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  1. Article ; Online: Enhanced Detection of Subway Insulator Defects Based on Improved YOLOv5

    Lifeng Huang / Yongzhen Li / Weizu Wang / Zemin He

    Applied Sciences, Vol 13, Iss 24, p

    2023  Volume 13044

    Abstract: Insulators, pivotal to the integrity of railway catenaries, demand impeccable functioning to prevent system failures. Their consistent assessment is vital for railway safety. Current insulator evaluations in subways predominantly involve human ... ...

    Abstract Insulators, pivotal to the integrity of railway catenaries, demand impeccable functioning to prevent system failures. Their consistent assessment is vital for railway safety. Current insulator evaluations in subways predominantly involve human intervention, a method fraught with inefficiencies, inaccuracies, and oversights, exacerbated by the complex backdrop of subway tunnels and minuscule defect dimensions. This study introduces an enhanced algorithm, anchored in the YOLOv5 framework, to refine insulator defect identification. Challenges in defect detection include limited, imbalanced data samples and adaptability. Addressing this, an accurate catenary model mirrors the subway line’s architecture, facilitating the creation of synthetic instances of both intact and impaired insulators. An atomization technique augments the dataset volume, fortifying the algorithm’s resilience in reduced visibility conditions, such as fog. Tackling sample equilibrium, the study introduces an equilibrium loss function, assigning disparate weights to various sample categories during training, thereby sharpening the algorithm’s focus on positive instances, particularly those that are challenging to discern, and rectifying the disproportion in sample categories. Incorporating lightweight structures like GhostNet and the Efficient Channel Attention Network (ECA-Net) channel attention scheme not only diminishes the network’s computational demands, thereby elevating the detection capabilities, but also minimizes superfluous data processing, enhancing the accuracy in identifying smaller targets. Empirical analyses indicate substantial model optimization: a size reduction to 60 pp of its original (from 15 MB to 9 MB), a near 1.4 pp increase in mean average precision (mAP) to 96.57%, and a tripling of the detection speed (from 30 to 90 FPS). Real-world image assessments further reveal a mAP improvement of approximately 2.5 pp (reaching 98.43%), confirming the model’s suitability for real-time applications.
    Keywords YOLOv5 ; railway ; insulator ; sample scarcity ; atomization ; lightweight ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Corrigendum to "Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice" [Experimental Neurology 363 (2023) 114350/manuscript number: EXNR-22-846].

    Kong, Liangliang / Sun, Ran / Zhou, Huimsin / Shi, Qifeng / Liu, Yan / Han, Min / Li, Weiping / Qun, Sen / Li, Weizu

    Experimental neurology

    2024  Volume 376, Page(s) 114719

    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2024.114719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Corrigendum to "Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice." [Biomed. Pharmacother. 150 (2022) 112936].

    Zhang, Duoduo / Ji, Pengmin / Sun, Ran / Zhou, Huimin / Huang, Lei / Kong, Liangliang / Li, Weiping / Li, Weizu

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 170, Page(s) 115965

    Language English
    Publishing date 2023-11-30
    Publishing country France
    Document type Published Erratum
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: PLC-CN-NFAT1 signaling-mediated Aβ and IL-1β crosstalk synergistically promotes hippocampal neuronal damage.

    Shi, Qifeng / Sun, Xiangyu / Zhang, Hui / Yang, Liu / Fu, Yinglin / Wang, Guohang / Su, Yong / Li, Weiping / Li, Weizu

    International immunopharmacology

    2024  Volume 134, Page(s) 112259

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Neuronal calcium overload plays an important role in Aβ deposition and neuroinflammation, which are strongly associated with AD. However, the specific mechanisms by which calcium ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease. Neuronal calcium overload plays an important role in Aβ deposition and neuroinflammation, which are strongly associated with AD. However, the specific mechanisms by which calcium overload contributes to neuroinflammation and AD and the relationship between them have not been elucidated. Phospholipase C (PLC) is involved in regulation of calcium homeostasis, and CN-NFAT1 signaling is dependent on intracellular Ca
    Language English
    Publishing date 2024-05-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.112259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.

