDS) in COVID-19. Targeting the pro-inflammatory functions of neutrophils may diminish lung injury in COVID-19 and ARDS. Neutrophils were isolated from peripheral blood of healthy donors, treated
    MeSH term(s) Humans ; Neutrophils/metabolism ; Immunoglobulins, Intravenous/therapeutic use ; Immunoglobulins, Intravenous/pharmacology ; Leukocyte Elastase/metabolism ; Lung Injury/metabolism ; Respiratory Distress Syndrome ; Cell-Free Nucleic Acids/metabolism ; Dexamethasone ; COVID-19 Drug Treatment
    Chemical Substances Immunoglobulins, Intravenous ; Leukocyte Elastase (EC 3.4.21.37) ; Cell-Free Nucleic Acids ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.993720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dexmedetomidine does not directly inhibit neutrophil extracellular trap production.

    Corriden, Ross / Schmidt, Benjamin E / Olson, Joshua / Okerblom, Jonathan / Masso-Silva, Jorge A / Nizet, Victor / Meier, Angela

    British journal of anaesthesia

    2021  Volume 128, Issue 2, Page(s) e51–e54

    MeSH term(s) Dexmedetomidine/pharmacology ; Extracellular Traps ; Humans ; Neutrophils
    Chemical Substances Dexmedetomidine (67VB76HONO)
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Host response to pulmonary fungal infections: A highlight on cell-driven immunity to

    Dutta, Orchi / Masso-Silva, Jorge A / Wang, Keyi / Rivera, Amariliz

    Current pharmacology reports

    2017  Volume 3, Issue 6, Page(s) 335–345

    Language English
    Publishing date 2017-10-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2198-641X
    ISSN 2198-641X
    DOI 10.1007/s40495-017-0111-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: A Heat-Killed

    Wang, Yina / Wang, Keyi / Masso-Silva, Jorge A / Rivera, Amariliz / Xue, Chaoyang

    mBio

    2019  Volume 10, Issue 6

    Abstract: Cryptococcus ... ...

    Abstract Cryptococcus neoformans
    MeSH term(s) Animals ; Aspergillus fumigatus/immunology ; Aspergillus fumigatus/physiology ; Cross Protection ; Cryptococcosis/immunology ; Cryptococcosis/microbiology ; Cryptococcosis/prevention & control ; Cryptococcus gattii/immunology ; Cryptococcus gattii/physiology ; Cryptococcus neoformans/chemistry ; Cryptococcus neoformans/genetics ; Cryptococcus neoformans/immunology ; Female ; Fungal Proteins/administration & dosage ; Fungal Proteins/genetics ; Fungal Proteins/immunology ; Fungal Vaccines/administration & dosage ; Fungal Vaccines/genetics ; Fungal Vaccines/immunology ; Hot Temperature ; Humans ; Invasive Fungal Infections/immunology ; Invasive Fungal Infections/microbiology ; Invasive Fungal Infections/prevention & control ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/genetics ; Vaccines, Inactivated/immunology
    Chemical Substances Fungal Proteins ; Fungal Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02145-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome.

    Sanchez-Azofra, Ana / Gu, Wanjun / Masso-Silva, Jorge A / Sanz-Rubio, David / Marin-Oto, Marta / Cubero, Pablo / Gil, Ana V / Moya, Esteban A / Barnes, Laura A / Mesarwi, Omar A / Marin, Traci / Simonson, Tatum S / Crotty Alexander, Laura E / Marin, Jose M / Malhotra, Atul

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 19, Issue 8, Page(s) 1447–1456

    Abstract: ... A, Gu W, Masso-Silva JA, et al. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease ...

    Abstract Study objectives: The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual, also known as overlap syndrome (OVS), is associated with higher cardiovascular risk and mortality than either OSA or COPD alone. However, the underlying mechanisms remain unclear. We hypothesized that patients with OVS have elevated systemic inflammatory biomarkers relative to patients with either disease alone, which could explain greater cardiovascular risk observed in OVS.
    Methods: We included 255 participants in the study, 55 with COPD alone, 100 with OSA alone, 50 with OVS, and 50 healthy controls. All participants underwent a home sleep study, spirometry, and a blood draw for high-sensitivity C-reactive protein and total blood count analysis. In a randomly selected subset of 186 participants, inflammatory protein profiling was performed using Bio-Rad Bio-Plex Pro Human Cytokine 27-Plex Assays. Biomarker level differences across groups were identified using a mixed linear model.
    Results: Levels of interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and granulocyte colony stimulating factor (G-CSF) were higher in participants with OVS and COPD compared with healthy controls and participants with OSA. Furthermore, participants with OVS had higher circulating levels of leukocytes and neutrophils than those with COPD, OSA, and controls.
    Conclusions: COPD and OVS are associated with higher systemic inflammation relative to OSA and healthy controls. This work proposes the potential utilization of interleukin 6, granulocyte colony stimulating factor, and high-sensitivity C-reactive protein as screening biomarkers for COPD in patients with OSA. Inflammatory pathways may not fully explain the higher cardiovascular risk observed in OVS, indicating the need for further investigation.
    Citation: Sanchez-Azofra A, Gu W, Masso-Silva JA, et al. Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome.
    MeSH term(s) Humans ; C-Reactive Protein ; Interleukin-6 ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea Syndromes/complications ; Pulmonary Disease, Chronic Obstructive/complications ; Inflammation/complications ; Biomarkers ; Autoimmune Diseases/complications ; Granulocyte Colony-Stimulating Factor
    Chemical Substances C-Reactive Protein (9007-41-4) ; Interleukin-6 ; Biomarkers ; Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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