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  1. Article ; Online: Adalimumab in drei Fällen von Anti-IL-17-refraktärer Acrodermatitis continua Hallopeau.

    Zhang, Zhenying / Wu, Xiaoyan / Han, Changxu / Chen, Minghua / Liu, Yuhua

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 7, Page(s) 785–787

    Language German
    Publishing date 2023-04-30
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15041_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6148: Show issues Location:
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  2. Article ; Online: Adalimumab treatment for acrodermatitis continua of Hallopeau: three cases refractory to IL-17 inhibition.

    Zhang, Zhenying / Wu, Xiaoyan / Han, Changxu / Chen, Minghua / Liu, Yuhua

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2023  Volume 21, Issue 7, Page(s) 785–787

    MeSH term(s) Humans ; Adalimumab/therapeutic use ; Acrodermatitis/drug therapy ; Interleukin-17 ; Psoriasis ; Antibodies, Monoclonal, Humanized/therapeutic use ; Exanthema ; Skin Diseases, Vesiculobullous
    Chemical Substances Adalimumab (FYS6T7F842) ; Interleukin-17 ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6148: Show issues Location:
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  3. Article: Arthroscopic Lateral Meniscus Root Repair With Reverse Suture Anchor Technique.

    Meng, Chenyang / Ren, Yizhong / Kong, Lingyue / Guo, Jiantao / Zhao, Yunan / Han, Changxu

    Arthroscopy techniques

    2024  Volume 13, Issue 2, Page(s) 102857

    Abstract: The stability of the knee joint is crucially dependent on the integrity of the lateral meniscus posterior root, which is often accompanied by anterior cruciate ligament injury. Anchor suture repair for lateral meniscus posterior root injury not only ... ...

    Abstract The stability of the knee joint is crucially dependent on the integrity of the lateral meniscus posterior root, which is often accompanied by anterior cruciate ligament injury. Anchor suture repair for lateral meniscus posterior root injury not only achieves better biomechanical effects but also ensures favorable prognosis. However, the placement of anchors often requires the establishment of a posterior approach, and the insertion of an anchor is a technical challenge. In light of this, we have applied the technique of reverse anchor fixation for repairing the lateral meniscus posterior root, which not only simplifies the procedure but also effectively reduces the "bungee effect."
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2023.09.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preparation and Properties of Atomic-Oxygen Resistant Polyimide Films Based on Multi-Ring Fluoro-Containing Dianhydride and Phosphorus-Containing Diamine.

    Wang, Zhenzhong / Ren, Xi / Zhang, Yan / Yang, Changxu / Han, Shujun / Qi, Yuexin / Liu, Jingang

    Polymers

    2024  Volume 16, Issue 3

    Abstract: Colorless and transparent polyimide (CPI) films with good atomic oxygen (AO) resistance and high thermal endurance are highly required in low earth orbit (LEO) space exploration. Conventional CPI films based on fluoro-containing 4,4'-( ... ...

    Abstract Colorless and transparent polyimide (CPI) films with good atomic oxygen (AO) resistance and high thermal endurance are highly required in low earth orbit (LEO) space exploration. Conventional CPI films based on fluoro-containing 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) have been widely used in space applications. However, the AO erosion yields and glass transition temperatures (T
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16030343
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  5. Article ; Online: Ligand-Free Iron-Catalyzed Construction of C-P Bonds via Phosphorylation of Alcohols: Synthesis of Phosphine Oxides and Phosphine Compounds.

    Gan, Liguang / Ye, Changxu / Pi, Tianshu / Wang, Lingling / Li, Chunya / Liu, Long / Huang, Tianzeng / Chen, Tieqiao / Han, Li-Biao

    The Journal of organic chemistry

    2024  

    Abstract: An efficient method for the construction of C-P(V) and C-P(III) bonds via the iron-catalyzed phosphorylation of alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare a series of phosphine oxides ...

    Abstract An efficient method for the construction of C-P(V) and C-P(III) bonds via the iron-catalyzed phosphorylation of alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare a series of phosphine oxides and phosphine compounds in good to excellent yields from the readily available alcohols and P-H compounds. A plausible mechanism is also proposed. We anticipate that this mode of transforming simple alcohols would apply in chemical synthesis widely.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.4c00439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  6. Article ; Online: Rapid and sustained response of acute generalized pustular psoriasis of von Zumbusch to Secukinumab.

