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Article ; Online: Late onset of subacute cutaneous lupus erythematosus following pembrolizumab therapy.

Andersson, Niklas W / Zachariae, Claus / Simonsen, Anne B

European journal of cancer (Oxford, England : 1990)

2021 Volume 145, Page(s) 168–170

Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Letter
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.12.017
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Prevalence, incidence, and severity of hand eczema in the general population - A systematic review and meta-analysis.

Quaade, Anna S / Simonsen, Anne B / Halling, Anne-Sofie / Thyssen, Jacob P / Johansen, Jeanne D

Contact dermatitis

2021 Volume 84, Issue 6, Page(s) 361–374

Abstract: Accurate assessments of the burden of hand eczema (HE) in the general population are important for public awareness and intervention. The aim of this systematic review and meta-analysis was to provide updated estimates of prevalence and incidence, ... ...

Abstract	Accurate assessments of the burden of hand eczema (HE) in the general population are important for public awareness and intervention. The aim of this systematic review and meta-analysis was to provide updated estimates of prevalence and incidence, alongside additional epidemiological endpoints on HE in the general population. PubMed, Embase and Web of Science were searched for studies reporting the prevalence and/or incidence of HE in the general population. Proportion meta-analyses were performed to calculate pooled estimates of prevalence, incidence, severity, and the proportion of individuals with HE and a history of atopic dermatitis. Sixty-six studies were included in the quantitative analysis encompassing 568 100 individuals. The pooled estimates for lifetime, 1-year, and point prevalence were 14.5% (95% confidence interval [CI]: 12.6-16.5), 9.1% (95% CI: 8.4-9.8) and 4.0% (95% CI: 2.6-5.7), respectively. The pooled incidence rate of HE was 7.3 cases/1000 person-years (95% CI: 5.4-9.5). The occurrence of HE was 1.5-2 times higher in females than males. More than one third suffered from moderate/severe disease and around one third had a history of atopic dermatitis. HE was a recurrent, long-lasting disease with an average age at onset of the early- to mid-twenties. In conclusion; HE is a highly prevalent disease in the general population and carries a significant risk of long-term or chronic disease.
MeSH term(s)	Age of Onset ; Comorbidity ; Dermatitis, Atopic/epidemiology ; Eczema/epidemiology ; Hand Dermatoses/epidemiology ; Humans ; Incidence ; Prevalence ; Severity of Illness Index ; Sex Distribution
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.13804
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Zs.A 1116: Show issues

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Article ; Online: Recurrence Risk in Patients with Cryptogenic Stroke, Patent Foramen Ovale, and Thrombophilia: A Systematic Review and Meta-Analysis.

Hviid, Claus V B / Simonsen, Claus Ziegler / Hvas, Anne-Mette

Thrombosis and haemostasis

2019 Volume 119, Issue 11, Page(s) 1839–1848

Abstract: Objective: A patent foramen ovale (PFO) is frequently associated with cryptogenic stroke in the young. Endovascular closure is superior to antithrombotic treatment in prevention of recurrence, but in the presence of a concomitant thrombophilia, the ... ...

Abstract	Objective: A patent foramen ovale (PFO) is frequently associated with cryptogenic stroke in the young. Endovascular closure is superior to antithrombotic treatment in prevention of recurrence, but in the presence of a concomitant thrombophilia, the best preventive strategy is unknown. This review investigates if thrombophilia increases the risk of recurrence in patients with cryptogenic stroke and PFO and attempts to evaluate the best antithrombotic strategy after PFO closure in these patients. Methods: Medline, Embase, and Web of Science were searched until April 2018. Study quality was assessed by the National Heart, Lung and Blood Institute Quality assessment tool. Odds ratio (OR) and hazard ratio for recurrence were pooled in a random effect model stratified by secondary preventive strategy. Results: Eleven studies were included. Inherited or acquired thrombophilia was associated with an increased risk of recurrence (OR = 2.41, 95% confidence interval [CI]: 1.44-4.06). Looking only at patients treated with PFO closure, the risk of recurrence just lost significance (OR = 2.07, 95% CI: 0.95-4.48). The antithrombotic treatment after PFO closure was heterogeneous and recurrent events occurred in patients with both inherited and acquired thrombophilia treated by antiplatelet as well as anticoagulant therapy. Conclusion: Thrombophilia is associated with an increased risk of recurrence in patients with PFO and cryptogenic stroke, which may persist after PFO closure. This suggests a need for antithrombotic therapy after PFO closure. Study heterogeneity precludes strong conclusions on antithrombotic treatment, but life-long antiplatelet therapy to patients without preexisting indication for anticoagulant therapy seems reasonable.
MeSH term(s)	Antibodies, Antiphospholipid/blood ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/epidemiology ; Antiphospholipid Syndrome/therapy ; Biomarkers/blood ; Blood Coagulation/genetics ; Fibrinolytic Agents/therapeutic use ; Foramen Ovale, Patent/epidemiology ; Foramen Ovale, Patent/therapy ; Genetic Predisposition to Disease ; Humans ; Prevalence ; Prognosis ; Recurrence ; Risk Assessment ; Risk Factors ; Secondary Prevention ; Stroke/epidemiology ; Stroke/prevention & control ; Thrombophilia/blood ; Thrombophilia/epidemiology ; Thrombophilia/genetics ; Thrombophilia/prevention & control ; Time Factors
Chemical Substances	Antibodies, Antiphospholipid ; Biomarkers ; Fibrinolytic Agents
Language	English
Publishing date	2019-08-04
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1055/s-0039-1693739
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Uh III Zs.192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 433: Show issues