    Kong, Liangliang / Liu, Yan / Li, Jingwei / Wang, Yanyan / Ji, Pengmin / Shi, Qifeng / Han, Min / Xu, Hanyang / Li, Weiping / Li, Weizu

    Journal of ethnopharmacology

    2024  Volume 330, Page(s) 118205

    Abstract: Ethnopharmacological relevance: Ginseng is a valuable herb in traditional Chinese medicine. Modern research has shown that it has various benefits, including tonifying vital energy, nourishing and strengthening the body, calming the mind, improving ... ...

    Abstract Ethnopharmacological relevance: Ginseng is a valuable herb in traditional Chinese medicine. Modern research has shown that it has various benefits, including tonifying vital energy, nourishing and strengthening the body, calming the mind, improving cognitive function, regulating fluids, and returning blood pressure, etc. Rg1 is a primary active component of ginseng. It protects hippocampal neurons, improves synaptic plasticity, enhances cognitive function, and boosts immunity. Furthermore, it exhibits anti-aging and anti-fatigue properties and holds great potential for preventing and managing neurodegenerative diseases (NDDs).
    Aim of the study: The objective of this study was to examine the role of Rg1 in treating chronic inflammatory NDDs and its molecular mechanisms.
    Materials and methods: In vivo, we investigated the protective effects of Rg1 against chronic neuroinflammation and cognitive deficits in mice induced by 200 μg/kg lipopolysaccharide (LPS) for 21 days using behavioral tests, pathological sections, Western blot, qPCR and immunostaining. In vitro experiments involved the stimulation of HT22 cells with 10 μg/ml of LPS, verification of the therapeutic effect of Rg1, and elucidation of its potential mechanism of action using H2DCFDA staining, BODIPY™ 581/591 C11, JC-1 staining, Western blot, and immunostaining.
    Results: Firstly, it was found that Rg1 significantly improved chronic LPS-induced behavioral and cognitive dysfunction in mice. Further studies showed that Rg1 significantly attenuated LPS-induced neuronal damage by reducing levels of IL-6, IL-1β and ROS, and inhibiting AIM2 inflammasome. Furthermore, chronic LPS exposure induced the onset of neuronal ferroptosis by increasing the lipid peroxidation product MDA and regulating the ferroptosis-associated proteins Gpx4, xCT, FSP1, DMT1 and TfR, which were reversed by Rg1 treatment. Additionally, Rg1 was found to activate Nrf2 and its downstream antioxidant enzymes, such as HO1 and NQO1, both in vivo and in vitro. In vitro studies also showed that the Nrf2 inhibitor ML385 could inhibit the anti-inflammatory, antioxidant, and anti-ferroptosis effects of Rg1.
    Conclusions: This study demonstrated that Rg1 administration ameliorated chronic LPS-induced cognitive deficits and neuronal ferroptosis in mice by inhibiting neuroinflammation and oxidative stress. The underlying mechanisms may be related to the inhibition of AIM2 inflammasome and activation of Nrf2 signaling. These findings provide valuable insights into the treatment of chronic neuroinflammation and associated NDDs.
    MeSH term(s) Animals ; Ginsenosides/pharmacology ; NF-E2-Related Factor 2/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Signal Transduction/drug effects ; Mice ; Male ; Ferroptosis/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Lipopolysaccharides/toxicity ; Mice, Inbred C57BL ; Inflammation/drug therapy ; Inflammation/metabolism ; Neuroinflammatory Diseases/drug therapy ; Neuroinflammatory Diseases/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Cell Line ; Anti-Inflammatory Agents/pharmacology ; DNA-Binding Proteins
    Chemical Substances Ginsenosides ; NF-E2-Related Factor 2 ; ginsenoside Rg1 (PJ788634QY) ; Nfe2l2 protein, mouse ; Aim2 protein, mouse ; Lipopolysaccharides ; Neuroprotective Agents ; Anti-Inflammatory Agents ; DNA-Binding Proteins
    Language English
    Publishing date 2024-04-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice.

    Kong, Liangliang / Sun, Ran / Zhou, Huimsin / Shi, Qifeng / Liu, Yan / Han, Min / Li, Weiping / Qun, Sen / Li, Weizu

    Experimental neurology

    2023  Volume 363, Page(s) 114350

    Abstract: As the prevalence of diabetes and health awareness increase, type 2 diabetes mellitus -associated cognitive dysfunction is receiving increasing attention. However, the pathogenesis is not entirely understood. Transient receptor potential cation channel 6 ...

