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  1. Article ; Online: How good are surgeons at disclosing periprosthetic joint infection at the time of revision, based on pre- and intra-operative assessment? A study on 16,922 primary total hip arthroplasties reported to the Norwegian Arthroplasty Register.

    Lutro, Olav / Mo, Synnøve / Tjørhom, Marianne Bollestad / Fenstad, Anne Marie / Leta, Tesfaye Hordofa / Bruun, Trond / Hallan, Geir / Furnes, Ove / Dale, Håvard

    Acta orthopaedica

    2024  Volume 95, Page(s) 67–72

    Abstract: Background and purpose: Revision due to infection, as reported to the Norwegian Arthroplasty Register (NAR), is a surrogate endpoint to periprosthetic joint infection (PJI). We aimed to find the accuracy of the reported causes of revision after primary ... ...

    Abstract Background and purpose: Revision due to infection, as reported to the Norwegian Arthroplasty Register (NAR), is a surrogate endpoint to periprosthetic joint infection (PJI). We aimed to find the accuracy of the reported causes of revision after primary total hip arthroplasty (THA) compared with PJI to see how good surgeons were at disclosing infection, based on pre- and intraoperative assessment.
    Patients and methods: We investigated the reasons for revision potentially caused by PJI following primary THA: infection, aseptic loosening, prolonged wound drainage, and pain only, reported to the NAR from surgeons in the region of Western Norway during the period 2010-2020. The electronic patient charts were investigated for information on clinical assessment, treatment, biochemistry, and microbiological findings. PJI was defined in accordance with the Musculoskeletal Infection Society (MSIS) definition. Sensitivity, specificity, and accuracy were calculated.
    Results: 363 revisions in the NAR were eligible for analyses. Causes of revision were (reported/validated): infection (153/177), aseptic loosening (139/133), prolonged wound drainage (37/13), and pain only (34/40). The sensitivity for reported revision due to infection compared with PJI was 80%, specificity was 94%, and accuracy-the surgeons' ability to disclose PJI or non-septic revision at time of revision-was 87%. The accuracy for the specific revision causes was highest for revision due to aseptic loosening (95%) and pain only (95%), and lowest for revision due to prolonged wound drainage (86%).
    Conclusion: The accuracy of surgeon-reported revisions due to infection as representing PJI was 87% in the NAR. Our study shows the importance of systematic correction of the reported cause of revision in arthroplasty registers, after results from adequately taken bacterial samples.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Hip Prosthesis/adverse effects ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/etiology ; Surgeons ; Pain ; Reoperation/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2024-01-30
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2180677-9
    ISSN 1745-3682 ; 1745-3674
    ISSN (online) 1745-3682
    ISSN 1745-3674
    DOI 10.2340/17453674.2024.39914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Experimental treatment for COVID-19 should be undertaken in randomised studies.

    Trøseid, Marius / Lutro, Olav / Ormaasen, Vidar

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140, Issue 7

    Title translation Utprøvende behandling for covid-19 bør foregå i randomiserte studier.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/therapy ; Randomized Controlled Trials as Topic ; SARS-CoV-2
    Keywords covid19
    Language Norwegian
    Publishing date 2020-04-01
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outdated guidelines on antibiotic use.

    Nordøy, Ingvild / Lutro, Olav / Longva, Jørn-Åge / Bekken, Gry Kloumann / Simonsen, Hans Erling

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2018  Volume 138, Issue 18

    Title translation Utdaterte retningslinjer om antibiotikabruk.
    MeSH term(s) Anti-Bacterial Agents ; Humans ; Sepsis
    Chemical Substances Anti-Bacterial Agents
    Language Norwegian
    Publishing date 2018-11-13
    Publishing country Norway
    Document type Journal Article ; Comment
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.18.0817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain: Subgroup Analyses of a Randomised Trial (the AIM Study).

    Kristoffersen, Per M / Vetti, Nils / Grøvle, Lars / Brox, Jens I / Haugli Bråten, Lars C / Grotle, Margreth / Julsrud Haugen, Anne / Rolfsen, Mads P / Froholdt, Anne / Skouen, Jan S / Lutro, Olav / Marchand, Gunn H / Anke, Audny / Zwart, John-Anker / Storheim, Kjersti / Assmus, Jörg / Espeland, Ansgar

    Spine

    2022  Volume 48, Issue 3, Page(s) 147–154

    Abstract: Study design: Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study].: Objective: The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low ... ...

