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  1. Article ; Online: Anterior Mitral Leaflet Dissection and Pseudoaneurysm Late After Transcatheter Aortic Valve Replacement: Look Beyond the Obvious.

    Del Val, David / López-Melgar, Beatriz / Rivero, Fernando / Valdivia-Mazeyra, Mariel Fabiola / Bastante, Teresa / Cuesta, Javier / Roquero, Pilar / Alfonso, Fernando

    Circulation. Cardiovascular imaging

    2022  Volume 15, Issue 3, Page(s) e013724

    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.121.013724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage: an autopsy study with clinical correlation and review of the literature.

    Valdivia-Mazeyra, Mariel F / Salas, Clara / Nieves-Alonso, Jesús M / Martín-Fragueiro, Luz / Bárcena, Carmen / Muñoz-Hernández, Patricia / Villar-Zarra, Karen / Martín-López, Javier / Ramasco-Rueda, Fernando / Fraga, Javier / Jiménez-Heffernan, José A

    Virchows Archiv : an international journal of pathology

    2020  Volume 478, Issue 3, Page(s) 487–496

    Abstract: Pulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly in acute lung injury. Although megakaryocytes are not mentioned as a characteristic histologic finding associated to pulmonary injury, a few studies reveal that their ... ...

    Abstract Pulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly in acute lung injury. Although megakaryocytes are not mentioned as a characteristic histologic finding associated to pulmonary injury, a few studies reveal that their number is increased in diffuse alveolar damage (DAD). In this autopsy study, we have observed a relevant number of pulmonary megakaryocytes in COVID-19 patients dying with acute lung injury (7.61 ± 5.59 megakaryocytes per 25 high-power fields vs. 1.14 ± 0.86 for the control group, p < 0.05). We analyzed samples of 18 patients, most of whom died after prolonged disease and use of mechanical ventilation. Most patients showed advanced DAD and abnormal coagulation parameters with high levels of fibrinogen, D-dimers, and variable thrombocytopenia. For comparison, pulmonary samples from a group of 14 non-COVID-19 patients dying with DAD were reviewed. They showed similar pulmonary histopathologic findings and an increase in the number of megakaryocytes (4 ± 4.17 vs. 1.14 ± 0.86 for the control group, p < 0.05). Megakaryocyte count in the COVID-19 group was greater but did not reach statistical significance (7.61 ± 5.59 vs. 4 ± 4.17, p = 0.063). Regardless of the cause, pulmonary megakaryocytes are increased in patients with DAD. Their high number seen in COVID-19 patients suggests a relation with the thrombotic events so often seen these patients. Since the lung is considered an active site of megakaryopoiesis, a prothrombotic status leading to platelet activation, aggregation and consumption may trigger a compensatory pulmonary response.
    MeSH term(s) Adult ; Aged ; Autopsy ; COVID-19/pathology ; COVID-19/virology ; Female ; Humans ; Lung/pathology ; Lung/virology ; Male ; Megakaryocytes/pathology ; Megakaryocytes/virology ; Middle Aged ; SARS-CoV-2/physiology ; Thrombosis/pathology ; Thrombosis/virology
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-020-02926-1
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  3. Article ; Online: Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage

    Valdivia-Mazeyra, Mariel F. / Salas, Clara / Nieves-Alonso, Jesús M. / Martín-Fragueiro, Luz / Bárcena, Carmen / Muñoz-Hernández, Patricia / Villar-Zarra, Karen / Martín-López, Javier / Ramasco-Rueda, Fernando / Fraga, Javier / Jiménez-Heffernan, José A.

