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Article ; Online: Why is pituitary carcinoma so rare?

Marrero-Rodríguez, Daniel / Taniguchi-Ponciano, Keiko / Mercado, Moises

Expert review of endocrinology & metabolism

2023 Volume 18, Issue 1, Page(s) 1–3

MeSH term(s)	Humans ; Pituitary Neoplasms/pathology ; Adenoma/pathology
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Editorial
ISSN	1744-8417
ISSN (online)	1744-8417
DOI	10.1080/17446651.2023.2167710
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Article ; Online: Association between Intracellular Calcium Signaling and Tumor Recurrence in Human Non-Functioning Pituitary Adenomas.

Santiago-Andres, Yorgui / Aquiles, Ana / Taniguchi-Ponciano, Keiko / Salame, Latife / Guinto, Gerardo / Mercado, Moises / Fiordelisio, Tatiana

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar tumor among studies on community-dwelling adults. They are characterized by the absence of hormonal hypersecretion syndrome, and patients present with compressive ... ...

Abstract	Clinically non-functioning pituitary adenomas (CNFPAs) are the second most frequent sellar tumor among studies on community-dwelling adults. They are characterized by the absence of hormonal hypersecretion syndrome, and patients present with compressive symptoms, such as a headache and visual field defects. Immunohistochemically, most CNFPAs are of gonadotrope differentiation, with only a few of them being truly null cell adenomas. Although these tumors express receptors for one or more hypothalamic releasing hormones, to what extent this has an impact on the biological and clinical behavior of these neoplasms remains to be defined. In this research, we evaluated the basal and hypothalamic secretagogue-stimulated intracellular calcium mobilization in 13 CNFPAs, trying to correlate this response to the phenotypic features of the patients. Our results indicate that the recurrence of a CNFPA correlates positively with cellular responsiveness, as measured by spontaneous intracellular calcium activity and the ability to respond to multiple hypothalamic secretagogues. We conclude that this finding may be a useful tool for predicting the clinicopathologic behavior of CNFPAs, by testing the variation of cellular responsiveness to hypothalamic secretagogues.
MeSH term(s)	Adult ; Humans ; Pituitary Neoplasms ; Calcium ; Calcium Signaling ; Neoplasm Recurrence, Local ; Secretagogues ; Calcium, Dietary ; Neoplasms, Second Primary
Chemical Substances	Calcium (SY7Q814VUP) ; Secretagogues ; Calcium, Dietary
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073968
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Article ; Online: The molecular biology of sporadic acromegaly.

Marrero-Rodríguez, Daniel / Moscona-Nissan, Alberto / Sidauy-Adissi, Jessica / Haidenberg-David, Fabian / Jonguitud-Zumaya, Esbeydi / de Jesus Chávez-Vera, Leonel / Martinez-Mendoza, Florencia / Taniguchi-Ponciano, Keiko / Mercado, Moises

Best practice & research. Clinical endocrinology & metabolism

2024 , Page(s) 101895

Abstract: GH-secreting tumors represent 15 % to 20 % of all pituitary neuroendocrine tumors (pitNETs), of which 95 % occur in a sporadic context, without an identifiable inherited cause. Recent multi-omic approaches have characterized the epigenomic, genomic, ... ...

Abstract	GH-secreting tumors represent 15 % to 20 % of all pituitary neuroendocrine tumors (pitNETs), of which 95 % occur in a sporadic context, without an identifiable inherited cause. Recent multi-omic approaches have characterized the epigenomic, genomic, transcriptomic, proteomic and kynomic landscape of pituitary tumors. Transcriptomic analysis has allowed us to discover specific transcription factors driving the differentiation of pituitary tumors and gene expression patterns. GH-secreting, along with PRL- and TSH-secreting pitNETs are driven by POU1F1; ACTH-secreting tumors are determined by TBX19; and non-functioning tumors, which are predominantly of gonadotrope differentiation are conditioned by NR5A1. Upregulation of certain miRNAs, such as miR-107, is associated with tumor progression, while downregulation of others, like miR-15a and miR-16-1, correlates with tumor size reduction. Additionally, miRNA expression profiles are linked to treatment resistance and clinical outcomes, providing insights into potential therapeutic targets. Specific somatic mutations in GNAS, PTTG1, GIPR, HGMA2, MAST and somatic variants associated with cAMP, calcium signaling, and ATP pathways have also been associated with the development of acromegaly. This review focuses on the oncogenic mechanisms by which sporadic acromegaly can develop, covering a complex series of molecular alterations that ultimately alter the balance between proliferation and apoptosis, and dysregulated hormonal secretion.
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052339-7
ISSN	1878-1594 ; 1532-1908 ; 1521-690X
ISSN (online)	1878-1594 ; 1532-1908
ISSN	1521-690X
DOI	10.1016/j.beem.2024.101895
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Article ; Online: Mesenchymal stem cells induce an immunosuppressive microenvironment in pituitary tumors.