    Abstract As the prevalence of diabetes and health awareness increase, type 2 diabetes mellitus -associated cognitive dysfunction is receiving increasing attention. However, the pathogenesis is not entirely understood. Transient receptor potential cation channel 6 (TRPC6) is highly correlated with intracellular Ca
    MeSH term(s) Mice ; Animals ; TRPC6 Cation Channel/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Amyloid beta-Peptides/metabolism ; Diabetes Mellitus, Experimental/complications ; Blood Glucose ; Calcium/metabolism ; Neuroinflammatory Diseases ; Signal Transduction ; Mice, Knockout
    Chemical Substances TRPC6 Cation Channel ; Amyloid beta-Peptides ; Blood Glucose ; Calcium (SY7Q814VUP) ; Trpc6 protein, mouse
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207148-4
    ISSN 1090-2430 ; 0014-4886
    ISSN (online) 1090-2430
    ISSN 0014-4886
    DOI 10.1016/j.expneurol.2023.114350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comprehensive analysis of mRNAs in the cerebral cortex in APP/PS1 double-transgenic mice with Alzheimer's disease based on high-throughput sequencing of N4-acetylcytidine.

    Ma, Yanzhen / Fan, Chang / Wang, Yongzhong / Li, Weizu / Jiang, Hui / Yang, Wenming

    Functional & integrative genomics

    2023  Volume 23, Issue 3, Page(s) 267

    Abstract: N4-acetylcytidine (ac4C), a significant modified nucleoside, participates in the development of many diseases. Messenger RNAs (mRNAs) contain most of the information of the genome and are the molecules that transmit information from genes to proteins. ... ...

    Abstract N4-acetylcytidine (ac4C), a significant modified nucleoside, participates in the development of many diseases. Messenger RNAs (mRNAs) contain most of the information of the genome and are the molecules that transmit information from genes to proteins. Alzheimer's disease (AD) is a progressive neurodegenerative disease in which fibrillar amyloid plaques are present. However, it remains unknown how mRNA ac4C modification affects the development of AD. In the current study, ac4C-modified mRNAs were comprehensively analyzed in AD mice by ac4C-RIP-seq and RNA-seq. Next, a protein-protein interaction (PPI) network was constructed to examine the relationships between the genes with differential ac4C modification levels and their RNA expression levels. The differentially expressed genes (DEGs) acquired above were subjected to Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to further analyze the molecular mechanisms in AD. In total, 3312 significant ac4C peaks were found on 2512 mRNAs, 1241 of which were hyperacetylated and 1271 of which were hypoacetylated. In addition, 956 mRNAs with differential expression were found, including 520 upregulated mRNAs and 436 downregulated mRNAs. Overall, 134 mRNAs with simultaneous changes at the ac4C levels as well as RNA expression levels were identified via joint analysis. Then, through PPI network construction and functional enrichment analysis, 37 key mRNAs were screened, which were predominantly enriched in GABAergic synapses and the PI3K/AKT signaling pathway. The significant difference in the abundance of mRNA ac4C modification indicates that this modification is associated with AD progression, which may provide insight for more investigations of the potential mechanisms.
    MeSH term(s) Mice ; Animals ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Mice, Transgenic ; RNA, Messenger/genetics ; Neurodegenerative Diseases ; Phosphatidylinositol 3-Kinases/genetics ; Cerebral Cortex/metabolism ; High-Throughput Nucleotide Sequencing
    Chemical Substances N-acetylcytidine (3768-18-1) ; RNA, Messenger ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
    Language English
    Publishing date 2023-08-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2014670-X
    ISSN 1438-7948 ; 1438-793X
    ISSN (online) 1438-7948
    ISSN 1438-793X
    DOI 10.1007/s10142-023-01192-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells.

    Zhou, Huimin / Liu, Yan / Su, Yong / Ji, Pengmin / Kong, Liangliang / Sun, Ran / Zhang, Duoduo / Xu, Hanyang / Li, Weiping / Li, Weizu

    Journal of ethnopharmacology

    2024  Volume 324, Page(s) 117794

    Abstract: Ethnopharmacological relevance: Ginseng (Panax ginseng C. A. Meyer) is a precious traditional Chinese medicine with multiple pharmacological effects. Ginsenoside Rg1 is a main active ingredient extracted from ginseng, which is known for its age-delaying ...