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Article ; Online: Biopsy-based optimization and calibration of a signal-intensity-ratio-based MRI method (1.5 Tesla) in a dextran-iron loaded mini-pig model, enabling estimation of very high liver iron concentrations.

Jensen, Peter D / Nielsen, Asbjørn H / Simonsen, Carsten W / Jensen, Kenneth K / Bøgsted, Martin / Jensen, Anne B H / Kjaergaard, Benedict

Magma (New York, N.Y.)

2022 Volume 35, Issue 5, Page(s) 843–859

Abstract: Objective: Magnetic resonance imaging (MRI)-based techniques for non-invasive assessing liver iron concentration (LIC) in patients with iron overload have a limited upper measuring range around 35 mg/g dry weight, caused by signal loss from accelerated ... ...

Abstract	Objective: Magnetic resonance imaging (MRI)-based techniques for non-invasive assessing liver iron concentration (LIC) in patients with iron overload have a limited upper measuring range around 35 mg/g dry weight, caused by signal loss from accelerated T1-, T2-, T2* shortening with increasing LIC. Expansion of this range is necessary to allow evaluation of patients with very high LIC. Aim: To assess measuring range of a gradient-echo R2* method and a T1-weighted spin-echo (SE), signal intensity ratio (SIR)-based method (TE = 25 ms, TR = 560 ms), and to extend the upper measuring range of the SIR method by optimizing echo time (TE) and repetition time (TR) in iron-loaded minipigs. Methods: Thirteen mini pigs were followed up during dextran-iron loading with repeated percutaneous liver biopsies for chemical LIC measurement and MRIs for parallel non-invasive estimation of LIC (81 examinations) using different TEs and TRs. Results: SIR and R2* method had similar upper measuring range around 34 mg/g and similar method agreement. Using TE = 12 ms and TR = 1200 ms extended the upper measuring range to 115 mg/g and yielded good method of agreement. Discussion: The wider measuring range is likely caused by lesser sensitivity of the SE sequence to iron, due to shorter TE, leading to later signal loss at high LIC, allowing evaluation of most severe hepatic iron overload. Validation in iron-loaded patients is necessary.
MeSH term(s)	Animals ; Biopsy ; Calibration ; Dextrans ; Iron ; Iron Overload/diagnostic imaging ; Liver/diagnostic imaging ; Liver/pathology ; Magnetic Resonance Imaging/methods ; Swine ; Swine, Miniature
Chemical Substances	Dextrans ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1160826-2
ISSN	1352-8661 ; 0968-5243
ISSN (online)	1352-8661
ISSN	0968-5243
DOI	10.1007/s10334-021-00998-x
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Zs.A 3788: Show issues

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Article ; Online: Social network analysis of Staphylococcus aureus carriage in a general youth population.

Stensen, Dina B / Cañadas, Rafael A Nozal / Småbrekke, Lars / Olsen, Karina / Nielsen, Christopher Sivert / Svendsen, Kristian / Hanssen, Anne Merethe / Ericson, Johanna U / Simonsen, Gunnar Skov / Bongo, Lars Ailo / Furberg, Anne-Sofie

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 123, Page(s) 200–209

Abstract: Objectives: Staphylococcus aureus carriage increases the risk of infection. We used social network analysis to evaluate whether contacts have the same S. aureus genotype indicating direct transmission or whether contagiousness is an indirect effect of ... ...