    Abstract Study design: Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study].
    Objective: The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low back pain.
    Summary of background data: The AIM study showed a small, clinically insignificant effect of amoxicillin on pain-related disability in patients with chronic low back pain and MC type 1 (edema type) on magnetic resonance imaging (MRI).
    Materials and methods: A total of 180 patients were randomised to receive 100 days of amoxicillin or placebo. MC edema was assessed on MRI at baseline and one-year follow-up. Per-protocol analyses were conducted in subgroups with MC edema on short tau inversion recovery (STIR) or T1/T2-weighted MRI at baseline. MC edema reductions (yes/no) in STIR and T1/T2 series were analyzed separately. The effect of amoxicillin in reducing MC edema was analyzed using logistic regression adjusted for prior disk surgery. To assess the effect of amoxicillin versus placebo within the group with the most abundant MC edema on STIR at baseline ("STIR3" group), we added age, STIR3 (yes/no), and STIR3×treatment group (interaction term) as independent variables and compared the marginal means (probabilities of edema reduction).
    Results: Compared to placebo, amoxicillin did not reduce MC edema on STIR (volume/intensity) in the total sample with edema on STIR at baseline (odds ratio 1.0, 95% CI: 0.5, 2.0; n=141) or within the STIR3 group (probability of edema reduction 0.69, 95% CI: 0.47, 0.92 with amoxicillin and 0.61, 95% CI: 0.43, 0.80 with placebo; n=41). Compared with placebo, amoxicillin did not reduce MC edema in T1/T2 series (volume of the type 1 part of MCs) (odds ratio: 1.0, 95% CI: 0.5, 2.3, n=104). Edema declined in >50% of patients in both treatment groups.
    Conclusions: From baseline to one-year follow-up, amoxicillin did not reduce MC edema compared with placebo.
    Level of evidence: 2.
    MeSH term(s) Humans ; Amoxicillin/therapeutic use ; Amoxicillin/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Low Back Pain/drug therapy ; Low Back Pain/pathology ; Lumbar Vertebrae/pathology ; Magnetic Resonance Imaging ; Edema/drug therapy
    Chemical Substances Amoxicillin (804826J2HU) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 752024-4
    ISSN 1528-1159 ; 0362-2436
    ISSN (online) 1528-1159
    ISSN 0362-2436
    DOI 10.1097/BRS.0000000000004513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A man with fever and joint pain.

    Lutro, Olav / Lillebø, Kristine / Schrama, Johannes Cornelis / Dale, Håvard / Sjursen, Haakon

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2016  Volume 136, Issue 23-24, Page(s) 1999–2001

    Title translation En mann med feber og leddsmerter.
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Arthralgia/microbiology ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/microbiology ; Fever/microbiology ; Gonorrhea/complications ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Humans ; Male ; Middle Aged ; Neisseria gonorrhoeae/isolation & purification ; Norway/epidemiology ; Travel
    Chemical Substances Anti-Bacterial Agents
    Language Norwegian
    Publishing date 2016-12
    Publishing country Norway
    Document type Case Reports
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.16.0266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increasing but levelling out risk of revision due to infection after total hip arthroplasty: a study on 108,854 primary THAs in the Norwegian Arthroplasty Register from 2005 to 2019.

    Dale, Håvard / Høvding, Pål / Tveit, Sindre M / Graff, Julie B / Lutro, Olav / Schrama, Johannes C / Wik, Tina S / Skråmm, Inge / Westberg, Marianne / Fenstad, Anne Marie / Hallan, Geir / Engesaeter, Lars B / Furnes, Ove

    Acta orthopaedica

    2020  Volume 92, Issue 2, Page(s) 208–214

    Abstract: Background and purpose - Focus on prevention, surveillance, and treatment of infection after total hip arthroplasty (THA) in the last decade has resulted in new knowledge and guidelines. Previous publications have suggested an increased incidence of ... ...

