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Article ; Online: The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals.

Mortazavi, Yasaman / Lidenge, Salum J / Tran, Tara / West, John T / Wood, Charles / Tso, For Yue

2020 Volume 12, Issue 3

Abstract: ... to which various KSHV envelope glycoproteins (gB, ORF28, ORF68, gH, gL, gM, gN and gpK8.1) adsorbed/removed KSHV ... individuals. Importantly, among the KSHV glycoproteins, the gH/gL complex, but neither gH nor gL alone, showed ... individuals regardless of their KS status. The findings suggest that the gH/gL complex is the predominant ...

Abstract	Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), one of the most prevalent cancers of people living with HIV/AIDS in sub-Saharan Africa. The seroprevalence for KSHV is high in the region, and no prophylactic vaccine against the virus is available. In this study, we characterized the antigenic targets of KSHV-specific neutralizing antibodies (nAbs) in asymptomatic KSHV-infected individuals and KS patients with high nAbs titers. We quantified the extent to which various KSHV envelope glycoproteins (gB, ORF28, ORF68, gH, gL, gM, gN and gpK8.1) adsorbed/removed KSHV-specific nAbs from the plasma of infected individuals. Our study revealed that plasma from a majority of KSHV neutralizers recognizes multiple viral glycoproteins. Moreover, the breadth of nAbs responses against these viral glycoproteins varies among endemic KS, epidemic KS and asymptomatic KSHV-infected individuals. Importantly, among the KSHV glycoproteins, the gH/gL complex, but neither gH nor gL alone, showed the highest adsorption of KSHV-specific nAbs. This activity was detected in 80% of the KSHV-infected individuals regardless of their KS status. The findings suggest that the gH/gL complex is the predominant antigenic determinant of KSHV-specific nAbs. Therefore, gH/gL is a potential target for development of KSHV prophylactic vaccines.
MeSH term(s)	Adult ; Aged ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Epitopes/immunology ; Female ; Genetic Vectors/genetics ; HEK293 Cells ; Herpesviridae Infections/immunology ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/physiology ; Humans ; Male ; Middle Aged ; Sarcoma, Kaposi ; Viral Envelope Proteins/immunology ; Viral Load ; Young Adult
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Viral Envelope Proteins
Language	English
Publishing date	2020-02-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12030256
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Dietary Green Tea Polyphenol Supplementation on the Health of Workers Exposed to High-voltage Power Lines.

J, Eslami / Gh, Mortazavi / S A R, Mortazavi / M, Paknahad

Journal of biomedical physics & engineering

2019 Volume 9, Issue 3, Page(s) 257–258

Language	English
Publishing date	2019-06-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2673599-4
ISSN	2251-7200
ISSN	2251-7200
DOI	10.31661/jbpe.v9i3Jun.664
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Article: Ionizing Radiation and Human Gender Proportion at Birth: A Concise Review of the Literature and A Complementary Analysis of Historical and Recent Data.

Eslami, J / Mortazavi, Gh / Mortazavi, S A R

Journal of biomedical physics & engineering

2017 Volume 7, Issue 4, Page(s) 315–316

Language	English
Publishing date	2017-12-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2673599-4
ISSN	2251-7200
ISSN	2251-7200
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: "Triple M" Effect: A Proposed Mechanism to Explain Increased Dental Amalgam Microleakage after Exposure to Radiofrequency Electromagnetic Radiation.

Mortazavi, Gh / Mortazavi, S A R / Mehdizadeh, A R

Journal of biomedical physics & engineering

2018 Volume 8, Issue 1, Page(s) 141–146

Abstract: A large body of evidence now indicates that the amount of mercury released from dental amalgam fillings can be significantly accelerated by exposure to radiofrequency electromagnetic fields (RF-EMFs) such as common mobile phones and magnetic resonance ... ...