    Abstract Ethnopharmacological relevance: Ginseng (Panax ginseng C. A. Meyer) is a precious traditional Chinese medicine with multiple pharmacological effects. Ginsenoside Rg1 is a main active ingredient extracted from ginseng, which is known for its age-delaying and antioxidant effects. Increasing evidence indicates that Rg1 exhibits anti-inflammatory properties in numerous diseases and may ameliorate oxidative damage and inflammation in many chronic liver diseases.
    Aim of the study: Chronic inflammatory injury in liver cells is an important pathological basis of many liver diseases. However, its mechanism remains unclear and therapeutic strategies to prevent its development need to be further explored. Thus, our study is to delve the protective effect and mechanism of Rg1 against chronic hepatic inflammatory injuries induced by lipopolysaccharide (LPS).
    Materials and methods: The chronic liver damage model in mice was build up by injecting intraperitoneally with LPS (200 μg/kg) for 21 days. Serum liver function indicators and levels of IL-1β, IL-6 and TNF-α were examined by using corresponding Kits. Hematoxylin and Eosin (H&E), Periodic acid-Schiff (PAS), and Masson stains were utilized to visualize hepatic histopathological damage, glycogen deposition, and liver fibrosis. The nuclear import of p-Nrf2 and the generation of Col4 in the liver were detected by IF, while IHC was employed to detect the expressions of NLRP3 and AIM2 in the hepatic. The Western blot and q-PCR were used to survey the expressions of proteins and mRNAs of fibrosis and apoptosis, and the expressions of Keap1, p-Nrf2 and NLRP3, NLRP1, AIM2 inflammasome-related proteins in mouse liver. The cell viability of human hepatocellular carcinoma cells (HepG2) was detected by Cell Counting Kit-8 to select the action concentration of LPS, and intracellular ROS generation was detected using a kit. The expressions of Nuclear Nrf2, HO-1, NQO1 and NLRP3, NLRP1, and AIM2 inflammasome-related proteins in HepG2 cells were detected by Western blot. Finally, the feasibility of the molecular interlinking between Rg1 and Nrf2 was demonstrated by molecular docking.
    Results: Rg1 treatment for 21 days decreased the levels of ALT, AST, and inflammatory factors of serum IL-1β, IL-6 and TNF-α in mice induced by LPS. Pathological results indicated that Rg1 treatment obviously alleviated hepatocellular injury and apoptosis, inflammatory cell infiltration and liver fibrosis in LPS stimulated mice. Rg1 promoted Keap1 degradation and enhanced the expressions of p-Nrf2, HO-1 and decreased the levels of NLRP1, NLRP3, AIM2, cleaved caspase-1, IL-1β and IL-6 in livers caused by LPS. Furthermore, Rg1 effectively suppressed the rise of ROS in HepG2 cells induced by LPS, whereas inhibition of Nrf2 reversed the role of Rg1 in reducing the production of ROS and NLRP3, NLRP1, and AIM2 expressions in LPS-stimulated HepG2 cells. Finally, the molecular docking illustrated that Rg1 exhibits a strong affinity towards Nrf2.
    Conclusion: The findings indicate that Rg1 significantly ameliorates chronic liver damage and fibrosis induced by LPS. The mechanism may be mediated through promoting the dissociation of Nrf2 from Keap1 and then activating Nrf2 signaling and further inhibiting NLRP3, NLRP1, and AIM2 inflammasomes in liver cells.
    MeSH term(s) Humans ; Mice ; Animals ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Lipopolysaccharides/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Reactive Oxygen Species/metabolism ; Interleukin-6/metabolism ; Molecular Docking Simulation ; Liver ; Hepatocytes/metabolism ; Liver Diseases/drug therapy ; Liver Diseases/prevention & control ; Liver Diseases/metabolism ; Liver Cirrhosis/metabolism ; Fibrosis ; Ginsenosides
    Chemical Substances Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Lipopolysaccharides ; Kelch-Like ECH-Associated Protein 1 ; ginsenoside Rg1 (PJ788634QY) ; NF-E2-Related Factor 2 ; Tumor Necrosis Factor-alpha ; Reactive Oxygen Species ; Interleukin-6 ; Ginsenosides
    Language English
    Publishing date 2024-01-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Trpc6

    Sun, Ran / Han, Min / Liu, Yan / Su, Yong / Shi, Qifeng / Huang, Lei / Kong, Liangliang / Li, Weizu / Li, Weiping

    Molecular medicine reports

    2023  Volume 29, Issue 1

    Abstract: Diabetic kidney disease (DKD), one of the common complications of type‑2 diabetes mellitus (T2DM), has become the principal cause of end‑stage kidney disease. Transient receptor potential channel 6 (TRPC6), one of non‑selective cation channels with ... ...