    Abstract Background and purpose - Focus on prevention, surveillance, and treatment of infection after total hip arthroplasty (THA) in the last decade has resulted in new knowledge and guidelines. Previous publications have suggested an increased incidence of surgical revisions due to infection after THA. We assessed whether there have been changes in the risk of revision due to deep infection after primary THAs reported to the Norwegian Arthroplasty Register (NAR) over the period 2005-2019.Patients and methods - Primary THAs reported to the NAR from January 1, 2005 to December 31, 2019 were included. Adjusted Cox regression analyses with the first revision due to deep infection after primary THA were performed. We investigated changes in the risk of revision as a function of time of primary THA. Time was stratified into 5-year periods. We studied the whole population of THAs, and the subgroups: all-cemented, all-uncemented, reverse hybrid (cemented cup), and hybrid THAs (cemented stem). In addition, we investigated factors that were associated with the risk of revision, and changes in the time span from primary THA to revision.Results - Of the 108,854 primary THAs that met the inclusion criteria, 1,365 (1.3%) were revised due to deep infection. The risk of revision due to infection, at any time after primary surgery, increased through the period studied. Compared with THAs implanted in 2005-2009, the relative risk of revision due to infection was 1.4 (95% CI 1.2-1.7) for 2010-2014, and 1.6 (1.1-1.9) for 2015-2019. We found an increased risk for all types of implant fixation. Compared to 2005-2009, for all THAs, the risk of revision due to infection 0-30 days postoperatively was 2.2 (1.8-2.8) for 2010-2014 and 2.3 (1.8-2.9) for 2015-2019, 31-90 days postoperatively 1.0 (0.7-1.6) for 2010-2014 and 1.6 (1.0-2.5) for 2015-2019, and finally 91 days-1 year postoperatively 1.1 (0.7-1.8) for 2010-2014 and 1.6 (1.0-2.6) for 2015-2019. From 1 to 5 years postoperatively, the risk of revision due to infection was similar to 2005-2009 for both the subsequent time periodsInterpretation - The risk of revision due to deep infection after THA increased throughout the period 2005-2019, but appears to have levelled out after 2010. The increase was mainly due to an increased risk of early revisions, and may partly have been caused by a change of practice rather than a change in the incidence of infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip ; Female ; Humans ; Male ; Middle Aged ; Norway/epidemiology ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Postoperative Complications/surgery ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Prosthesis-Related Infections/surgery ; Registries ; Reoperation ; Risk Factors ; Time Factors
    Language English
    Publishing date 2020-11-24
    Publishing country Sweden
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2180677-9
    ISSN 1745-3682 ; 1745-3674
    ISSN (online) 1745-3682
    ISSN 1745-3674
    DOI 10.1080/17453674.2020.1851533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - secondary analyses of a randomised, placebo-controlled trial (the AIM study).

    Bråten, Lars Christian Haugli / Grøvle, Lars / Espeland, Ansgar / Pripp, Are Hugo / Grotle, Margreth / Helllum, Christian / Haugen, Anne Julsrud / Froholdt, Anne / Rolfsen, Mads Peder / Nygaard, Øystein Petter / Lutro, Olav / Kristoffersen, Per Martin / Anke, Audny / Schistad, Elina Iordanova / Skouen, Jan Sture / Brox, Jens Ivar / Zwart, John-Anker / Storheim, Kjersti

    BMC musculoskeletal disorders

    2020  Volume 21, Issue 1, Page(s) 458

    Abstract: Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of ...

    Abstract Background: Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin treatment in patients with chronic low back pain and type I or II Modic changes at the level of a previous lumbar disc herniation.
    Methods: We performed analyses of effect modifiers on data from AIM, a double-blind parallel-group multicentre trial. One hundred eighty patients with chronic low back pain, previous disc herniation, Modic change type I (n = 118) or type II (n = 62) were randomised to 3-months oral treatment with 750 mg amoxicillin (n = 89) or placebo (n = 91) three times daily. The primary outcome was the Roland-Morris Disability Questionnaire (RMDQ) score (possible values 0-24) at 1-year follow-up in the intention-to-treat population. The predefined minimal clinically important between-group mean difference was 4 RMDQ points (not reached in the primary analysis of AIM). Predefined baseline characteristics were analysed as potential effect modifiers, four primary (type I Modic changes, previous disc surgery, positive pain provocation test, high CRP) and five exploratory (disturbed sleep, constant low back pain, short duration of low back pain, younger age, and male) using ANCOVA with interaction terms.
    Results: None of the four primary potential effect modifiers had strong evidence of modifying the treatment effect. In patients younger than 40 years the difference in mean RMDQ score between the treatment groups was - 4.0 (95%CI, - 6.9 to - 1.2), compared to - 0.5 (95%CI, - 2.3 to 1.3) in patients 40 years or older, both in favour of amoxicillin treatment (exploratory analysis).
    Conclusions: We did not find evidence for convincing clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes. Our results for younger age in these explorative analyses should not affect clinical treatment decisions without confirmation in future studies.
    Trial registration: ClinicalTrials.gov NCT02323412 , First registered 23 December 2014.
    MeSH term(s) Administration, Oral ; Anti-Bacterial Agents/therapeutic use ; Humans ; Intention ; Low Back Pain/diagnostic imaging ; Low Back Pain/drug therapy ; Lumbar Vertebrae/diagnostic imaging ; Male ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-07-13
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-020-03422-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania.

    Leta, Tesfaye H / Fenstad, Anne Marie / Lygre, Stein Håkon L / Lie, Stein Atle / Lindberg-Larsen, Martin / Pedersen, Alma B / W-Dahl, Annette / Rolfson, Ola / Bülow, Erik / Ashforth, James A / Van Steenbergen, Liza N / Nelissen, Rob G H H / Harries, Dylan / De Steiger, Richard / Lutro, Olav / Hakulinen, Emmi / Mäkelä, Keijo / Willis, Jinny / Wyatt, Michael /
    Frampton, Chris / Grimberg, Alexander / Steinbrück, Arnd / Wu, Yinan / Armaroli, Cristiana / Molinari, Marco / Picus, Roberto / Mullen, Kyle / Illgen, Richard / Stoica, Ioan C / Vorovenci, Andreea E / Dragomirescu, Dan / Dale, Håvard / Brand, Christian / Christen, Bernhard / Shapiro, Joanne / Wilkinson, J Mark / Armstrong, Richard / Wooster, Kate / Hallan, Geir / Gjertsen, Jan-Erik / Chang, Richard N / Prentice, Heather A / Paxton, Elizabeth W / Furnes, Ove

    Acta orthopaedica

    2023  Volume 94, Page(s) 416–425

    Abstract: Background and purpose: Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA).! ...