Abstract	Objectives: Staphylococcus aureus carriage increases the risk of infection. We used social network analysis to evaluate whether contacts have the same S. aureus genotype indicating direct transmission or whether contagiousness is an indirect effect of contacts sharing the same lifestyle or characteristics. Methods: The Fit Futures 1 study collected data on social contact among 1038 high school students. S. aureus carriage was determined from two nasal swab cultures and the genotype was determined by spa-typing of positive throat swabs. Results: S. aureus carriage and spa-type were transmitted in the social network (P < 0.001). The probability of carriage increased by 5% for each S. aureus positive contact. Male sex was associated with a 15% lower risk of transmission compared to the female sex, although the carriage prevalence was higher for men (36% vs 24%). Students with medium physical activity levels, medium/high alcohol use, or normal weight had a higher number of contacts and an increased risk of transmission (P < 0.002). Conclusion: We demonstrated the direct social transmission of S. aureus. Lifestyle factors are associated with the risk of transmission, suggesting the effects of indirect social groups on S. aureus carriage, such as friends having more similar environmental exposures. The male predominance in the carriage is determined by sex-specific predisposing host characteristics as the social transmission is less frequent in males than females. Information on social networks may add to a better understanding of S. aureus epidemiology.
MeSH term(s)	Adolescent ; Carrier State/epidemiology ; Female ; Genotype ; Humans ; Male ; Methicillin-Resistant Staphylococcus aureus ; Prevalence ; Social Network Analysis ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus/genetics
Language	English
Publishing date	2022-08-31
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.08.018
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Zs.A 4516: Show issues

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Article ; Online: Basal stress controls ice-flow variability during a surge cycle of Hagen Bræ, Greenland

Øyvind A. Winton / Sebastian B. Simonsen / Anne M. Solgaard / Robert McNabb / Nanna B. Karlsson

Journal of Glaciology, Vol 68, Pp 503-

2022 Volume 517

Abstract: Basal conditions play an essential role in the dynamics of outlet glaciers, but direct observations at the bed of glaciers are challenging to obtain. Instead, inverse methods can be used to infer basal parameters from surface observations. Here, we use a ...

Abstract	Basal conditions play an essential role in the dynamics of outlet glaciers, but direct observations at the bed of glaciers are challenging to obtain. Instead, inverse methods can be used to infer basal parameters from surface observations. Here, we use a simple ice-flow model as a forward model in an inversion scheme to retrieve the spatio-temporally variable basal stress parameter for Hagen Bræ, North Greenland, from 1990 to 2020. Hagen Bræ is a surge-type glacier with up to an order of magnitude variability of winter velocities near the grounding line. We find that downstream changes in the basal stress parameter can explain most of the variation of flow velocity, and we further identify a region of high resistance ~20–40 km from the grounding line. We hypothesise that this region of high resistance plays an important role in controlling glacier discharge.
Keywords	Arctic glaciology ; glacier flow ; glacier modelling ; glacier surges ; ice velocity ; Environmental sciences ; GE1-350 ; Meteorology. Climatology ; QC851-999
Subject code	551
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
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Article ; Online: Body Contouring Surgery Improves Long-Term Satisfaction with Appearance and Health-Related Quality of Life after Bariatric Surgery.

Poulsen, Lotte / Rae, Charlene / Simonsen, Nina / Klassen, Anne F / Lorenzen, Mike / Rose, Michael / Juhl, Claus B / Støving, René Klinkby / Cano, Stefan J / Andries, Alin / Pusic, Andrea L / Sorensen, Jens Ahm

Plastic and reconstructive surgery

2023 Volume 151, Issue 6, Page(s) 1307–1316

Abstract: Background: Patient-reported outcomes are crucial in bariatric surgery (BaS) and body contouring surgery (BC) because patients' goals include improvement in appearance and health-related quality of life (HR-QOL). The BODY-Q is a patient-reported outcome ...

Abstract	Background: Patient-reported outcomes are crucial in bariatric surgery (BaS) and body contouring surgery (BC) because patients' goals include improvement in appearance and health-related quality of life (HR-QOL). The BODY-Q is a patient-reported outcome measure developed to measure change in satisfaction with appearance and HR-QOL in BaS and BC patients. The aim of this study was to examine BODY-Q scores over the entire weight loss journey, and to investigate the impact of BC after BaS. Methods: Patients completed the BODY-Q before and after BaS and BC at four hospital departments in Denmark between 2015 and 2019. Cross-sectional scores were analyzed by phase of weight loss journey using one-way analysis of variance. Scores for patients who provided longitudinal assessments were analyzed using repeated measures analysis of variance and paired t test. The impact of BC was examined over time after BaS, using an independent t test from before BaS through more than 7 years after BaS. Results: The study included 1527 patients who provided 2285 BODY-Q assessments. The cross-sectional analysis by phase of weight loss journey showed higher scores after BaS, lower scores before BC, and highest-level scores after BC. The longitudinal analysis showed higher postoperative mean scores compared with preoperative scores for both BaS and BC. The analysis over time after BaS revealed lower mean scores in patients who did not receive BC. Conclusion: The authors' results provide evidence of the positive impact of BaS and BC on patients' lives and emphasize the importance of considering BC to finalize the weight loss journey, as it helps to maintain improvements in appearance and HR-QOL. Clinical question/level of evidence: Therapeutic, IV.
MeSH term(s)	Humans ; Quality of Life ; Body Contouring ; Cross-Sectional Studies ; Patient Satisfaction ; Bariatric Surgery ; Weight Loss
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010165
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Zs.MO 293: Show issues