Marrero-Rodriguez, Daniel / Cortes-Morales, Victor A / Cano-Zaragoza, Amayrani / Martinez-Mendoza, Florencia / Kerbel-Suton, Jacobo / Vela-Patiño, Sandra / Chavez-Santoscoy, Alejandra / Hinojosa-Alvarez, Silvia / Hernandez-Perez, Jesus / Gomez-Apo, Erick / Fajardo-Orduña, Guadalupe R / Taniguchi-Ponciano, Keiko / Montesinos, Juan Jose / Mercado, Moises

The Journal of clinical endocrinology and metabolism

2024

Abstract: Background: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in ... ...

Abstract	Background: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in pituitary tumors (PT) remains unknown. Herein we report the presence of MSCs in 2 ACTH-secreting PT causing Cushing disease (MCU), 2 nonfunctioning adenomas of gonadotrope differentiation (MNF) and 2 non tumoral pituitary glands (MS). Methods: We have analyzed their transcriptomic profiles by RNAseq and compared MSC in terms of their immunosuppressive effects against lymphoid T cell and macrophage populations by means of co-cultures and flow cytometry. Results: Our transcriptomic analysis revealed molecular differences between MSC derived from non-tumoral pituitaries and MSC derived from PT. Two distinct subpopulations of MSC, one displaying immunosuppressive properties and the other with increased pro-proliferative capabilities, regardless of their origin. MSC derived from ACTH- and nonfunctioning PT, but not those derived from non-tumoral glands significantly inhibited the proliferation of activated T cells, favored the generation of Tregs and promote M2 macrophage polarization. Such immunosuppressive effects were correlated with an upregulation of programmed death ligand 1 and intracellular expression of macrophage colony stimulating factor (M-CSF) and IL-10. Importantly, MSC derived from ACTH-PT showed a higher immunosuppressive potential than MSC isolated from nonfunctioning tumors. Conclusion: This study demonstrates the presence of at least two MSC subpopulations in the pituitary gland and suggests that immunosuppressive effects of MSC may have important implications in PT growth.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgae212
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Article ; Online: Genomics, Transcriptomics, and Epigenetics of Sporadic Pituitary Tumors.

Marrero-Rodríguez, Daniel / Vela-Patiño, Sandra / Martinez-Mendoza, Florencia / Valenzuela-Perez, Alejandra / Peña-Martínez, Eduardo / Cano-Zaragoza, Amayrani / Kerbel, Jacobo / Andonegui-Elguera, Sergio / Glick-Betech, Shimon S / Hermoso-Mier, Karla X / Mercado-Medrez, Sophia / Moscona-Nissan, Alberto / Taniguchi-Ponciano, Keiko / Mercado, Moises

Archives of medical research

2023 Volume 54, Issue 8, Page(s) 102915

Abstract: Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing ... ...

Abstract	Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central hyperthyroidism. Nonfunctioning PT do not result in a hormonal hypersecretion syndrome and most of them are of gonadotrope differentiation; other non-functioning PT include null cell adenomas and silent ACTH-, GH- and PRL-adenomas. Less than 5% of PT occur in a familial or syndromic context whereby germline mutations of specific genes account for their molecular pathogenesis. In contrast, the more common sporadic PT do not result from a single molecular abnormality but rather emerge from several oncogenic events that culminate in an increased proliferation of pituitary cells, and in the case of functioning tumors, in a non-regulated hormonal hypersecretion. In recent years, important advances in the understanding of the molecular pathogenesis of PT have been made, including the genomic, transcriptomic, epigenetic, and proteomic characterization of these neoplasms. In this review, we summarize the available molecular information pertaining the oncogenesis of PT.
MeSH term(s)	Male ; Pregnancy ; Humans ; Female ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/pathology ; Proteomics ; Adenoma/genetics ; Adenoma/pathology ; Genomics ; Adrenocorticotropic Hormone/genetics ; Adrenocorticotropic Hormone/metabolism ; Gene Expression Profiling ; Epigenesis, Genetic
Chemical Substances	Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2023-11-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2023.102915
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Article: HPV infection profile in cervical lesions.

González-Yebra, Beatriz / Mojica-Larrea, Miriam / Alonso, Ruth / González, Ana L / Romero-Morelos, Pablo / Taniguchi-Ponciano, Keiko / Ruiz-Romero, Jorge A / López-Romero, Ricardo / Salcedo, Mauricio

Gaceta medica de Mexico

2022 Volume 158, Issue 4, Page(s) 222–228

Abstract: Introduction: The prevalence of the different genotypes of human papillomavirus (HPV) varies depending on lesion severity and geographic region.: Objective: To identify multiple HPV infections in low- and high-grade cervical lesions in a group of ... ...