Abstract	A large body of evidence now indicates that the amount of mercury released from dental amalgam fillings can be significantly accelerated by exposure to radiofrequency electromagnetic fields (RF-EMFs) such as common mobile phones and magnetic resonance imaging (MRI). Studies performed on the increased microleakage of dental amalgam restorations after exposure to RF-EMFs have further supported these findings. Although the accelerated microleakage induced by RF-EMFs is clinically significant, the entire mechanisms of this phenomenon are not clearly understood. In this paper, we introduce "Triple M" effect, a new evidence-based theory which can explain the accelerated microleakage of dental amalgam fillings after exposure to different sources of electromagnetic radiation. Based on this theory, there are saliva-filled tiny spaces between amalgam and the tooth. Exposure of the oral cavity to RF-EMFs increases the energy of these small amounts of saliva. Due to the small mass of saliva in these tiny spaces, a small amount of energy will be required for heating. Moreover, reflection of the radiofrequency radiation on the inner walls of the tiny spaces causes interference which in turn produces some "hot spots" in these spaces. Finally, formation of gas bubbles in response to increased temperature and very rapid expansion of these bubbles will accelerate the microleakage of amalgam. Experiments that confirm the validity of this theory are discussed.
Language	English
Publishing date	2018-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2673599-4
ISSN	2251-7200
ISSN	2251-7200
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Metformin on Experimental Varicocele in Rats.

Karimi, H / Asghari, A / Jahandideh, A / Akbari, Gh / Mortazavi, P

Archives of Razi Institute

2021 Volume 76, Issue 2, Page(s) 371–384

Abstract: The current study aimed to determine the effect of metformin (MET) on histopathologic evaluation and antioxidant enzyme activity in experimental varicocele-induced rats. A total of 60 rats were randomly divided into six experimental groups. Group 1 ( ... ...

Abstract	The current study aimed to determine the effect of metformin (MET) on histopathologic evaluation and antioxidant enzyme activity in experimental varicocele-induced rats. A total of 60 rats were randomly divided into six experimental groups. Group 1 (control) received no medication and underwent no surgery. In group 2 (sham), the rats received no medication and the abdominal cavity was opened; however, there was no varicocele induction. In group 3 (varicocele), the abdominal cavity was opened and the rats underwent varicocele induction and received no medication. In group 4, the abdominal cavity was opened and the animals received 25 mg/kg of MET for 42 days and were varicocele-induced. Groups 5 and 6 were similar to group 4 except that the animals received 50 and 100 mg/kg of MET, respectively. At the end of the 21st and 42nd days, the rats were euthanized and the left testis was removed for histological analysis and measurement of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), and total antioxidant status levels. According to the results, a dose-dependent difference was observed in testis damage grade in the MET treated groups, compared to that reported for the varicocele group (p <0.05). No difference was observed between 25 and 50 mg/kg of MET (P>0.05). Tissue MDA levels significantly increased in varicocele rats (p <0.05); however, MET (25, 50, and 100 mg/kg) in a dose-dependent manner decreased varicocele-induced MDA (p <0.05). Experimental varicocele significantly decreased SOD activity, compared to that reported for the control group (p <0.05). The administration of MET (25, 50, and 100 mg/kg) significantly increased tissue SOD activity in varicocele rats (p <0.05). The MET (25, 50, and 100 mg/kg) in a dose-dependent manner increased GPx activity in varicocele rats (p <0.05). There was no difference in MDA, SOD, and GPx levels between 25 and 50 mg/kg MET groups (P>0.05). The aforementioned findings suggested that MET treatment had beneficial effects on varicocele.
MeSH term(s)	Animals ; Male ; Rats ; Malondialdehyde ; Metformin/therapeutic use ; Rats, Wistar ; Testis ; Varicocele
Chemical Substances	Malondialdehyde (4Y8F71G49Q) ; Metformin (9100L32L2N)
Language	English
Publishing date	2021-07-01
Publishing country	Iran
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2555498-0
ISSN	2008-9872 ; 0365-3439
ISSN (online)	2008-9872
ISSN	0365-3439
DOI	10.22092/ari.2020.128136.1406
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Article ; Online: Effects of Dietary Green Tea Polyphenol Supplementation on the Health of Workers Exposed to High-voltage Power Lines

Eslami J. / Mortazavi Gh. / Mortazavi S. A. R. / Paknahad M.