    Wu, Xiaoyan / Yan, Tianmeng / Han, Changxu / Ma, Li / Zeng, Lihua / Chen, Xiaohong / Zhang, Zhenying

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 37, Issue 3, Page(s) e338–e341

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Skin Diseases, Vesiculobullous ; Acute Disease
    Chemical Substances secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2022-10-08
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18609
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  7. Article ; Online: Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis.

    Lan, Yu / Wu, Xiaoyan / Zhong, Xinyu / Song, Pengfei / Liu, Leying / Liu, Yuhua / Ai, Xuechen / Han, Changxu / Zhang, Zhenying

    Experimental dermatology

    2024  Volume 33, Issue 2, Page(s) e15026

    Abstract: Generalized pustular psoriasis (GPP) is considered to be a distinct clinical entity from psoriasis vulgaris (PV), with different clinical and histological manifestations. The pathogenesis of GPP has not been thoroughly elucidated, especially in those ... ...

    Abstract Generalized pustular psoriasis (GPP) is considered to be a distinct clinical entity from psoriasis vulgaris (PV), with different clinical and histological manifestations. The pathogenesis of GPP has not been thoroughly elucidated, especially in those patients lacking interleukin (IL)36RN. In present study, we performed RNA sequence analysis on skin lesions from 10 GPP patients (4 with and 6 without IL36RN mutation) and 10 PV patients without IL36RN mutation. Compared with PV, significantly overexpressed genes in GPP patients were enriched in IL-17 signalling pathway (MMP1, MMP3, DEFB4A and DEFB4B, etc.) and associated with neutrophil infiltration (MMP1, MMP3, ANXA and SERPINB, etc.). GPP with IL36RN mutations evidenced WNT11 upregulation and IL36RN downregulation in comparison to those GPP without IL36RN mutations. The expression of IL-17A/IL-36 in skin or serum and the origin of IL-17A in skin were also investigated. IL-17A expression in skin was significantly higher in GPP than PV patients, whereas, there were no differences in skin IL-36α/IL-36γ/IL-36RA or serum IL-17A/IL-36α/IL-36γ between GPP than PV. Besides, double immunofluorescence staining of MPO/IL-17A or CD3/IL-17A further confirmed that the majority of IL-17A in GPP skin was derived from neutrophils, but not T cells. These data emphasized the role of neutrophil-derived IL-17A in the pathogenesis of GPP with or without IL36RN mutations. Targeting neutrophil-derived IL-17A might be a promising treatment for GPP.
    MeSH term(s) Humans ; Interleukin-17/genetics ; Interleukins/genetics ; Interleukins/metabolism ; Matrix Metalloproteinase 1 ; Matrix Metalloproteinase 3 ; Neutrophils/metabolism ; Psoriasis/drug therapy ; Skin Diseases, Vesiculobullous
    Chemical Substances IL36RN protein, human ; Interleukin-17 ; Interleukins ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; IL17A protein, human
    Language English
    Publishing date 2024-02-27
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15026
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    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Exosomal miR-429 derived from adipose-derived stem cells ameliorated chondral injury in osteoarthritis via autophagy by targeting FEZ2.

    Meng, Chenyang / Na, Yuyan / Han, Changxu / Ren, Yizhong / Liu, Ming / Ma, Penglei / Bai, Rui

    International immunopharmacology

    2023  Volume 120, Page(s) 110315

    Abstract: Background: Osteoarthritis (OA) is the most prevalent musculoskeletal disease, imposing a significant public health burden. Exosomes might be an effective means of treating OA.: Purpose: To investigate the role of exosomes from adipose tissue-derived ...