Title translation	Perfil de infecciones por VPH en lesiones cervicales.
Abstract	Introduction: The prevalence of the different genotypes of human papillomavirus (HPV) varies depending on lesion severity and geographic region. Objective: To identify multiple HPV infections in low- and high-grade cervical lesions in a group of women from the Mexican Bajío region referred with inconclusive cytology. Methods: Pilot study of women referred from primary care units of Guanajuato, Mexico, with cytology suggestive of cervical lesion. Cervical smears were subjected to DNA extraction and HPV genotyping using microarrays. Results: 100 consecutive cases were collected and 90 were analyzed; HPV positivity was observed in 26% of healthy women, and 62% had some degree of cervical lesion. The most common HPV genotypes were 59, 31, 16 and 51. Multiple infections were found in most samples. Conclusions: HPV heterogeneity was identified in the samples of the study population in contrast to worldwide reports; furthermore, multiple infections are common in precursor lesions and decrease in high-grade lesions. These data could have an impact on current HPV vaccination programs.
MeSH term(s)	Humans ; Female ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Pilot Projects ; Papillomaviridae/genetics ; Genotype ; Prevalence ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-10-18
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	425456-9
ISSN	0016-3813
ISSN	0016-3813
DOI	10.24875/GMM.M22000679
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Article ; Online: The hallmarks of cancer… in pituitary tumors?

Marrero-Rodríguez, Daniel / Taniguchi-Ponciano, Keiko / Kerbel, Jacobo / Cano-Zaragoza, Amayrani / Remba-Shapiro, Ilan / Silva-Román, Gloria / Vela-Patiño, Sandra / Andonegui-Elguera, Sergio / Valenzuela-Perez, Alejandra / Mercado, Moisés

Reviews in endocrine & metabolic disorders

2022 Volume 24, Issue 2, Page(s) 177–190

Abstract: Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation. This classical review, along with two revisions published in 2011 and 2022, has remain a classic of the ... ...

Abstract	Over 20 years ago, Hanahan and Weinberg published a seminal review that addressed the biological processes that underly malignant transformation. This classical review, along with two revisions published in 2011 and 2022, has remain a classic of the oncology literature. Since many of the addressed biological processes may apply to non-malignant tumorigenesis, we evaluated to what extent these hallmarks pertain to the development of pituitary adenomas.Some of the biological processes analyzed in this review include genome instability generated by somatic USP8 and GNAS mutations in Cushing's diseases and acromegaly respectively; non-mutational epigenetic reprograming through changes in methylation; induction of angiogenesis through alterations of VEGF gene expression; promotion of proliferative signals mediated by EGFR; evasion of growth suppression by disrupting cyclin dependent kinase inhibitors; avoidance of immune destruction; and the promotion of inflammation mediated by alteration of gene expression of immune check points. We also elaborate further on the existence of oncogene induced senescence in pituitary tumors. We conclude that a better understanding of these processes can help us dilucidated why pituitary tumors are so resistant to malignant transformation and can potentially contribute to the development of novel anticancer treatments.
MeSH term(s)	Humans ; Pituitary Neoplasms/genetics ; Pituitary Neoplasms/pathology ; Adenoma/pathology ; Mutation ; Acromegaly
Language	English
Publishing date	2022-12-31
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-022-09777-y
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Article ; Online: An Update on Gastroenteropancreatic Neuroendocrine Neoplasms: From Mysteries to Paradigm Shifts.

Ramírez-Rentería, Claudia / Ferreira-Hermosillo, Aldo / Marrero-Rodríguez, Daniel / Taniguchi-Ponciano, Keiko / Melgar-Manzanilla, Virgilio / Mercado, Moisés

Archives of medical research

2020 Volume 51, Issue 8, Page(s) 765–776

Abstract: Although neuroendocrine neoplasms (NEN) were once thought to be rare and mostly "benign" diseases, they are now being redefined in light of recently discovered molecular information. NENs constitute a spectrum of variably differentiated neoplasms, ... ...