Journal of Biomedical Physics and Engineering, Vol 9, Iss 3, Pp 257-

2019 Volume 258

Abstract: ... no ... ...

Abstract	no abstract
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Is Induction of Anomalies in Lymphocytes of the Residents of High Background Radiation Areas Associated with Increased Cancer Risk?

S M J, Mortazavi / Gh, Mortazavi / S A R, Mortazavi / M, Paknahad

Journal of biomedical physics & engineering

2019 Volume 9, Issue 3, Page(s) 367–372

Abstract: Man has been exposed to different levels of natural background radiation since the creation of human life. There are inhabited areas around the world with extraordinary levels of natural background radiation. The level of natural radiation in these areas ...

Abstract	Man has been exposed to different levels of natural background radiation since the creation of human life. There are inhabited areas around the world with extraordinary levels of natural background radiation. The level of natural radiation in these areas is up to two orders of magnitude higher than other places. Areas such as Yangjiang, China; Guarapari, Brazil; and Kerala, India are among the areas with high levels of natural radiation. Ramsar a coastal city in North Iran has some inhabited areas with the highest known levels of background radiation around the world. People who live in high background radiation areas (HBRAs) such as Ramsar do not record any detrimental biological effects. While some cytogenetic studies conducted in HBRAs have shown increased frequencies of unstable chromosome aberration, other investigations failed to find a significant difference. This short review is an attempt to verify if induction of chromosomal anomalies in the lymphocytes of the residents of high background radiation areas is associated with increased cancer risk.
Language	English
Publishing date	2019-06-01
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2673599-4
ISSN	2251-7200
ISSN	2251-7200
DOI	10.31661/jbpe.v9i3Jun.654
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Article ; Online: Effects of Metformin on Experimental Varicocele in Rats

H Karimi / A Asghari / A Jahandideh / Gh Akbari / P Mortazavi

Archives of Razi Institute, Vol 76, Iss 2, Pp 371-

2021 Volume 384

Abstract	The current study aimed to determine the effect of metformin (MET) on histopathologic evaluation and antioxidant enzyme activity in experimental varicocele-induced rats. A total of 60 rats were randomly divided into six experimental groups. Group 1 (control) received no medication and underwent no surgery. In group 2 (sham), the rats received no medication and the abdominal cavity was opened; however, there was no varicocele induction. In group 3 (varicocele), the abdominal cavity was opened and the rats underwent varicocele induction and received no medication. In group 4, the abdominal cavity was opened and the animals received 25 mg/kg of MET for 42 days and were varicocele-induced. Groups 5 and 6 were similar to group 4 except that the animals received 50 and 100 mg/kg of MET, respectively. At the end of the 21st and 42nd days, the rats were euthanized and the left testis was removed for histological analysis and measurement of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), and total antioxidant status levels. According to the results, a dose-dependent difference was observed in testis damage grade in the MET treated groups, compared to that reported for the varicocele group (p <0.05). No difference was observed between 25 and 50 mg/kg of MET (P>0.05). Tissue MDA levels significantly increased in varicocele rats (p <0.05); however, MET (25, 50, and 100 mg/kg) in a dose-dependent manner decreased varicocele-induced MDA (p <0.05). Experimental varicocele significantly decreased SOD activity, compared to that reported for the control group (p <0.05). The administration of MET (25, 50, and 100 mg/kg) significantly increased tissue SOD activity in varicocele rats (p <0.05). The MET (25, 50, and 100 mg/kg) in a dose-dependent manner increased GPx activity in varicocele rats (p <0.05). There was no difference in MDA, SOD, and GPx levels between 25 and 50 mg/kg MET groups (P>0.05). The aforementioned findings suggested that MET treatment had beneficial ...
Keywords	antioxidant ; histologic evaluation ; metformin ; varicocele ; rat ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Razi Vaccine and Serum Research Institute
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Is Induction of Anomalies in Lymphocytes of the Residents of High Background Radiation Areas Associated with Increased Cancer Risk?