    Abstract Background and purpose: Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA).
    Patients and methods: This observational study is based on 2,971,357 primary TKAs reported in 2010-2020 to national/regional joint arthroplasty registries in Australia, Denmark, Finland, Germany, Italy, the Netherlands, New Zealand, Norway, Romania, South Africa, Sweden, Switzerland, the UK, and the USA. Aggregate-level data on trends and types of bone cement, antibiotic agents, and doses and duration of SAP used was extracted from participating registries.
    Results: ALBC was used in 77% of the TKAs with variation ranging from 100% in Norway to 31% in the USA. Palacos R+G was the most common (62%) ALBC type used. The primary antibiotic used in ALBC was gentamicin (94%). Use of ALBC in combination with SAP was common practice (77%). Cefazolin was the most common (32%) SAP agent. The doses and duration of SAP used varied from one single preoperative dosage as standard practice in Bolzano, Italy (98%) to 1-day 4 doses in Norway (83% of the 40,709 TKAs reported to the Norwegian arthroplasty register).
    Conclusion: The proportion of ALBC usage in primary TKA varies internationally, with gentamicin being the most common antibiotic. ALBC in combination with SAP was common practice, with cefazolin the most common SAP agent. The type of ALBC and type, dose, and duration of SAP varied among participating countries.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Knee/adverse effects ; Bone Cements/therapeutic use ; Cefazolin ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/prevention & control ; Prosthesis-Related Infections/drug therapy ; Gentamicins ; North America ; Europe ; Oceania ; Africa
    Chemical Substances Anti-Bacterial Agents ; Bone Cements ; Cefazolin (IHS69L0Y4T) ; Gentamicins
    Language English
    Publishing date 2023-08-09
    Publishing country Sweden
    Document type Observational Study ; Journal Article
    ZDB-ID 2180677-9
    ISSN 1745-3682 ; 1745-3674
    ISSN (online) 1745-3682
    ISSN 1745-3674
    DOI 10.2340/17453674.2023.17737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bacterial and Hematological Findings in Infected Total Hip Arthroplasties in Norway Assessment of 278 Revisions Due to Infection in the Norwegian Arthroplasty Register.

    Langvatn, Håkon / Lutro, Olav / Dale, Håvard / Schrama, Johannes Cornelis / Hallan, Geir / Espehaug, Birgitte / Sjursen, Haakon / Engesæter, Lars B

    The open orthopaedics journal

    2015  Volume 9, Page(s) 445–449

    Abstract: Our aim was to assess the bacterial findings in infected total hip arthroplasties (THAs) in Norway. We also wanted to investigate the relationship between causal bacteria and hematological findings. Revisions reported to the Norwegian Arthroplasty ... ...

    Abstract Our aim was to assess the bacterial findings in infected total hip arthroplasties (THAs) in Norway. We also wanted to investigate the relationship between causal bacteria and hematological findings. Revisions reported to the Norwegian Arthroplasty Register (NAR) due to infection after total hip arthroplasty during the period 1993 through September 2007 were identified. One single observer visited ten representative hospitals where clinical history, preoperative blood samples and the bacterial findings of intraoperative samples were collected. Bacterial growth in two or more samples was found in 278 revisions, and thus included. The following bacteria were identified: Coagulase-negative staphylococci (CoNS) (41%), Staphylococcus aureus (S. aureus) (19%), streptococci (11%), polymicrobial infections (10%), enterococci (9%), Gram-negative bacteria (6%) and others (4%). CoNS were the most common bacteria throughout the period but in the acute postoperative infections (< 3 weeks) S. aureus was the most frequent bacterial finding. We found no change in the distribution of the bacterial groups over time. S. aureus appears correlated with a higher C-reactive protein value (CRP) (mean 140 (95% Confidence interval (CI): 101-180)) than CoNS (mean 42 (CI: 31-53)). S. aureus also correlated with a higher erythrocyte sedimentation rate value (ESR) (mean 67 (CI: 55-79)) than CoNS (mean 47 (CI: 39-54)).
    Language English
    Publishing date 2015-09-30
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395994-0
    ISSN 1874-3250
    ISSN 1874-3250
    DOI 10.2174/1874325001509010445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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