Abstract	Although neuroendocrine neoplasms (NEN) were once thought to be rare and mostly "benign" diseases, they are now being redefined in light of recently discovered molecular information. NENs constitute a spectrum of variably differentiated neoplasms, ranging from well-differentiated tumors with a protracted course over many years to very aggressive neuroendocrine carcinomas. Although the majority of NEN are non-functional lesions, some of these tumors, do produce a hormonal hypersecretion syndrome. Their reappraisal has led scientist to unveil previously unknown oncogenic pathways and connections that resulted in a new category in the International Classification of Diseases (ICD-11) and a revised version of the World Health Organization Classification (WHO 2018). Complex diseases like NEN require a multidisciplinary approach that includes the perspectives of endocrinologists, medical and surgical oncologists, radiation oncologists, imaging specialists and pathologists. There are currently virtually thousands of ongoing trials evaluating the efficacy and safety of several molecular targeted therapies. The purpose of this review was to critically evaluate recent information regarding the pathogenesis, diagnosis and treatment of NEN.
MeSH term(s)	Female ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/pathology ; Humans ; Male ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1156844-6
ISSN	1873-5487 ; 0188-4409 ; 0188-0128
ISSN (online)	1873-5487
ISSN	0188-4409 ; 0188-0128
DOI	10.1016/j.arcmed.2020.06.018
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Article: Liposomes Bearing Non-Bilayer Phospholipid Arrangements Induce Specific IgG Anti-Lipid Antibodies by Activating NK1.1

Landa-Saldívar, Carla / Reséndiz-Mora, Albany / Sánchez-Barbosa, Sandra / Sotelo-Rodríguez, Anahi / Barrera-Aveleida, Giovanna / Nevárez-Lechuga, Irene / Galarce-Sosa, Iván / Taniguchi-Ponciano, Keiko / Cruz-Guzmán, Oriana Del Rocío / Wong-Baeza, Isabel / Escobar-Gutiérrez, Alejandro / Baeza, Isabel / Wong-Baeza, Carlos

Membranes

2022 Volume 12, Issue 7

Abstract: Liposomes are artificial models of cellular membranes that are used as delivery systems for genes, drugs and protein antigens. We have previously used them to study the antigenic properties of their phospholipids. Here, we used them to induce the ... ...

Abstract	Liposomes are artificial models of cellular membranes that are used as delivery systems for genes, drugs and protein antigens. We have previously used them to study the antigenic properties of their phospholipids. Here, we used them to induce the production of IgG anti-non-bilayer phospholipid arrangements (NPAs) antibodies in mice; these antibodies cause cell lysis and trigger a lupus-like disease in mice. We studied the mechanisms that lead to the production of these antibodies, and provide evidence that NK1.1
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes12070643
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Article ; Online: The invasive margin of early-stage human colon tumors is infiltrated with neutrophils of an antitumoral phenotype.

Vadillo, Eduardo / Mantilla, Alejandra / Aguilar-Flores, Cristina / De León-Rodríguez, Saraí Gisel / Vela-Patiño, Sandra / Badillo, Juan / Taniguchi-Ponciano, Keiko / Marrero-Rodríguez, Daniel / Ramírez, Lourdes / León-Vega, Iliana Itzel / Fuentes-Castañeda, Carmen / Piña-Sánchez, Patricia / Prieto-Chávez, Jessica Lakshmi / Pérez-Kondelkova, Vadim / Montesinos, Juan José / Bonifaz, Laura / Pelayo, Rosana / Mayani, Héctor / Schnoor, Michael

Journal of leukocyte biology

2023 Volume 114, Issue 6, Page(s) 672–683

Abstract: Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading to ... ...

Abstract	Neutrophils infiltrate several types of cancer; however, whether their presence is associated with disease progression remains controversial. Here, we show that colon tumors overexpress neutrophil chemoattractants compared to healthy tissues, leading to their recruitment to the invasive margin and the central part of colon tumors. Of note, tumor-associated neutrophils expressing tumor necrosis factor α, which usually represents an antitumoral phenotype, were predominantly located in the invasive margin. Tumor-associated neutrophils from the invasive margin displayed an antitumoral phenotype with higher ICAM-1 and CD95 expression than neutrophils from healthy adjacent tissues. A higher neutrophil/lymphocyte ratio was found at later stages compared to the early phases of colon cancer. A neutrophil/lymphocyte ratio ≤3.5 predicted tumor samples had significantly more neutrophils at the invasive margin and the central part. Moreover, tumor-associated neutrophils at the invasive margin of early-stage tumors showed higher ICAM-1 and CD95 expression. Coculture of colon cancer cell lines with primary neutrophils induced ICAM-1 and CD95 expression, confirming our in situ findings. Thus, our data demonstrate that tumor-associated neutrophils with an antitumoral phenotype characterized by high ICAM-1 and CD95 expression infiltrate the invasive margin of early-stage colon tumors, suggesting that these cells can combat the disease at its early courses. The presence of tumor-associated neutrophils with antitumoral phenotype could help predict outcomes of patients with colon cancer.
MeSH term(s)	Humans ; Neutrophils/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; Colonic Neoplasms/pathology ; Phenotype
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiad123
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