    Abstract Background: Osteoarthritis (OA) is the most prevalent musculoskeletal disease, imposing a significant public health burden. Exosomes might be an effective means of treating OA.
    Purpose: To investigate the role of exosomes from adipose tissue-derived stromal cells (ADSCs) in OA. We explored whether exosomes from ADSCs could be absorbed by OA chondrocytes, whether there were differences in miR-429 expression in the exosomes of ADSCs and chondrocytes, and whether ADSC exosomal miR-429 could enhance chondrocyte proliferation to exert therapeutic effects in OA.
    Study design: Controlled laboratory study.
    Methods: ADSCs were isolated and cultured from 4-week-old Sprague-Dawley rats. ADSCs and chondrocytes were identified by flow cytometry assay and fluorescent staining, respectively. The exosomes were extracted and identified. Exosome transport was verified by cell staining and co-culture. Beclin 1, collagen II, LC3-II/I, miR-429, and FEZ2 mRNA and protein expression were investigated with real-time PCR and western blotting, respectively. Chondrocyte proliferation was investigated with Cell Counting Kit-8 (CCK-8) assay. The association between miR-429 and FEZ2 was verified with luciferase assay. A rat OA model was established and rat knee joint cartilage tissue was examined with hematoxylin-eosin and toluidine blue staining.
    Results: Both ADSCs and chondrocytes secreted exosomes and ADSC-derived exosomes could be absorbed by the chondrocytes. ADCS exosomes contained higher miR-429 levels than chondrocyte exosomes. The luciferase assay demonstrated that miR-429 directly targeted FEZ2. Compared with the OA group, miR-429 promoted chondrocyte proliferation while FEZ2 decreased it. miR-429 promoted autophagy by targeting FEZ2 to ameliorate cartilage injury. In vivo, miR-429 promoted autophagy to alleviate OA by targeting FEZ2.
    Conclusion: ADSC exosomes could be beneficial for OA and could be absorbed by chondrocytes to promote chondrocyte proliferation through miR-429. miR-429 ameliorated cartilage injury in OA by targeting FEZ2 and promoting autophagy.
    MeSH term(s) Rats ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cells, Cultured ; Rats, Sprague-Dawley ; Chondrocytes/metabolism ; Osteoarthritis/metabolism ; Autophagy/genetics ; Stem Cells/metabolism
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-05-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5408: Show issues Location:
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  9. Article ; Online: Increased flare of acne caused by long-time mask wearing during COVID-19 pandemic among general population.

    Han, Changxu / Shi, Jialiang / Chen, Yan / Zhang, Zhenying

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13704

    MeSH term(s) Acne Vulgaris/etiology ; Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Female ; Humans ; Male ; Masks/adverse effects ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5181: Show issues Location:
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  10. Article ; Online: Synthesis and Characterization of Organo-Soluble Polyimides Based on Polycondensation Chemistry of Fluorene-Containing Dianhydride and Amide-Bridged Diamines with Good Optical Transparency and Glass Transition Temperatures over 400 °C.

    Ren, Xi / Wang, Zhenzhong / He, Zhibin / Yang, Changxu / Qi, Yuexin / Han, Shujun / Chen, Shujing / Yu, Haifeng / Liu, Jingang

    Polymers

    2023  Volume 15, Issue 17

    Abstract: Polymeric optical films with light colors, good optical transparency and high thermal resistance have gained increasing attention in advanced optoelectronic areas in recent years. However, it is somewhat inter-conflicting for achieving the good optical ... ...

    Abstract Polymeric optical films with light colors, good optical transparency and high thermal resistance have gained increasing attention in advanced optoelectronic areas in recent years. However, it is somewhat inter-conflicting for achieving the good optical properties to the conventional thermal resistant polymers, such as the standard aromatic polyimide (PI) films, which are well known for the excellent combined properties and also the deep colors. In this work, a series of wholly aromatic PI films were prepared via the polycondensation chemistry of one fluorene-containing dianhydride, 9,9-bis(3,4-dicarboxyphenyl)fluorene dianhydride (FDAn) and several aromatic diamines with amide linkages in the main chain, including 9,9-bis [4-(4-aminobenzamide)phenyl]fluorene (FDAADA), 2,2'-bis(trifluoromethyl)-4,4'-bis[4-(4-aminobenzamide)] biphenyl (ABTFMB), and 2,2'-bis(trifluoromethyl)-4,4'-bis[4-(4-amino-3-methyl)benzamide] biphenyl (MABTFMB). The derived FLPI-1 (FDAn-FDAADA), FLPI-2 (FDAn-ABTFMB) and FLPI-3 (FDAn-MABTFMB) resins showed good solubility in the polar aprotic solvents, such as N-methyl-2-pyrrolidone (NMP), N,N-dimethylacetamide (DMAc) and dimethyl sulfoxide (DMSO). The solution-processing FDAn-PI films exhibited good optical transmittance over 80.0% at a wavelength of 500 nm (T
    Language English
    Publishing date 2023-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15173549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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