Mortazavi S. M. J. / Mortazavi Gh. / Mortazavi S. A. R. / Paknahad M.

Journal of Biomedical Physics and Engineering, Vol 9, Iss 3, Pp 367-

2019 Volume 372

Abstract: ... with increased cancer risk. Citation: Mortazavi S. M. J, Mortazavi Gh, Mortazavi S. A. R, Paknahad M. Is ...

Abstract	Man has been exposed to different levels of natural background radiation since the creation of human life. There are inhabited areas around the world with extraordinary levels of natural background radiation. The level of natural radiation in these areas is up to two orders of magnitude higher than other places. Areas such as Yangjiang, China; Guarapari, Brazil; and Kerala, India are among the areas with high levels of natural radiation. Ramsar a coastal city in North Iran has some inhabited areas with the highest known levels of background radiation around the world. People who live in high background radiation areas (HBRAs) such as Ramsar do not record any detrimental biological effects. While some cytogenetic studies conducted in HBRAs have shown increased frequencies of unstable chromosome aberration, other investigations failed to find a significant difference. This short review is an attempt to verify if induction of chromosomal anomalies in the lymphocytes of the residents of high background radiation areas is associated with increased cancer risk. Citation: Mortazavi S. M. J, Mortazavi Gh, Mortazavi S. A. R, Paknahad M. Is Induction of Anomalies in Lymphocytes of the Residents of High Background Radiation Areas Associated with Increased Cancer Risk?. J Biomed Phys Eng. 2019;9(3):367-372. https://doi.org/10.31661/ jbpe.v9i3Jun.654.
Keywords	Human Lymphocytes ; High Background Radiation Areas ; Natural Radiation ; Cancer Risk ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	535
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ionizing Radiation and Human Gender Proportion at Birth

Eslami J. / Mortazavi Gh. / Mortazavi S. A. R.

Journal of Biomedical Physics and Engineering, Vol 7, Iss 4, Pp 315-

A Concise Review of the Literature and A Complementary Analysis of Historical and Recent Data

2017 Volume 316

Abstract: ... the level of natural background radiation varies on Earth at least two orders of magnitude [2]. Mortazavi et ...

Abstract	Dear Editor, This letter considers an article by Scherb et al. entitled “Ionizing radiation and the human gender proportion at birth: A concise review of the literature and a complementary analysis of historical and recent data” published in Early Human Development (DOI: http://dx.doi.org/10.1016/j.earlhumdev.2015.10.012) [1]. The authors of this challenging paper have reviewed the literature regarding the effect of exposure to ionizing radiation on gender ratio at birth. Scherb et al. have stated that above-thebackground levels of ionizing radiation may alter the gender ratio at birth: “We are of the strong opinion that gradually increasing the level of background radiation poses an increased genetic risk to humans and creature and that more research should be initiated in this respect. This has implications for the nuclear power industry, and emphasizes the importance of finding safe methods for processing and storing nuclear waste”. They also claimed that the data they presented confirm the existence of an impact of ionizing radiation on human secondary sex. This paper bears a very basic shortcoming. We know that at present, the level of natural background radiation varies on Earth at least two orders of magnitude [2]. Mortazavi et al. have previously published reports on the health effects of exposure to elevated levels of natural ionizing radiation in HBNRAs of Ramsar [2-6]. While radiation level in Ramsar is up to 260 mSv y−1 (the highest background radiation levels known among inhabited areas, up to 13 times higher than the recommended dose limit for radiation workers in Iran that is 20 mSv y−1), people living in high background radiation areas of Ramsar show no observable detrimental effect. It is worth mentioning that if a radiation dose of a few hundred mSv per year has adverse health effects and causes genetic abnormalities or an increased risk of cancer, it should be evident to the residents of these hot areas [6]. Moreover, the residents had a similar sex ratio as that of unexposed urban areas in ...
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	535
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Shiraz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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