    Virchows Archiv ; ISSN 0945-6317 1432-2307

    an autopsy study with clinical correlation and review of the literature

    2020  

    Keywords Pathology and Forensic Medicine ; Cell Biology ; Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00428-020-02926-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Increased number of pulmonary megakaryocytes in COVID-19 patients with diffuse alveolar damage: an autopsy study with clinical correlation and review of the literature

    Valdivia-Mazeyra, Mariel F / Salas, Clara / Nieves-Alonso, Jesús M / Martín-Fragueiro, Luz / Bárcena, Carmen / Muñoz-Hernández, Patricia / Villar-Zarra, Karen / Martín-López, Javier / Ramasco-Rueda, Fernando / Fraga, Javier / Jiménez-Heffernan, José A

    Virchows arch

    Abstract: Pulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly in acute lung injury. Although megakaryocytes are not mentioned as a characteristic histologic finding associated to pulmonary injury, a few studies reveal that their ... ...

    Abstract Pulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly in acute lung injury. Although megakaryocytes are not mentioned as a characteristic histologic finding associated to pulmonary injury, a few studies reveal that their number is increased in diffuse alveolar damage (DAD). In this autopsy study, we have observed a relevant number of pulmonary megakaryocytes in COVID-19 patients dying with acute lung injury (7.61 ± 5.59 megakaryocytes per 25 high-power fields vs. 1.14 ± 0.86 for the control group, p < 0.05). We analyzed samples of 18 patients, most of whom died after prolonged disease and use of mechanical ventilation. Most patients showed advanced DAD and abnormal coagulation parameters with high levels of fibrinogen, D-dimers, and variable thrombocytopenia. For comparison, pulmonary samples from a group of 14 non-COVID-19 patients dying with DAD were reviewed. They showed similar pulmonary histopathologic findings and an increase in the number of megakaryocytes (4 ± 4.17 vs. 1.14 ± 0.86 for the control group, p < 0.05). Megakaryocyte count in the COVID-19 group was greater but did not reach statistical significance (7.61 ± 5.59 vs. 4 ± 4.17, p = 0.063). Regardless of the cause, pulmonary megakaryocytes are increased in patients with DAD. Their high number seen in COVID-19 patients suggests a relation with the thrombotic events so often seen these patients. Since the lung is considered an active site of megakaryopoiesis, a prothrombotic status leading to platelet activation, aggregation and consumption may trigger a compensatory pulmonary response.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #754539
    Database COVID19

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  5. Article ; Online: MICa/b-dependent activation of natural killer cells by CD64

    Sánchez-Cerrillo, Ildefonso / Calzada-Fraile, Diego / Triguero-Martínez, Ana / Calvet-Mirabent, Marta / Popova, Olga / Delgado-Arévalo, Cristina / Valdivia-Mazeyra, Mariel / Ramírez-Huesca, Marta / de Luis, Enrique Vázquez / Benguría, Alberto / Aceña-Gonzalo, Teresa / Moreno-Vellisca, Roberto / de Llano, Magdalena Adrados / de la Fuente, Hortensia / Tsukalov, Ilya / Delgado-Wicke, Pablo / Fernández-Ruiz, Elena / Roy-Vallejo, Emilia / Tejedor-Lázaro, Reyes /
    Ramiro, Almudena / Iborra, Salvador / Sánchez-Madrid, Francisco / Dopazo, Ana / Álvaro, Isidoro González / Castañeda, Santos / Martin-Gayo, Enrique

    The EMBO journal

    2023  Volume 42, Issue 23, Page(s) e113714

    Abstract: Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS ... ...

    Abstract Primary Sjögren's syndrome (pSS) is an inflammatory autoimmune disorder largely mediated by type I and II interferon (IFN). The potential contribution of innate immune cells, such as natural killer (NK) cells and dendritic cells (DC), to the pSS pathology remains understudied. Here, we identified an enriched CD16
    MeSH term(s) Humans ; NK Cell Lectin-Like Receptor Subfamily K/genetics ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Autoimmunity ; Killer Cells, Natural ; Dendritic Cells
    Chemical Substances mica (V8A1AW0880) ; NK Cell Lectin-Like Receptor Subfamily K
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2023113714
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