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Article ; Online: Restructuring of the plasma membrane upon damage by LC3-associated macropinocytosis.

Sønder, Stine Lauritzen / Häger, Swantje Christin / Heitmann, Anne Sofie Busk / Frankel, Lisa B / Dias, Catarina / Simonsen, Adam Cohen / Nylandsted, Jesper

Science advances

2021 Volume 7, Issue 27

Abstract: The plasma membrane shapes and protects the eukaryotic cell from its surroundings and is crucial for cell life. Although initial repair mechanisms to reseal injured membranes are well established, less is known about how cells restructure damaged ... ...

Abstract	The plasma membrane shapes and protects the eukaryotic cell from its surroundings and is crucial for cell life. Although initial repair mechanisms to reseal injured membranes are well established, less is known about how cells restructure damaged membranes in the aftermath to restore homeostasis. Here, we show that cells respond to plasma membrane injury by activating proteins associated with macropinocytosis specifically at the damaged membrane. Subsequent to membrane resealing, cells form large macropinosomes originating from the repair site, which eventually become positive for autophagy-related LC3B protein. This process occurs independent of ULK1, ATG13, and WIPI2 but dependent on ATG7, p62, and Rubicon. Internalized macropinosomes shrink in the cytoplasm, likely by osmotic draining, and eventually fuse with lysosomes. We propose that a form of macropinocytosis coupled to noncanonical autophagy, which we term LC3-associated macropinocytosis (LAM) functions to remove damaged material from the plasma membrane and restore membrane integrity upon injury.
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abg1969
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Article: Success in Weight Management Among Patients with Type 2 Diabetes: Do Perceived Autonomy Support, Autonomous Motivation, and Self-Care Competence Play a Role?

Koponen, Anne M / Simonsen, Nina / Suominen, Sakari B

Behavioral medicine (Washington, D.C.)

2017 Volume 44, Issue 2, Page(s) 151–159

Abstract: Based on self-determination theory (SDT), this study investigated whether the three central SDT variables-perceived autonomy support (from a physician), autonomous motivation and self-care competence-were associated with success in weight management (SWM) ...

Abstract	Based on self-determination theory (SDT), this study investigated whether the three central SDT variables-perceived autonomy support (from a physician), autonomous motivation and self-care competence-were associated with success in weight management (SWM) among primary care patients with type 2 diabetes when the effect of other important life-context factors was controlled for. Patients participated in a mail survey in 2011. Those who had tried to change their health behavior during the past two years in order to lose weight, either with or without success (n = 1433, mean age 63 years, 50% men), were included in this study. The successors were more autonomously motivated and energetic than the non-successors. Moreover, male gender, younger age, taking oral medication only, and receiving less social support in diabetes care predicted better success. Autonomous motivation predicted SWM; self-care competence also played a role by partly mediating the effect of autonomous motivation on SWM. These results support the idea of SDT that internalizing the value of weight management and its health benefits is necessary for long-term maintenance of health behavior change. Perceived autonomy support was not directly associated with SWM. However, physicians can promote patients' weight management by supporting their autonomous motivation and self-care competence.
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Diabetes Mellitus, Type 2/psychology ; Female ; Humans ; Male ; Middle Aged ; Motivation ; Personal Autonomy ; Physician-Patient Relations ; Self Care/psychology ; Weight Loss ; Young Adult
Language	English
Publishing date	2017-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	623101-9
ISSN	0896-4289
ISSN	0896-4289
DOI	10.1080/08964289.2017.1292997
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Article ; Online: Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population.

Stensen, Dina B / Småbrekke, Lars / Olsen, Karina / Grimnes, Guri / Sivert Nielsen, Christopher / Sollid, Johanna U E / Simonsen, Gunnar Skov / Almås, Bjørg / Furberg, Anne-Sofie

European journal of endocrinology

2021 Volume 184, Issue 6, Page(s) X3

Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1530/EJE-20-0877e
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