    Abstract Diabetic kidney disease (DKD), one of the common complications of type‑2 diabetes mellitus (T2DM), has become the principal cause of end‑stage kidney disease. Transient receptor potential channel 6 (TRPC6), one of non‑selective cation channels with significant calcium‑permeability, is associated with renal fibrosis. However, the mechanism of TRPC6 in T2DM‑induced renal fibrosis is still not entirely understood. The present study explored the potential mechanism of
    MeSH term(s) Mice ; Animals ; TRPC6 Cation Channel/genetics ; Calcineurin/metabolism ; TRPC Cation Channels/genetics ; TRPC Cation Channels/metabolism ; Calcium/metabolism ; Diabetic Nephropathies/metabolism ; Signal Transduction ; Diabetes Mellitus, Type 2/complications ; Fibrosis ; Mice, Knockout
    Chemical Substances TRPC6 Cation Channel ; Calcineurin (EC 3.1.3.16) ; TRPC Cation Channels ; Calcium (SY7Q814VUP) ; Trpc6 protein, mouse
    Language English
    Publishing date 2023-12-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2023.13136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice

    Dong, Xianan / Kong, Liangliang / Huang, Lei / Su, Yong / Li, Xuewang / Yang, Liu / Ji, Pengmin / Li, Weiping / Li, Weizu

    Journal of Ginseng Research. 2023 May, v. 47, no. 3 p.458-468

    2023  

    Abstract: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect ...

    Abstract As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined. Recent studies demonstrated that Ginsenoside Rg1 (Rg1) has promising neuroprotective properties, but the effect and mechanism in diabetes-associated cognitive dysfunction (DACD) deserve further investigation. After establishing the T2DM model with a high-fat diet and STZ intraperitoneal injection, Rg1 was given for 8 weeks. The behavior alterations and neuronal lesions were judged using the open field test (OFT) and Morris water maze (MWM), as well as HE and Nissl staining. The protein or mRNA changes of NOX2, p-PLC, TRPC6, CN, NFAT1, APP, BACE1, NCSTN, and Aβ1-42 were investigated by immunoblot, immunofluorescence or qPCR. Commercial kits were used to evaluate the levels of IP3, DAG, and calcium ion (Ca²⁺) in brain tissues. Rg1 therapy improved memory impairment and neuronal injury, decreased ROS, IP3, and DAG levels to revert Ca²⁺ overload, downregulated the expressions of p-PLC, TRPC6, CN, and NFAT1 nuclear translocation, and alleviated Aβ deposition in T2DM mice. In addition, Rg1 therapy elevated the expression of PSD95 and SYN in T2DM mice, which in turn improved synaptic dysfunction. Rg1 therapy may improve neuronal injury and DACD via mediating PLC–CN–NFAT1 signal pathway to reduce Aβ generation in T2DM mice.
    Keywords Panax ; brain ; calcium ; cognitive disorders ; diabetes mellitus ; etiology ; fluorescent antibody technique ; ginsenosides ; high fat diet ; intraperitoneal injection ; memory disorders ; models ; neurons ; pathogenesis ; research ; signal transduction ; therapeutics ; Type II Diabetes Mellitus ; Cognitive dysfunction ; Ginsenoside Rg1 ; Calcium homeostasis ; Phospholipase C ; ANOVA ; APP ; Aβ ; BACE1 ; Ca2+ ; CN ; CTF-β ; DACD ; DAG ; DHE ; DM ; FBG ; HFD ; IP3 ; MWM ; NCSTN ; NFAT1 ; NOX2 ; OFT ; PIP2 ; PLC ; PSD95 ; Rg1 ; ROS ; SYN ; T2DM ; TRPC6
    Language English
    Dates of publication 2023-05
    Size p. 458-468.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2765273-7
    ISSN 2093-4947 ; 1226-8453
    ISSN (online) 2093-4947
    ISSN 1226-8453
    DOI 10.1016/j.jgr.2022.12.006
    Database NAL-Catalogue (AGRICOLA)

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